LOCUS       NM_024805               5590 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ribosome binding factor A (RBFA), transcript variant
            1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_024805
VERSION     NM_024805.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5590)
  AUTHORS   Zhou,W., Liu,X., Lv,M., Shi,Y. and Zhang,L.
  TITLE     The recognition mode between hsRBFA and mitoribosome 12S rRNA
            during mitoribosomal biogenesis
  JOURNAL   Nucleic Acids Res 51 (3), 1353-1363 (2023)
   PUBMED   36620886
  REMARK    GeneRIF: The recognition mode between hsRBFA and mitoribosome 12S
            rRNA during mitoribosomal biogenesis.
REFERENCE   2  (bases 1 to 5590)
  AUTHORS   Kuwasako,K., Suzuki,S., Nameki,N., Takizawa,M., Takahashi,M.,
            Tsuda,K., Nagata,T., Watanabe,S., Tanaka,A., Kobayashi,N.,
            Kigawa,T., Guntert,P., Shirouzu,M., Yokoyama,S. and Muto,Y.
  TITLE     1H, 13C, and 15N resonance assignments and solution structures of
            the KH domain of human ribosome binding factor A, mtRbfA, involved
            in mitochondrial ribosome biogenesis
  JOURNAL   Biomol NMR Assign 16 (2), 297-303 (2022)
   PUBMED   35666428
  REMARK    GeneRIF: (1)H, (13)C, and (15)N resonance assignments and solution
            structures of the KH domain of human ribosome binding factor A,
            mtRbfA, involved in mitochondrial ribosome biogenesis.
REFERENCE   3  (bases 1 to 5590)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 5590)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5590)
  AUTHORS   Rozanska,A., Richter-Dennerlein,R., Rorbach,J., Gao,F., Lewis,R.J.,
            Chrzanowska-Lightowlers,Z.M. and Lightowlers,R.N.
  TITLE     The human RNA-binding protein RBFA promotes the maturation of the
            mitochondrial ribosome
  JOURNAL   Biochem J 474 (13), 2145-2158 (2017)
   PUBMED   28512204
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK307212.1, BC057772.1 and AC090360.9.
            
            On Nov 22, 2018 this sequence version replaced NM_024805.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK024825.1, SRR5189664.145658.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000306735.10/
                                                  ENSP00000305696.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AK307212.1         89-132
            45-794              BC057772.1         1-750
            795-795             AC090360.9         107784-107784
            796-1316            BC057772.1         752-1272
            1317-5590           AC090360.9         108306-112579
FEATURES             Location/Qualifiers
     source          1..5590
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q23"
     gene            1..5590
                     /gene="RBFA"
                     /gene_synonym="C18orf22; HsT169"
                     /note="ribosome binding factor A"
                     /db_xref="GeneID:79863"
                     /db_xref="HGNC:HGNC:26120"
                     /db_xref="MIM:620768"
     exon            1..220
                     /gene="RBFA"
                     /gene_synonym="C18orf22; HsT169"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1094
                     /gene="RBFA"
                     /gene_synonym="C18orf22; HsT169"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; putative ribosome-binding factor A,
                     mitochondrial; ribosome binding factor A (putative)"
                     /codon_start=1
                     /product="putative ribosome-binding factor A,
                     mitochondrial isoform 1 precursor"
                     /protein_id="NP_079081.2"
                     /db_xref="CCDS:CCDS12021.1"
                     /db_xref="GeneID:79863"
                     /db_xref="HGNC:HGNC:26120"
                     /db_xref="MIM:620768"
                     /translation="MWAAAGGLWRSRAGLRALFRSRDAALFPGCERGLHCSAVSCKNW
                     LKKFASKTKKKVWYESPSLGSHSTYKPSKLEFLMRSTSKKTRKEDHARLRALNGLLYK
                     ALTDLLCTPEVSQELYDLNVELSKVSLTPDFSACRAYWKTTLSAEQNAHMEAVLQRSA
                     AHMRHLLMSQQTLRNVPPIVFVQDKGNAALAELDQLLAVADFGPRDERDNFVQNDFRD
                     PDAPQPCGTTEPTTSSSLCGIDHEALNKQIMEYKRRKDKGLGGLVWQGQVAELTTQMK
                     KGRKRAKPRLEQDSSLKSYLSGEEVEDDLDLVGAPEYECYAPDTEELEAERGGGRTED
                     GHSCGASRE"
     exon            221..263
                     /gene="RBFA"
                     /gene_synonym="C18orf22; HsT169"
                     /inference="alignment:Splign:2.1.0"
     exon            264..440
                     /gene="RBFA"
                     /gene_synonym="C18orf22; HsT169"
                     /inference="alignment:Splign:2.1.0"
     exon            441..553
                     /gene="RBFA"
                     /gene_synonym="C18orf22; HsT169"
                     /inference="alignment:Splign:2.1.0"
     exon            554..638
                     /gene="RBFA"
                     /gene_synonym="C18orf22; HsT169"
                     /inference="alignment:Splign:2.1.0"
     exon            639..712
                     /gene="RBFA"
                     /gene_synonym="C18orf22; HsT169"
                     /inference="alignment:Splign:2.1.0"
     exon            713..5590
                     /gene="RBFA"
                     /gene_synonym="C18orf22; HsT169"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5564..5569
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBFA"
                     /gene_synonym="C18orf22; HsT169"
                     /note="hexamer: AATAAA"
     polyA_site      5590
                     /gene="RBFA"
                     /gene_synonym="C18orf22; HsT169"
                     /note="major polyA site"
ORIGIN      
        1 agttgtcgct ccgcgcctgc gcccgttgtc tccctgctcg ctccgggtcc cggcgccgcg
       61 ccatgtgggc tgcggcgggc gggctgtggc gctcccgcgc gggtctccgg gccctgttcc
      121 gtagccgcga tgctgcgcta tttccaggct gcgagcgggg acttcactgc tctgctgtct
      181 cctgcaagaa ctggctcaag aaatttgcct cgaaaaccaa aaaaaaggtt tggtatgaaa
      241 gtccttcctt gggttctcac tcgacttaca aaccatccaa gttggaattc ctcatgagga
      301 gcacctcaaa gaaaaccagg aaggaagacc atgcgcgcct gagggccctg aacggcctcc
      361 tctataaggc actgacagac ctgctgtgta cccctgaagt gagtcaggag ctgtatgacc
      421 ttaacgtgga gctctccaag gtttccctga ctccagactt ctcagcctgc cgagcgtact
      481 ggaagacaac gctctctgct gagcagaacg cacacatgga ggctgtcctg cagagaagtg
      541 ccgcgcacat gaggcacctt ttgatgtccc agcagaccct gaggaatgtg ccaccgatag
      601 tgtttgttca agacaaggga aatgcagctc tagctgagct tgatcagtta ctggcagtcg
      661 cagactttgg accccgggat gaaagagaca actttgtaca aaatgatttc agggaccctg
      721 atgccccaca accctgcggc accacagagc cgaccacaag ctccagtctg tgtgggatcg
      781 atcatgaggc gctcaacaag cagattatgg agtacaaaag gaggaaagat aaagggctcg
      841 ggggcctggt gtggcagggg caggtggctg agctgacaac gcagatgaaa aagggaagga
      901 agagggccaa gccccgcctg gagcaggaca gctccctcaa gagttacctg tcaggcgagg
      961 aggttgaaga tgacctggac ctggttggtg ccccggagta cgaatgctat gccccggaca
     1021 cagaggagtt ggaggcagag agaggaggtg gcagaacaga ggatggccac agctgcggag
     1081 caagcaggga gtagatggag aggctctgcc catcccacat ttgcagggaa aagcattggc
     1141 acgcaacgca gcatgtggct tcattgaggc agttgatgga gttaaaccat ctgctcttct
     1201 gctacttcaa cattttctag cttttccgtg tatctaaaca caatttgcta cacaagtcac
     1261 tgtttttttt tccatgcact gtgtgtaatt taaaaattaa atggccatct tatcacagat
     1321 tctcacaaaa agaaaatggt aaaatagtgt ctctgagatg ctggcatggc cacctccacc
     1381 tgcagagccc tgccaggtgc cagtgagtgc ttggcccgag gggtcaggcc acagcagtgg
     1441 ccggggtaag aactgaacct gcaaacctgg ggagaacaga gggtccccag agcctcccaa
     1501 ccccctggag ctgggctccg tccctggggc tgctgggctg gcacgtggcg ccgggggctc
     1561 catccctggg gctgctgggt cggcacgtgg cgccgggggc tccgtccctg actggcctct
     1621 tcacagcttt gtgcagcagg ctccaccttc tggttcaggc caaggttggg cagaaagtga
     1681 gttgggtttg ctggggcttc ctgggcgacc ccggctctga ccgtggttcc atcacgcctg
     1741 aagtagtaac acttttccct tggtgcccgt ggccagctag tgtattttct aatccatcca
     1801 aaggtgaaac agacttggtc tttgccttct gaagagtgtg cgactctgag tcatactgaa
     1861 ttctttgtgt cacctccgac gcaaagattc gttttgctgt ttatcagaag agaaaacaca
     1921 gattccatac cttgtcagct cctatttagt tcggcttccc tcttaatgtc ccagcccctg
     1981 tgagctgtca ggttctaaat tcagaattct ctcaattctg tcaggttctg cactacgagt
     2041 cagtgtcatc cctccaagcc ctggctctct gccagtgcag cagggctgtg agaatcaaga
     2101 cggcacaggg aaggcatctg tcccagcatt tgcacatgac aggtgcccac ggtgcaggag
     2161 tagaatctgt ggaagcagca gtggctttag ttgctgtgcc ctgccacctc ctccccaaaa
     2221 aggagaagtg tccaagggat agcagacccg tagcactgag cggcctgccg tgctgaccac
     2281 tggatccagg ccacgtgctg cagacagcgg ctgtgggcga gtgatgaggc cactacccag
     2341 aaagctgcat gtgcactgtg tggggtaagg acagtaggag atgctgctgc aagatgctga
     2401 ctcccttgtt tttcttttca tttgtgctct gggactaagc tgtgtataag tcatcaaatg
     2461 gcagaagcaa gatttttctt ttgagatcta ggaaattatt tgtttatact ctacactctt
     2521 atttcctata tcaggatggg gaggccacta cctcaggcca gttaaactaa gaagaaagaa
     2581 tttaaggcaa tttgtaagga tagacaaaac cccacatgat ggtatgagta ggagagagaa
     2641 aaaaaaaagg gagccagaaa ttaggttaca aagtgtacac cacacataaa ggctgatgcc
     2701 tctgttacac cgtgagccaa atgtttatct ctagggtttc tggtagccag ttgcggggtg
     2761 tccagtgaag gggtgtacat gtctgtggtt aatcatatag gtcaggataa tgaggtgata
     2821 ctgcagtgac aaatggcaaa tctccctggc ttacaacaac cagtttgcct cttattcttc
     2881 taggggacca tcatgggctg aggtcaggcc aaggcctttt gtatctggtg ttactggaac
     2941 atggctatgt gaattcattt atgtacaaga gacctcccca tcctgatgta ggaaatgaat
     3001 ggtgatgatt tacgagcgca acatcctaaa aaacgttttt gtatttccct agcaagataa
     3061 cttcaggtta caaggctctg gtacttgacc atgatgactc catgagaaaa cagcagaacg
     3121 ccagctttgc aggtacctcc acagcactgc cgggctggga acagggccag tgcttgcacc
     3181 agcgctggag ggggccacag cagagtaaag acagagtctg ccatgcagga gtgcttcgca
     3241 ggtcaggcac tgctctgagt gctttgtgtt aacctgcccc ccgcccccta acttgggaaa
     3301 ggtgttaaag aaggagagaa cgccctcaat ggtgtgtcct ttgcatacac acctttgcat
     3361 gcatctgatg tgcccaggct gtgttttatt gttctagcaa tttattgtta caaaacagat
     3421 tgctgccatc aatttgtctc aggtccttct agcacatctg acagggacta gtgtctagag
     3481 ccatgaggac agagaccaga agggacaaga aggagtgggc agagggaatg gaaggtagag
     3541 ttaggcccag agagccccag gctgctgccc agacctccac gcctgtgccg gatgtggtgt
     3601 tggcatccat agcagtctcg caaagttgtt ctcattttcc aaataaggaa tctgaggccc
     3661 agggagaggt gaagtgctgc aggagatcca accaggcgcc ggctcagtgc ctcctagaaa
     3721 gaggagtgtg ggcacgtttg caggggatcc aaccaggcgt cagctcagtg cctcctagaa
     3781 agtggagtgt gggcatgttt gcaggggatc caaccaggcg tcggctcagt gcctcctaga
     3841 aagtggagtg tgggcacgtt tgcaggggat ccaaccaggc gtctgctcag tgcctcctag
     3901 aaagtggagt gtgggcacgt ttgtagggga tcccaccagg catcagctca gtgcctccta
     3961 gaaagaggag tgtgggcacg tttcagagaa aactggctta ggcctccctg tttctggcgt
     4021 ggccttccct gggagcgagt tagggacacg gaagctcacc cgcttctgaa tgggtccact
     4081 cctggggatt tccgcggcct tccctgggag cgggttaggg acacggaagc tcaccccctt
     4141 ctgaatgggt ccactcctgg ggatttccgc ggccttccct gggagcgggt tagggacatg
     4201 gaagctcacc ctcttctgaa tgggtccact cctggggatt tccacggcct ttcctgggag
     4261 caggttaggg acatggaagc tcacgccctt ctgaatgggt ccactcccgg ggatttccat
     4321 ggccttccct ggatgatcca ctcctgggga ttttccgcag ctctccagat gacgtgcacg
     4381 cacactaaac acccagaagt tagggaggca ctgatccagt gaagtcctca gatcaacctt
     4441 gtgagctttt tacaagtacc tgtcactgtt aaactgctga tgaaatgtga aacgacttca
     4501 caggttttca gtctgataag ctctcctgtg tcactgtccc ttaccttgtt agtaaaggtc
     4561 aatggttctc aaagttccgg gcacatcccc tgggggctca taaaaccaga ctgtcggcca
     4621 cttcagcctt ctggttcgct gttccttggt aatgcagatg gcccagtaag caactctaca
     4681 aacattagaa cattttgagg tagacagggg aacttaatca ccccttgtag gcccccagaa
     4741 gactggaccc aacatccagc acaatgcctc tcagccttgg ctgtgcatct gaaacacctg
     4801 ctgtttgaag acacctgggc ctggagacgg gccagagcca ccttggtggt ctgagtatga
     4861 ggccagcatt agaacctctg ctctacgggt gactgccctg ggttgatttt tttccagtat
     4921 tatctttagt acagaatctt ttcctctcta agggcctgag accctctctt aggaatagaa
     4981 gtacagtttt cttccccact ccttttgtcc agaaggaaaa cctggtttta catcagaaac
     5041 ttgaggtact ttgaaaattt gccagctgcc ttgaaggaga gagggcttga gtgtattttg
     5101 ggggaagaat gaggggacaa cagggcaggg agaagggaca gagctagagg aaggacaggc
     5161 ctgtgccacc caggccaggg taaggggagc agagaccttt tggttcctgg tttgtgacac
     5221 aggaagggag ggaactgggg aggacaggtc atgatcagtg tttcctgatt aaaaattttt
     5281 tatttttatt tttaattatc atgggcacag agtaggtgta tatatttgtg gggtacatga
     5341 gatgttttga tacagacatg caatgtgaaa aagcacatca tggagactgg ggcacccatc
     5401 ccctcaagca tttatccttt gtgccacaaa caatccgatt atattgtttt agttattttt
     5461 aaatatgcaa ttaaattgtt attgactata gtcacccttc tgtgctgctg ctctactgtg
     5521 gcctcaaaga tcataaatgc tgtgggtgct ggcaagatac tgaaataaat taattctgta
     5581 tttctaaaaa
//
