LOCUS       NM_001394115            7169 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens RNA binding fox-1 homolog 2 (RBFOX2), transcript
            variant 26, mRNA.
ACCESSION   NM_001394115 XM_017028688
VERSION     NM_001394115.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7169)
  AUTHORS   Maurin,M., Ranjouri,M., Megino-Luque,C., Newberg,J.Y., Du,D.,
            Martin,K., Miner,R.E. 3rd, Prater,M.S., Wee,D.K.B., Centeno,B.,
            Pruett-Miller,S.M., Stewart,P., Fleming,J.B., Yu,X.,
            Bravo-Cordero,J.J., Guccione,E., Black,M.A. and Mann,K.M.
  TITLE     RBFOX2 deregulation promotes pancreatic cancer progression and
            metastasis through alternative splicing
  JOURNAL   Nat Commun 14 (1), 8444 (2023)
   PUBMED   38114498
  REMARK    GeneRIF: RBFOX2 deregulation promotes pancreatic cancer progression
            and metastasis through alternative splicing.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7169)
  AUTHORS   Li,S., Chen,Y., Xie,Y., Zhan,H., Zeng,Y., Zeng,K., Wang,L.,
            Zhan,Z., Li,C., Zhao,L., Chen,X., Tan,Y., Wang,Z., Bu,J., Song,Y.,
            Deng,F. and Zhou,A.
  TITLE     FBXO7 Confers Mesenchymal Properties and Chemoresistance in
            Glioblastoma by Controlling Rbfox2-Mediated Alternative Splicing
  JOURNAL   Adv Sci (Weinh) 10 (33), e2303561 (2023)
   PUBMED   37822160
  REMARK    GeneRIF: FBXO7 Confers Mesenchymal Properties and Chemoresistance
            in Glioblastoma by Controlling Rbfox2-Mediated Alternative
            Splicing.
REFERENCE   3  (bases 1 to 7169)
  AUTHORS   Yang,Y., Lee,G.C., Nakagaki-Silva,E., Huang,Y., Peacey,M.,
            Partridge,R., Gooding,C. and Smith,C.W.J.
  TITLE     Cell-type specific regulator RBPMS switches alternative splicing
            via higher-order oligomerization and heterotypic interactions with
            other splicing regulators
  JOURNAL   Nucleic Acids Res 51 (18), 9961-9982 (2023)
   PUBMED   37548402
REFERENCE   4  (bases 1 to 7169)
  AUTHORS   Xie,S., Li,Z., Zhong,Y., Fang,Q., Ma,A., Wang,Y., Zeng,L., Lin,T.
            and Xie,D.
  TITLE     RBFOX2 confers tumor growth by PI3K/AKT and MAPK signaling in
            gastric cancer
  JOURNAL   Eur J Cancer Prev 32 (5), 468-477 (2023)
   PUBMED   37264873
  REMARK    GeneRIF: RBFOX2 confers tumor growth by PI3K/AKT and MAPK signaling
            in gastric cancer.
REFERENCE   5  (bases 1 to 7169)
  AUTHORS   Jbara,A., Lin,K.T., Stossel,C., Siegfried,Z., Shqerat,H.,
            Amar-Schwartz,A., Elyada,E., Mogilevsky,M., Raitses-Gurevich,M.,
            Johnson,J.L., Yaron,T.M., Ovadia,O., Jang,G.H., Danan-Gotthold,M.,
            Cantley,L.C., Levanon,E.Y., Gallinger,S., Krainer,A.R., Golan,T.
            and Karni,R.
  TITLE     RBFOX2 modulates a metastatic signature of alternative splicing in
            pancreatic cancer
  JOURNAL   Nature 617 (7959), 147-153 (2023)
   PUBMED   36949200
  REMARK    GeneRIF: RBFOX2 modulates a metastatic signature of alternative
            splicing in pancreatic cancer.
REFERENCE   6  (bases 1 to 7169)
  AUTHORS   Underwood,J.G., Boutz,P.L., Dougherty,J.D., Stoilov,P. and
            Black,D.L.
  TITLE     Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal
            splicing regulators in mammals
  JOURNAL   Mol Cell Biol 25 (22), 10005-10016 (2005)
   PUBMED   16260614
  REMARK    GeneRIF: Fox-1 and Fox-2 isoforms specifically activate splicing of
            neuronally regulated exons, which requires UGCAUG enhancer elements
REFERENCE   7  (bases 1 to 7169)
  AUTHORS   Collins,J.E., Goward,M.E., Cole,C.G., Smink,L.J., Huckle,E.J.,
            Knowles,S., Bye,J.M., Beare,D.M. and Dunham,I.
  TITLE     Reevaluating human gene annotation: a second-generation analysis of
            chromosome 22
  JOURNAL   Genome Res 13 (1), 27-36 (2003)
   PUBMED   12529303
REFERENCE   8  (bases 1 to 7169)
  AUTHORS   Norris,J.D., Fan,D., Sherk,A. and McDonnell,D.P.
  TITLE     A negative coregulator for the human ER
  JOURNAL   Mol Endocrinol 16 (3), 459-468 (2002)
   PUBMED   11875103
REFERENCE   9  (bases 1 to 7169)
  AUTHORS   Lieberman,A.P., Friedlich,D.L., Harmison,G., Howell,B.W.,
            Jordan,C.L., Breedlove,S.M. and Fischbeck,K.H.
  TITLE     Androgens regulate the mammalian homologues of invertebrate sex
            determination genes tra-2 and fox-1
  JOURNAL   Biochem Biophys Res Commun 282 (2), 499-506 (2001)
   PUBMED   11401487
REFERENCE   10 (bases 1 to 7169)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z95114.19, AL079295.1 and
            AL049748.2.
            
            On Apr 1, 2021 this sequence version replaced XM_017028688.1.
            
            Summary: This gene is one of several human genes similar to the C.
            elegans gene Fox-1. This gene encodes an RNA binding protein that
            is thought to be a key regulator of alternative exon splicing in
            the nervous system and other cell types. The protein binds to a
            conserved UGCAUG element found downstream of many alternatively
            spliced exons and promotes inclusion of the alternative exon in
            mature transcripts. The protein also interacts with the estrogen
            receptor 1 transcription factor and regulates estrogen receptor 1
            transcriptional activity. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2828498.1,
                                           SRR14038194.1604407.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-585               Z95114.19          12749-13333         c
            586-636             AL079295.1         145500-145550       c
            637-861             AL079295.1         16432-16656         c
            862-1005            AL049748.2         96467-96610         c
            1006-1059           AL049748.2         92892-92945         c
            1060-1152           AL049748.2         83124-83216         c
            1153-1213           AL049748.2         80290-80350         c
            1214-1267           AL049748.2         76282-76335         c
            1268-1360           AL049748.2         76069-76161         c
            1361-1493           AL049748.2         74755-74887         c
            1494-1582           AL049748.2         61340-61428         c
            1583-1655           AL049748.2         60790-60862         c
            1656-7169           AL049748.2         53603-59116         c
FEATURES             Location/Qualifiers
     source          1..7169
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..7169
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /note="RNA binding fox-1 homolog 2"
                     /db_xref="GeneID:23543"
                     /db_xref="HGNC:HGNC:9906"
                     /db_xref="MIM:612149"
     exon            1..585
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     CDS             400..1710
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /note="isoform 26 is encoded by transcript variant 26;
                     repressor of tamoxifen transcriptional activity; fox-1
                     homologue; fox-1 homolog B; RNA-binding motif protein 9;
                     hexaribonucleotide-binding protein 2; RNA binding protein,
                     fox-1 homolog 2"
                     /codon_start=1
                     /product="RNA binding protein fox-1 homolog 2 isoform 26"
                     /protein_id="NP_001381044.1"
                     /db_xref="GeneID:23543"
                     /db_xref="HGNC:HGNC:9906"
                     /db_xref="MIM:612149"
                     /translation="MAEGAQPHQPPQLGPGAAARGMKRESELELPVPGAGGDGADPGL
                     SKRPRTEEAAADGGGGMQNEPLTPGYHGFPARDSQGNQEPTTTPDAMVQPFTTIPFPP
                     PPQNGIPTEYGVPHTQDYAGQTGEHNLTLYGSTQAHGEQSSNSPSTQNGSLTTEGGAQ
                     TDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERG
                     SKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLS
                     PVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAA
                     AFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVDMQPTDMHSLLLQPQPPLLQPLQPLT
                     VTVMAGCTQPTPTMPLPLPLAMELALWRVYTEVATADLPPTEVT"
     exon            586..636
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            637..861
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1005
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1059
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1152
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1213
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1267
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1360
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1493
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1582
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1655
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..7169
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7150..7155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /note="hexamer: AATAAA"
     polyA_site      7169
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /note="major polyA site"
ORIGIN      
        1 ggaccgcccc cttcctccct cggccggcgt gctgtgaggg agagtgtgag ccagcgcggc
       61 cggtgggcga gctccgggag tgcgagaggc ggggcggcgc ggcgggccgg gccgggtttc
      121 gcgtgtgcgt gcgggggcgc gagcgagtgc tcatcacgac ccgccagtgg ccccgcgccg
      181 acaacccggc gggcgggcgg gcggggagca agcggtcagg caaggagcgg cggccgcgag
      241 gcgcggaggg gcgcggagtc cgctcgcgcg cacgcacgca cgcacgcggg ggcgggggca
      301 ggcgcgcgcc cgcctgtcgc gacagtcggg gccgaggccc agggggaggt ggcctgtcgc
      361 gggtcgcccg gctcccggag gcgagggggg cgcgggcgga tggcggaggg cgcccagccg
      421 catcagccgc ctcagctcgg gcccggcgcc gccgcccggg gcatgaagcg ggagtcggag
      481 ctggagctgc cggtgcccgg agcgggagga gacggagccg atcccggcct gagcaagcgg
      541 ccgcgcactg aggaggcggc ggccgacggt ggcggcggga tgcagaacga gcctctgact
      601 ccaggttatc atggattccc agcgcgggac agccagggta accaggagcc gacaacaact
      661 cctgacgcaa tggttcagcc ttttactacc atcccatttc caccacctcc gcagaatgga
      721 attcccacag agtatggggt gccacacact caagactatg ccggccagac cggtgagcat
      781 aacctgacac tctacggaag tacgcaagcc cacggggagc agagcagcaa ctcacccagc
      841 acacaaaatg gatctcttac gacagaaggt ggagcacaga cagacggcca gcagtcacag
      901 acacaaagta gtgaaaattc agagagtaaa tctaccccga aacggctgca tgtctctaat
      961 attcctttcc gcttccggga ccctgacctc cggcagatgt ttgggcagtt tggcaaaatc
     1021 ctagatgtag aaataatctt taatgaacgt ggctctaagg gattcgggtt cgtaactttc
     1081 gagaatagtg ctgatgcaga cagggccagg gagaaattac acggcaccgt ggtagagggc
     1141 cgtaaaatcg aggtgaataa tgctacagca cgtgtaatga ccaataagaa gatggtcaca
     1201 ccatatgcaa atggttggaa attaagccca gtagttggag ctgtatatgg tccggagtta
     1261 tatgcagcat ccagctttca agcagatgtg tccctaggca atgatgcagc agtgccccta
     1321 tcaggaagag ggggtatcaa cacttacatt cctttaatca ttcctggctt cccttaccct
     1381 actgcagcca ccacggcagc cgctttcaga ggagcccatt tgaggggcag agggcggaca
     1441 gtatatggtg cagtccgagc ggtacctcca acagccatcc ccgcctatcc aggggtggat
     1501 atgcagccta cagatatgca cagcctgcta ctgcaaccgc agccaccgct gctgcagccg
     1561 ctgcagccgc ttacagtgac ggttatggca gggtgtacac agccgacccc taccatgccc
     1621 ttgcccctgc cgctagctat ggagttggcg ctgtggcgag tttataccga ggtggctaca
     1681 gccgatttgc cccctactga agtgacgtga gacccctgca aatgggacag ccccccagtt
     1741 catgaggcct ggctattgca atatttacta gtagaggaac tctatagcaa gatgaagagg
     1801 aaaaacaaac aaacaaacaa aaaaaaacac aaaaaaagaa agaatacttt tttatacctc
     1861 actatgttct ttgaatatgt atttttcctt taaatttctg cctttaattc ttttgttcca
     1921 aagattgtgc atttttttct tttttttttt aaactgtggt aaaaaaaaaa aaaataatgc
     1981 atttccatgt ctgtatgtcc gtgcttagct tattctatca atcacggaag aggcagtcaa
     2041 ggaggaagga gagacattag gagccgataa atgcatctga tcagaaatca gcagacagaa
     2101 ttaccaaagt gtatctggtg ctgaatgact gggggacaag cagaagtgga agagatcttt
     2161 ctgcaacagg atattcttct agtcttctga gtttctggtc tttgacaggc aattctggtt
     2221 ggctgtggct ggaatccaca tgctgataga taggaatttg tgcttacaaa gcaggagaat
     2281 taaaaagacg ctttcctctc ctcttccctc ctgtcttctc cgttcttttt acaatcatct
     2341 tacacgcaca gcctgagaca gctggcatag tttttggaat tatagtattg atatttccaa
     2401 acgtgctctc agacagtgga taataaacac ctcattagga aaccgatctc agaatgaact
     2461 ctggagtatg aaaaagatca tttctttttg ttcctgtaac ctagcattcc ttctaggctt
     2521 cttctccttt aattgaacca cagcttagct catgtattct tttattaaca ccctgctctc
     2581 atgtccataa gattcaggaa tttaggaccc agggacagaa aagtgaataa gccagtgacc
     2641 agatttcccc cagatgtctt gaggattaga agtacaaatt gttgacagcc attaaagagg
     2701 gtgaggaagg gaaaaggaat attagaagat ctggtatttc ttactttttt cttgcctcag
     2761 aaagtacaaa gtttaaaaaa tagaataaag aatctgctgg ggaaagatag agtaccaggt
     2821 cctaggtcag tagtccctgg aagttttggt gatgaggaca tggaagggca ggcagaggca
     2881 ctttgtactt gctccaaagc cataggaatt ttcatcttcc agagccttta tgagtcactt
     2941 ctctatccac agtcttgagc ctgtggctat cccgctgagc ttctcactgt cctccaaaaa
     3001 caccccgctg agcacccgga ccactttgta cacattaaca ctacaggaca taaaatgcag
     3061 aggccctgag attgctgccc tcccatattg gaaggagggt ctgcgatggc aagggtcttc
     3121 tatatcacca gaaagagtcg cgcagtgagt cactgccgtt gccatctggc tgtaattttc
     3181 tatgttatca aggtaggagg gagtgtttct cttctagctg ttagatagaa ctgataaaag
     3241 caagtgtcct acagcatttc ccaaatgaag gcattaggaa atagaaaagc acggtctttt
     3301 tggctccctg gtctagtcac attggtacta gggtgacctt tcacccaagg gacagctgct
     3361 aaagggagta attcagagac atggagcttc tggttatggg tttgttttgg gtttgttttt
     3421 aactcctgcc tccacacatg ttcttgactg ataactgact catgtccctg aattaaaatg
     3481 actgacctat gacagcatca agcattcttt gtaagcagag tgatatatct gagagggcgt
     3541 tgacctgttg tgtagaatac atatcctttc ccccttcaga atcctgtctc gcctcgtaac
     3601 tgggagagag gctgtgcctg aaactagggg cgatgtcaag gaagctagag gcctcgatgc
     3661 aattattact gactctgggg aggaagacag agaataaggg gacaccaact gcccagtcca
     3721 ctggccattt ttaagggtcc ccccacccca agccaaagtt tggtttgttg ctgttaagac
     3781 aatttttgtt gtatgtatat aaatatttta gttagaggag cggggaatgg gatgcgggct
     3841 ttcacagttc tagggaatgg gggcagggag gattttgctt ttgcttttgc tttgagggag
     3901 aactttagct gactaaaaaa acagaagttt ggggtcatga tcacaaaggg gccattccca
     3961 aaagatggca agccacgtat tcagtggaga ctaggccaaa ttctaaatgg ttttatccat
     4021 agcaggggag aataggagaa tgagtttaag agtttttctc ttcttttttc ctagaaagag
     4081 gtaaggataa tgggaaaggt agagaaggcg gctcccacag accttttaag agaggcagaa
     4141 tcttgagctt gaggcacctt gagtgcatct cagttcagct ggttctggct gaggcctcca
     4201 aaggcaagct ctgtgctttc cagtggtttc tgctgcattt ccagggatgg tgtttaacac
     4261 cgcttcctcc agctcccttt tctaagaaag aataaatgga gttctgcttt ttatgaaagg
     4321 gtctttggtt ttcagtgtca acactgagaa ttggggctct tgcaagcatc tggatttcac
     4381 agtatcaacc tccccgtcac cttttgaact ttgagactcc gtacggtcaa cttcaccaga
     4441 ggcaggttgc tcgaagcagc actgcttgtc tgttcctgac tctggttctc actgtattaa
     4501 aaaagagagt cagaggagtc tggcatttcg tgagtttgtt agaggatgct ggctgataat
     4561 tccagaaaac ttactgatgc taaatcacag tacatgcatg attctttttc agctttacta
     4621 tagttcatga cctggacttt ctgtactctt ggaagctggg ctccttaaag gaggcctcta
     4681 gtgaacacct ttatctccat gtccctctta gagcccagag agctgcccat aggcattttc
     4741 cagaattcct catgtcacct agttcaattt ccattaactc agatcagcca ttgtgattca
     4801 ccatttgtca ggctctcagg tttaacaaaa cctactatca ccatcatcct tcaacagcca
     4861 cagtctgaat tgagccaaca tttttttttc tttgagaaag aagtggactg gggcacaact
     4921 tttagtctga ggggagctag tggaaatcta gacaatagaa gtcatcgata gcagcttttc
     4981 ctcaaatgtg tgactcctca ggggctaaac tgctcttagc ttagaattat gctttactag
     5041 agatctagca gataagtggg ttaatcacta ccatcctgta actagttata tagcttccag
     5101 acatgaggga gacatcaaac agggatggaa gcaaccccaa ggatatgcaa gaagggcatg
     5161 atgaaccccc ttccctctgg caggagaaca aggccaacca agggacagac tggaaagcac
     5221 ttagatgttt aaggaggaga aaggggaagc tttgaccagt ccttgccttt tgccaagttc
     5281 agccagttct ccgctgcttg caacctctag cgcagtaaca tttgcagaat tgcagatttt
     5341 cccccagata ctaggaggaa agggactttg gggggtgggg aaggggtcgt ggtgttttaa
     5401 aagcataagt tacctgtttg cactgtttta agataggaaa aaaaaatagt gggcaaggtg
     5461 aacatcagac gtaaatttgt gtgtttttat tttgtcatgc tcttgaaaat gtttgaccat
     5521 ttgtagtata cacagtgaaa cttgattctc tgttgcataa aacactatat ttttttggaa
     5581 atgttactgt ccaaaagcct cttccctccc tttccttttc ctatgtactt ccttcatact
     5641 tgctttactg atcagccagg caatagccat ccaagagcta gagcatgaaa cagggccctt
     5701 tccaagtagg ctctgggtgt cctaagccag cgtgtgccct ctggtttagt gagtgtaata
     5761 gagtccctgg cacctttctt tgcaaatgag gctaacagac cagactgcag caagttatca
     5821 gattcctcaa tcagatgcac taggagtgag gagcccaggg atggaggggg ttcctgaagt
     5881 attgcagttg gctgtagtag ctgagttctt ttccatgtta ccgaaactgt agccagttac
     5941 agtttactca ggaaaacggt agatcaattc agccatggta gtgctggttg gcagggattg
     6001 gtaacggaga gaactgctca tcagccaaaa ctcaagcctt gccttttagg aggccaccag
     6061 cagagggact tggtcctcct tgtctggtac ttgtgtacat gccggtgacc tgaggactcc
     6121 actcacactg gcgagcaaaa agggagcagt gattctcttt tctctcccca ccccctgccc
     6181 tttgttacca acaccagttt cccagggggt acatgagttt ctgaattttt aaaaaatgtt
     6241 tttggtttgg tttttctggg gactgataag tgctttaagc aatgtccata ccccgtcaag
     6301 actcccagct tagtcatttt cttgtatttt tctgttcaca gtatttgtgt gtgtgcttgt
     6361 tttggcagct cattttggct gtattatata ttgagtgatg aattgatcct cttttttccc
     6421 taagggatat gaattgtttt tcttgtgtta tattctgctt gtgaatagct ggagcaaacc
     6481 tggggctgac acgcgtaagc tagggctgca aagcgagaag agagccggtg gagtgtactt
     6541 gtccctgaca ggctgaccta cctgagtctc tgagcttttc agtccaaatc tttgcaaggc
     6601 tcaaaatgcc acagaacctc tcctcttctc cccactcccc atggcaggga ccggaccatc
     6661 cctacatgca acatgctgtt cctccagccc ctcccattgc catggcaaaa caggtacctt
     6721 tggggcatgg gggcattaca tgggatgctt gtgtaatcga ccacctagcc ttctctctcc
     6781 cctcccgtcc tcccccagaa tcacttccta ggacacccga gctgcttgcc cagggtcctg
     6841 tttccctgct aactccagag aagcatccca gggctttgtg acagtctcta attcccttcc
     6901 cttctcgtta agaatcatat tgtatagtag ctttcagacc atacagtatt cattgggtta
     6961 ctcctattat tatcaagtag ctggaattgt gaaggtcgga gtagttagat ctttagcttt
     7021 tattccttat ttttttgtat tactctccat gtgtataaat tattgatcat gttgctggct
     7081 tttataaact ctaagcgaag gaggagcact gcctcagcct ttgcacatgg taatgaagca
     7141 ctgtttttaa ataaaagaga gaaacacca
//
