LOCUS       NM_002893               2281 bp    mRNA    linear   PRI 10-JAN-2025
DEFINITION  Homo sapiens RB binding protein 7, chromatin remodeling factor
            (RBBP7), transcript variant 2, mRNA.
ACCESSION   NM_002893 XM_001128430 XM_001128441
VERSION     NM_002893.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2281)
  AUTHORS   Zhan,Y., Yin,A., Su,X., Tang,N., Zhang,Z., Chen,Y., Wang,W. and
            Wang,J.
  TITLE     Interpreting the molecular mechanisms of RBBP4/7 and their roles in
            human diseases (Review)
  JOURNAL   Int J Mol Med 53 (5) (2024)
   PUBMED   38577935
  REMARK    GeneRIF: Interpreting the molecular mechanisms of RBBP4/7 and their
            roles in human diseases (Review).
            Review article
REFERENCE   2  (bases 1 to 2281)
  AUTHORS   Fang,Y., Tang,W., Qu,S., Li,Z., Zhang,X., Miao,Y., Zeng,Z. and
            Huang,H.
  TITLE     RBBP7, regulated by SP1, enhances the Warburg effect to facilitate
            the proliferation of hepatocellular carcinoma cells via PI3K/AKT
            signaling
  JOURNAL   J Transl Med 22 (1), 170 (2024)
   PUBMED   38368381
  REMARK    GeneRIF: RBBP7, regulated by SP1, enhances the Warburg effect to
            facilitate the proliferation of hepatocellular carcinoma cells via
            PI3K/AKT signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2281)
  AUTHORS   Li,J., Zheng,H., Hou,J., Chen,J., Zhang,F., Yang,X., Jin,F. and
            Xi,Y.
  TITLE     X-linked RBBP7 mutation causes maturation arrest and testicular
            tumors
  JOURNAL   J Clin Invest 133 (20), e171541 (2023)
   PUBMED   37843278
  REMARK    GeneRIF: X-linked RBBP7 mutation causes maturation arrest and
            testicular tumors.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2281)
  AUTHORS   Guo,L., Xia,Y., Li,H., Wang,Z., Xu,H., Dai,X., Zhang,Y., Zhang,H.,
            Fan,W., Wei,F., Li,Q., Zhang,L., Cao,L., Zhang,S., Hu,W. and Gu,H.
  TITLE     FIT links c-Myc and P53 acetylation by recruiting RBBP7 during
            colorectal carcinogenesis
  JOURNAL   Cancer Gene Ther 30 (8), 1124-1133 (2023)
   PUBMED   37225855
  REMARK    GeneRIF: FIT links c-Myc and P53 acetylation by recruiting RBBP7
            during colorectal carcinogenesis.
REFERENCE   5  (bases 1 to 2281)
  AUTHORS   Wang,R., Huang,Z., Lin,Z., Chen,B., Pang,X., Du,C. and Fan,H.
  TITLE     Hypoxia-induced RBBP7 promotes esophagus cancer progression by
            inducing CDK4 expression
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 54 (2), 179-186 (2022)
   PUBMED   35538026
  REMARK    GeneRIF: Hypoxia-induced RBBP7 promotes esophagus cancer
            progression by inducing CDK4 expression.
REFERENCE   6  (bases 1 to 2281)
  AUTHORS   Zhang,Y., Sun,Z.W., Iratni,R., Erdjument-Bromage,H., Tempst,P.,
            Hampsey,M. and Reinberg,D.
  TITLE     SAP30, a novel protein conserved between human and yeast, is a
            component of a histone deacetylase complex
  JOURNAL   Mol Cell 1 (7), 1021-1031 (1998)
   PUBMED   9651585
REFERENCE   7  (bases 1 to 2281)
  AUTHORS   Verreault,A., Kaufman,P.D., Kobayashi,R. and Stillman,B.
  TITLE     Nucleosomal DNA regulates the core-histone-binding subunit of the
            human Hat1 acetyltransferase
  JOURNAL   Curr Biol 8 (2), 96-108 (1998)
   PUBMED   9427644
REFERENCE   8  (bases 1 to 2281)
  AUTHORS   Zhang,Y., Iratni,R., Erdjument-Bromage,H., Tempst,P. and
            Reinberg,D.
  TITLE     Histone deacetylases and SAP18, a novel polypeptide, are components
            of a human Sin3 complex
  JOURNAL   Cell 89 (3), 357-364 (1997)
   PUBMED   9150135
REFERENCE   9  (bases 1 to 2281)
  AUTHORS   Qian,Y.W. and Lee,E.Y.
  TITLE     Dual retinoblastoma-binding proteins with properties related to a
            negative regulator of ras in yeast
  JOURNAL   J Biol Chem 270 (43), 25507-25513 (1995)
   PUBMED   7503932
REFERENCE   10 (bases 1 to 2281)
  AUTHORS   Huang,S., Lee,W.H. and Lee,E.Y.
  TITLE     A cellular protein that competes with SV40 T antigen for binding to
            the retinoblastoma gene product
  JOURNAL   Nature 350 (6314), 160-162 (1991)
   PUBMED   2005966
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB460068.1, BC114501.1,
            AL929302.16 and CN414343.1.
            
            On Jun 2, 2019 this sequence version replaced NM_002893.3.
            
            Summary: This protein is a ubiquitously expressed nuclear protein
            and belongs to a highly conserved subfamily of WD-repeat proteins.
            It is found among several proteins that binds directly to
            retinoblastoma protein, which regulates cell proliferation. The
            encoded protein is found in many histone deacetylase complexes,
            including mSin3 co-repressor complex. It is also present in protein
            complexes involved in chromatin assembly. This protein can interact
            with BRCA1 tumor-suppressor gene and may have a role in the
            regulation of cell proliferation and differentiation. Two
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Nov 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (2)
            has a shorter and distinct N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.3169955.1,
                                           SRR14038197.187113.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380087.7/ ENSP00000369427.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                DB460068.1         53-105
            54-1703             BC114501.1         1-1650
            1704-1967           AL929302.16        34331-34594         c
            1968-1972           CN414343.1         157-161
            1973-2281           AL929302.16        34017-34325         c
FEATURES             Location/Qualifiers
     source          1..2281
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.2"
     gene            1..2281
                     /gene="RBBP7"
                     /gene_synonym="RbAp46; SPGFX9"
                     /note="RB binding protein 7, chromatin remodeling factor"
                     /db_xref="GeneID:5931"
                     /db_xref="HGNC:HGNC:9890"
                     /db_xref="MIM:300825"
     exon            1..325
                     /gene="RBBP7"
                     /gene_synonym="RbAp46; SPGFX9"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..1587
                     /gene="RBBP7"
                     /gene_synonym="RbAp46; SPGFX9"
                     /note="isoform 2 is encoded by transcript variant 2; G1/S
                     transition control protein-binding protein RbAp46; histone
                     acetyltransferase type B subunit 2; retinoblastoma-binding
                     protein p46; retinoblastoma-binding protein RbAp46;
                     histone-binding protein RBBP7; RBBP-7;
                     nucleosome-remodeling factor subunit RBAP46;
                     retinoblastoma-binding protein 7"
                     /codon_start=1
                     /product="histone-binding protein RBBP7 isoform 2"
                     /protein_id="NP_002884.1"
                     /db_xref="CCDS:CCDS14179.1"
                     /db_xref="GeneID:5931"
                     /db_xref="HGNC:HGNC:9890"
                     /db_xref="MIM:300825"
                     /translation="MASKEMFEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSL
                     TVQWLPEVTKPEGKDYALHWLVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKG
                     EFGGFGSVTGKIECEIKINHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKP
                     DPSGECNPDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDA
                     KAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVN
                     CLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILAS
                     SGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSV
                     SEDNIMQIWQMAENIYNDEESDVTTSELEGQGS"
     exon            326..470
                     /gene="RBBP7"
                     /gene_synonym="RbAp46; SPGFX9"
                     /inference="alignment:Splign:2.1.0"
     exon            471..616
                     /gene="RBBP7"
                     /gene_synonym="RbAp46; SPGFX9"
                     /inference="alignment:Splign:2.1.0"
     exon            617..790
                     /gene="RBBP7"
                     /gene_synonym="RbAp46; SPGFX9"
                     /inference="alignment:Splign:2.1.0"
     exon            791..906
                     /gene="RBBP7"
                     /gene_synonym="RbAp46; SPGFX9"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1067
                     /gene="RBBP7"
                     /gene_synonym="RbAp46; SPGFX9"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1194
                     /gene="RBBP7"
                     /gene_synonym="RbAp46; SPGFX9"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1272
                     /gene="RBBP7"
                     /gene_synonym="RbAp46; SPGFX9"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1349
                     /gene="RBBP7"
                     /gene_synonym="RbAp46; SPGFX9"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1407
                     /gene="RBBP7"
                     /gene_synonym="RbAp46; SPGFX9"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1518
                     /gene="RBBP7"
                     /gene_synonym="RbAp46; SPGFX9"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..2281
                     /gene="RBBP7"
                     /gene_synonym="RbAp46; SPGFX9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1953..1958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBBP7"
                     /gene_synonym="RbAp46; SPGFX9"
                     /note="hexamer: AATAAA"
     polyA_site      1972
                     /gene="RBBP7"
                     /gene_synonym="RbAp46; SPGFX9"
                     /note="major polyA site"
     regulatory      2257..2262
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBBP7"
                     /gene_synonym="RbAp46; SPGFX9"
                     /note="hexamer: AATAAA"
     polyA_site      2281
                     /gene="RBBP7"
                     /gene_synonym="RbAp46; SPGFX9"
ORIGIN      
        1 acttttccca gggcggatgc gcctgcgctc agctgcctgg gcgggctggg aggcgcgggt
       61 tgaaaagtct cgttccaagt ttggagagag agagaagagc gcctcagacc tcggtacccg
      121 cgagcgggga ggaggcagga aagaaggacg cggcgtctgg ggagcaccca ggcagcaaga
      181 cggggcccgg gctttcgaca gtggggagtg tgacgcgctt gggaaaggca ggagcgccag
      241 cggtcgggct gctcttggct aacgagagga gtccgaggcg gcggcgaggg gcgaacgacc
      301 cgacgcaaga tggcgagtaa agagatgttt gaagatactg tggaggagcg tgtcatcaat
      361 gaagaatata aaatctggaa gaagaataca ccgtttctat atgacctggt tatgacccat
      421 gctcttcagt ggcccagtct taccgttcag tggcttcctg aagtgactaa acctgaagga
      481 aaagattatg cccttcattg gctagtgctg gggactcata cgtctgatga gcagaatcat
      541 ctggtggttg ctcgagtaca tattcccaat gatgatgcac agtttgatgc ttcccattgt
      601 gacagtgaca agggtgaatt tggtggcttt ggttctgtaa caggaaaaat tgaatgtgaa
      661 attaaaatca atcacgaagg agaagtaaac cgtgctcgtt acatgccgca gaatcctcac
      721 atcattgcta caaaaacacc atcttctgat gtgttggttt ttgactatac aaaacaccct
      781 gctaaaccag acccaagtgg agaatgtaat cctgatctca gattaagagg tcaccagaag
      841 gaaggctatg gtctctcctg gaattcaaat ttgagtggac atctcctaag tgcatctgat
      901 gaccatactg tttgtctgtg ggatataaac gcaggaccaa aagaaggcaa aattgtggat
      961 gctaaagcca tctttactgg ccactcagct gttgtagagg atgtggcctg gcacctgctg
     1021 cacgagtcat tgtttggatc tgttgctgat gatcagaaac ttatgatatg ggacaccagg
     1081 tccaatacca cctccaagcc gagtcacttg gtggatgcgc acactgccga agtcaactgc
     1141 ctctcattca atccctacag cgaatttatt ctagccaccg gctctgcgga taagaccgta
     1201 gctttatggg atctgcgtaa cttaaaatta aaactccata ccttcgaatc tcataaagat
     1261 gaaattttcc aggtccactg gtctccacat aatgaaacta ttctggcttc aagtggtact
     1321 gaccgccgcc tgaatgtgtg ggatttaagt aaaattgggg aagaacaatc agcagaagat
     1381 gcagaagatg ggcctccaga actcctgttt attcatggag gacacactgc taagatttca
     1441 gattttagct ggaaccccaa tgagccttgg gtcatttgct cagtgtctga ggataacatc
     1501 atgcagatat ggcaaatggc tgaaaatatt tacaatgatg aagagtcaga tgtcacgaca
     1561 tccgaactgg agggacaagg atcttaaacc caaagtacga gaaatgtttc tgttgaatgt
     1621 aatgctacat gaatgcttga tttatcaagc gccaaaaagg cattgtatag taggaaatgt
     1681 aagtggggtg gcttatggct tctttatcct ctgattctag cactttcaag tgagctgttg
     1741 cgtactgtat catattgtag ctattaggga agagaagaat gttgcttaag aaagaacatc
     1801 accattgatt ttaaatacaa gtagcagggt attgcctttg attcaactgt tttaagtcct
     1861 cattttctca aactaagtgc ttgctgttcc caaatatgca agaataactt ttacactttt
     1921 tccttccaac acttcttgat tggctttgca gaaataaagt tttaaaataa aacttgtgtt
     1981 tttttaaaag cttagtgggg gggggcgggg gagtctactt tttgagtaga aatgggtaaa
     2041 atggtacctt tggactccta cagttaaggt cacatggata atgaaagaat acacagaagc
     2101 tgttaagttt atcatacata tttacttaat ctatacagaa tcaagtagat aaaatcagat
     2161 tcacattagt gaaaaatctc tacaaaatgt ctttgaaaag caaaacgaga ctgcctctta
     2221 acaattcgta tcctcatgaa agacgtgggc tgtaaaaata aagcagtgtg tttagcacaa
     2281 a
//
