LOCUS       NM_006910               6858 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens RB binding protein 6, ubiquitin ligase (RBBP6),
            transcript variant 1, mRNA.
ACCESSION   NM_006910
VERSION     NM_006910.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6858)
  AUTHORS   Zhang,W., Shi,J. and Liu,G.
  TITLE     Abnormal expression of long non-coding RNA FGD5-AS1 affects the
            development of ovarian cancer through regulating miR-107/RBBP6 axis
  JOURNAL   Chin J Physiol 66 (3), 171-180 (2023)
   PUBMED   37322627
  REMARK    GeneRIF: Abnormal expression of long non-coding RNA FGD5-AS1
            affects the development of ovarian cancer through regulating
            miR-107/RBBP6 axis.
REFERENCE   2  (bases 1 to 6858)
  AUTHORS   Boreikaite,V., Elliott,T.S., Chin,J.W. and Passmore,L.A.
  TITLE     RBBP6 activates the pre-mRNA 3' end processing machinery in humans
  JOURNAL   Genes Dev 36 (3-4), 210-224 (2022)
   PUBMED   35177536
  REMARK    GeneRIF: RBBP6 activates the pre-mRNA 3' end processing machinery
            in humans.
REFERENCE   3  (bases 1 to 6858)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   4  (bases 1 to 6858)
  AUTHORS   Mao,J., Gao,W., Xue,L., Wang,J. and Zhao,L.
  TITLE     The lncRNA SLCO4A1-AS1/miR-876-3p/RBBP6 axis regulates cell
            proliferation and apoptosis in acute lymphocytic leukemia via the
            JNK signaling pathway
  JOURNAL   Int J Lab Hematol 43 (5), 1050-1061 (2021)
   PUBMED   33683013
  REMARK    GeneRIF: The lncRNA SLCO4A1-AS1/miR-876-3p/RBBP6 axis regulates
            cell proliferation and apoptosis in acute lymphocytic leukemia via
            the JNK signaling pathway.
REFERENCE   5  (bases 1 to 6858)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 6858)
  AUTHORS   Yoshitake,Y., Nakatsura,T., Monji,M., Senju,S., Matsuyoshi,H.,
            Tsukamoto,H., Hosaka,S., Komori,H., Fukuma,D., Ikuta,Y.,
            Katagiri,T., Furukawa,Y., Ito,H., Shinohara,M., Nakamura,Y. and
            Nishimura,Y.
  TITLE     Proliferation potential-related protein, an ideal esophageal cancer
            antigen for immunotherapy, identified using complementary DNA
            microarray analysis
  JOURNAL   Clin Cancer Res 10 (19), 6437-6448 (2004)
   PUBMED   15475430
REFERENCE   7  (bases 1 to 6858)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   8  (bases 1 to 6858)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   9  (bases 1 to 6858)
  AUTHORS   Gao,S., Witte,M.M. and Scott,R.E.
  TITLE     P2P-R protein localizes to the nucleolus of interphase cells and
            the periphery of chromosomes in mitotic cells which show maximum
            P2P-R immunoreactivity
  JOURNAL   J Cell Physiol 191 (2), 145-154 (2002)
   PUBMED   12064457
  REMARK    Erratum:[J Cell Physiol 2002 Sep;192(3):359-60]
REFERENCE   10 (bases 1 to 6858)
  AUTHORS   Sakai,Y., Saijo,M., Coelho,K., Kishino,T., Niikawa,N. and Taya,Y.
  TITLE     cDNA sequence and chromosomal localization of a novel human
            protein, RBQ-1 (RBBP6), that binds to the retinoblastoma gene
            product
  JOURNAL   Genomics 30 (1), 98-101 (1995)
   PUBMED   8595913
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010321.8, BF727303.1,
            BI489954.1, BM314442.1, AB112074.1, AK026954.1 and AL359564.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006910.4.
            
            Summary: The retinoblastoma tumor suppressor (pRB) protein binds
            with many other proteins. In various human cancers, pRB suppresses
            cellular proliferation and is inactivated. Cell cycle-dependent
            phosphorylation regulates the activity of pRB. This gene encodes a
            protein which binds to underphosphorylated but not phosphorylated
            pRB. Multiple alternatively spliced transcript variants that encode
            different isoforms have been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) is the longest transcript and
            it encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB112074.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319715.10/ ENSP00000317872.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AC010321.8         121123-121143       c
            22-565              BF727303.1         1-544
            566-652             BI489954.1         531-617
            653-1225            BM314442.1         2-574
            1226-6079           AB112074.1         209-5062
            6080-6533           AK026954.1         1529-1982
            6534-6804           AL359564.1         1686-1956
            6805-6858           AK026954.1         2253-2306
FEATURES             Location/Qualifiers
     source          1..6858
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.1"
     gene            1..6858
                     /gene="RBBP6"
                     /gene_synonym="MY038; P2P-R; PACT; RBQ-1; SNAMA"
                     /note="RB binding protein 6, ubiquitin ligase"
                     /db_xref="GeneID:5930"
                     /db_xref="HGNC:HGNC:9889"
                     /db_xref="MIM:600938"
     exon            1..1227
                     /gene="RBBP6"
                     /gene_synonym="MY038; P2P-R; PACT; RBQ-1; SNAMA"
                     /inference="alignment:Splign:2.1.0"
     CDS             1062..6440
                     /gene="RBBP6"
                     /gene_synonym="MY038; P2P-R; PACT; RBQ-1; SNAMA"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     proliferation potential-related protein; RB-binding
                     Q-protein 1; E3 ubiquitin-protein ligase RBBP6;
                     retinoblastoma binding protein 6; protein P2P-R;
                     retinoblastoma-binding Q protein 1; p53-associated
                     cellular protein of testis; RING-type E3 ubiquitin
                     transferase RBBP6"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RBBP6 isoform 1"
                     /protein_id="NP_008841.2"
                     /db_xref="CCDS:CCDS10621.1"
                     /db_xref="GeneID:5930"
                     /db_xref="HGNC:HGNC:9889"
                     /db_xref="MIM:600938"
                     /translation="MSCVHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADC
                     DLQITNAQTKEEYTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAI
                     DDSSASISLAQLTKTANLAEANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYT
                     CFRCGKPGHYIKNCPTNGDKNFESGPRIKKSTGIPRSFMMEVKDPNMKGAMLTNTGKY
                     AIPTIDAEAYAIGKKEKPPFLPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCG
                     NSYCDECIRTALLESDEHTCPTCHQNDVSPDALIANKFLRQAVNNFKNETGYTKRLRK
                     QLPPPPPPIPPPRPLIQRNLQPLMRSPISRQQDPLMIPVTSSSTHPAPSISSLTSNQS
                     SLAPPVSGNPSSAPAPVPDITATVSISVHSEKSDGPFRDSDNKILPAAALASEHSKGT
                     SSIAITALMEEKGYQVPVLGTPSLLGQSLLHGQLIPTTGPVRINTARPGGGRPGWEHS
                     NKLGYLVSPPQQIRRGERSCYRSINRGRHHSERSQRTQGPSLPATPVFVPVPPPPLYP
                     PPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVPPPGFPPAPANLSTPWVSSGVQTAH
                     SNTIPTTQAPPLSREEFYREQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRS
                     FSRSKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGK
                     SRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNR
                     YREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSAN
                     RENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNT
                     KSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTD
                     SLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSK
                     KENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTP
                     RKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEK
                     RKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSA
                     PAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSS
                     STLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSK
                     WDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTK
                     DVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNE
                     QGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNEL
                     TRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTK
                     RPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKS
                     TVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDK
                     IVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDS
                     KKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDD
                     QKVKSVTV"
     exon            1228..1327
                     /gene="RBBP6"
                     /gene_synonym="MY038; P2P-R; PACT; RBQ-1; SNAMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1364
                     /gene="RBBP6"
                     /gene_synonym="MY038; P2P-R; PACT; RBQ-1; SNAMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1409
                     /gene="RBBP6"
                     /gene_synonym="MY038; P2P-R; PACT; RBQ-1; SNAMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1498
                     /gene="RBBP6"
                     /gene_synonym="MY038; P2P-R; PACT; RBQ-1; SNAMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1595
                     /gene="RBBP6"
                     /gene_synonym="MY038; P2P-R; PACT; RBQ-1; SNAMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1735
                     /gene="RBBP6"
                     /gene_synonym="MY038; P2P-R; PACT; RBQ-1; SNAMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1908
                     /gene="RBBP6"
                     /gene_synonym="MY038; P2P-R; PACT; RBQ-1; SNAMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2012
                     /gene="RBBP6"
                     /gene_synonym="MY038; P2P-R; PACT; RBQ-1; SNAMA"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2350
                     /gene="RBBP6"
                     /gene_synonym="MY038; P2P-R; PACT; RBQ-1; SNAMA"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2447
                     /gene="RBBP6"
                     /gene_synonym="MY038; P2P-R; PACT; RBQ-1; SNAMA"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2526
                     /gene="RBBP6"
                     /gene_synonym="MY038; P2P-R; PACT; RBQ-1; SNAMA"
                     /inference="alignment:Splign:2.1.0"
     exon            2527..2581
                     /gene="RBBP6"
                     /gene_synonym="MY038; P2P-R; PACT; RBQ-1; SNAMA"
                     /inference="alignment:Splign:2.1.0"
     exon            2582..2650
                     /gene="RBBP6"
                     /gene_synonym="MY038; P2P-R; PACT; RBQ-1; SNAMA"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..3013
                     /gene="RBBP6"
                     /gene_synonym="MY038; P2P-R; PACT; RBQ-1; SNAMA"
                     /inference="alignment:Splign:2.1.0"
     exon            3014..3115
                     /gene="RBBP6"
                     /gene_synonym="MY038; P2P-R; PACT; RBQ-1; SNAMA"
                     /inference="alignment:Splign:2.1.0"
     exon            3116..4870
                     /gene="RBBP6"
                     /gene_synonym="MY038; P2P-R; PACT; RBQ-1; SNAMA"
                     /inference="alignment:Splign:2.1.0"
     exon            4871..6858
                     /gene="RBBP6"
                     /gene_synonym="MY038; P2P-R; PACT; RBQ-1; SNAMA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6831..6836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBBP6"
                     /gene_synonym="MY038; P2P-R; PACT; RBQ-1; SNAMA"
                     /note="hexamer: AATAAA"
     polyA_site      6858
                     /gene="RBBP6"
                     /gene_synonym="MY038; P2P-R; PACT; RBQ-1; SNAMA"
                     /note="major polyA site"
ORIGIN      
        1 gcagtggggc gctcgtccga agccaggccg cgtccgccat agtacctggc ttggaggtgt
       61 cgccgccgct cggtgagagc ccccgagcgg cagggggcca acacaaaaag ggagccggag
      121 aagccctagc cgctgcccag cagcttgcgg gcgtgttctc gcggttccgg gcctcaaggc
      181 gacggaaacg aaaggcgagc gaagcgcgga ggatccggcg agaagaagcg tcagggagcc
      241 tcggcggtgt ccccggggtc cgccgaagcc acccggccgc cggctggggc ccggggtggt
      301 gaggaagtgc tccgaggcct cgccgaggcc tagcgccggc tttgtgtccg aggcggcggc
      361 ggcggcgggg ggaggcggag ccgggggcgg cctgcgggaa ggcctctcct ccgccgaccg
      421 cgcgttttcg gcctaggccg tggggccgct cgtggcctcc ggggagcagg cgccaggggt
      481 ttgtgtgcgg tgggggcctg ggcctgggcc tggggaagct gacgccggtc gtccggaagc
      541 caggaggagg cgtgaggccg ctcgtggact ccgggcctag gccctctccc ctcaaccttc
      601 tcccggggcc tgggtcaccc caatccacgg agagagagac ccgccgggag gtgcggccgc
      661 gctatggacc cctgaccccg tggggtcgct cggactctta acgtgtggac tgaccgctac
      721 tgactgcacc gccaatcccc ccgtctctgc cggcccctta gcatgagcga gggggaccca
      781 gccgggtgac attgtgcccg ttggcggatt ctcgatttcc cctcttcccc gtcctcgtcc
      841 tcctcctccc ccatgaagtg attctgagta tcggggggtc tctggattat tgttctgacg
      901 aacccctgct tgtggttggg gggtatttaa tctgaggcct tagggtcctt cggtgtcttt
      961 gagtgttttg tgtgtacata ttttgctctt aaagtttata aatatacgta tattgagagt
     1021 gtccacgtct cctcgctgaa ccttaggaat cccttggcac catgtcctgt gtgcattata
     1081 aattttcctc taaactcaac tatgataccg tcacctttga tgggctccac atctccctct
     1141 gcgacttaaa gaagcagatt atggggagag agaagctgaa agctgccgac tgcgacctgc
     1201 agatcaccaa tgcgcagacg aaagaagaat atactgatga taatgctctg attcctaaga
     1261 attcttctgt aattgttaga agaattccta ttggaggtgt taaatctaca agcaagacat
     1321 atgttataag tcgaactgaa ccagcgatgg caactacaaa agcaattgat gactcttccg
     1381 cgtctatttc tctggcccag cttacaaaga ctgccaatct ggctgaagcc aatgcttctg
     1441 aagaagataa aattaaagca atgatgtcgc aatctggcca tgaatacgac ccaatcaatt
     1501 acatgaagaa acctctaggt ccaccacctc catcttacac gtgtttccgt tgtggtaaac
     1561 ctggacatta tattaagaat tgcccaacaa atggggataa aaactttgaa tctggtccta
     1621 ggattaaaaa gagcactgga attcccagaa gtttcatgat ggaagtgaaa gatcctaata
     1681 tgaaaggtgc aatgcttacc aacactggaa aatatgcaat accaactata gatgcagaag
     1741 catatgcaat tgggaagaaa gagaaacctc ccttcttacc agaggagcca tcttcttcct
     1801 cagaagaaga tgatcctatc ccagatgaat tgttgtgtct catctgcaag gatattatga
     1861 ctgatgctgt tgtgattccc tgctgtggaa acagttactg tgatgaatgt ataagaacag
     1921 cactcctgga atcagatgag cacacatgtc cgacgtgtca tcaaaatgat gtttctcctg
     1981 atgctttaat tgccaataaa tttttacgac aggctgtaaa taacttcaaa aatgaaactg
     2041 gctatacaaa aagactacga aaacagttac ctcctccacc acccccaata ccacctccga
     2101 gaccactgat tcagaggaac ctacaacctc tgatgagatc tccgatatca agacaacaag
     2161 atcctcttat gattccagtg acatcttcat caactcaccc agctccgtct atatcttcat
     2221 taacttctaa tcagtcttcc ttggcccctc ctgtgtctgg aaatccgtct tctgctccag
     2281 ctcctgtacc tgatataact gcaacagtat ccatatcagt tcattcagaa aaatcagatg
     2341 gaccttttcg ggattctgat aataaaatat tgccagctgc agctcttgca tcagagcact
     2401 caaagggaac ctcctcaatt gcaattaccg ctcttatgga agagaagggt taccaggtgc
     2461 ctgttcttgg aaccccatct ttgcttggac agtcattatt gcatggacag ttgatcccca
     2521 caactggtcc agtaagaata aatactgctc gtccaggtgg tggtcgacca ggctgggaac
     2581 attccaacaa acttggctat ctggtttctc caccacaaca aattagaaga ggggagagga
     2641 gctgctacag aagtataaac cgtgggcgac accacagcga aagatcacag aggactcaag
     2701 gcccgtcact accagcaact ccagtctttg tacctgttcc accacctcct ttgtatccgc
     2761 ctcctcccca tacacttcct ctccctccgg gtgttcctcc tccacagttt tctcctcagt
     2821 ttcctcctgg ccagccacca cccgctgggt atagtgtccc tcctccaggg tttcctccag
     2881 ctcctgccaa tttatcaaca ccttgggtat catcaggagt gcagacagct cattcaaata
     2941 ccatcccaac aacacaagca ccacctttgt ccagggaaga attctataga gagcagcgac
     3001 gactaaaaga agaggaaaag aaaaagtcca agctagatga gtttacaaat gattttgcta
     3061 aggaattgat ggaatacaaa aagattcaaa aggagcgtag gcgctcattt tccaggtcta
     3121 aatctcccta tagtggttct tcgtattcaa gaagttcata tacttattct aaatcaagat
     3181 ctggttcaac acgttcacgc tcttattctc gatcattcag ccgctcacat tctcgttcct
     3241 attcacggtc acctccatac cccagaagag gcagaggcaa gagccgcaat taccgttcac
     3301 ggtctagatc tcatggatat catcgatcta ggtcaaggtc acccccttac agacgctatc
     3361 attcacgatc aagatctcct caagcgttta ggggacagtc tcctaataaa cgtaatgtac
     3421 ctcaagggga aacagaacgt gaatatttta atagatacag agaagttcca ccaccatatg
     3481 acatgaaagc atattatggg agaagtgttg actttagaga cccatttgaa aaagaacgct
     3541 accgagaatg ggagagaaaa tatagagagt ggtatgaaaa atattataaa ggttatgctg
     3601 ctggagcaca gcctagaccc tcagcaaata gagagaactt ttctccagag agatttttgc
     3661 cacttaacat caggaattct cccttcacaa gaggccgcag agaagactat gttggtgggc
     3721 aaagtcatag aagtcgaaac ataggtagca actatccaga aaagctttca gcaagagatg
     3781 gtcacaatca gaaggataat acaaagtcaa aagagaagga gagtgaaaac gctccaggag
     3841 atggtaaagg aaataagcat aagaaacaca gaaaaagaag aaaaggggag gaaagtgagg
     3901 gttttctgaa cccagagtta ttagagactt ctaggaaatc aagagaacct acaggtgttg
     3961 aagaaaataa aacagactca ttgtttgttc tcccaagtag agatgatgcc acacctgtta
     4021 gagatgaacc aatggatgca gaatcaatca cttttaaatc agtgtctgaa aaagacaaga
     4081 gagaaaggga taaaccaaaa gcaaagggtg ataaaaccaa acggaagaat gatggatctg
     4141 ctgtgtccaa aaaagaaaat attgtaaaac ctgctaaagg accccaagaa aaagtagatg
     4201 gagaacgtga gagatctcct cgatctgaac ctccaattaa aaaagccaaa gaggagactc
     4261 cgaagactga caatactaaa tcatcatctt cctctcagaa ggatgaaaaa atcactggaa
     4321 cccccagaaa agctcactct aaatcagcaa aagaacacca agaaacaaaa ccagtcaaag
     4381 aggaaaaagt gaagaaggac tattccaaag atgtcaaatc agaaaagcta acaactaagg
     4441 aagaaaaggc caagaagcct aatgagaaaa acaaaccact tgataataag ggagaaaaaa
     4501 gaaaaagaaa aactgaagaa aaaggcgtag ataaagattt tgagtcttct tcaatgaaaa
     4561 tctcgaaact agaagtgact gaaatagtga aaccatcacc aaagcgcaaa atggaacctg
     4621 atactgaaaa aatggatagg acccctgaaa aggacaaaat ttctttaagt gcgccagcca
     4681 aaaaaatcaa actcaacaga gaaactggga agaaaattgg aagtacagaa aatatatcaa
     4741 acacaaaaga accctctgaa aaattggagt caacatctag caaagttaaa caagaaaaag
     4801 tcaaaggaaa ggtcagacga aaagtgactg gaactgaagg atccagctca actctggtgg
     4861 attacaccag tacgagctca actggaggca gtcctgtgcg gaaatctgaa gaaaaaacag
     4921 atacaaagcg aactgtgatt aaaacgatgg aagaatataa taatgacaat accgcgccag
     4981 ctgaagatgt tatcattatg attcaggttc ctcaatccaa atgggataaa gatgactttg
     5041 aatctgaaga agaagatgtt aaatccacac agcctatatc aagtgtagga aaacctgcta
     5101 gtgttataaa aaatgttagt acaaagccat caaatatagt caagtatcct gagaaagaaa
     5161 gtgagccatc cgagaaaatt cagaaattca ccaaggacgt gagccatgaa atcatacaac
     5221 atgaggttaa aagttcaaaa aactctgcat ctagtgaaaa agggaaaacc aaagatcgag
     5281 attattcagt gttggaaaag gagaaccctg aaaagaggaa gaacagcact cagccagaga
     5341 aagagagtaa tttggaccgt ctgaatgaac aaggaaattt taaaagtctg tctcaatctt
     5401 ccaaagaggc tagaacgtca gataaacatg attccactcg tgcttcctca aataaagact
     5461 tcactcccaa tagagacaaa aaaactgact atgacaccag agagtattca agttccaaac
     5521 gtagagatga aaagaatgaa ttaacaagac gaaaagactc tccttctcgg aataaagatt
     5581 ctgcatctgg acagaaaaat aaaccaaggg aagagagaga tttgcctaaa aaaggaacag
     5641 gagattccaa aaaaagtaat tctagtccct caagagacag aaaacctcat gatcacaaag
     5701 ccacttatga tactaaacgg ccaaatgaag agacaaaatc tgtagataaa aatccttgta
     5761 aggatcgtga gaagcatgta ttagaagcaa ggaacaataa agagtcaagt ggcaataaac
     5821 tactttatat acttaaccca ccagagacac aggttgaaaa agagcaaatt actgggcaaa
     5881 ttgacaagag tactgtcaag cctaaacccc agttaagtca ttcctctaga ctttcctctg
     5941 acttaactag agaaactgat gaagctgctt ttgaaccaga ctataatgaa agtgacagtg
     6001 aaagtaatgt ttctgtaaaa gaagaggaat cttcaggaaa catttctaag gacctgaaag
     6061 ataaaatagt ggagaaagca aaagagagcc tggacacagc agcagttgtc caggtgggca
     6121 taagcaggaa tcagagccac agcagcccca gcgtcagccc cagcagaagc cacagtcctt
     6181 ctggaagcca gacccgaagc cacagtagca gtgccagctc agcagaaagt caggacagca
     6241 agaagaagaa gaaaaagaag gaaaagaaaa aacacaagaa acataaaaag cataagaagc
     6301 ataagaaaca tgcaggcact gaagtggaat tggaaaaaag ccaaaaacac aaacacaaga
     6361 aaaagaagtc aaagaagaac aaagataaag agaaggagaa ggagaaagat gaccaaaaag
     6421 tgaaatctgt cactgtgtaa aaagacagat tttttaaatt gacttaatta ctaagtcatc
     6481 tgtattaaat tttgttataa tgtaaagaga ttcaagcctt gtaaataatg acatggaaga
     6541 ccctgtgctg cacttaaaat attgctgctt gattatttga tttttacatc agagctttat
     6601 aacacgaact tttgtacaga attgtgagtt gtgaccatgt aacatgagag gttttgctag
     6661 ggcctattat ttttaaccac cattaattag ttggggtgga gtttactgta atgtgaaatt
     6721 ttcacatttg aattttttaa ttgcctggca aaagctgata taagttctaa aatatcagca
     6781 gaatgatttg ctgaattcat tacaaccctg ttatgtcact ttttgattac aataaaagtt
     6841 ttcagtaaac ttttcaaa
//
