LOCUS       NM_001349990            6692 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens RNA binding fox-1 homolog 2 (RBFOX2), transcript
            variant 10, mRNA.
ACCESSION   NM_001349990 XM_017028692
VERSION     NM_001349990.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6692)
  AUTHORS   Maurin,M., Ranjouri,M., Megino-Luque,C., Newberg,J.Y., Du,D.,
            Martin,K., Miner,R.E. 3rd, Prater,M.S., Wee,D.K.B., Centeno,B.,
            Pruett-Miller,S.M., Stewart,P., Fleming,J.B., Yu,X.,
            Bravo-Cordero,J.J., Guccione,E., Black,M.A. and Mann,K.M.
  TITLE     RBFOX2 deregulation promotes pancreatic cancer progression and
            metastasis through alternative splicing
  JOURNAL   Nat Commun 14 (1), 8444 (2023)
   PUBMED   38114498
  REMARK    GeneRIF: RBFOX2 deregulation promotes pancreatic cancer progression
            and metastasis through alternative splicing.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6692)
  AUTHORS   Li,S., Chen,Y., Xie,Y., Zhan,H., Zeng,Y., Zeng,K., Wang,L.,
            Zhan,Z., Li,C., Zhao,L., Chen,X., Tan,Y., Wang,Z., Bu,J., Song,Y.,
            Deng,F. and Zhou,A.
  TITLE     FBXO7 Confers Mesenchymal Properties and Chemoresistance in
            Glioblastoma by Controlling Rbfox2-Mediated Alternative Splicing
  JOURNAL   Adv Sci (Weinh) 10 (33), e2303561 (2023)
   PUBMED   37822160
  REMARK    GeneRIF: FBXO7 Confers Mesenchymal Properties and Chemoresistance
            in Glioblastoma by Controlling Rbfox2-Mediated Alternative
            Splicing.
REFERENCE   3  (bases 1 to 6692)
  AUTHORS   Yang,Y., Lee,G.C., Nakagaki-Silva,E., Huang,Y., Peacey,M.,
            Partridge,R., Gooding,C. and Smith,C.W.J.
  TITLE     Cell-type specific regulator RBPMS switches alternative splicing
            via higher-order oligomerization and heterotypic interactions with
            other splicing regulators
  JOURNAL   Nucleic Acids Res 51 (18), 9961-9982 (2023)
   PUBMED   37548402
REFERENCE   4  (bases 1 to 6692)
  AUTHORS   Xie,S., Li,Z., Zhong,Y., Fang,Q., Ma,A., Wang,Y., Zeng,L., Lin,T.
            and Xie,D.
  TITLE     RBFOX2 confers tumor growth by PI3K/AKT and MAPK signaling in
            gastric cancer
  JOURNAL   Eur J Cancer Prev 32 (5), 468-477 (2023)
   PUBMED   37264873
  REMARK    GeneRIF: RBFOX2 confers tumor growth by PI3K/AKT and MAPK signaling
            in gastric cancer.
REFERENCE   5  (bases 1 to 6692)
  AUTHORS   Jbara,A., Lin,K.T., Stossel,C., Siegfried,Z., Shqerat,H.,
            Amar-Schwartz,A., Elyada,E., Mogilevsky,M., Raitses-Gurevich,M.,
            Johnson,J.L., Yaron,T.M., Ovadia,O., Jang,G.H., Danan-Gotthold,M.,
            Cantley,L.C., Levanon,E.Y., Gallinger,S., Krainer,A.R., Golan,T.
            and Karni,R.
  TITLE     RBFOX2 modulates a metastatic signature of alternative splicing in
            pancreatic cancer
  JOURNAL   Nature 617 (7959), 147-153 (2023)
   PUBMED   36949200
  REMARK    GeneRIF: RBFOX2 modulates a metastatic signature of alternative
            splicing in pancreatic cancer.
REFERENCE   6  (bases 1 to 6692)
  AUTHORS   Underwood,J.G., Boutz,P.L., Dougherty,J.D., Stoilov,P. and
            Black,D.L.
  TITLE     Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal
            splicing regulators in mammals
  JOURNAL   Mol Cell Biol 25 (22), 10005-10016 (2005)
   PUBMED   16260614
  REMARK    GeneRIF: Fox-1 and Fox-2 isoforms specifically activate splicing of
            neuronally regulated exons, which requires UGCAUG enhancer elements
REFERENCE   7  (bases 1 to 6692)
  AUTHORS   Collins,J.E., Goward,M.E., Cole,C.G., Smink,L.J., Huckle,E.J.,
            Knowles,S., Bye,J.M., Beare,D.M. and Dunham,I.
  TITLE     Reevaluating human gene annotation: a second-generation analysis of
            chromosome 22
  JOURNAL   Genome Res 13 (1), 27-36 (2003)
   PUBMED   12529303
REFERENCE   8  (bases 1 to 6692)
  AUTHORS   Norris,J.D., Fan,D., Sherk,A. and McDonnell,D.P.
  TITLE     A negative coregulator for the human ER
  JOURNAL   Mol Endocrinol 16 (3), 459-468 (2002)
   PUBMED   11875103
REFERENCE   9  (bases 1 to 6692)
  AUTHORS   Lieberman,A.P., Friedlich,D.L., Harmison,G., Howell,B.W.,
            Jordan,C.L., Breedlove,S.M. and Fischbeck,K.H.
  TITLE     Androgens regulate the mammalian homologues of invertebrate sex
            determination genes tra-2 and fox-1
  JOURNAL   Biochem Biophys Res Commun 282 (2), 499-506 (2001)
   PUBMED   11401487
REFERENCE   10 (bases 1 to 6692)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z82217.1, AL079295.1 and
            AL049748.2.
            
            On May 31, 2019 this sequence version replaced NM_001349990.1.
            
            Summary: This gene is one of several human genes similar to the C.
            elegans gene Fox-1. This gene encodes an RNA binding protein that
            is thought to be a key regulator of alternative exon splicing in
            the nervous system and other cell types. The protein binds to a
            conserved UGCAUG element found downstream of many alternatively
            spliced exons and promotes inclusion of the alternative exon in
            mature transcripts. The protein also interacts with the estrogen
            receptor 1 transcription factor and regulates estrogen receptor 1
            transcriptional activity. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.107547.1,
                                           SRR1660803.117493.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                Z82217.1           18999-19066         c
            69-119              AL079295.1         145500-145550       c
            120-344             AL079295.1         16432-16656         c
            345-488             AL049748.2         96467-96610         c
            489-542             AL049748.2         92892-92945         c
            543-635             AL049748.2         83124-83216         c
            636-696             AL049748.2         80290-80350         c
            697-750             AL049748.2         76282-76335         c
            751-843             AL049748.2         76069-76161         c
            844-976             AL049748.2         74755-74887         c
            977-1016            AL049748.2         70972-71011         c
            1017-1105           AL049748.2         61340-61428         c
            1106-1178           AL049748.2         60790-60862         c
            1179-6692           AL049748.2         53603-59116         c
FEATURES             Location/Qualifiers
     source          1..6692
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..6692
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /note="RNA binding fox-1 homolog 2"
                     /db_xref="GeneID:23543"
                     /db_xref="HGNC:HGNC:9906"
                     /db_xref="MIM:612149"
     exon            1..68
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1223
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /note="isoform 10 is encoded by transcript variant 10;
                     repressor of tamoxifen transcriptional activity; fox-1
                     homologue; fox-1 homolog B; RNA-binding motif protein 9;
                     hexaribonucleotide-binding protein 2; RNA binding protein,
                     fox-1 homolog 2"
                     /codon_start=1
                     /product="RNA binding protein fox-1 homolog 2 isoform 10"
                     /protein_id="NP_001336919.1"
                     /db_xref="GeneID:23543"
                     /db_xref="HGNC:HGNC:9906"
                     /db_xref="MIM:612149"
                     /translation="MSSDSMDQPRNPCENEPLTPGYHGFPARDSQGNQEPTTTPDAMV
                     QPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTGEHNLTLYGSTQAHGEQSSNSPSTQN
                     GSLTTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKIL
                     DVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMV
                     TPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGF
                     PYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYA
                     AYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGY
                     SRFAPY"
     exon            69..119
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            120..344
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            345..488
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            489..542
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            543..635
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            636..696
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            697..750
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            751..843
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            844..976
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1016
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1105
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1178
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..6692
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6673..6678
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /note="hexamer: AATAAA"
     polyA_site      6692
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /note="major polyA site"
ORIGIN      
        1 agaattccag gaaggaagag agagtgatgt catcagattc catggaccag cccaggaacc
       61 cctgtgagaa cgagcctctg actccaggtt atcatggatt cccagcgcgg gacagccagg
      121 gtaaccagga gccgacaaca actcctgacg caatggttca gccttttact accatcccat
      181 ttccaccacc tccgcagaat ggaattccca cagagtatgg ggtgccacac actcaagact
      241 atgccggcca gaccggtgag cataacctga cactctacgg aagtacgcaa gcccacgggg
      301 agcagagcag caactcaccc agcacacaaa atggatctct tacgacagaa ggtggagcac
      361 agacagacgg ccagcagtca cagacacaaa gtagtgaaaa ttcagagagt aaatctaccc
      421 cgaaacggct gcatgtctct aatattcctt tccgcttccg ggaccctgac ctccggcaga
      481 tgtttgggca gtttggcaaa atcctagatg tagaaataat ctttaatgaa cgtggctcta
      541 agggattcgg gttcgtaact ttcgagaata gtgctgatgc agacagggcc agggagaaat
      601 tacacggcac cgtggtagag ggccgtaaaa tcgaggtgaa taatgctaca gcacgtgtaa
      661 tgaccaataa gaagatggtc acaccatatg caaatggttg gaaattaagc ccagtagttg
      721 gagctgtata tggtccggag ttatatgcag catccagctt tcaagcagat gtgtccctag
      781 gcaatgatgc agcagtgccc ctatcaggaa gagggggtat caacacttac attcctttaa
      841 tcattcctgg cttcccttac cctactgcag ccaccacggc agccgctttc agaggagccc
      901 atttgagggg cagagggcgg acagtatatg gtgcagtccg agcggtacct ccaacagcca
      961 tccccgccta tccaggtgtg gtttaccagg acggatttta cggtgctgac ctctatggtg
     1021 gatatgcagc ctacagatat gcacagcctg ctactgcaac cgcagccacc gctgctgcag
     1081 ccgctgcagc cgcttacagt gacggttatg gcagggtgta cacagccgac ccctaccatg
     1141 cccttgcccc tgccgctagc tatggagttg gcgctgtggc gagtttatac cgaggtggct
     1201 acagccgatt tgccccctac tgaagtgacg tgagacccct gcaaatggga cagcccccca
     1261 gttcatgagg cctggctatt gcaatattta ctagtagagg aactctatag caagatgaag
     1321 aggaaaaaca aacaaacaaa caaaaaaaaa cacaaaaaaa gaaagaatac ttttttatac
     1381 ctcactatgt tctttgaata tgtatttttc ctttaaattt ctgcctttaa ttcttttgtt
     1441 ccaaagattg tgcatttttt tctttttttt tttaaactgt ggtaaaaaaa aaaaaaataa
     1501 tgcatttcca tgtctgtatg tccgtgctta gcttattcta tcaatcacgg aagaggcagt
     1561 caaggaggaa ggagagacat taggagccga taaatgcatc tgatcagaaa tcagcagaca
     1621 gaattaccaa agtgtatctg gtgctgaatg actgggggac aagcagaagt ggaagagatc
     1681 tttctgcaac aggatattct tctagtcttc tgagtttctg gtctttgaca ggcaattctg
     1741 gttggctgtg gctggaatcc acatgctgat agataggaat ttgtgcttac aaagcaggag
     1801 aattaaaaag acgctttcct ctcctcttcc ctcctgtctt ctccgttctt tttacaatca
     1861 tcttacacgc acagcctgag acagctggca tagtttttgg aattatagta ttgatatttc
     1921 caaacgtgct ctcagacagt ggataataaa cacctcatta ggaaaccgat ctcagaatga
     1981 actctggagt atgaaaaaga tcatttcttt ttgttcctgt aacctagcat tccttctagg
     2041 cttcttctcc tttaattgaa ccacagctta gctcatgtat tcttttatta acaccctgct
     2101 ctcatgtcca taagattcag gaatttagga cccagggaca gaaaagtgaa taagccagtg
     2161 accagatttc ccccagatgt cttgaggatt agaagtacaa attgttgaca gccattaaag
     2221 agggtgagga agggaaaagg aatattagaa gatctggtat ttcttacttt tttcttgcct
     2281 cagaaagtac aaagtttaaa aaatagaata aagaatctgc tggggaaaga tagagtacca
     2341 ggtcctaggt cagtagtccc tggaagtttt ggtgatgagg acatggaagg gcaggcagag
     2401 gcactttgta cttgctccaa agccatagga attttcatct tccagagcct ttatgagtca
     2461 cttctctatc cacagtcttg agcctgtggc tatcccgctg agcttctcac tgtcctccaa
     2521 aaacaccccg ctgagcaccc ggaccacttt gtacacatta acactacagg acataaaatg
     2581 cagaggccct gagattgctg ccctcccata ttggaaggag ggtctgcgat ggcaagggtc
     2641 ttctatatca ccagaaagag tcgcgcagtg agtcactgcc gttgccatct ggctgtaatt
     2701 ttctatgtta tcaaggtagg agggagtgtt tctcttctag ctgttagata gaactgataa
     2761 aagcaagtgt cctacagcat ttcccaaatg aaggcattag gaaatagaaa agcacggtct
     2821 ttttggctcc ctggtctagt cacattggta ctagggtgac ctttcaccca agggacagct
     2881 gctaaaggga gtaattcaga gacatggagc ttctggttat gggtttgttt tgggtttgtt
     2941 tttaactcct gcctccacac atgttcttga ctgataactg actcatgtcc ctgaattaaa
     3001 atgactgacc tatgacagca tcaagcattc tttgtaagca gagtgatata tctgagaggg
     3061 cgttgacctg ttgtgtagaa tacatatcct ttcccccttc agaatcctgt ctcgcctcgt
     3121 aactgggaga gaggctgtgc ctgaaactag gggcgatgtc aaggaagcta gaggcctcga
     3181 tgcaattatt actgactctg gggaggaaga cagagaataa ggggacacca actgcccagt
     3241 ccactggcca tttttaaggg tccccccacc ccaagccaaa gtttggtttg ttgctgttaa
     3301 gacaattttt gttgtatgta tataaatatt ttagttagag gagcggggaa tgggatgcgg
     3361 gctttcacag ttctagggaa tgggggcagg gaggattttg cttttgcttt tgctttgagg
     3421 gagaacttta gctgactaaa aaaacagaag tttggggtca tgatcacaaa ggggccattc
     3481 ccaaaagatg gcaagccacg tattcagtgg agactaggcc aaattctaaa tggttttatc
     3541 catagcaggg gagaatagga gaatgagttt aagagttttt ctcttctttt ttcctagaaa
     3601 gaggtaagga taatgggaaa ggtagagaag gcggctccca cagacctttt aagagaggca
     3661 gaatcttgag cttgaggcac cttgagtgca tctcagttca gctggttctg gctgaggcct
     3721 ccaaaggcaa gctctgtgct ttccagtggt ttctgctgca tttccaggga tggtgtttaa
     3781 caccgcttcc tccagctccc ttttctaaga aagaataaat ggagttctgc tttttatgaa
     3841 agggtctttg gttttcagtg tcaacactga gaattggggc tcttgcaagc atctggattt
     3901 cacagtatca acctccccgt caccttttga actttgagac tccgtacggt caacttcacc
     3961 agaggcaggt tgctcgaagc agcactgctt gtctgttcct gactctggtt ctcactgtat
     4021 taaaaaagag agtcagagga gtctggcatt tcgtgagttt gttagaggat gctggctgat
     4081 aattccagaa aacttactga tgctaaatca cagtacatgc atgattcttt ttcagcttta
     4141 ctatagttca tgacctggac tttctgtact cttggaagct gggctcctta aaggaggcct
     4201 ctagtgaaca cctttatctc catgtccctc ttagagccca gagagctgcc cataggcatt
     4261 ttccagaatt cctcatgtca cctagttcaa tttccattaa ctcagatcag ccattgtgat
     4321 tcaccatttg tcaggctctc aggtttaaca aaacctacta tcaccatcat ccttcaacag
     4381 ccacagtctg aattgagcca acattttttt ttctttgaga aagaagtgga ctggggcaca
     4441 acttttagtc tgaggggagc tagtggaaat ctagacaata gaagtcatcg atagcagctt
     4501 ttcctcaaat gtgtgactcc tcaggggcta aactgctctt agcttagaat tatgctttac
     4561 tagagatcta gcagataagt gggttaatca ctaccatcct gtaactagtt atatagcttc
     4621 cagacatgag ggagacatca aacagggatg gaagcaaccc caaggatatg caagaagggc
     4681 atgatgaacc cccttccctc tggcaggaga acaaggccaa ccaagggaca gactggaaag
     4741 cacttagatg tttaaggagg agaaagggga agctttgacc agtccttgcc ttttgccaag
     4801 ttcagccagt tctccgctgc ttgcaacctc tagcgcagta acatttgcag aattgcagat
     4861 tttcccccag atactaggag gaaagggact ttggggggtg gggaaggggt cgtggtgttt
     4921 taaaagcata agttacctgt ttgcactgtt ttaagatagg aaaaaaaaat agtgggcaag
     4981 gtgaacatca gacgtaaatt tgtgtgtttt tattttgtca tgctcttgaa aatgtttgac
     5041 catttgtagt atacacagtg aaacttgatt ctctgttgca taaaacacta tatttttttg
     5101 gaaatgttac tgtccaaaag cctcttccct ccctttcctt ttcctatgta cttccttcat
     5161 acttgcttta ctgatcagcc aggcaatagc catccaagag ctagagcatg aaacagggcc
     5221 ctttccaagt aggctctggg tgtcctaagc cagcgtgtgc cctctggttt agtgagtgta
     5281 atagagtccc tggcaccttt ctttgcaaat gaggctaaca gaccagactg cagcaagtta
     5341 tcagattcct caatcagatg cactaggagt gaggagccca gggatggagg gggttcctga
     5401 agtattgcag ttggctgtag tagctgagtt cttttccatg ttaccgaaac tgtagccagt
     5461 tacagtttac tcaggaaaac ggtagatcaa ttcagccatg gtagtgctgg ttggcaggga
     5521 ttggtaacgg agagaactgc tcatcagcca aaactcaagc cttgcctttt aggaggccac
     5581 cagcagaggg acttggtcct ccttgtctgg tacttgtgta catgccggtg acctgaggac
     5641 tccactcaca ctggcgagca aaaagggagc agtgattctc ttttctctcc ccaccccctg
     5701 ccctttgtta ccaacaccag tttcccaggg ggtacatgag tttctgaatt tttaaaaaat
     5761 gtttttggtt tggtttttct ggggactgat aagtgcttta agcaatgtcc ataccccgtc
     5821 aagactccca gcttagtcat tttcttgtat ttttctgttc acagtatttg tgtgtgtgct
     5881 tgttttggca gctcattttg gctgtattat atattgagtg atgaattgat cctctttttt
     5941 ccctaaggga tatgaattgt ttttcttgtg ttatattctg cttgtgaata gctggagcaa
     6001 acctggggct gacacgcgta agctagggct gcaaagcgag aagagagccg gtggagtgta
     6061 cttgtccctg acaggctgac ctacctgagt ctctgagctt ttcagtccaa atctttgcaa
     6121 ggctcaaaat gccacagaac ctctcctctt ctccccactc cccatggcag ggaccggacc
     6181 atccctacat gcaacatgct gttcctccag cccctcccat tgccatggca aaacaggtac
     6241 ctttggggca tgggggcatt acatgggatg cttgtgtaat cgaccaccta gccttctctc
     6301 tcccctcccg tcctccccca gaatcacttc ctaggacacc cgagctgctt gcccagggtc
     6361 ctgtttccct gctaactcca gagaagcatc ccagggcttt gtgacagtct ctaattccct
     6421 tcccttctcg ttaagaatca tattgtatag tagctttcag accatacagt attcattggg
     6481 ttactcctat tattatcaag tagctggaat tgtgaaggtc ggagtagtta gatctttagc
     6541 ttttattcct tatttttttg tattactctc catgtgtata aattattgat catgttgctg
     6601 gcttttataa actctaagcg aaggaggagc actgcctcag cctttgcaca tggtaatgaa
     6661 gcactgtttt taaataaaag agagaaacac ca
//
