LOCUS       NM_002895               5686 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens RB transcriptional corepressor like 1 (RBL1),
            transcript variant 1, mRNA.
ACCESSION   NM_002895
VERSION     NM_002895.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5686)
  AUTHORS   Nakanoh,S., Kadiwala,J., Pinte,L., Morell,C.M., Lenaerts,A.S. and
            Vallier,L.
  TITLE     Simultaneous depletion of RB, RBL1 and RBL2 affects endoderm
            differentiation of human embryonic stem cells
  JOURNAL   PLoS One 17 (11), e0269122 (2022)
   PUBMED   36413521
  REMARK    GeneRIF: Simultaneous depletion of RB, RBL1 and RBL2 affects
            endoderm differentiation of human embryonic stem cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5686)
  AUTHORS   Fowle,H., Zhao,Z., Xu,Q., Wasserman,J.S., Wang,X., Adeyemi,M.,
            Feiser,F., Kurimchak,A.N., Atar,D., McEwan,B.C., Kettenbach,A.N.,
            Page,R., Peti,W., Dunbrack,R.L. and Grana,X.
  TITLE     PP2A/B55alpha substrate recruitment as defined by the
            retinoblastoma-related protein p107
  JOURNAL   Elife 10, e63181 (2021)
   PUBMED   34661528
  REMARK    GeneRIF: PP2A/B55alpha substrate recruitment as defined by the
            retinoblastoma-related protein p107.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5686)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   4  (bases 1 to 5686)
  AUTHORS   Wong,P.F., Jamal,J., Tong,K.L., Khor,E.S., Yeap,C.E., Jong,H.L.,
            Lee,S.T., Mustafa,M.R. and Abubakar,S.
  TITLE     Deregulation of hsa-miR-20b expression in TNF-alpha-induced
            premature senescence of human pulmonary microvascular endothelial
            cells
  JOURNAL   Microvasc Res 114, 26-33 (2017)
   PUBMED   28595801
REFERENCE   5  (bases 1 to 5686)
  AUTHORS   Iwahori,S., Umana,A.C., VanDeusen,H.R. and Kalejta,R.F.
  TITLE     Human cytomegalovirus-encoded viral cyclin-dependent kinase (v-CDK)
            UL97 phosphorylates and inactivates the retinoblastoma
            protein-related p107 and p130 proteins
  JOURNAL   J Biol Chem 292 (16), 6583-6599 (2017)
   PUBMED   28289097
  REMARK    GeneRIF: UL97 phosphorylates and inactivates the retinoblastoma
            protein-related p107 and p130 proteins
REFERENCE   6  (bases 1 to 5686)
  AUTHORS   Datta,P.K., Raychaudhuri,P. and Bagchi,S.
  TITLE     Association of p107 with Sp1: genetically separable regions of p107
            are involved in regulation of E2F- and Sp1-dependent transcription
  JOURNAL   Mol Cell Biol 15 (10), 5444-5452 (1995)
   PUBMED   7565695
REFERENCE   7  (bases 1 to 5686)
  AUTHORS   Zhu,L., Zhu,L., Xie,E. and Chang,L.S.
  TITLE     Differential roles of two tandem E2F sites in repression of the
            human p107 promoter by retinoblastoma and p107 proteins
  JOURNAL   Mol Cell Biol 15 (7), 3552-3562 (1995)
   PUBMED   7791762
REFERENCE   8  (bases 1 to 5686)
  AUTHORS   Dyson,N., Guida,P., Munger,K. and Harlow,E.
  TITLE     Homologous sequences in adenovirus E1A and human papillomavirus E7
            proteins mediate interaction with the same set of cellular proteins
  JOURNAL   J Virol 66 (12), 6893-6902 (1992)
   PUBMED   1331501
REFERENCE   9  (bases 1 to 5686)
  AUTHORS   Faha,B., Ewen,M.E., Tsai,L.H., Livingston,D.M. and Harlow,E.
  TITLE     Interaction between human cyclin A and adenovirus E1A-associated
            p107 protein
  JOURNAL   Science 255 (5040), 87-90 (1992)
   PUBMED   1532458
REFERENCE   10 (bases 1 to 5686)
  AUTHORS   Ewen,M.E., Xing,Y.G., Lawrence,J.B. and Livingston,D.M.
  TITLE     Molecular cloning, chromosomal mapping, and expression of the cDNA
            for p107, a retinoblastoma gene product-related protein
  JOURNAL   Cell 66 (6), 1155-1164 (1991)
   PUBMED   1833063
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC375054.1, AK290380.1,
            AL365505.15 and BQ004524.1.
            
            On May 17, 2019 this sequence version replaced NM_002895.4.
            
            Summary: The protein encoded by this gene is similar in sequence
            and possibly function to the product of the retinoblastoma 1 (RB1)
            gene. The RB1 gene product is a tumor suppressor protein that
            appears to be involved in cell cycle regulation, as it is
            phosphorylated in the S to M phase transition and is
            dephosphorylated in the G1 phase of the cell cycle. Both the RB1
            protein and the product of this gene can form a complex with
            adenovirus E1A protein and SV40 large T-antigen, with the SV40
            large T-antigen binding only to the unphosphorylated form of each
            protein. In addition, both proteins can inhibit the transcription
            of cell cycle genes containing E2F binding sites in their
            promoters. Due to the sequence and biochemical similarities with
            the RB1 protein, it is thought that the protein encoded by this
            gene may also be a tumor suppressor. Two transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853566.17348.1,
                                           SRR14038194.549036.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373664.8/ ENSP00000362768.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 DC375054.1         221-226
            7-3472              AK290380.1         1-3466
            3473-5104           AL365505.15        87027-88658         c
            5105-5686           BQ004524.1         11-592              c
FEATURES             Location/Qualifiers
     source          1..5686
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.23"
     gene            1..5686
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
                     /note="RB transcriptional corepressor like 1"
                     /db_xref="GeneID:5933"
                     /db_xref="HGNC:HGNC:9893"
                     /db_xref="MIM:116957"
     exon            1..225
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..3276
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
                     /note="isoform a is encoded by transcript variant 1; 107
                     kDa retinoblastoma-associated protein; retinoblastoma-like
                     protein 1; retinoblastoma-like 1"
                     /codon_start=1
                     /product="retinoblastoma-like protein 1 isoform a"
                     /protein_id="NP_002886.2"
                     /db_xref="CCDS:CCDS13289.1"
                     /db_xref="GeneID:5933"
                     /db_xref="HGNC:HGNC:9893"
                     /db_xref="MIM:116957"
                     /translation="MFEDKPHAEGAAVVAAAGEALQALCQELNLDEGSAAEALDDFTA
                     IRGNYSLEGEVTHWLACSLYVACRKSIIPTVGKGIMEGNCVSLTRILRSAKLSLIQFF
                     SKMKKWMDMSNLPQEFRERIERLERNFEVSTVIFKKYEPIFLDIFQNPYEEPPKLPRS
                     RKQRRIPCSVKDLFNFCWTLFVYTKGNFRMIGDDLVNSYHLLLCCLDLIFANAIMCPN
                     RQDLLNPSFKGLPSDFHTADFTASEEPPCIIAVLCELHDGLLVEAKGIKEHYFKPYIS
                     KLFDRKILKGECLLDLSSFTDNSKAVNKEYEEYVLTVGDFDERIFLGADAEEEIGTPR
                     KFTRDTPLGKLTAQANVEYNLQQHFEKKRSFAPSTPLTGRRYLREKEAVITPVASATQ
                     SVSRLQSIVAGLKNAPSDQLINIFESCVRNPVENIMKILKGIGETFCQHYTQSTDEQP
                     GSHIDFAVNRLKLAEILYYKILETVMVQETRRLHGMDMSVLLEQDIFHRSLMACCLEI
                     VLFAYSSPRTFPWIIEVLNLQPFYFYKVIEVVIRSEEGLSRDMVKHLNSIEEQILESL
                     AWSHDSALWEALQVSANKVPTCEEVIFPNNFETGNGGNVQGHLPLMPMSPLMHPRVKE
                     VRTDSGSLRRDMQPLSPISVHERYSSPTAGSAKRRLFGEDPPKEMLMDKIITEGTKLK
                     IAPSSSITAENVSILPGQTLLTMATAPVTGTTGHKVTIPLHGVANDAGEITLIPLSMN
                     TNQESKVKSPVSLTAHSLIGASPKQTNLTKAQEVHSTGINRPKRTGSLALFYRKVYHL
                     ASVRLRDLCLKLDVSNELRRKIWTCFEFTLVHCPDLMKDRHLDQLLLCAFYIMAKVTK
                     EERTFQEIMKSYRNQPQANSHVYRSVLLKSIPREVVAYNKNINDDFEMIDCDLEDATK
                     TPDCSSGPVKEERGDLIKFYNTIYVGRVKSFALKYDLANQDHMMDAPPLSPFPHIKQQ
                     PGSPRRISQQHSIYISPHKNGSGLTPRSALLYKFNGSPSKSLKDINNMIRQGEQRTKK
                     RVIAIDSDAESPAKRVCQENDDVLLKRLQDVVSERANH"
     exon            226..359
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            360..560
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            561..625
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            626..754
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            755..915
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            916..965
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1152
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1319
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1432
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1536
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1674
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1839
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1972
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2239
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2451
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2452..2628
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..2700
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..2791
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2792..2940
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2941..3105
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3106..5686
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3295..3300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
                     /note="hexamer: GATAAA"
     polyA_site      3322
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
                     /note="major polyA site"
     regulatory      4222..4227
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
                     /note="hexamer: AATAAA"
     polyA_site      4251
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
     regulatory      5178..5183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
                     /note="hexamer: AACAAA"
     polyA_site      5203
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
     regulatory      5256..5261
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
                     /note="hexamer: TATAAA"
     polyA_site      5273
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
     polyA_site      5582
                     /gene="RBL1"
                     /gene_synonym="CP107; p107; PRB1"
ORIGIN      
        1 gtgggtagcg cgcctgggag ggagaaagaa gtcgggggcc gtggcgcgca gcccgcgggg
       61 cctgaaggga tgttcgagga caagccccac gctgaggggg cggcggtggt cgccgcagcc
      121 ggggaggcgc tacaggccct gtgccaggag ctgaacctgg acgaggggag cgcggccgaa
      181 gccctggacg actttactgc catccgaggc aactacagcc tagagggaga agttacacac
      241 tggttggcat gttcattata tgttgcatgc cgcaaaagca ttattcccac ggttggaaag
      301 ggtatcatgg aaggcaactg tgtttcactt accagaatac tacgttcagc taaattaagt
      361 ttaatacaat tttttagtaa aatgaagaaa tggatggaca tgtcaaatct accacaagaa
      421 tttcgtgaac gtatagaaag gctagagaga aattttgagg tgtctactgt aatattcaaa
      481 aaatatgagc caattttttt agatatattt caaaatccat atgaagaacc accaaagtta
      541 ccacgaagcc ggaagcagag gaggattcct tgcagtgtta aggatctgtt taatttctgt
      601 tggacacttt ttgtttatac taagggtaat tttcggatga ttggggatga cttagtaaac
      661 tcttatcatt tacttctatg ctgcttggat ctgatttttg ccaatgcgat tatgtgccca
      721 aatagacaag acttgctaaa tccatcattt aaaggtttac catctgattt tcatactgct
      781 gactttacgg cttctgaaga gccaccctgc atcattgctg tactgtgtga actgcatgat
      841 ggacttctcg tagaagcaaa aggaataaag gagcactact ttaagccata tatttcaaaa
      901 ctctttgaca ggaagatatt aaaaggagaa tgcctcctgg acctttcaag ttttactgat
      961 aatagcaaag cagtgaataa ggagtatgaa gagtatgttc taactgttgg tgattttgat
     1021 gagaggatct ttttgggagc agacgcagaa gaggaaattg gaacacctcg aaagttcact
     1081 cgtgacaccc cattagggaa actgacagca caggctaatg tggagtataa ccttcaacag
     1141 cactttgaaa aaaaaaggtc atttgcacct tctaccccac tgaccggacg gagatattta
     1201 cgagaaaaag aagcagtcat tactcctgtt gcatcagcca cccaaagtgt gagccggtta
     1261 cagagtattg tggctggtct gaaaaatgca ccaagtgacc aacttataaa tatttttgaa
     1321 tcttgtgtgc gtaatcctgt ggaaaacatt atgaaaatac taaaaggaat aggagagact
     1381 ttctgtcaac actatactca atcaacagat gaacagccag gatctcacat agactttgct
     1441 gtaaacagac taaagctggc agaaattttg tattataaaa tactagagac tgtaatggtt
     1501 caggaaacac gaagacttca tggaatggac atgtcagttc ttttagagca agatatattt
     1561 catcgttcct tgatggcttg ttgtttggaa attgtgctct ttgcctatag ctcacctcgt
     1621 acttttcctt ggattattga agttctcaac ttgcaaccat tttactttta taaggttatt
     1681 gaggtggtga tccgctcaga agaggggctc tcaagggaca tggtgaaaca cctaaacagc
     1741 attgaagaac agattttgga gagtttagca tggagtcacg attctgcact gtgggaggct
     1801 ctccaggttt ctgcaaacaa agttcctacc tgtgaagaag ttatattccc aaataacttt
     1861 gaaacaggaa atggaggaaa tgtgcaggga catcttcccc tgatgccaat gtctcctcta
     1921 atgcacccaa gagtcaagga agttcgaact gacagtggga gtcttcgaag agatatgcaa
     1981 ccattgtctc caatttctgt ccatgaacgc tacagttctc ctaccgcagg gagtgctaag
     2041 agaagactct ttggagagga ccccccaaag gaaatgctta tggacaagat cataacagaa
     2101 ggaacaaaat tgaaaatcgc tccttcttca agcattactg ctgaaaatgt atcaatttta
     2161 cctggtcaaa ctcttctaac aatggccaca gccccagtaa caggaacaac aggacataaa
     2221 gttacaattc cattacatgg tgtcgcaaat gatgctggag agatcacact gatacctctt
     2281 tccatgaata caaatcagga gtccaaagtc aagagtcctg tatcacttac tgctcattca
     2341 ttaattggtg cttctccaaa acagaccaat ctgactaaag cacaagaggt acattcaact
     2401 ggaataaaca ggccaaagag aactgggtcc ttagcactat tttacagaaa ggtctatcat
     2461 ttggcaagtg tacgcttacg tgatctatgt ctaaaactgg atgtttcaaa tgagttacga
     2521 aggaagatat ggacgtgttt tgaattcact ttagttcact gtcctgatct aatgaaagac
     2581 aggcatttgg atcagctcct cctttgtgcc ttttatatca tggcaaaggt aacaaaagaa
     2641 gaaagaactt ttcaagaaat tatgaaaagt tataggaatc agccccaagc taatagtcac
     2701 gtatatagaa gtgttctgct gaaaagtatt ccaagagaag ttgtggcata taataaaaat
     2761 ataaatgatg actttgaaat gatagattgt gacttagaag atgctacaaa aacacctgac
     2821 tgttccagtg gaccagtgaa agaggaaaga ggtgatctta taaaatttta caatacaata
     2881 tatgtaggaa gagtgaagtc atttgcactg aaatacgact tggcgaatca ggaccatatg
     2941 atggatgctc caccactctc tccttttcca catattaaac aacagccagg ctcaccacgc
     3001 cgcatttccc agcagcactc catttatatt tccccgcaca agaatgggtc aggccttaca
     3061 ccaagaagcg ctctgctgta caagttcaat ggcagccctt ctaagagttt gaaagatatc
     3121 aacaacatga taaggcaagg tgagcagaga accaagaagc gagtaatagc catcgatagt
     3181 gatgcagaat cccctgccaa acgcgtctgt caagaaaatg atgacgtttt actgaaacga
     3241 ctacaggatg ttgtcagtga aagagcaaat cattaatgtt gttcttgttt ctatgataaa
     3301 agcactttca gattgttctg cagaaagttg gagctctgtc cttcaaacct tttagcccta
     3361 tagatgataa atatcactgg gttataagaa aaaattgcac aaaaattatg tgctttttaa
     3421 aatatttatc caaaatgtag ttgacagaga tgtattttga gttggattgg aaaggaatat
     3481 tttaagtgcc ttttaaaaat actaatagtc cggccaggcg ctgtggctca cgcctgtaat
     3541 cccaggactt tgggaggcca aggcgggcag atcaccggag gtcaggagtt cgagaccagc
     3601 ctgaccaaca tggagaaacc ccatctctac taaaaataca aaattagccg ggtgtggtgg
     3661 cgcatgcctg taatcccagc tacttgggag gctgaggcag aattgcttga acccaggaag
     3721 cggaggttgt ggtgagccaa ggttgcgcca ctgcactcca gcctgggcaa caagagtaaa
     3781 actccatctc aaaaaatata tatatatata taaataggga atttttttta atgtttgctc
     3841 cttgagtttt caagatgaaa taaggagaaa ccccataact ttttagctct cttttaaaaa
     3901 taaatgtctc cttctgtgtt ctgtaatatg aggataaata atctactttt gatagcatgc
     3961 tttgagatat ttgtattctt aatttaatat tgaaggaagg ggttggttcc catagtacct
     4021 ggccagaggg ttatatacca tcctgtctct ggcccactgt ggtaattcca catccaggta
     4081 ccaccgccat tcagagttgt ctcacccctt ctcgtgcctt ttctctcctt gagctttata
     4141 aacagatttg tacctgagcc ccagtgctac actcatcctt gctttccagc cctaagccat
     4201 ctcagcctga tgtcacaacc caataaatgg ggcactttct tcttttgtaa actattatca
     4261 ttttggtttc tgtgacatta acttaattat atatgatcgt attaactcat gtagttctca
     4321 aaataggcag ctgcttctga agccagtaaa ataaaattca gttagttatt aaaaactaaa
     4381 ttcctattag taaggtaaca ccatgattat gtgtgatata ctgtttttga gatcatagtt
     4441 atcagtcatt ctcaatatct aattgagtcc ctaagaatat tttaaacctt ttaaaaatca
     4501 cataaatatc atctcatgcc tcataattct aatatattta atacatcagt aaaatagctg
     4561 cttattactt cccacacttt gttctcagta ttgttagtgc atcatgagtt tcctgctagt
     4621 gtttgaccac tgggtactcc tgaagatgtt ttttagtact agggatgctt ttcagtatta
     4681 gggatgcttt tttcagtact agggatgtac tagggagtac tgagtactcc tgaagatgtt
     4741 tttcagtact agggatgctt ttttcagtgt tagggatgct tttcagtact agggatgctt
     4801 ttttcagtgc tagggatgct tttcagtact agggatgctt tccaaaatat cacctcttta
     4861 acgtttactt tttctagtgt gtgtctggaa tccaaaggac atgaataagc cactcataat
     4921 taattttgag aagttttatc aaatgtttat gtttctaact gcaaacctta attttggaaa
     4981 ggcacaatgt ttaactcacc tatgtttaac catggctaat ttaaaatagt ctaagatttg
     5041 gccgtcacta attagtattc tcaagaattt catttttcaa ttttaagaag aaaagggatt
     5101 ttggtcacat tttgcttgta aatgaaaatt acatcctcat tctttgtgta gtatctacac
     5161 attgttataa gccaaaaaac aaagtctgtc tggaatcttt gtacatattt gtatgttgct
     5221 ataattgtta tttttatctt cattattgtg caaaatataa atgagcattt gtacattgac
     5281 tgtataagaa accatgggcc aggtcctgtg gctcatgcct ataatcccaa cactttggga
     5341 ggctgaggca ggaggattgc ttcagtccag gagttcaaga ctaacctggg caacatagcc
     5401 ctcatctcta caaaaaataa aaaaattagt tgggtgtgat ggcatgtgcc tgtagtccca
     5461 gctactcagg agactgacat gagaggatca cttgagactg ggagattctg aggctgcagt
     5521 gagctgtgat tgcaccacta cactccatcc taggtgagag ggcaagaccc tttctcagaa
     5581 aaggaaaaaa agaaattctg gacatgtttt tatcagtttt caggacttgg tatcaatgta
     5641 catagaatgg ctaataaaaa ttggaattga gattattgaa aaaaaa
//
