LOCUS       NM_001415891            4793 bp    mRNA    linear   PRI 10-APR-2024
DEFINITION  Homo sapiens RNA binding fox-1 homolog 1 (RBFOX1), transcript
            variant 14, mRNA.
ACCESSION   NM_001415891 XM_017023324
VERSION     NM_001415891.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4793)
  AUTHORS   Kostic,M., Raymond,J.J., Freyre,C.A.C., Henry,B., Tumkaya,T.,
            Khlghatyan,J., Dvornik,J., Li,J., Hsiao,J.S., Cheon,S.H., Chung,J.,
            Sun,Y., Dolmetsch,R.E., Worringer,K.A. and Ihry,R.J.
  TITLE     Patient Brain Organoids Identify a Link between the 16p11.2 Copy
            Number Variant and the RBFOX1 Gene
  JOURNAL   ACS Chem Neurosci 14 (22), 3993-4012 (2023)
   PUBMED   37903506
  REMARK    GeneRIF: Patient Brain Organoids Identify a Link between the
            16p11.2 Copy Number Variant and the RBFOX1 Gene.
REFERENCE   2  (bases 1 to 4793)
  AUTHORS   O'Leary,A., Fernandez-Castillo,N., Gan,G., Yang,Y., Yotova,A.Y.,
            Kranz,T.M., Grunewald,L., Freudenberg,F., Anton-Galindo,E.,
            Cabana-Dominguez,J., Harneit,A., Schweiger,J.I., Schwarz,K., Ma,R.,
            Chen,J., Schwarz,E., Rietschel,M., Tost,H., Meyer-Lindenberg,A.,
            Pane-Farre,C.A., Kircher,T., Hamm,A.O., Burguera,D., Mota,N.R.,
            Franke,B., Schweiger,S., Winter,J., Heinz,A., Erk,S.,
            Romanczuk-Seiferth,N., Walter,H., Strohle,A., Fehm,L., Fydrich,T.,
            Lueken,U., Weber,H., Lang,T., Gerlach,A.L., Nothen,M.M.,
            Alpers,G.W., Arolt,V., Witt,S., Richter,J., Straube,B., Cormand,B.,
            Slattery,D.A. and Reif,A.
  TITLE     Behavioural and functional evidence revealing the role of RBFOX1
            variation in multiple psychiatric disorders and traits
  JOURNAL   Mol Psychiatry 27 (11), 4464-4473 (2022)
   PUBMED   35948661
  REMARK    GeneRIF: Behavioural and functional evidence revealing the role of
            RBFOX1 variation in multiple psychiatric disorders and traits.
REFERENCE   3  (bases 1 to 4793)
  AUTHORS   Thibord,F., Chan,M.V., Chen,M.H. and Johnson,A.D.
  TITLE     A year of COVID-19 GWAS results from the GRASP portal reveals
            potential genetic risk factors
  JOURNAL   HGG Adv 3 (2), 100095 (2022)
   PUBMED   35224516
REFERENCE   4  (bases 1 to 4793)
  AUTHORS   Morini,A., Drossart,T., Timsit,M.O., Sibony,M., Vasiliu,V.,
            Gimenez-Roqueplo,A.P., Favier,J., Badoual,C., Mejean,A.,
            Burnichon,N. and Verkarre,V.
  TITLE     Low-grade oncocytic renal tumor (LOT): mutations in mTOR pathway
            genes and low expression of FOXI1
  JOURNAL   Mod Pathol 35 (3), 352-360 (2022)
   PUBMED   34531523
  REMARK    GeneRIF: Low-grade oncocytic renal tumor (LOT): mutations in mTOR
            pathway genes and low expression of FOXI1.
REFERENCE   5  (bases 1 to 4793)
  AUTHORS   Tascon-Arcila,J., Rojas-Jimenez,S., Cornejo-Sanchez,D.,
            Gomez-Builes,P., Ucroz-Benavides,A., Holguin,B.M.,
            Restrepo-Arbelaez,D., Gomez-Castillo,C., Solarte-Mia,R.,
            Cornejo-Ochoa,W. and Pineda-Trujillo,N.
  TITLE     Differential Clinical Features in Colombian Patients With Rolandic
            Epilepsy and Suggestion of Unlikely Association With GRIN2A,
            RBFOX1, or RBFOX3 Gene Variants
  JOURNAL   J Child Neurol 36 (10), 875-882 (2021)
   PUBMED   34039076
  REMARK    GeneRIF: Differential Clinical Features in Colombian Patients With
            Rolandic Epilepsy and Suggestion of Unlikely Association With
            GRIN2A, RBFOX1, or RBFOX3 Gene Variants.
REFERENCE   6  (bases 1 to 4793)
  AUTHORS   Ponthier,J.L., Schluepen,C., Chen,W., Lersch,R.A., Gee,S.L.,
            Hou,V.C., Lo,A.J., Short,S.A., Chasis,J.A., Winkelmann,J.C. and
            Conboy,J.G.
  TITLE     Fox-2 splicing factor binds to a conserved intron motif to promote
            inclusion of protein 4.1R alternative exon 16
  JOURNAL   J Biol Chem 281 (18), 12468-12474 (2006)
   PUBMED   16537540
  REMARK    GeneRIF: Fox-1 and Fox-2 splicing factors have roles in alternative
            splicing of protein 4.1R
REFERENCE   7  (bases 1 to 4793)
  AUTHORS   Auweter,S.D., Fasan,R., Reymond,L., Underwood,J.G., Black,D.L.,
            Pitsch,S. and Allain,F.H.
  TITLE     Molecular basis of RNA recognition by the human alternative
            splicing factor Fox-1
  JOURNAL   EMBO J 25 (1), 163-173 (2006)
   PUBMED   16362037
  REMARK    GeneRIF: These results demonstrate the unusual molecular mechanism
            of sequence-specific RNA recognition by Fox-1, which is exceptional
            in its high affinity for a defined but short sequence element.
REFERENCE   8  (bases 1 to 4793)
  AUTHORS   Underwood,J.G., Boutz,P.L., Dougherty,J.D., Stoilov,P. and
            Black,D.L.
  TITLE     Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal
            splicing regulators in mammals
  JOURNAL   Mol Cell Biol 25 (22), 10005-10016 (2005)
   PUBMED   16260614
  REMARK    GeneRIF: Fox-1 and Fox-2 isoforms specifically activate splicing of
            neuronally regulated exons, which requires UGCAUG enhancer elements
REFERENCE   9  (bases 1 to 4793)
  AUTHORS   Kiehl,T.R., Shibata,H., Vo,T., Huynh,D.P. and Pulst,S.M.
  TITLE     Identification and expression of a mouse ortholog of A2BP1
  JOURNAL   Mamm Genome 12 (8), 595-601 (2001)
   PUBMED   11471052
REFERENCE   10 (bases 1 to 4793)
  AUTHORS   Shibata,H., Huynh,D.P. and Pulst,S.M.
  TITLE     A novel protein with RNA-binding motifs interacts with ataxin-2
  JOURNAL   Hum Mol Genet 9 (9), 1303-1313 (2000)
   PUBMED   10814712
  REMARK    Erratum:[Hum Mol Genet 2000 Jul 22;9(12):1903]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009135.12, AC007217.5,
            AC007012.1, AC022206.3, AC027683.6, AC005774.1 and KF456152.1.
            
            On Jan 5, 2023 this sequence version replaced XM_017023324.3.
            
            Summary: The Fox-1 family of RNA-binding proteins is evolutionarily
            conserved, and regulates tissue-specific alternative splicing in
            metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or
            in flanking introns. The protein binds to the C-terminus of
            ataxin-2 and may contribute to the restricted pathology of
            spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of
            the SCA2 gene which causes familial neurodegenerative diseases.
            Fox-1 and ataxin-2 are both localized in the trans-Golgi network.
            Several alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Nov 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.164117.1,
                                           SRR3476690.523976.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related :: locus in the vicinity of disease-associated
                                   variant(s)
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-878               AC009135.12        94903-95780         c
            879-941             AC007217.5         32786-32848         c
            942-989             AC007012.1         112090-112137       c
            990-1031            AC022206.3         121295-121336       c
            1032-1274           AC027683.6         19963-20205
            1275-1418           AC027683.6         81593-81736
            1419-1472           AC027683.6         89063-89116
            1473-1565           AC027683.6         97365-97457
            1566-1626           AC027683.6         99187-99247
            1627-1680           AC027683.6         109101-109154
            1681-1761           AC005774.1         141289-141369       c
            1762-1894           AC005774.1         118025-118157       c
            1895-1934           AC005774.1         107004-107043       c
            1935-1999           AC005774.1         95134-95198         c
            2000-2075           KF456152.1         87-162
            2076-4793           AC005774.1         58632-61349         c
FEATURES             Location/Qualifiers
     source          1..4793
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..4793
                     /gene="RBFOX1"
                     /gene_synonym="2BP1; A2BP1; FOX-1; FOX1; HRNBP1"
                     /note="RNA binding fox-1 homolog 1"
                     /db_xref="GeneID:54715"
                     /db_xref="HGNC:HGNC:18222"
                     /db_xref="MIM:605104"
     exon            1..878
                     /gene="RBFOX1"
                     /gene_synonym="2BP1; A2BP1; FOX-1; FOX1; HRNBP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             876..2198
                     /gene="RBFOX1"
                     /gene_synonym="2BP1; A2BP1; FOX-1; FOX1; HRNBP1"
                     /note="isoform 13 is encoded by transcript variant 14;
                     ataxin 2-binding protein 1; fox-1 homolog A; fox-1-like
                     RNA-binding protein 1; hexaribonucleotide-binding protein
                     1; RNA binding protein, fox-1 homolog 1"
                     /codon_start=1
                     /product="RNA binding protein fox-1 homolog 1 isoform 13"
                     /protein_id="NP_001402820.1"
                     /db_xref="GeneID:54715"
                     /db_xref="HGNC:HGNC:18222"
                     /db_xref="MIM:605104"
                     /translation="METGQRTHASGTYSFLDRTQHSDIKADCNTCVEIEDRKVSRQQM
                     NCEREQLRGNQEAAAAPDTMAQPYASAQFAPPQNGIPAEYTAPHPHPAPEYTGQTTVP
                     EHTLNLYPPAQTHSEQSPADTSAQTVSGTATQTDDAAPTDGQPQTQPSENTENKSQPK
                     RLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREK
                     LHGTVVEGRKIEVNNATARVMTNKKTVNPYTNGWKLNPVVGAVYSPEFYAGTVLLCQA
                     NQEGSSMYSAPSSLVYTSAMPGFPYPAATAAAAYRGAHLRGRGRTVYNTFRAAAPPPP
                     IPAYGGVVYQDGFYGADIYGGYAAYRYAQPTPATAAAYSDSYGRVYAADPYHHALAPA
                     PTYGVGAMNAFAPLTDAKTRSHADDVGLVLSSLQASIYRGGYNRFAPY"
     exon            879..941
                     /gene="RBFOX1"
                     /gene_synonym="2BP1; A2BP1; FOX-1; FOX1; HRNBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            942..989
                     /gene="RBFOX1"
                     /gene_synonym="2BP1; A2BP1; FOX-1; FOX1; HRNBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1031
                     /gene="RBFOX1"
                     /gene_synonym="2BP1; A2BP1; FOX-1; FOX1; HRNBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1274
                     /gene="RBFOX1"
                     /gene_synonym="2BP1; A2BP1; FOX-1; FOX1; HRNBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1418
                     /gene="RBFOX1"
                     /gene_synonym="2BP1; A2BP1; FOX-1; FOX1; HRNBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1472
                     /gene="RBFOX1"
                     /gene_synonym="2BP1; A2BP1; FOX-1; FOX1; HRNBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1565
                     /gene="RBFOX1"
                     /gene_synonym="2BP1; A2BP1; FOX-1; FOX1; HRNBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1626
                     /gene="RBFOX1"
                     /gene_synonym="2BP1; A2BP1; FOX-1; FOX1; HRNBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1680
                     /gene="RBFOX1"
                     /gene_synonym="2BP1; A2BP1; FOX-1; FOX1; HRNBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1761
                     /gene="RBFOX1"
                     /gene_synonym="2BP1; A2BP1; FOX-1; FOX1; HRNBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1894
                     /gene="RBFOX1"
                     /gene_synonym="2BP1; A2BP1; FOX-1; FOX1; HRNBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..1934
                     /gene="RBFOX1"
                     /gene_synonym="2BP1; A2BP1; FOX-1; FOX1; HRNBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..1999
                     /gene="RBFOX1"
                     /gene_synonym="2BP1; A2BP1; FOX-1; FOX1; HRNBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2075
                     /gene="RBFOX1"
                     /gene_synonym="2BP1; A2BP1; FOX-1; FOX1; HRNBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..4793
                     /gene="RBFOX1"
                     /gene_synonym="2BP1; A2BP1; FOX-1; FOX1; HRNBP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4769..4774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBFOX1"
                     /gene_synonym="2BP1; A2BP1; FOX-1; FOX1; HRNBP1"
                     /note="hexamer: AATAAA"
     polyA_site      4793
                     /gene="RBFOX1"
                     /gene_synonym="2BP1; A2BP1; FOX-1; FOX1; HRNBP1"
                     /note="major polyA site"
ORIGIN      
        1 agattatttt tggctccgca gccggggctg ctcgctgctt gtcgcgcgct cacacacaca
       61 cagacacaca cgcacacaca cacatgcaca cattttctcg cgctctctcc ggctctcctt
      121 tgtttatttt ctaatctata tttttactgg aagatttcct ctttattctc tcccgccctc
      181 ctacaagcgc tcttgctggc cgtctgggtg cacacaccgc tccctcgatc accccagccc
      241 ccttcctggt ctcccgagcg cggggtttga aggtcacctc ctttccagtc cccgtgcgag
      301 ccgcgctgcc gccgcctcct ccagccagag tcggtgggac tggctgcgct gccctgaagt
      361 ggttctccaa gcagcgcgga gggtggcgga cggcggacgg agcccagggg ccgcgtcggg
      421 tggggaaacc cgaactcgcg gaggggaatc cctccccctc cgccccagcc ccccagcagc
      481 acccgcggtg gggcgggggc gctctgccag ccccgggaac agcagaggcg gcggcactgg
      541 ctggacccac gcgcgcgcct ccggggctga agaaggaagg agtgagccga gccgagcacc
      601 ccacatctgg aggggacagc cagccgtggg ccccgccccg gcgtccggag caggagaact
      661 ccgagcttct tgcccaggca gagagagcag gagcggaccg cgcgcccggg attgagagtc
      721 cttgcgctcc agacccccac ccagtggccg ccagggtccc cgcctgtccg gaccctcgcc
      781 gcgcccaggc aggcgcgcca gggcggggct gacctgcccg cgaagttgcg gacagtgcgt
      841 gagaaaccag cacccccttc cgccgcctcc agcttatgga aactggtcaa agaactcatg
      901 caagtggaac ttacagcttc cttgatcgga ctcagcattc agatatcaaa gcagactgca
      961 atacctgcgt ggaaatagaa gacagaaagg tttcaagaca acagatgaat tgtgaaagag
     1021 agcagctaag gggtaatcag gaagcagccg ctgcccctga cacaatggct cagccttacg
     1081 cttcggccca gtttgctccc ccgcagaacg gtatccccgc ggaatacacg gcccctcatc
     1141 cccaccccgc gccagagtac acaggccaga ccacggttcc cgagcacaca ttaaacctgt
     1201 accctcccgc ccagacgcac tccgagcaga gcccggcgga cacgagcgct cagaccgtct
     1261 ctggcaccgc cacacagaca gatgacgcag caccgacgga tggccagccc cagacacaac
     1321 cttctgaaaa cacggaaaac aagtctcagc ccaagcggct gcatgtctcc aatatcccct
     1381 tcaggttccg ggatccggac ctcagacaaa tgtttggtca atttggtaaa atcttagatg
     1441 ttgaaattat ttttaatgag cgaggctcaa agggatttgg tttcgtaact ttcgaaaata
     1501 gtgccgatgc ggacagggcg agggagaaat tacacggcac cgtggtagag ggccgtaaaa
     1561 tcgaggtaaa taatgccaca gcacgtgtaa tgacaaataa aaagaccgtc aacccttata
     1621 caaatggctg gaaattgaat ccagttgtgg gtgcagtcta cagtcccgaa ttctatgcag
     1681 gcacggtcct gttgtgccag gccaaccagg agggatcttc catgtacagt gcccccagtt
     1741 cacttgtata tacttctgca atgccaggct tcccgtatcc agcagccacc gccgcggccg
     1801 cctaccgagg ggcgcacctg cgaggccgcg gtcgcaccgt gtacaacacc ttcagggccg
     1861 cggcgccccc gcccccgatc ccggcctacg gcggtgttgt ttaccaggat ggattttatg
     1921 gtgcagacat ttatggtggt tatgctgcat accgctacgc ccagcctacc cctgccactg
     1981 ccgctgccta cagtgacagt tacggacgag tttatgctgc cgacccctac caccacgcac
     2041 ttgctccagc ccccacctac ggcgttggtg ccatgaatgc ttttgcacct ttgactgatg
     2101 ccaagactag gagccatgct gatgatgtgg gtctcgttct ttcttcattg caggctagta
     2161 tataccgagg gggatacaac cgttttgctc catactaaat gacaaaacca taaaaacctt
     2221 ccaatgtggg gagaaaggaa gctttccgag gcctgagtat tgcaatacat gcagtagtac
     2281 atcattttag caactctaaa aaaaaaaaaa atacaaataa aaaggaaaaa aaattacatt
     2341 ttttatctta tacctcagat attttgttct gtgtatttta atattgtggg tctttaattt
     2401 ctgaaggttc cgtagtttgg ttgctggctg taggagtttt tgtggttgat ctagacagat
     2461 gctagataat gaataaaaac tggtttaggg ccatatccag agtgctatat tatgtaaatg
     2521 aattatatat gctgaatatt aagctactgg ggttatcagc tatttgggaa gagtgtaagt
     2581 gactacagta gtcatttttt tctgcacctg cattatttta ttttgcgaaa ggggaggttg
     2641 ggaggggctt aggggattgg aactggggtt tggctgaaag aaaaaaaaaa aaatgtaact
     2701 gatgaatcta aacgacccac tgcaccaaca atcatttatc aatggttcta agttactcat
     2761 tgccagttca agccaaaggt catgttgtta agggggtgct tctagtagca cttgtgcatc
     2821 tgagttgaat gaagctgtgc aaacccaccc tttaaaccat tccacccggc agtattcagc
     2881 ttcttaacca gtcgctattt aggaaaaaaa acccactagt taggccatca acaagcattc
     2941 tttttatatt tcttccagta taataaatta ttgatatcac tgctgacttt tatattatgg
     3001 gagggaaaaa ataacattaa taaaaaggtg ataaaaaagc actgtttcta tttttttctt
     3061 tttttccaaa aaaagaaagt aataaaaact taaattcttt gtaccagtta aaaaaaatgt
     3121 ataaaattta catctgtgca gtggagttgt taagttctag aaacagtcta tgaagcttta
     3181 gttttagcct agtagaacaa ctgttagaga cagacgtata atttttatgg aattacatga
     3241 taatcatatt cggatttata gaagcatttt acaagtattg caatcattga gtagagataa
     3301 tcatggtatt ttcatcagct tggtactttt tgaaacgtga ctgcgttgtg tgaacaatct
     3361 gcaatttttc agtccgtgag atcctgccct tccacctctt tcccataccc ccaaggatta
     3421 tctcaaaatg atctctttag ttctgtctcc aaggcccagg acacttgtca gaaggatgca
     3481 aaaaaagaaa aaagtacatc caccctctta atcccaaaag aacaaagtct ccccaccttt
     3541 ctcggatgca gggccagagt gacacagccg aaaaattgca gtttgtctgt acttctgttt
     3601 gaactttcca cgttgtcctg tttacaagtt aacttaagtt ggggtatccg tcacgggtct
     3661 tcctgttttg tatttaaata aaaacaacag cagcaggctg tccctgagta gttttgctgc
     3721 cataggttaa gtcctcatgt gtacagtgca ggccctgtgg cccgcacttc agtaagttat
     3781 caactctcac cgctgtgaac ctgccaatcc gctgtaacaa ctctgcttta aaacaaaacc
     3841 aaacaaaact ttaaaaaaaa atgtgtgatc cagctttctc ttgccatcct atgtgcatgc
     3901 cgtaagatca gttggatatt aaaccatcaa taaagtttca caagatttga aaacaaagtt
     3961 tctgtagctt cgatacctaa gacagacgat agtgatcttg aaaagagaaa agggggaggg
     4021 gggagctact tatcagccaa aagcatataa agtgttcttt tcaccagact tctttgggtg
     4081 ggtgagggga ggggcaagag ggtgttttat agcatcacta agacattctc attcccccac
     4141 ctggaaaaca gtgttatggc aatgggtgcc tggttgatgt tcttaaagga aacgaattat
     4201 taaaacacta tgacatcctc cagagggaag aaagagtagg agcagggggc tatggagaat
     4261 aaatttctcc caattgccgc ctcagatttc aaaatccaga atttgtattg tgtttcgaat
     4321 cacaaacata gaattcttac tgtgttggtt aaagtaaaat tcatttgcag ttttgatttt
     4381 catcaatgag ctgtactttc ccccatgact gtatgtagtt ttaataaaat catttagagt
     4441 gagtgagtgc caaccgatgt tgcagaatct tttgtctagg cactccaaga tgccaataag
     4501 tcattttaaa atgtatgtca gagatgtaaa caaacatttt ggattttttt taaacagtat
     4561 ttatttggaa tgttttcatt tatctaaata actattgcta ttatgaatta tggaaaatta
     4621 atattatgtg tggcatatag tgacttctta acacacacat cacgcaatct gcaaacccag
     4681 aaaatgtgta tatctgtctt tagaaattag tgtttatatc acttacagtg gtttgtgaat
     4741 aaagaaaact ggtttgtaat atcaaaaaaa taaaagctta gtctgaaaag gta
//
