LOCUS       NM_022128               1247 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ribokinase (RBKS), transcript variant 1, mRNA.
ACCESSION   NM_022128
VERSION     NM_022128.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1247)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1247)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1247)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1247)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1247)
  AUTHORS   Quiroga-Roger,D., Babul,J. and Guixe,V.
  TITLE     Role of monovalent and divalent metal cations in human ribokinase
            catalysis and regulation
  JOURNAL   Biometals 28 (2), 401-413 (2015)
   PUBMED   25749547
  REMARK    GeneRIF: Asn199 and Glu202 play an important role in the regulation
            of human ribokinase activity.
REFERENCE   6  (bases 1 to 1247)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
REFERENCE   7  (bases 1 to 1247)
  AUTHORS   Park,J., van Koeverden,P., Singh,B. and Gupta,R.S.
  TITLE     Identification and characterization of human ribokinase and
            comparison of its properties with E. coli ribokinase and human
            adenosine kinase
  JOURNAL   FEBS Lett 581 (17), 3211-3216 (2007)
   PUBMED   17585908
  REMARK    GeneRIF: Identification and characterization of human ribokinase.
REFERENCE   8  (bases 1 to 1247)
  AUTHORS   Bork,P., Sander,C. and Valencia,A.
  TITLE     Convergent evolution of similar enzymatic function on different
            protein folds: the hexokinase, ribokinase, and galactokinase
            families of sugar kinases
  JOURNAL   Protein Sci 2 (1), 31-40 (1993)
   PUBMED   8382990
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC017425.1, AJ404857.1 and
            BF436282.1.
            
            On Nov 22, 2018 this sequence version replaced NM_022128.2.
            
            Summary: This gene encodes a member of the carbohydrate kinase PfkB
            family. The encoded protein phosphorylates ribose to form
            ribose-5-phosphate in the presence of ATP and magnesium as a first
            step in ribose metabolism. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Dec 2013].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.602201.1,
                                           SRR1660805.200425.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302188.8/ ENSP00000306817.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                BC017425.1         12-42
            32-1227             AJ404857.1         1-1196
            1228-1247           BF436282.1         21-40               c
FEATURES             Location/Qualifiers
     source          1..1247
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.2"
     gene            1..1247
                     /gene="RBKS"
                     /gene_synonym="RBSK; RK"
                     /note="ribokinase"
                     /db_xref="GeneID:64080"
                     /db_xref="HGNC:HGNC:30325"
                     /db_xref="MIM:611132"
     exon            1..131
                     /gene="RBKS"
                     /gene_synonym="RBSK; RK"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1011
                     /gene="RBKS"
                     /gene_synonym="RBSK; RK"
                     /EC_number="2.7.1.15"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="ribokinase isoform 1"
                     /protein_id="NP_071411.1"
                     /db_xref="CCDS:CCDS1762.1"
                     /db_xref="GeneID:64080"
                     /db_xref="HGNC:HGNC:30325"
                     /db_xref="MIM:611132"
                     /translation="MAASGEPQRQWQEEVAAVVVVGSCMTDLVSLTSRLPKTGETIHG
                     HKFFIGFGGKGANQCVQAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTK
                     DAATGTASIIVNNEGQNIIVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEITPATS
                     LEALTMARRSGVKTLFNPAPAIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAG
                     EAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALA
                     FYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSYPYKKDLPLTLF"
     exon            132..264
                     /gene="RBKS"
                     /gene_synonym="RBSK; RK"
                     /inference="alignment:Splign:2.1.0"
     exon            265..328
                     /gene="RBKS"
                     /gene_synonym="RBSK; RK"
                     /inference="alignment:Splign:2.1.0"
     exon            329..391
                     /gene="RBKS"
                     /gene_synonym="RBSK; RK"
                     /inference="alignment:Splign:2.1.0"
     exon            392..556
                     /gene="RBKS"
                     /gene_synonym="RBSK; RK"
                     /inference="alignment:Splign:2.1.0"
     exon            557..648
                     /gene="RBKS"
                     /gene_synonym="RBSK; RK"
                     /inference="alignment:Splign:2.1.0"
     exon            649..837
                     /gene="RBKS"
                     /gene_synonym="RBSK; RK"
                     /inference="alignment:Splign:2.1.0"
     exon            838..1247
                     /gene="RBKS"
                     /gene_synonym="RBSK; RK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1032..1037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBKS"
                     /gene_synonym="RBSK; RK"
                     /note="hexamer: AATATA"
     regulatory      1044..1049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBKS"
                     /gene_synonym="RBSK; RK"
                     /note="hexamer: AATAAA"
     polyA_site      1054
                     /gene="RBKS"
                     /gene_synonym="RBSK; RK"
                     /note="major polyA site"
     polyA_site      1088
                     /gene="RBKS"
                     /gene_synonym="RBSK; RK"
                     /note="major polyA site"
     polyA_site      1140
                     /gene="RBKS"
                     /gene_synonym="RBSK; RK"
                     /note="major polyA site"
     regulatory      1210..1215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBKS"
                     /gene_synonym="RBSK; RK"
                     /note="hexamer: ATTAAA"
     polyA_site      1247
                     /gene="RBKS"
                     /gene_synonym="RBSK; RK"
ORIGIN      
        1 gcagaggtca ccgtccaggt tggacagcag cacctttgag cgatggcggc gtctggggaa
       61 ccccagaggc agtggcaaga ggaggtggcg gcggtggtag tggtgggctc ctgcatgacc
      121 gacctggtca gtcttacttc tcgtttgcca aaaactggag aaaccatcca tggacataag
      181 ttttttattg gctttggagg gaaaggtgcc aaccagtgtg tccaagctgc tcggcttgga
      241 gcaatgacgt ccatggtgtg taaggttggc aaagattctt ttggcaatga ttatatagaa
      301 aacttaaaac agaatgatat ttctacagaa tttacatatc agactaaaga tgctgctaca
      361 ggaactgctt ctataattgt caataatgaa ggccagaata tcattgtcat agtggctgga
      421 gcaaatttac ttttgaatac ggaggatctg agggcagcag ccaatgtcat tagcagagcc
      481 aaagtcatgg tctgccagct cgaaataact ccagcaactt ctttggaagc cctaacaatg
      541 gcccgcagga gtggagtgaa aaccttgttc aatccagccc ctgccattgc tgacctggat
      601 ccccagttct acaccctctc agatgtgttc tgctgcaatg aaagtgaggc tgagatttta
      661 actggcctca cggtgggcag cgctgcagat gctggggagg ctgcattagt gctcttgaaa
      721 aggggctgcc aggtggtaat cattacctta ggggctgaag gatgtgtggt gctgtcacag
      781 acagaacctg agccaaagca cattcccaca gagaaagtca aggctgtgga taccacgggt
      841 gctggtgaca gctttgtggg agctctggcc ttctacctgg cttactatcc aaatctgtcc
      901 ttggaagaca tgctcaacag atccaatttc attgcagcag tcagtgtcca ggctgcagga
      961 acacagtcat cttaccctta caaaaaagac cttccgctta ctctgttttg attgctatta
     1021 gtcccaaaat aaatatacct gggaataaaa tgtacttggg ggtggctgct cctggctaat
     1081 gcttattaga aaatgtcctc gtcccctttc tttgcaaata ttagttcttt tacgaagtca
     1141 tcctcaagct tcaatttatt tataacgatg attcttttgc tttccatgca tttgcacaaa
     1201 acaaccagaa ttaaagattc cacaaccaag atctgtacaa acataaa
//
