LOCUS       NM_001099673             887 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ribosomal biogenesis factor (RBIS), transcript variant
            4, mRNA.
ACCESSION   NM_001099673
VERSION     NM_001099673.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 887)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 887)
  AUTHORS   Badertscher,L., Wild,T., Montellese,C., Alexander,L.T., Bammert,L.,
            Sarazova,M., Stebler,M., Csucs,G., Mayer,T.U., Zamboni,N., Zemp,I.,
            Horvath,P. and Kutay,U.
  TITLE     Genome-wide RNAi Screening Identifies Protein Modules Required for
            40S Subunit Synthesis in Human Cells
  JOURNAL   Cell Rep 13 (12), 2879-2891 (2015)
   PUBMED   26711351
REFERENCE   3  (bases 1 to 887)
  AUTHORS   Tafforeau,L., Zorbas,C., Langhendries,J.L., Mullineux,S.T.,
            Stamatopoulou,V., Mullier,R., Wacheul,L. and Lafontaine,D.L.
  TITLE     The complexity of human ribosome biogenesis revealed by systematic
            nucleolar screening of Pre-rRNA processing factors
  JOURNAL   Mol Cell 51 (4), 539-551 (2013)
   PUBMED   23973377
REFERENCE   4  (bases 1 to 887)
  AUTHORS   Orvedahl,A., Sumpter,R. Jr., Xiao,G., Ng,A., Zou,Z., Tang,Y.,
            Narimatsu,M., Gilpin,C., Sun,Q., Roth,M., Forst,C.V., Wrana,J.L.,
            Zhang,Y.E., Luby-Phelps,K., Xavier,R.J., Xie,Y. and Levine,B.
  TITLE     Image-based genome-wide siRNA screen identifies selective autophagy
            factors
  JOURNAL   Nature 480 (7375), 113-117 (2011)
   PUBMED   22020285
REFERENCE   5  (bases 1 to 887)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   6  (bases 1 to 887)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 887)
  AUTHORS   Kumar,S., Connor,J.R., Dodds,R.A., Halsey,W., Van Horn,M., Mao,J.,
            Sathe,G., Mui,P., Agarwal,P., Badger,A.M., Lee,J.C., Gowen,M. and
            Lark,M.W.
  TITLE     Identification and initial characterization of 5000 expressed
            sequenced tags (ESTs) each from adult human normal and
            osteoarthritic cartilage cDNA libraries
  JOURNAL   Osteoarthritis Cartilage 9 (7), 641-653 (2001)
   PUBMED   11597177
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC055092.1 and AC011773.9.
            
            On Nov 23, 2018 this sequence version replaced NM_001099673.2.
            
            Transcript Variant: This variant (4) differs in the 5' UTR,
            compared to variant 1. Variants 1-4 encode the same isoform (1).
            
            CCDS Note: The coding region was updated to include a 6-nt
            insertion found in the GRCh38 reference genome assembly and in
            aligning transcripts, resulting in two extra amino acids in the
            protein C-terminus.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.570162.1,
                                           SRR1660807.422880.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2150385, SAMEA2467146
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000619594.5/ ENSP00000484492.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-882               BC055092.1         5-886
            883-887             AC011773.9         116486-116490       c
FEATURES             Location/Qualifiers
     source          1..887
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.2"
     gene            1..887
                     /gene="RBIS"
                     /gene_synonym="C8orf59"
                     /note="ribosomal biogenesis factor"
                     /db_xref="GeneID:401466"
                     /db_xref="HGNC:HGNC:32235"
     exon            1..69
                     /gene="RBIS"
                     /gene_synonym="C8orf59"
                     /inference="alignment:Splign:2.1.0"
     exon            70..186
                     /gene="RBIS"
                     /gene_synonym="C8orf59"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..375
                     /gene="RBIS"
                     /gene_synonym="C8orf59"
                     /note="isoform 1 is encoded by transcript variant 4;
                     uncharacterized protein C8orf59; ribosome biogenesis
                     factor identified in screen"
                     /codon_start=1
                     /product="ribosomal biogenesis factor isoform 1"
                     /protein_id="NP_001093143.1"
                     /db_xref="CCDS:CCDS55255.1"
                     /db_xref="GeneID:401466"
                     /db_xref="HGNC:HGNC:32235"
                     /translation="MAKNKLRGPKSRNVFHIASQKNFKAKNKAKPVTTNLKKINIMNE
                     EKVNRVNKAFVNVQKELAHFAKSISLEPLQKELIPQQRHESKPVNVDEATRLMALL"
     exon            187..303
                     /gene="RBIS"
                     /gene_synonym="C8orf59"
                     /inference="alignment:Splign:2.1.0"
     exon            304..887
                     /gene="RBIS"
                     /gene_synonym="C8orf59"
                     /inference="alignment:Splign:2.1.0"
     regulatory      411..416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBIS"
                     /gene_synonym="C8orf59"
                     /note="hexamer: AATAAA"
     polyA_site      433
                     /gene="RBIS"
                     /gene_synonym="C8orf59"
                     /note="major polyA site"
     regulatory      866..871
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBIS"
                     /gene_synonym="C8orf59"
                     /note="hexamer: ATTAAA"
     polyA_site      887
                     /gene="RBIS"
                     /gene_synonym="C8orf59"
ORIGIN      
        1 ctagacgccg tacgtgccag atggtgttac ctggagctta aaaagctgca cgcaagtgtt
       61 aaacttctga caatggccaa gaacaaatta agagggccga agtccaggaa tgtatttcac
      121 atagccagcc aaaaaaactt taaggctaaa aacaaagcaa aaccagttac cactaatctt
      181 aagaagataa acattatgaa tgaggaaaaa gttaacagag taaataaagc ttttgtaaat
      241 gtacaaaagg aacttgcaca tttcgcaaaa agcatttcac ttgaacctct gcagaaagaa
      301 ctgattcctc agcagcgtca tgaaagcaaa ccagttaatg ttgatgaagc tacaagatta
      361 atggctctgt tgtaatatac tggtgatgca tctaattctc cacaaagacc aataaattga
      421 atgttttata caattttatt tttaaaaatc ttgttaatgt acaggcattg gcacatttta
      481 aaaacaaact acataaacag atctttccta taacctagga aagtggaatg tcagaagtca
      541 acaaaatgtg ataaacttaa agtgctaaaa cagaaggcac ttcacaaaat ctgttcactg
      601 aaacagttat atatcctcgt ttacatcctt cactttacaa gtggcagtga acgtctgttt
      661 ggatagaagg acatacagaa atacaggcag tttagtggca gtaaaaatat aagacaagta
      721 atgagtcctt ggccaacttg tttttgatga cctgtagtgt cctttaactt tcctccttaa
      781 gaagaaaaaa cagaaggatt cacaattaga agaaaagttg aaatccagaa tatagttact
      841 tttgggagtg gggacgtttg tggatattaa atcacttatc ccctaaa
//
