LOCUS       NM_006606               3843 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens RB binding protein 9, serine hydrolase (RBBP9), mRNA.
ACCESSION   NM_006606
VERSION     NM_006606.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3843)
  AUTHORS   Pai,G., Roohollahi,K., Rockx,D., de Jong,Y., Stoepker,C.,
            Pennings,C., Rooimans,M., Vriend,L., Piersma,S., Jimenez,C.R., De
            Menezes,R.X., Van Beusechem,V.W., Brakenhoff,R.H., Te Riele,H.,
            Wolthuis,R.M.F. and Dorsman,J.C.
  TITLE     Genome-wide siRNA screens identify RBBP9 function as a potential
            target in Fanconi anaemia-deficient head-and-neck squamous cell
            carcinoma
  JOURNAL   Commun Biol 6 (1), 37 (2023)
   PUBMED   36639418
  REMARK    GeneRIF: Genome-wide siRNA screens identify RBBP9 function as a
            potential target in Fanconi anaemia-deficient head-and-neck
            squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3843)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3843)
  AUTHORS   Vorobiev,S.M., Huang,Y.J., Seetharaman,J., Xiao,R., Acton,T.B.,
            Montelione,G.T. and Tong,L.
  TITLE     Human retinoblastoma binding protein 9, a serine hydrolase
            implicated in pancreatic cancers
  JOURNAL   Protein Pept Lett 19 (2), 194-197 (2012)
   PUBMED   21933118
  REMARK    GeneRIF: Structure- function studies of RBBP9 suggest possible
            routes for novel cancer drug discovery programs.
            Review article
REFERENCE   4  (bases 1 to 3843)
  AUTHORS   Nachmany,H., Wald,S., Abekasis,M., Bulvik,S. and Weil,M.
  TITLE     Two potential biomarkers identified in mesenchymal stem cells and
            leukocytes of patients with sporadic amyotrophic lateral sclerosis
  JOURNAL   Dis Markers 32 (4), 211-220 (2012)
   PUBMED   22430187
  REMARK    GeneRIF: blood samples of lateral sclerosis patients were found to
            have significantly different levels of expression of CyFIP2 and
            RbBP9 compared to the levels of expression in control subjects.
REFERENCE   5  (bases 1 to 3843)
  AUTHORS   O'Connor,M.D., Wederell,E., Robertson,G., Delaney,A., Morozova,O.,
            Poon,S.S., Yap,D., Fee,J., Zhao,Y., McDonald,H., Zeng,T., Hirst,M.,
            Marra,M.A., Aparicio,S.A. and Eaves,C.J.
  TITLE     Retinoblastoma-binding proteins 4 and 9 are important for human
            pluripotent stem cell maintenance
  JOURNAL   Exp Hematol 39 (8), 866-79 (2011)
   PUBMED   21689726
  REMARK    GeneRIF: Data identified RBBP4 and RBBP9 as required for
            maintenance of multiple PS cell types, and both RBBPs were bound to
            RB in PS cells.
REFERENCE   6  (bases 1 to 3843)
  AUTHORS   Chen,J., Ji,C., Gu,S., Zhao,E., Dai,J., Huang,L., Qian,J., Ying,K.,
            Xie,Y. and Mao,Y.
  TITLE     Isolation and identification of a novel cDNA that encodes human
            yrdC protein
  JOURNAL   J Hum Genet 48 (4), 164-169 (2003)
   PUBMED   12730717
REFERENCE   7  (bases 1 to 3843)
  AUTHORS   Chen,J.Z., Yang,Q.S., Wang,S., Meng,X.F., Ying,K., Xie,Y. and
            Ma,Y.M.
  TITLE     Cloning and expression of a novel retinoblastoma binding protein
            cDNA, RBBP10
  JOURNAL   Biochem Genet 40 (7-8), 273-282 (2002)
   PUBMED   12296629
  REMARK    GeneRIF: RBBP10 was expressed widely in various human tissues, and
            the expression level is somewhat higher in tumor tissues than in
            normal tissues.
REFERENCE   8  (bases 1 to 3843)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   9  (bases 1 to 3843)
  AUTHORS   Woitach,J.T., Hong,R., Keck,C.L., Zimonjic,D.B., Popescu,N.C. and
            Thorgeirsson,S.S.
  TITLE     Assignment of the Bog gene (RBBP9) to syntenic regions of mouse
            chromosome 2G1-H1 and human chromosome 20p11.2 by fluorescence in
            situ hybridization
  JOURNAL   Cytogenet Cell Genet 85 (3-4), 252-253 (1999)
   PUBMED   10449909
REFERENCE   10 (bases 1 to 3843)
  AUTHORS   Woitach,J.T., Zhang,M., Niu,C.H. and Thorgeirsson,S.S.
  TITLE     A retinoblastoma-binding protein that affects cell-cycle control
            and confers transforming ability
  JOURNAL   Nat Genet 19 (4), 371-374 (1998)
   PUBMED   9697699
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121893.21.
            
            On Nov 26, 2018 this sequence version replaced NM_006606.2.
            
            Summary: The protein encoded by this gene is a retinoblastoma
            binding protein that may play a role in the regulation of cell
            proliferation and differentiation. Two alternatively spliced
            transcript variants of this gene with identical predicted protein
            products have been reported, one of which is a nonsense-mediated
            decay candidate. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015938.1, SRR1660807.49110.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267769 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337227.9/ ENSP00000336866.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               AL121893.21        87605-87761         c
            158-200             AL121893.21        86374-86416         c
            201-306             AL121893.21        84494-84599         c
            307-392             AL121893.21        80931-81016         c
            393-3843            AL121893.21        77076-80526         c
FEATURES             Location/Qualifiers
     source          1..3843
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.23"
     gene            1..3843
                     /gene="RBBP9"
                     /gene_synonym="BOG; RBBP10"
                     /note="RB binding protein 9, serine hydrolase"
                     /db_xref="GeneID:10741"
                     /db_xref="HGNC:HGNC:9892"
                     /db_xref="MIM:602908"
     exon            1..157
                     /gene="RBBP9"
                     /gene_synonym="BOG; RBBP10"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..619
                     /gene="RBBP9"
                     /gene_synonym="BOG; RBBP10"
                     /note="retinoma-binding protein 9; B5T overexpressed gene
                     protein; putative hydrolase RBBP9; RBBP-9; RBBP-10;
                     retinoblastoma-binding protein 10; retinoblastoma-binding
                     protein 9"
                     /codon_start=1
                     /product="serine hydrolase RBBP9"
                     /protein_id="NP_006597.2"
                     /db_xref="CCDS:CCDS13136.1"
                     /db_xref="GeneID:10741"
                     /db_xref="HGNC:HGNC:9892"
                     /db_xref="MIM:602908"
                     /translation="MASPSKAVIVPGNGGGDVTTHGWYGWVKKELEKIPGFQCLAKNM
                     PDPITARESIWLPFMETELHCDEKTIIIGHSSGAIAAMRYAETHRVYAIVLVSAYTSD
                     LGDENERASGYFTRPWQWEKIKANCPYIVQFGSTDDPFLPWKEQQEVADRLETKLHKF
                     TDCGHFQNTEFHELITVVKSLLKVPA"
     exon            158..200
                     /gene="RBBP9"
                     /gene_synonym="BOG; RBBP10"
                     /inference="alignment:Splign:2.1.0"
     exon            201..306
                     /gene="RBBP9"
                     /gene_synonym="BOG; RBBP10"
                     /inference="alignment:Splign:2.1.0"
     exon            307..392
                     /gene="RBBP9"
                     /gene_synonym="BOG; RBBP10"
                     /inference="alignment:Splign:2.1.0"
     exon            393..3843
                     /gene="RBBP9"
                     /gene_synonym="BOG; RBBP10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3819..3824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBBP9"
                     /gene_synonym="BOG; RBBP10"
                     /note="hexamer: ATTAAA"
     polyA_site      3843
                     /gene="RBBP9"
                     /gene_synonym="BOG; RBBP10"
                     /note="major polyA site"
ORIGIN      
        1 gcaggctggg ctcagctccg ctggacccgc gctggggaac tctggcctcg ctgcactcat
       61 ggcttctcct agcaaggcag tgattgttcc cgggaacgga ggcggggatg tgaccaccca
      121 cggctggtat ggctgggtga aaaaggagct ggagaagata cctggtttcc agtgtttggc
      181 taaaaacatg cccgacccaa ttacagcacg agagagcatc tggctgccct tcatggagac
      241 agagctgcac tgtgatgaga agactatcat cattggccac agttctgggg ccatcgcggc
      301 catgaggtat gcagaaacac atcgagtata tgctattgta ttagtgtctg cgtacacatc
      361 agacttgggg gatgaaaatg agcgtgcaag tggatacttc acccgcccct ggcagtggga
      421 gaagatcaag gccaactgcc cttacattgt gcagtttggc tctactgacg acccgttcct
      481 tccctggaag gaacaacaag aagtggccga taggttggaa accaaattgc acaaattcac
      541 tgactgtggc cactttcaga acacagagtt tcatgaactg attactgttg taaagtcttt
      601 gctgaaagta ccagcataga ctgtatgatt tctgctattt tgcatcccaa tataggagta
      661 gaataatatc tactatcagc tgattactag acacatagaa catccagtta agttccgtaa
      721 gtgcctgaaa aacaaacaca agtttcaaca ttcaatctaa gttacaaata gcacttccat
      781 tttccataga ctctaaaact ccccaaattg ctatgaacta ccacagtatt ttcctcattt
      841 gataagaaac ataaggacag cttaactacc cttctctatc cgaagtgagt cagaaacaga
      901 acccaggttt cttgattccc actcctgagt aaaattaaat aggttttatg tatgttgcag
      961 gtattgcaca cttttcctct ttgaaatcaa acttttctat ttcactgggg aaagaaaaca
     1021 tgactgaaag tccagagtgt tagcttagag ctcaaaatac tagctgctgt ttcaagctgg
     1081 ccccagacat taaactcaga ctagggcctt cacctctgac acttgcccct aagtccttca
     1141 gacatgttga gagagactga gacaggagtc ttccggagtc aggcaggaag gagaagcaca
     1201 gcaatataca ttcataatat acgtacaact gactagattt gtttgagaca agagtggtgg
     1261 gatcagagcc atgtggagag ctcatggcct gtctaaattg ttgccatgtg gaaatggggc
     1321 agagtgttgc caattttctg attttttgtg tggaaaaaaa tctccaaatt gtagttttta
     1381 aatttgggga atgcaaatat atatatatat acacacacac acacacacat acacatacaa
     1441 tccatataca tatggagtat gtaagttggc aataacagta tacatcaaaa aatttacaaa
     1501 cactgcaaga caaataaaat ccaagccatc catttgtgac cacagtcata agcattcact
     1561 tagccagggg cttttagata attgtctgtg aagtctgaga aaagactaag ataaccaaga
     1621 tgaacataat gtcaaaggac gaaatcatgg ggacaatttg gattttgttc caaaagacaa
     1681 gtgtttttaa aaagaacctt tccatacttc gtgttctgtt ctatagagtt aaacctttta
     1741 acttccatgg ccctttagat ctctttcaag cacattccat tttcttctga tcatacttcc
     1801 tcagaaaacc tttttttggc tgggtgtggt ggctcatgcc tgtaatccca gcactgtggg
     1861 aggctgaggt ggttgtattg cttgaggcca ggtgtttgag gccagccagg gcaacacagc
     1921 aagaccccat ctctacaaaa tattaaaaca ttagctaggc atggtggtgc acacctgtag
     1981 tcctagcttc ttgggaggct gaggcaggat tgcttgagcc caggagtttg agccttcagt
     2041 gagctatgat cgcgccactg tactccatcc tgggtgatgg agcgaagaac ctgtctctta
     2101 aaaaaaaaaa ttttttttta attaaaaaaa cccacccttt ttcatttccc aacatttttt
     2161 ggctattatg atcgctatgt gttccttcaa ataatttcca gtgaatccac acttgatgtt
     2221 gcaaagccta agtttgctgc agaaatacaa tttcctacac ttcataccta aaggagattc
     2281 agagctatcg ctcaaaacca aaagtcttgg tttttaaatg tgcttagaca aaaaaaatca
     2341 ggaaaggtac cctaatcgtt caacagcaat catctttggg gaatgggcat tttggtaggt
     2401 aaagtgtggt ggacgtcctt attattattt ttgagacagt gtcttgctct gtctcccagg
     2461 ctggaggtca gtggcacaaa tctcagctca ctctaacctg cacctcccgg gttcaagtga
     2521 ttctcatctc agcctcccaa gtagtgtgaa ctaaaggcat gtgccaccac gcctggctaa
     2581 tttttgtatt tttagtagag acagggtttc accatgttgg ccaggctggt ctcgaactcc
     2641 tggcctcaag tgatccaccc acctcagccg cccaaagtgt tgggattaca ggcatgagcc
     2701 accatgcccg gccccttatt ttactttatc ctcctgatta tttgaatttg ttacactaag
     2761 catgtatttt ataatcaaaa ataattaaga tttaaaacaa tgtatttgac tactaaaaag
     2821 caaattatat aaatcagttg aataataatg ttgttaaaga ggctgtttag cactaatttg
     2881 accaaatcta tagtcaaagt ttgattctac ttgaattttt tggaaatttg ctgttgtatt
     2941 acttattctt tgccttgttc tctgtgaagt cctttcctaa aaaagaaact tatacaattt
     3001 agttcacaaa actttgttga cctctttctc tgtagaaatg aaaactaaat atatataatt
     3061 gagaaataat tctgatactc ttcattccta taaaagtaat taagatagac ctataggatt
     3121 gttgaacttt gctgccaaat atagtaacca gtaaccacag ctagctgtaa aattgaaaat
     3181 tcagttcagt caaactagcc atatttcaag tgctcaacag ccactggtgg ctattggtta
     3241 ccttactgac cagccaatat aggctatttc cgtcattata gaaagctcta ttggacaaca
     3301 ttggtctagg acatatattt tgtattttcc cctcacccac catccaataa tgagtaatag
     3361 cacaaagtaa aagtgactta atttgaaatt acttctgttt ggctagtttg cttagctgat
     3421 caccaccaac atcataggtc tataaatcac ccaactaaga tcaggggtgt ttcatgggaa
     3481 aatctacaca aactattcat taaaaaccat agagccatgg actgtcattt ctgatttctg
     3541 tttgattctt tgtggtcatc attgaatata caggggcctc tatacactct ggggagtatc
     3601 tattctcagg tgagcaaaat accgaatact gaatggaaat caactgtaag tattaggact
     3661 tcatatgcaa cttgaatttt tggtgctgtc cggagtctag agccccacaa tctgttttgg
     3721 ttacagttta tccctgtagg ataaatgatc catttaacta ttcatcagag gtgctgtaat
     3781 tttaaattgt ctcttgtctc cttcagttaa ttttcagaat taaaaacata ccatgggaaa
     3841 aaa
//
