LOCUS       NM_001082576            6846 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens RNA binding fox-1 homolog 2 (RBFOX2), transcript
            variant 3, mRNA.
ACCESSION   NM_001082576
VERSION     NM_001082576.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6846)
  AUTHORS   Maurin,M., Ranjouri,M., Megino-Luque,C., Newberg,J.Y., Du,D.,
            Martin,K., Miner,R.E. 3rd, Prater,M.S., Wee,D.K.B., Centeno,B.,
            Pruett-Miller,S.M., Stewart,P., Fleming,J.B., Yu,X.,
            Bravo-Cordero,J.J., Guccione,E., Black,M.A. and Mann,K.M.
  TITLE     RBFOX2 deregulation promotes pancreatic cancer progression and
            metastasis through alternative splicing
  JOURNAL   Nat Commun 14 (1), 8444 (2023)
   PUBMED   38114498
  REMARK    GeneRIF: RBFOX2 deregulation promotes pancreatic cancer progression
            and metastasis through alternative splicing.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6846)
  AUTHORS   Li,S., Chen,Y., Xie,Y., Zhan,H., Zeng,Y., Zeng,K., Wang,L.,
            Zhan,Z., Li,C., Zhao,L., Chen,X., Tan,Y., Wang,Z., Bu,J., Song,Y.,
            Deng,F. and Zhou,A.
  TITLE     FBXO7 Confers Mesenchymal Properties and Chemoresistance in
            Glioblastoma by Controlling Rbfox2-Mediated Alternative Splicing
  JOURNAL   Adv Sci (Weinh) 10 (33), e2303561 (2023)
   PUBMED   37822160
  REMARK    GeneRIF: FBXO7 Confers Mesenchymal Properties and Chemoresistance
            in Glioblastoma by Controlling Rbfox2-Mediated Alternative
            Splicing.
REFERENCE   3  (bases 1 to 6846)
  AUTHORS   Yang,Y., Lee,G.C., Nakagaki-Silva,E., Huang,Y., Peacey,M.,
            Partridge,R., Gooding,C. and Smith,C.W.J.
  TITLE     Cell-type specific regulator RBPMS switches alternative splicing
            via higher-order oligomerization and heterotypic interactions with
            other splicing regulators
  JOURNAL   Nucleic Acids Res 51 (18), 9961-9982 (2023)
   PUBMED   37548402
REFERENCE   4  (bases 1 to 6846)
  AUTHORS   Xie,S., Li,Z., Zhong,Y., Fang,Q., Ma,A., Wang,Y., Zeng,L., Lin,T.
            and Xie,D.
  TITLE     RBFOX2 confers tumor growth by PI3K/AKT and MAPK signaling in
            gastric cancer
  JOURNAL   Eur J Cancer Prev 32 (5), 468-477 (2023)
   PUBMED   37264873
  REMARK    GeneRIF: RBFOX2 confers tumor growth by PI3K/AKT and MAPK signaling
            in gastric cancer.
REFERENCE   5  (bases 1 to 6846)
  AUTHORS   Jbara,A., Lin,K.T., Stossel,C., Siegfried,Z., Shqerat,H.,
            Amar-Schwartz,A., Elyada,E., Mogilevsky,M., Raitses-Gurevich,M.,
            Johnson,J.L., Yaron,T.M., Ovadia,O., Jang,G.H., Danan-Gotthold,M.,
            Cantley,L.C., Levanon,E.Y., Gallinger,S., Krainer,A.R., Golan,T.
            and Karni,R.
  TITLE     RBFOX2 modulates a metastatic signature of alternative splicing in
            pancreatic cancer
  JOURNAL   Nature 617 (7959), 147-153 (2023)
   PUBMED   36949200
  REMARK    GeneRIF: RBFOX2 modulates a metastatic signature of alternative
            splicing in pancreatic cancer.
REFERENCE   6  (bases 1 to 6846)
  AUTHORS   Underwood,J.G., Boutz,P.L., Dougherty,J.D., Stoilov,P. and
            Black,D.L.
  TITLE     Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal
            splicing regulators in mammals
  JOURNAL   Mol Cell Biol 25 (22), 10005-10016 (2005)
   PUBMED   16260614
  REMARK    GeneRIF: Fox-1 and Fox-2 isoforms specifically activate splicing of
            neuronally regulated exons, which requires UGCAUG enhancer elements
REFERENCE   7  (bases 1 to 6846)
  AUTHORS   Collins,J.E., Goward,M.E., Cole,C.G., Smink,L.J., Huckle,E.J.,
            Knowles,S., Bye,J.M., Beare,D.M. and Dunham,I.
  TITLE     Reevaluating human gene annotation: a second-generation analysis of
            chromosome 22
  JOURNAL   Genome Res 13 (1), 27-36 (2003)
   PUBMED   12529303
REFERENCE   8  (bases 1 to 6846)
  AUTHORS   Norris,J.D., Fan,D., Sherk,A. and McDonnell,D.P.
  TITLE     A negative coregulator for the human ER
  JOURNAL   Mol Endocrinol 16 (3), 459-468 (2002)
   PUBMED   11875103
REFERENCE   9  (bases 1 to 6846)
  AUTHORS   Lieberman,A.P., Friedlich,D.L., Harmison,G., Howell,B.W.,
            Jordan,C.L., Breedlove,S.M. and Fischbeck,K.H.
  TITLE     Androgens regulate the mammalian homologues of invertebrate sex
            determination genes tra-2 and fox-1
  JOURNAL   Biochem Biophys Res Commun 282 (2), 499-506 (2001)
   PUBMED   11401487
REFERENCE   10 (bases 1 to 6846)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA493176.1, CR456559.1,
            AL049748.2 and AA610054.1.
            
            On May 31, 2019 this sequence version replaced NM_001082576.2.
            
            Summary: This gene is one of several human genes similar to the C.
            elegans gene Fox-1. This gene encodes an RNA binding protein that
            is thought to be a key regulator of alternative exon splicing in
            the nervous system and other cell types. The protein binds to a
            conserved UGCAUG element found downstream of many alternatively
            spliced exons and promotes inclusion of the alternative exon in
            mature transcripts. The protein also interacts with the estrogen
            receptor 1 transcription factor and regulates estrogen receptor 1
            transcriptional activity. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.13853.1,
                                           SRR3476690.518867.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               DA493176.1         124-303
            181-1434            CR456559.1         1-1254
            1435-6520           AL049748.2         53929-59014         c
            6521-6846           AA610054.1         9-334               c
FEATURES             Location/Qualifiers
     source          1..6846
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..6846
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /note="RNA binding fox-1 homolog 2"
                     /db_xref="GeneID:23543"
                     /db_xref="HGNC:HGNC:9906"
                     /db_xref="MIM:612149"
     exon            1..273
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..1377
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /note="isoform 3 is encoded by transcript variant 3;
                     repressor of tamoxifen transcriptional activity; fox-1
                     homologue; fox-1 homolog B; RNA-binding motif protein 9;
                     hexaribonucleotide-binding protein 2; RNA binding protein,
                     fox-1 homolog 2"
                     /codon_start=1
                     /product="RNA binding protein fox-1 homolog 2 isoform 3"
                     /protein_id="NP_001076045.1"
                     /db_xref="CCDS:CCDS46701.1"
                     /db_xref="GeneID:23543"
                     /db_xref="HGNC:HGNC:9906"
                     /db_xref="MIM:612149"
                     /translation="MEKKKMVTQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGV
                     PHTQDYAGQTGEHNLTLYGSTQAHGEQSSNSPSTQNGSLTTEGGAQTDGQQSQTQSSE
                     NSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENS
                     ADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELY
                     AASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGR
                     TVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAA
                     YSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSRFAPY"
     exon            274..498
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            499..642
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            643..696
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            697..789
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            790..850
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            851..904
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            905..997
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1130
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1170
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1259
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1332
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..6846
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6827..6832
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /note="hexamer: AATAAA"
     polyA_site      6846
                     /gene="RBFOX2"
                     /gene_synonym="dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2;
                     HRNBP2; RBM9; RTA"
                     /note="major polyA site"
ORIGIN      
        1 cttcagccat ctgcctgaga tatgggaggg agctggagaa agaaggaggg ggagagactg
       61 ccagagagga agagaaaaga aaggaagaaa cattagaaag aaaaaggaag gaaaacggta
      121 taaagagaga tcaattaccc acccttaaat agctagattg gggggggagg ggggtggaaa
      181 agaaagctgt ggaggtgtgc cccagcacgg ctgctttgaa aggtttatca tctatccgtt
      241 tggtttatgg agaaaaagaa aatggtaact cagggtaacc aggagccgac aacaactcct
      301 gacgcaatgg ttcagccttt tactaccatc ccatttccac cacctccgca gaatggaatt
      361 cccacagagt atggggtgcc acacactcaa gactatgccg gccagaccgg tgagcataac
      421 ctgacactct acggaagtac gcaagcccac ggggagcaga gcagcaactc acccagcaca
      481 caaaatggat ctcttacgac agaaggtgga gcacagacag acggccagca gtcacagaca
      541 caaagtagtg aaaattcaga gagtaaatct accccgaaac ggctgcatgt ctctaatatt
      601 cctttccgct tccgggaccc tgacctccgg cagatgtttg ggcagtttgg caaaatccta
      661 gatgtagaaa taatctttaa tgaacgtggc tctaagggat tcgggttcgt aactttcgag
      721 aatagtgctg atgcagacag ggccagggag aaattacacg gcaccgtggt agagggccgt
      781 aaaatcgagg tgaataatgc tacagcacgt gtaatgacca ataagaagat ggtcacacca
      841 tatgcaaatg gttggaaatt aagcccagta gttggagctg tatatggtcc ggagttatat
      901 gcagcatcca gctttcaagc agatgtgtcc ctaggcaatg atgcagcagt gcccctatca
      961 ggaagagggg gtatcaacac ttacattcct ttaatcattc ctggcttccc ttaccctact
     1021 gcagccacca cggcagccgc tttcagagga gcccatttga ggggcagagg gcggacagta
     1081 tatggtgcag tccgagcggt acctccaaca gccatccccg cctatccagg tgtggtttac
     1141 caggacggat tttacggtgc tgacctctat ggtggatatg cagcctacag atatgcacag
     1201 cctgctactg caaccgcagc caccgctgct gcagccgctg cagccgctta cagtgacggt
     1261 tatggcaggg tgtacacagc cgacccctac catgcccttg cccctgccgc tagctatgga
     1321 gttggcgctg tggcgagttt ataccgaggt ggctacagcc gatttgcccc ctactgaagt
     1381 gacgtgagac ccctgcaaat gggacagccc cccagttcat gaggcctggc tattgcaata
     1441 tttactagta gaggaactct atagcaagat gaagaggaaa aacaaacaaa caaacaaaaa
     1501 aaaacacaaa aaaagaaaga atactttttt atacctcact atgttctttg aatatgtatt
     1561 tttcctttaa atttctgcct ttaattcttt tgttccaaag attgtgcatt tttttctttt
     1621 tttttttaaa ctgtggtaaa aaaaaaaaaa ataatgcatt tccatgtctg tatgtccgtg
     1681 cttagcttat tctatcaatc acggaagagg cagtcaagga ggaaggagag acattaggag
     1741 ccgataaatg catctgatca gaaatcagca gacagaatta ccaaagtgta tctggtgctg
     1801 aatgactggg ggacaagcag aagtggaaga gatctttctg caacaggata ttcttctagt
     1861 cttctgagtt tctggtcttt gacaggcaat tctggttggc tgtggctgga atccacatgc
     1921 tgatagatag gaatttgtgc ttacaaagca ggagaattaa aaagacgctt tcctctcctc
     1981 ttccctcctg tcttctccgt tctttttaca atcatcttac acgcacagcc tgagacagct
     2041 ggcatagttt ttggaattat agtattgata tttccaaacg tgctctcaga cagtggataa
     2101 taaacacctc attaggaaac cgatctcaga atgaactctg gagtatgaaa aagatcattt
     2161 ctttttgttc ctgtaaccta gcattccttc taggcttctt ctcctttaat tgaaccacag
     2221 cttagctcat gtattctttt attaacaccc tgctctcatg tccataagat tcaggaattt
     2281 aggacccagg gacagaaaag tgaataagcc agtgaccaga tttcccccag atgtcttgag
     2341 gattagaagt acaaattgtt gacagccatt aaagagggtg aggaagggaa aaggaatatt
     2401 agaagatctg gtatttctta cttttttctt gcctcagaaa gtacaaagtt taaaaaatag
     2461 aataaagaat ctgctgggga aagatagagt accaggtcct aggtcagtag tccctggaag
     2521 ttttggtgat gaggacatgg aagggcaggc agaggcactt tgtacttgct ccaaagccat
     2581 aggaattttc atcttccaga gcctttatga gtcacttctc tatccacagt cttgagcctg
     2641 tggctatccc gctgagcttc tcactgtcct ccaaaaacac cccgctgagc acccggacca
     2701 ctttgtacac attaacacta caggacataa aatgcagagg ccctgagatt gctgccctcc
     2761 catattggaa ggagggtctg cgatggcaag ggtcttctat atcaccagaa agagtcgcgc
     2821 agtgagtcac tgccgttgcc atctggctgt aattttctat gttatcaagg taggagggag
     2881 tgtttctctt ctagctgtta gatagaactg ataaaagcaa gtgtcctaca gcatttccca
     2941 aatgaaggca ttaggaaata gaaaagcacg gtctttttgg ctccctggtc tagtcacatt
     3001 ggtactaggg tgacctttca cccaagggac agctgctaaa gggagtaatt cagagacatg
     3061 gagcttctgg ttatgggttt gttttgggtt tgtttttaac tcctgcctcc acacatgttc
     3121 ttgactgata actgactcat gtccctgaat taaaatgact gacctatgac agcatcaagc
     3181 attctttgta agcagagtga tatatctgag agggcgttga cctgttgtgt agaatacata
     3241 tcctttcccc cttcagaatc ctgtctcgcc tcgtaactgg gagagaggct gtgcctgaaa
     3301 ctaggggcga tgtcaaggaa gctagaggcc tcgatgcaat tattactgac tctggggagg
     3361 aagacagaga ataaggggac accaactgcc cagtccactg gccattttta agggtccccc
     3421 caccccaagc caaagtttgg tttgttgctg ttaagacaat ttttgttgta tgtatataaa
     3481 tattttagtt agaggagcgg ggaatgggat gcgggctttc acagttctag ggaatggggg
     3541 cagggaggat tttgcttttg cttttgcttt gagggagaac tttagctgac taaaaaaaca
     3601 gaagtttggg gtcatgatca caaaggggcc attcccaaaa gatggcaagc cacgtattca
     3661 gtggagacta ggccaaattc taaatggttt tatccatagc aggggagaat aggagaatga
     3721 gtttaagagt ttttctcttc ttttttccta gaaagaggta aggataatgg gaaaggtaga
     3781 gaaggcggct cccacagacc ttttaagaga ggcagaatct tgagcttgag gcaccttgag
     3841 tgcatctcag ttcagctggt tctggctgag gcctccaaag gcaagctctg tgctttccag
     3901 tggtttctgc tgcatttcca gggatggtgt ttaacaccgc ttcctccagc tcccttttct
     3961 aagaaagaat aaatggagtt ctgcttttta tgaaagggtc tttggttttc agtgtcaaca
     4021 ctgagaattg gggctcttgc aagcatctgg atttcacagt atcaacctcc ccgtcacctt
     4081 ttgaactttg agactccgta cggtcaactt caccagaggc aggttgctcg aagcagcact
     4141 gcttgtctgt tcctgactct ggttctcact gtattaaaaa agagagtcag aggagtctgg
     4201 catttcgtga gtttgttaga ggatgctggc tgataattcc agaaaactta ctgatgctaa
     4261 atcacagtac atgcatgatt ctttttcagc tttactatag ttcatgacct ggactttctg
     4321 tactcttgga agctgggctc cttaaaggag gcctctagtg aacaccttta tctccatgtc
     4381 cctcttagag cccagagagc tgcccatagg cattttccag aattcctcat gtcacctagt
     4441 tcaatttcca ttaactcaga tcagccattg tgattcacca tttgtcaggc tctcaggttt
     4501 aacaaaacct actatcacca tcatccttca acagccacag tctgaattga gccaacattt
     4561 ttttttcttt gagaaagaag tggactgggg cacaactttt agtctgaggg gagctagtgg
     4621 aaatctagac aatagaagtc atcgatagca gcttttcctc aaatgtgtga ctcctcaggg
     4681 gctaaactgc tcttagctta gaattatgct ttactagaga tctagcagat aagtgggtta
     4741 atcactacca tcctgtaact agttatatag cttccagaca tgagggagac atcaaacagg
     4801 gatggaagca accccaagga tatgcaagaa gggcatgatg aacccccttc cctctggcag
     4861 gagaacaagg ccaaccaagg gacagactgg aaagcactta gatgtttaag gaggagaaag
     4921 gggaagcttt gaccagtcct tgccttttgc caagttcagc cagttctccg ctgcttgcaa
     4981 cctctagcgc agtaacattt gcagaattgc agattttccc ccagatacta ggaggaaagg
     5041 gactttgggg ggtggggaag gggtcgtggt gttttaaaag cataagttac ctgtttgcac
     5101 tgttttaaga taggaaaaaa aaatagtggg caaggtgaac atcagacgta aatttgtgtg
     5161 tttttatttt gtcatgctct tgaaaatgtt tgaccatttg tagtatacac agtgaaactt
     5221 gattctctgt tgcataaaac actatatttt tttggaaatg ttactgtcca aaagcctctt
     5281 ccctcccttt ccttttccta tgtacttcct tcatacttgc tttactgatc agccaggcaa
     5341 tagccatcca agagctagag catgaaacag ggccctttcc aagtaggctc tgggtgtcct
     5401 aagccagcgt gtgccctctg gtttagtgag tgtaatagag tccctggcac ctttctttgc
     5461 aaatgaggct aacagaccag actgcagcaa gttatcagat tcctcaatca gatgcactag
     5521 gagtgaggag cccagggatg gagggggttc ctgaagtatt gcagttggct gtagtagctg
     5581 agttcttttc catgttaccg aaactgtagc cagttacagt ttactcagga aaacggtaga
     5641 tcaattcagc catggtagtg ctggttggca gggattggta acggagagaa ctgctcatca
     5701 gccaaaactc aagccttgcc ttttaggagg ccaccagcag agggacttgg tcctccttgt
     5761 ctggtacttg tgtacatgcc ggtgacctga ggactccact cacactggcg agcaaaaagg
     5821 gagcagtgat tctcttttct ctccccaccc cctgcccttt gttaccaaca ccagtttccc
     5881 agggggtaca tgagtttctg aatttttaaa aaatgttttt ggtttggttt ttctggggac
     5941 tgataagtgc tttaagcaat gtccataccc cgtcaagact cccagcttag tcattttctt
     6001 gtatttttct gttcacagta tttgtgtgtg tgcttgtttt ggcagctcat tttggctgta
     6061 ttatatattg agtgatgaat tgatcctctt ttttccctaa gggatatgaa ttgtttttct
     6121 tgtgttatat tctgcttgtg aatagctgga gcaaacctgg ggctgacacg cgtaagctag
     6181 ggctgcaaag cgagaagaga gccggtggag tgtacttgtc cctgacaggc tgacctacct
     6241 gagtctctga gcttttcagt ccaaatcttt gcaaggctca aaatgccaca gaacctctcc
     6301 tcttctcccc actccccatg gcagggaccg gaccatccct acatgcaaca tgctgttcct
     6361 ccagcccctc ccattgccat ggcaaaacag gtacctttgg ggcatggggg cattacatgg
     6421 gatgcttgtg taatcgacca cctagccttc tctctcccct cccgtcctcc cccagaatca
     6481 cttcctagga cacccgagct gcttgcccag ggtcctgttt ccctgctaac tccagagaag
     6541 catcccaggg ctttgtgaca gtctctaatt cccttccctt ctcgttaaga atcatattgt
     6601 atagtagctt tcagaccata cagtattcat tgggttactc ctattattat caagtagctg
     6661 gaattgtgaa ggtcggagta gttagatctt tagcttttat tccttatttt tttgtattac
     6721 tctccatgtg tataaattat tgatcatgtt gctggctttt ataaactcta agcgaaggag
     6781 gagcactgcc tcagcctttg cacatggtaa tgaagcactg tttttaaata aaagagagaa
     6841 acacca
//
