LOCUS       NM_001349999            7212 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens RNA binding fox-1 homolog 2 (RBFOX2), transcript
            variant 18, mRNA.
ACCESSION   NM_001349999 XM_005261431
VERSION     NM_001349999.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7212)
  AUTHORS   Maurin,M., Ranjouri,M., Megino-Luque,C., Newberg,J.Y., Du,D.,
            Martin,K., Miner,R.E. 3rd, Prater,M.S., Wee,D.K.B., Centeno,B.,
            Pruett-Miller,S.M., Stewart,P., Fleming,J.B., Yu,X.,
            Bravo-Cordero,J.J., Guccione,E., Black,M.A. and Mann,K.M.
  TITLE     RBFOX2 deregulation promotes pancreatic cancer progression and
            metastasis through alternative splicing
  JOURNAL   Nat Commun 14 (1), 8444 (2023)
   PUBMED   38114498
  REMARK    GeneRIF: RBFOX2 deregulation promotes pancreatic cancer progression
            and metastasis through alternative splicing.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7212)
  AUTHORS   Li,S., Chen,Y., Xie,Y., Zhan,H., Zeng,Y., Zeng,K., Wang,L.,
            Zhan,Z., Li,C., Zhao,L., Chen,X., Tan,Y., Wang,Z., Bu,J., Song,Y.,
            Deng,F. and Zhou,A.
  TITLE     FBXO7 Confers Mesenchymal Properties and Chemoresistance in
            Glioblastoma by Controlling Rbfox2-Mediated Alternative Splicing
  JOURNAL   Adv Sci (Weinh) 10 (33), e2303561 (2023)
   PUBMED   37822160
  REMARK    GeneRIF: FBXO7 Confers Mesenchymal Properties and Chemoresistance
            in Glioblastoma by Controlling Rbfox2-Mediated Alternative
            Splicing.
REFERENCE   3  (bases 1 to 7212)
  AUTHORS   Yang,Y., Lee,G.C., Nakagaki-Silva,E., Huang,Y., Peacey,M.,
            Partridge,R., Gooding,C. and Smith,C.W.J.
  TITLE     Cell-type specific regulator RBPMS switches alternative splicing
            via higher-order oligomerization and heterotypic interactions with
            other splicing regulators
  JOURNAL   Nucleic Acids Res 51 (18), 9961-9982 (2023)
   PUBMED   37548402
REFERENCE   4  (bases 1 to 7212)
  AUTHORS   Xie,S., Li,Z., Zhong,Y., Fang,Q., Ma,A., Wang,Y., Zeng,L., Lin,T.
            and Xie,D.
  TITLE     RBFOX2 confers tumor growth by PI3K/AKT and MAPK signaling in
            gastric cancer
  JOURNAL   Eur J Cancer Prev 32 (5), 468-477 (2023)
   PUBMED   37264873
  REMARK    GeneRIF: RBFOX2 confers tumor growth by PI3K/AKT and MAPK signaling
            in gastric cancer.
REFERENCE   5  (bases 1 to 7212)
  AUTHORS   Jbara,A., Lin,K.T., Stossel,C., Siegfried,Z., Shqerat,H.,
            Amar-Schwartz,A., Elyada,E., Mogilevsky,M., Raitses-Gurevich,M.,
            Johnson,J.L., Yaron,T.M., Ovadia,O., Jang,G.H., Danan-Gotthold,M.,
            Cantley,L.C., Levanon,E.Y., Gallinger,S., Krainer,A.R., Golan,T.
            and Karni,R.
  TITLE     RBFOX2 modulates a metastatic signature of alternative splicing in
            pancreatic cancer
  JOURNAL   Nature 617 (7959), 147-153 (2023)
   PUBMED   36949200
  REMARK    GeneRIF: RBFOX2 modulates a metastatic signature of alternative
            splicing in pancreatic cancer.
REFERENCE   6  (bases 1 to 7212)
  AUTHORS   Underwood,J.G., Boutz,P.L., Dougherty,J.D., Stoilov,P. and
            Black,D.L.
  TITLE     Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal
            splicing regulators in mammals
  JOURNAL   Mol Cell Biol 25 (22), 10005-10016 (2005)
   PUBMED   16260614
  REMARK    GeneRIF: Fox-1 and Fox-2 isoforms specifically activate splicing of
            neuronally regulated exons, which requires UGCAUG enhancer elements
REFERENCE   7  (bases 1 to 7212)
  AUTHORS   Collins,J.E., Goward,M.E., Cole,C.G., Smink,L.J., Huckle,E.J.,
            Knowles,S., Bye,J.M., Beare,D.M. and Dunham,I.
  TITLE     Reevaluating human gene annotation: a second-generation analysis of
            chromosome 22
  JOURNAL   Genome Res 13 (1), 27-36 (2003)
   PUBMED   12529303
REFERENCE   8  (bases 1 to 7212)
  AUTHORS   Norris,J.D., Fan,D., Sherk,A. and McDonnell,D.P.
  TITLE     A negative coregulator for the human ER
  JOURNAL   Mol Endocrinol 16 (3), 459-468 (2002)
   PUBMED   11875103
REFERENCE   9  (bases 1 to 7212)
  AUTHORS   Lieberman,A.P., Friedlich,D.L., Harmison,G., Howell,B.W.,
            Jordan,C.L., Breedlove,S.M. and Fischbeck,K.H.
  TITLE     Androgens regulate the mammalian homologues of invertebrate sex
            determination genes tra-2 and fox-1
  JOURNAL   Biochem Biophys Res Commun 282 (2), 499-506 (2001)
   PUBMED   11401487
REFERENCE   10 (bases 1 to 7212)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z95114.19, AL079295.1 and
            AL049748.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 21, 2020 this sequence version replaced NM_001349999.1.
            
            Summary: This gene is one of several human genes similar to the C.
            elegans gene Fox-1. This gene encodes an RNA binding protein that
            is thought to be a key regulator of alternative exon splicing in
            the nervous system and other cell types. The protein binds to a
            conserved UGCAUG element found downstream of many alternatively
            spliced exons and promotes inclusion of the alternative exon in
            mature transcripts. The protein also interacts with the estrogen
            receptor 1 transcription factor and regulates estrogen receptor 1
            transcriptional activity. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.247388.1,
                                           SRR1803612.233046.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000695854.1/ ENSP00000512219.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-585               Z95114.19          12749-13333         c
            586-636             AL079295.1         145500-145550       c
            637-861             AL079295.1         16432-16656         c
            862-1008            AL049748.2         96467-96613         c
            1009-1062           AL049748.2         92892-92945         c
            1063-1155           AL049748.2         83124-83216         c
            1156-1216           AL049748.2         80290-80350         c
            1217-1270           AL049748.2         76282-76335         c
            1271-1363           AL049748.2         76069-76161         c
            1364-1496           AL049748.2         74755-74887         c
            1497-1536           AL049748.2         70972-71011         c
            1537-1625           AL049748.2         61340-61428         c
            1626-1698           AL049748.2         60790-60862         c
            1699-7212           AL049748.2         53603-59116         c
FEATURES             Location/Qualifiers
     source          1..7212
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..7212
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /note="RNA binding fox-1 homolog 2"
                     /db_xref="GeneID:23543"
                     /db_xref="HGNC:HGNC:9906"
                     /db_xref="MIM:612149"
     exon            1..585
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     CDS             400..1743
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /note="isoform 18 is encoded by transcript variant 18;
                     repressor of tamoxifen transcriptional activity; fox-1
                     homologue; fox-1 homolog B; RNA-binding motif protein 9;
                     hexaribonucleotide-binding protein 2; RNA binding protein,
                     fox-1 homolog 2"
                     /codon_start=1
                     /product="RNA binding protein fox-1 homolog 2 isoform 18"
                     /protein_id="NP_001336928.2"
                     /db_xref="CCDS:CCDS93157.1"
                     /db_xref="GeneID:23543"
                     /db_xref="HGNC:HGNC:9906"
                     /db_xref="MIM:612149"
                     /translation="MAEGAQPHQPPQLGPGAAARGMKRESELELPVPGAGGDGADPGL
                     SKRPRTEEAAADGGGGMQNEPLTPGYHGFPARDSQGNQEPTTTPDAMVQPFTTIPFPP
                     PPQNGIPTEYGVPHTQDYAGQTGEHNLTLYGSTQAHGEQSSNSPSTQNGSLTQTEGGA
                     QTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNER
                     GSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKL
                     SPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTA
                     AAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPAT
                     ATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSRFAPY"
     exon            586..636
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            637..861
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1008
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1062
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1155
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1216
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1270
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1363
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1496
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1536
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1625
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1698
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..7212
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7193..7198
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /note="hexamer: AATAAA"
     polyA_site      7212
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /note="major polyA site"
ORIGIN      
        1 ggaccgcccc cttcctccct cggccggcgt gctgtgaggg agagtgtgag ccagcgcggc
       61 cggtgggcga gctccgggag tgcgagaggc ggggcggcgc ggcgggccgg gccgggtttc
      121 gcgtgtgcgt gcgggggcgc gagcgagtgc tcatcacgac ccgccagtgg ccccgcgccg
      181 acaacccggc gggcgggcgg gcggggagca agcggtcagg caaggagcgg cggccgcgag
      241 gcgcggaggg gcgcggagtc cgctcgcgcg cacgcacgca cgcacgcggg ggcgggggca
      301 ggcgcgcgcc cgcctgtcgc gacagtcggg gccgaggccc agggggaggt ggcctgtcgc
      361 gggtcgcccg gctcccggag gcgagggggg cgcgggcgga tggcggaggg cgcccagccg
      421 catcagccgc ctcagctcgg gcccggcgcc gccgcccggg gcatgaagcg ggagtcggag
      481 ctggagctgc cggtgcccgg agcgggagga gacggagccg atcccggcct gagcaagcgg
      541 ccgcgcactg aggaggcggc ggccgacggt ggcggcggga tgcagaacga gcctctgact
      601 ccaggttatc atggattccc agcgcgggac agccagggta accaggagcc gacaacaact
      661 cctgacgcaa tggttcagcc ttttactacc atcccatttc caccacctcc gcagaatgga
      721 attcccacag agtatggggt gccacacact caagactatg ccggccagac cggtgagcat
      781 aacctgacac tctacggaag tacgcaagcc cacggggagc agagcagcaa ctcacccagc
      841 acacaaaatg gatctcttac gcagacagaa ggtggagcac agacagacgg ccagcagtca
      901 cagacacaaa gtagtgaaaa ttcagagagt aaatctaccc cgaaacggct gcatgtctct
      961 aatattcctt tccgcttccg ggaccctgac ctccggcaga tgtttgggca gtttggcaaa
     1021 atcctagatg tagaaataat ctttaatgaa cgtggctcta agggattcgg gttcgtaact
     1081 ttcgagaata gtgctgatgc agacagggcc agggagaaat tacacggcac cgtggtagag
     1141 ggccgtaaaa tcgaggtgaa taatgctaca gcacgtgtaa tgaccaataa gaagatggtc
     1201 acaccatatg caaatggttg gaaattaagc ccagtagttg gagctgtata tggtccggag
     1261 ttatatgcag catccagctt tcaagcagat gtgtccctag gcaatgatgc agcagtgccc
     1321 ctatcaggaa gagggggtat caacacttac attcctttaa tcattcctgg cttcccttac
     1381 cctactgcag ccaccacggc agccgctttc agaggagccc atttgagggg cagagggcgg
     1441 acagtatatg gtgcagtccg agcggtacct ccaacagcca tccccgccta tccaggtgtg
     1501 gtttaccagg acggatttta cggtgctgac ctctatggtg gatatgcagc ctacagatat
     1561 gcacagcctg ctactgcaac cgcagccacc gctgctgcag ccgctgcagc cgcttacagt
     1621 gacggttatg gcagggtgta cacagccgac ccctaccatg cccttgcccc tgccgctagc
     1681 tatggagttg gcgctgtggc gagtttatac cgaggtggct acagccgatt tgccccctac
     1741 tgaagtgacg tgagacccct gcaaatggga cagcccccca gttcatgagg cctggctatt
     1801 gcaatattta ctagtagagg aactctatag caagatgaag aggaaaaaca aacaaacaaa
     1861 caaaaaaaaa cacaaaaaaa gaaagaatac ttttttatac ctcactatgt tctttgaata
     1921 tgtatttttc ctttaaattt ctgcctttaa ttcttttgtt ccaaagattg tgcatttttt
     1981 tctttttttt tttaaactgt ggtaaaaaaa aaaaaaataa tgcatttcca tgtctgtatg
     2041 tccgtgctta gcttattcta tcaatcacgg aagaggcagt caaggaggaa ggagagacat
     2101 taggagccga taaatgcatc tgatcagaaa tcagcagaca gaattaccaa agtgtatctg
     2161 gtgctgaatg actgggggac aagcagaagt ggaagagatc tttctgcaac aggatattct
     2221 tctagtcttc tgagtttctg gtctttgaca ggcaattctg gttggctgtg gctggaatcc
     2281 acatgctgat agataggaat ttgtgcttac aaagcaggag aattaaaaag acgctttcct
     2341 ctcctcttcc ctcctgtctt ctccgttctt tttacaatca tcttacacgc acagcctgag
     2401 acagctggca tagtttttgg aattatagta ttgatatttc caaacgtgct ctcagacagt
     2461 ggataataaa cacctcatta ggaaaccgat ctcagaatga actctggagt atgaaaaaga
     2521 tcatttcttt ttgttcctgt aacctagcat tccttctagg cttcttctcc tttaattgaa
     2581 ccacagctta gctcatgtat tcttttatta acaccctgct ctcatgtcca taagattcag
     2641 gaatttagga cccagggaca gaaaagtgaa taagccagtg accagatttc ccccagatgt
     2701 cttgaggatt agaagtacaa attgttgaca gccattaaag agggtgagga agggaaaagg
     2761 aatattagaa gatctggtat ttcttacttt tttcttgcct cagaaagtac aaagtttaaa
     2821 aaatagaata aagaatctgc tggggaaaga tagagtacca ggtcctaggt cagtagtccc
     2881 tggaagtttt ggtgatgagg acatggaagg gcaggcagag gcactttgta cttgctccaa
     2941 agccatagga attttcatct tccagagcct ttatgagtca cttctctatc cacagtcttg
     3001 agcctgtggc tatcccgctg agcttctcac tgtcctccaa aaacaccccg ctgagcaccc
     3061 ggaccacttt gtacacatta acactacagg acataaaatg cagaggccct gagattgctg
     3121 ccctcccata ttggaaggag ggtctgcgat ggcaagggtc ttctatatca ccagaaagag
     3181 tcgcgcagtg agtcactgcc gttgccatct ggctgtaatt ttctatgtta tcaaggtagg
     3241 agggagtgtt tctcttctag ctgttagata gaactgataa aagcaagtgt cctacagcat
     3301 ttcccaaatg aaggcattag gaaatagaaa agcacggtct ttttggctcc ctggtctagt
     3361 cacattggta ctagggtgac ctttcaccca agggacagct gctaaaggga gtaattcaga
     3421 gacatggagc ttctggttat gggtttgttt tgggtttgtt tttaactcct gcctccacac
     3481 atgttcttga ctgataactg actcatgtcc ctgaattaaa atgactgacc tatgacagca
     3541 tcaagcattc tttgtaagca gagtgatata tctgagaggg cgttgacctg ttgtgtagaa
     3601 tacatatcct ttcccccttc agaatcctgt ctcgcctcgt aactgggaga gaggctgtgc
     3661 ctgaaactag gggcgatgtc aaggaagcta gaggcctcga tgcaattatt actgactctg
     3721 gggaggaaga cagagaataa ggggacacca actgcccagt ccactggcca tttttaaggg
     3781 tccccccacc ccaagccaaa gtttggtttg ttgctgttaa gacaattttt gttgtatgta
     3841 tataaatatt ttagttagag gagcggggaa tgggatgcgg gctttcacag ttctagggaa
     3901 tgggggcagg gaggattttg cttttgcttt tgctttgagg gagaacttta gctgactaaa
     3961 aaaacagaag tttggggtca tgatcacaaa ggggccattc ccaaaagatg gcaagccacg
     4021 tattcagtgg agactaggcc aaattctaaa tggttttatc catagcaggg gagaatagga
     4081 gaatgagttt aagagttttt ctcttctttt ttcctagaaa gaggtaagga taatgggaaa
     4141 ggtagagaag gcggctccca cagacctttt aagagaggca gaatcttgag cttgaggcac
     4201 cttgagtgca tctcagttca gctggttctg gctgaggcct ccaaaggcaa gctctgtgct
     4261 ttccagtggt ttctgctgca tttccaggga tggtgtttaa caccgcttcc tccagctccc
     4321 ttttctaaga aagaataaat ggagttctgc tttttatgaa agggtctttg gttttcagtg
     4381 tcaacactga gaattggggc tcttgcaagc atctggattt cacagtatca acctccccgt
     4441 caccttttga actttgagac tccgtacggt caacttcacc agaggcaggt tgctcgaagc
     4501 agcactgctt gtctgttcct gactctggtt ctcactgtat taaaaaagag agtcagagga
     4561 gtctggcatt tcgtgagttt gttagaggat gctggctgat aattccagaa aacttactga
     4621 tgctaaatca cagtacatgc atgattcttt ttcagcttta ctatagttca tgacctggac
     4681 tttctgtact cttggaagct gggctcctta aaggaggcct ctagtgaaca cctttatctc
     4741 catgtccctc ttagagccca gagagctgcc cataggcatt ttccagaatt cctcatgtca
     4801 cctagttcaa tttccattaa ctcagatcag ccattgtgat tcaccatttg tcaggctctc
     4861 aggtttaaca aaacctacta tcaccatcat ccttcaacag ccacagtctg aattgagcca
     4921 acattttttt ttctttgaga aagaagtgga ctggggcaca acttttagtc tgaggggagc
     4981 tagtggaaat ctagacaata gaagtcatcg atagcagctt ttcctcaaat gtgtgactcc
     5041 tcaggggcta aactgctctt agcttagaat tatgctttac tagagatcta gcagataagt
     5101 gggttaatca ctaccatcct gtaactagtt atatagcttc cagacatgag ggagacatca
     5161 aacagggatg gaagcaaccc caaggatatg caagaagggc atgatgaacc cccttccctc
     5221 tggcaggaga acaaggccaa ccaagggaca gactggaaag cacttagatg tttaaggagg
     5281 agaaagggga agctttgacc agtccttgcc ttttgccaag ttcagccagt tctccgctgc
     5341 ttgcaacctc tagcgcagta acatttgcag aattgcagat tttcccccag atactaggag
     5401 gaaagggact ttggggggtg gggaaggggt cgtggtgttt taaaagcata agttacctgt
     5461 ttgcactgtt ttaagatagg aaaaaaaaat agtgggcaag gtgaacatca gacgtaaatt
     5521 tgtgtgtttt tattttgtca tgctcttgaa aatgtttgac catttgtagt atacacagtg
     5581 aaacttgatt ctctgttgca taaaacacta tatttttttg gaaatgttac tgtccaaaag
     5641 cctcttccct ccctttcctt ttcctatgta cttccttcat acttgcttta ctgatcagcc
     5701 aggcaatagc catccaagag ctagagcatg aaacagggcc ctttccaagt aggctctggg
     5761 tgtcctaagc cagcgtgtgc cctctggttt agtgagtgta atagagtccc tggcaccttt
     5821 ctttgcaaat gaggctaaca gaccagactg cagcaagtta tcagattcct caatcagatg
     5881 cactaggagt gaggagccca gggatggagg gggttcctga agtattgcag ttggctgtag
     5941 tagctgagtt cttttccatg ttaccgaaac tgtagccagt tacagtttac tcaggaaaac
     6001 ggtagatcaa ttcagccatg gtagtgctgg ttggcaggga ttggtaacgg agagaactgc
     6061 tcatcagcca aaactcaagc cttgcctttt aggaggccac cagcagaggg acttggtcct
     6121 ccttgtctgg tacttgtgta catgccggtg acctgaggac tccactcaca ctggcgagca
     6181 aaaagggagc agtgattctc ttttctctcc ccaccccctg ccctttgtta ccaacaccag
     6241 tttcccaggg ggtacatgag tttctgaatt tttaaaaaat gtttttggtt tggtttttct
     6301 ggggactgat aagtgcttta agcaatgtcc ataccccgtc aagactccca gcttagtcat
     6361 tttcttgtat ttttctgttc acagtatttg tgtgtgtgct tgttttggca gctcattttg
     6421 gctgtattat atattgagtg atgaattgat cctctttttt ccctaaggga tatgaattgt
     6481 ttttcttgtg ttatattctg cttgtgaata gctggagcaa acctggggct gacacgcgta
     6541 agctagggct gcaaagcgag aagagagccg gtggagtgta cttgtccctg acaggctgac
     6601 ctacctgagt ctctgagctt ttcagtccaa atctttgcaa ggctcaaaat gccacagaac
     6661 ctctcctctt ctccccactc cccatggcag ggaccggacc atccctacat gcaacatgct
     6721 gttcctccag cccctcccat tgccatggca aaacaggtac ctttggggca tgggggcatt
     6781 acatgggatg cttgtgtaat cgaccaccta gccttctctc tcccctcccg tcctccccca
     6841 gaatcacttc ctaggacacc cgagctgctt gcccagggtc ctgtttccct gctaactcca
     6901 gagaagcatc ccagggcttt gtgacagtct ctaattccct tcccttctcg ttaagaatca
     6961 tattgtatag tagctttcag accatacagt attcattggg ttactcctat tattatcaag
     7021 tagctggaat tgtgaaggtc ggagtagtta gatctttagc ttttattcct tatttttttg
     7081 tattactctc catgtgtata aattattgat catgttgctg gcttttataa actctaagcg
     7141 aaggaggagc actgcctcag cctttgcaca tggtaatgaa gcactgtttt taaataaaag
     7201 agagaaacac ca
//
