LOCUS       NM_001385814            3123 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens RNA binding fox-1 homolog 3 (RBFOX3), transcript
            variant 14, mRNA.
ACCESSION   NM_001385814
VERSION     NM_001385814.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3123)
  AUTHORS   Xu,Z., Zheng,L. and Li,S.
  TITLE     Paclitaxel-induced inhibition of NSCLC invasion and migration via
            RBFOX3-mediated circIGF1R biogenesis
  JOURNAL   Sci Rep 14 (1), 774 (2024)
   PUBMED   38191906
  REMARK    GeneRIF: Paclitaxel-induced inhibition of NSCLC invasion and
            migration via RBFOX3-mediated circIGF1R biogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3123)
  AUTHORS   Wang,X., Guo,Z., Zhu,H., Xin,J., Yuan,L., Qin,C., Wang,M.,
            Zhang,Z., Wang,Y. and Chu,H.
  TITLE     Genetic variants in splicing factor genes and susceptibility to
            bladder cancer
  JOURNAL   Gene 809, 146022 (2022)
   PUBMED   34673209
  REMARK    GeneRIF: Genetic variants in splicing factor genes and
            susceptibility to bladder cancer.
REFERENCE   3  (bases 1 to 3123)
  AUTHORS   Ungari,M., Manotti,L., Tanzi,G., Varotti,E., Ferrero,G.,
            Gusolfino,M.D., Trombatore,M., Cavazzuti,L. and Tolomini,M.
  TITLE     NeuN, a DNA-binding neuron-specific protein expressed by Merkel
            cell carcinoma: analysis of 15 cases
  JOURNAL   Pathologica 113 (6), 421-426 (2021)
   PUBMED   34974547
  REMARK    GeneRIF: NeuN, a DNA-binding neuron-specific protein expressed by
            Merkel cell carcinoma: analysis of 15 cases.
REFERENCE   4  (bases 1 to 3123)
  AUTHORS   Behesti,H., Kocabas,A., Buchholz,D.E., Carroll,T.S. and Hatten,M.E.
  TITLE     Altered temporal sequence of transcriptional regulators in the
            generation of human cerebellar granule cells
  JOURNAL   Elife 10, e67074 (2021)
   PUBMED   34842137
  REMARK    GeneRIF: Altered temporal sequence of transcriptional regulators in
            the generation of human cerebellar granule cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3123)
  AUTHORS   Tascon-Arcila,J., Rojas-Jimenez,S., Cornejo-Sanchez,D.,
            Gomez-Builes,P., Ucroz-Benavides,A., Holguin,B.M.,
            Restrepo-Arbelaez,D., Gomez-Castillo,C., Solarte-Mia,R.,
            Cornejo-Ochoa,W. and Pineda-Trujillo,N.
  TITLE     Differential Clinical Features in Colombian Patients With Rolandic
            Epilepsy and Suggestion of Unlikely Association With GRIN2A,
            RBFOX1, or RBFOX3 Gene Variants
  JOURNAL   J Child Neurol 36 (10), 875-882 (2021)
   PUBMED   34039076
  REMARK    GeneRIF: Differential Clinical Features in Colombian Patients With
            Rolandic Epilepsy and Suggestion of Unlikely Association With
            GRIN2A, RBFOX1, or RBFOX3 Gene Variants.
REFERENCE   6  (bases 1 to 3123)
  AUTHORS   Beaty,T.H., Taub,M.A., Scott,A.F., Murray,J.C., Marazita,M.L.,
            Schwender,H., Parker,M.M., Hetmanski,J.B., Balakrishnan,P.,
            Mansilla,M.A., Mangold,E., Ludwig,K.U., Noethen,M.M., Rubini,M.,
            Elcioglu,N. and Ruczinski,I.
  TITLE     Confirming genes influencing risk to cleft lip with/without cleft
            palate in a case-parent trio study
  JOURNAL   Hum Genet 132 (7), 771-781 (2013)
   PUBMED   23512105
  REMARK    GeneRIF: In addition, eight genes classified as 'second tier' hits
            in the original study (PAX7, THADA, COL8A1/FILIP1L, DCAF4L2,
            GADD45G, NTN1, RBFOX3 and FOXE1) showed evidence of linkage and
            association in this replication sample.
REFERENCE   7  (bases 1 to 3123)
  AUTHORS   Hagel,C., Treszl,A., Fehlert,J., Harder,J., von Haxthausen,F.,
            Kern,M., von Bueren,A.O. and Kordes,U.
  TITLE     Supra- and infratentorial pediatric ependymomas differ
            significantly in NeuN, p75 and GFAP expression
  JOURNAL   J Neurooncol 112 (2), 191-197 (2013)
   PUBMED   23371454
  REMARK    GeneRIF: High NeuN levels are associated with supratentorial
            ependymomas.
REFERENCE   8  (bases 1 to 3123)
  AUTHORS   Dredge,B.K. and Jensen,K.B.
  TITLE     NeuN/Rbfox3 nuclear and cytoplasmic isoforms differentially
            regulate alternative splicing and nonsense-mediated decay of Rbfox2
  JOURNAL   PLoS One 6 (6), e21585 (2011)
   PUBMED   21747913
REFERENCE   9  (bases 1 to 3123)
  AUTHORS   Kim,K.K., Adelstein,R.S. and Kawamoto,S.
  TITLE     Identification of neuronal nuclei (NeuN) as Fox-3, a new member of
            the Fox-1 gene family of splicing factors
  JOURNAL   J Biol Chem 284 (45), 31052-31061 (2009)
   PUBMED   19713214
  REMARK    GeneRIF: NeuN (neuronal nuclei) is a neuron-specific nuclear
            protein identified by anti-NeuN antibody, and widely used as the
            postmitotic neuron marker. NeuN is identified as the Fox-3 gene
            product by mass spectrometry, immunoblotting, RNAi, and
            immunostaining.
REFERENCE   10 (bases 1 to 3123)
  AUTHORS   Underwood,J.G., Boutz,P.L., Dougherty,J.D., Stoilov,P. and
            Black,D.L.
  TITLE     Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal
            splicing regulators in mammals
  JOURNAL   Mol Cell Biol 25 (22), 10005-10016 (2005)
   PUBMED   16260614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC233701.6, AC055858.18,
            AC020689.8, AC021534.19 and AC073624.28.
            
            Summary: This gene encodes a member of the RNA-binding FOX protein
            family which is involved in the regulation of alternative splicing
            of pre-mRNA. The protein has an N-terminal proline-rich region, an
            RNA recognition motif (RRM) domain, and a C-terminal alanine-rich
            region. This gene produces the neuronal nuclei (NeuN) antigen that
            has been widely used as a marker for post-mitotic neurons. This
            gene has its highest expression in the central nervous system and
            plays a prominent role in neural tissue development and regulation
            of adult brain function. Mutations in this gene have been
            associated with numerous neurological disorders. Alternative
            splicing of this gene results in multiple transcript variants
            encoding distinct isoforms. [provided by RefSeq, May 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR3476690.63973.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1968189,
                                    SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               AC233701.6         124379-124604
            227-371             AC055858.18        43075-43219
            372-472             AC020689.8         108171-108271
            473-727             AC021534.19        169552-169806
            728-865             AC021534.19        178512-178649
            866-919             AC021534.19        181174-181227
            920-962             AC021534.19        182046-182088
            963-1012            AC073624.28        1-50
            1013-1073           AC073624.28        1568-1628
            1074-1127           AC073624.28        5467-5520
            1128-1260           AC073624.28        5788-5920
            1261-1441           AC073624.28        6379-6559
            1442-1503           AC073624.28        7638-7699
            1504-1582           AC073624.28        8683-8761
            1583-3123           AC073624.28        12327-13867
FEATURES             Location/Qualifiers
     source          1..3123
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..3123
                     /gene="RBFOX3"
                     /gene_synonym="FOX-3; FOX3; HRNBP3; NEUN"
                     /note="RNA binding fox-1 homolog 3"
                     /db_xref="GeneID:146713"
                     /db_xref="HGNC:HGNC:27097"
                     /db_xref="MIM:616999"
     exon            1..226
                     /gene="RBFOX3"
                     /gene_synonym="FOX-3; FOX3; HRNBP3; NEUN"
                     /inference="alignment:Splign:2.1.0"
     exon            227..371
                     /gene="RBFOX3"
                     /gene_synonym="FOX-3; FOX3; HRNBP3; NEUN"
                     /inference="alignment:Splign:2.1.0"
     exon            372..472
                     /gene="RBFOX3"
                     /gene_synonym="FOX-3; FOX3; HRNBP3; NEUN"
                     /inference="alignment:Splign:2.1.0"
     exon            473..727
                     /gene="RBFOX3"
                     /gene_synonym="FOX-3; FOX3; HRNBP3; NEUN"
                     /inference="alignment:Splign:2.1.0"
     CDS             506..1585
                     /gene="RBFOX3"
                     /gene_synonym="FOX-3; FOX3; HRNBP3; NEUN"
                     /note="isoform 2 is encoded by transcript variant 14;
                     fox-1 homolog C; hexaribonucleotide binding protein 3;
                     neuN antigen; neuronal nuclei antigen; RNA binding
                     protein, fox-1 homolog 3"
                     /codon_start=1
                     /product="RNA binding protein fox-1 homolog 3 isoform 2"
                     /protein_id="NP_001372743.1"
                     /db_xref="CCDS:CCDS92410.1"
                     /db_xref="GeneID:146713"
                     /db_xref="HGNC:HGNC:27097"
                     /db_xref="MIM:616999"
                     /translation="MAQPYPPAQYPPPPQNGIPAEYAPPPPHPTQDYSGQTPVPTEHG
                     MTLYTPAQTHPEQPGSEASTQPIAGTQTVPQTDEAAQTDSQPLHPSDPTEKQQPKRLH
                     VSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFETSSDADRAREKLNG
                     TIVEGRKIEVNNATARVMTNKKTGNPYTNGWKLNPVVGAVYGPEFYAVTGFPYPTTGT
                     AVAYRGAHLRGRGRAVYNTFRAAPPPPPIPTYGAALEQTLVKMPVPWAGLAPCPLPPQ
                     QTPEPAYPTSPAFPPLSCPFASRVVYQDGFYGAEIYGGYAAYRYAQPAAAAAAYSDSY
                     GRVYAAADPYHHTIGPAATYSIGTM"
     exon            728..865
                     /gene="RBFOX3"
                     /gene_synonym="FOX-3; FOX3; HRNBP3; NEUN"
                     /inference="alignment:Splign:2.1.0"
     exon            866..919
                     /gene="RBFOX3"
                     /gene_synonym="FOX-3; FOX3; HRNBP3; NEUN"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1012
                     /gene="RBFOX3"
                     /gene_synonym="FOX-3; FOX3; HRNBP3; NEUN"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1073
                     /gene="RBFOX3"
                     /gene_synonym="FOX-3; FOX3; HRNBP3; NEUN"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1127
                     /gene="RBFOX3"
                     /gene_synonym="FOX-3; FOX3; HRNBP3; NEUN"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1260
                     /gene="RBFOX3"
                     /gene_synonym="FOX-3; FOX3; HRNBP3; NEUN"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1441
                     /gene="RBFOX3"
                     /gene_synonym="FOX-3; FOX3; HRNBP3; NEUN"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1503
                     /gene="RBFOX3"
                     /gene_synonym="FOX-3; FOX3; HRNBP3; NEUN"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1582
                     /gene="RBFOX3"
                     /gene_synonym="FOX-3; FOX3; HRNBP3; NEUN"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..3123
                     /gene="RBFOX3"
                     /gene_synonym="FOX-3; FOX3; HRNBP3; NEUN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3096..3101
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBFOX3"
                     /gene_synonym="FOX-3; FOX3; HRNBP3; NEUN"
                     /note="hexamer: AATAAA"
     polyA_site      3123
                     /gene="RBFOX3"
                     /gene_synonym="FOX-3; FOX3; HRNBP3; NEUN"
                     /note="major polyA site"
ORIGIN      
        1 agcagaacct cctcggacag cggccccagc cgggccccag cagctcgcgt ggtcggagga
       61 gaagcagctg ccacagctgc cgcccgagcc cggcctcgcg cgccccttgc cgctggctcg
      121 ccggtgcctg tgcggcccca ggacgccgct gcccgctcgg cggccgggat gcagccgggg
      181 catggccgcc ggcccccagt cacctgccgc ggggagcgct gagcccgttg aaattctgcc
      241 tctgagaagc taacagtctt cctgtggtcg ccactcctcc ccagcagccc cctccttgcc
      301 aaggacggtc cagaaggagc cccactgggg cctccccgct cagcaaagca gacctcacct
      361 cccactacca gcttgaagtc acagcagcca gaggaaattc tgccaccatt ttcccaggtc
      421 tgcagcccct ccagctggga acctgctcct ggagccatcc ctctgcaaac agagcgatca
      481 ggacgccacg gctccgcctg aagcgatggc ccagccctac ccccccgccc agtacccccc
      541 tccgccacag aacggcatcc ctgccgagta cgccccgccc ccaccgcacc ccacgcagga
      601 ctactccggc cagaccccgg tccccacaga gcatggcatg accctgtaca caccagcaca
      661 gacccacccc gagcagccag gctccgaggc cagcacacag cccatcgccg ggacccagac
      721 agtgccgcag acagacgagg cggcacagac ggacagccag ccgctccacc cctccgaccc
      781 tacagagaag cagcagccca agcggctaca cgtctccaac atccccttcc ggttcaggga
      841 ccccgacttg cggcaaatgt tcgggcaatt cggaaaaatt ttagacgtgg agatcatttt
      901 taacgagcgg ggctccaagg gttttgggtt tgtaactttt gaaactagct cagatgctga
      961 ccgagcccgg gagaagctga atgggacgat cgtagaggga cggaaaattg aggtcaataa
     1021 tgccacggcc cgagtgatga ccaacaagaa gacggggaac ccctacacca acggctggaa
     1081 gctaaatcca gtggtcggcg cagtctacgg gcctgaattc tatgcagtga cggggttccc
     1141 ctaccccacc accggcacag ccgttgccta ccggggcgca catcttcggg gccggggccg
     1201 ggccgtgtat aatacatttc gggctgcgcc acccccaccc cccatcccga cttacggagc
     1261 ggcactggag caaacgcttg ttaaaatgcc agtcccatgg gcggggctgg caccgtgccc
     1321 cctccctcct cagcagacac cggagccggc ctaccccacc tctccagcgt tcccaccact
     1381 ttcttgtccg tttgcttcca gggtcgtgta tcaggatgga ttttatggtg ctgagattta
     1441 tggaggctac gcagcctaca gatacgctca gcccgctgca gcggcggcag cctacagcga
     1501 cagttacggc agagtctacg cagctgccga cccgtaccat cacaccatcg ggcccgcggc
     1561 gacctacagc attggaacca tgtgaaacct tccaccgttt ccttctcgga ccatgaaggg
     1621 caaaaacaaa aaaacaaaaa aaatcacaaa acaaaaaaaa caaaaaaaga tgttaagatc
     1681 caagcaacaa aaaaaaaacc aaccaaacca agaggcatcc aaccaagtcc aagtcccgcg
     1741 tcctggccac acgcccgcac cgagggagca cgccggcagg ggcgccgagg agcggcccca
     1801 ggacaggacg gccccaccgc gtcctggctg gcagcacagt gggaacacgc ccctccgtct
     1861 caggcagtgg gggagttgga ggggaagggg cctcccttgt gggacccgtg gggggctctg
     1921 ttttccatcc agtcttcctt tcccagcccc caactcccaa gacagacagt gtggagccca
     1981 gcggcggcgg agcaggcccg ggcctgagca ggcaggcgct gctagcaaga cttgatcttt
     2041 gtggccagct gtgccagggg gccggcgggg ctgaggggtg cgggcagctt tcatcccagg
     2101 ggctccactg ggccccgtca ccctcctgtc gcgtcccctg cgtcccacct ccctcctgcc
     2161 cggcagtccc gcccgtgccc ccagcctggc gaggaagccg tccaacagta gccccggggc
     2221 cagctcccaa cagaaagggc tgacgtggct ccaggactca ggggcgctcc atgggaggac
     2281 gaaggaagcc cagccagcca ggagccactc ctcacacctc caagtgtggc caagtgggcc
     2341 ctgaggccaa ggacttactt gctcttcctg gccatctctc cctttctgga ggaggcccgg
     2401 ggcctgtgta caccaaggct gacctcgtgc tgcctgctgg gacccagccc tccctgccgc
     2461 tcccctgtga gcccagtcca ccgtgggcgc ccagggccag ggacgggcca gcgcccggct
     2521 gcatcgcgag gttgggagtc acagtggctg tgggcctgga cgggcacagc cagagcaggg
     2581 gcccatggga agggcaaggg atggggaagc ctgggccggc cccttccctg ctcccaaggc
     2641 aggtgtccag gtggcgggag cagcaccaag gacagccagg cttacccggt gggaggagca
     2701 ggagcagagc aggtggcagg gaggaacccc tggcgaggca gggagcactg aagtagggaa
     2761 gcagcaaaaa atacaggctc ccaacgtggc tccactgtct catgaagtgt caaaaattta
     2821 aaaatacacc tcactttcta ttcagcatca gctattgaaa tggaattctc cttttctatt
     2881 cccgttgtac atagccccac gccctgcctc cggctttgtc ctctgtacag agccccctgt
     2941 cccctctgct gttccggacc cttttcttgc agcagctcaa ccccccgact cactcagatc
     3001 cccaggactg cagccgagcc ccgggcttcc tttcttacca ttctgtatgc ttccaaggtg
     3061 tgaccattca aactaacagt attattaaga ttattaataa agatttcttt cttcaaacca
     3121 gga
//
