LOCUS       NM_005057               4367 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens RB binding protein 5, histone lysine methyltransferase
            complex subunit (RBBP5), transcript variant 1, mRNA.
ACCESSION   NM_005057
VERSION     NM_005057.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4367)
  AUTHORS   Chen,Y., Su,H., Zhao,J., Na,Z., Jiang,K., Bacchiocchi,A., Loh,K.H.,
            Halaban,R., Wang,Z., Cao,X. and Slavoff,S.A.
  TITLE     Unannotated microprotein EMBOW regulates the interactome and
            chromatin and mitotic functions of WDR5
  JOURNAL   Cell Rep 42 (9), 113145 (2023)
   PUBMED   37725512
REFERENCE   2  (bases 1 to 4367)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4367)
  AUTHORS   Xie,H., Zhao,J., Wan,J., Zhao,J., Wang,Q., Yang,X., Yang,W., Lin,P.
            and Yu,X.
  TITLE     Long non-coding RNA AC245100.4 promotes prostate cancer
            tumorigenesis via the microRNA-145-5p/RBBP5 axis
  JOURNAL   Oncol Rep 45 (2), 619-629 (2021)
   PUBMED   33416179
  REMARK    GeneRIF: Long noncoding RNA AC245100.4 promotes prostate cancer
            tumorigenesis via the microRNA1455p/RBBP5 axis.
            Erratum:[Oncol Rep. 2023 Mar;49(3):62. doi: 10.3892/or.2023.8499..
            PMID: 36799194]
REFERENCE   4  (bases 1 to 4367)
  AUTHORS   Patel,A., Dharmarajan,V., Vought,V.E. and Cosgrove,M.S.
  TITLE     On the mechanism of multiple lysine methylation by the human mixed
            lineage leukemia protein-1 (MLL1) core complex
  JOURNAL   J Biol Chem 284 (36), 24242-24256 (2009)
   PUBMED   19556245
REFERENCE   5  (bases 1 to 4367)
  AUTHORS   Southall,S.M., Wong,P.S., Odho,Z., Roe,S.M. and Wilson,J.R.
  TITLE     Structural basis for the requirement of additional factors for MLL1
            SET domain activity and recognition of epigenetic marks
  JOURNAL   Mol Cell 33 (2), 181-191 (2009)
   PUBMED   19187761
REFERENCE   6  (bases 1 to 4367)
  AUTHORS   Lee,J.H., Tate,C.M., You,J.S. and Skalnik,D.G.
  TITLE     Identification and characterization of the human Set1B histone
            H3-Lys4 methyltransferase complex
  JOURNAL   J Biol Chem 282 (18), 13419-13428 (2007)
   PUBMED   17355966
REFERENCE   7  (bases 1 to 4367)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   8  (bases 1 to 4367)
  AUTHORS   Scacheri,P.C., Davis,S., Odom,D.T., Crawford,G.E., Perkins,S.,
            Halawi,M.J., Agarwal,S.K., Marx,S.J., Spiegel,A.M., Meltzer,P.S.
            and Collins,F.S.
  TITLE     Genome-wide analysis of menin binding provides insights into MEN1
            tumorigenesis
  JOURNAL   PLoS Genet 2 (4), e51 (2006)
   PUBMED   16604156
  REMARK    GeneRIF: analysis of menin's role as a tumor suppressor and binding
            sites of Rbbp5 and MLL1
REFERENCE   9  (bases 1 to 4367)
  AUTHORS   Goo,Y.H., Sohn,Y.C., Kim,D.H., Kim,S.W., Kang,M.J., Jung,D.J.,
            Kwak,E., Barlev,N.A., Berger,S.L., Chow,V.T., Roeder,R.G.,
            Azorsa,D.O., Meltzer,P.S., Suh,P.G., Song,E.J., Lee,K.J., Lee,Y.C.
            and Lee,J.W.
  TITLE     Activating signal cointegrator 2 belongs to a novel steady-state
            complex that contains a subset of trithorax group proteins
  JOURNAL   Mol Cell Biol 23 (1), 140-149 (2003)
   PUBMED   12482968
REFERENCE   10 (bases 1 to 4367)
  AUTHORS   Saijo,M., Sakai,Y., Kishino,T., Niikawa,N., Matsuura,Y., Morino,K.,
            Tamai,K. and Taya,Y.
  TITLE     Molecular cloning of a human protein that binds to the
            retinoblastoma protein and chromosomal mapping
  JOURNAL   Genomics 27 (3), 511-519 (1995)
   PUBMED   7558034
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA797022.1, BC075059.2,
            AL583832.14 and BQ020418.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005057.3.
            
            Summary: This gene encodes a ubiquitously expressed nuclear protein
            which belongs to a highly conserved subfamily of WD-repeat
            proteins. The encoded protein binds directly to retinoblastoma
            protein, which regulates cell proliferation. It interacts
            preferentially with the underphosphorylated retinoblastoma protein
            via the E1A-binding pocket B. Three alternatively spliced
            transcript variants that encode different protein isoforms have
            been described for this gene. [provided by RefSeq, Jul 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053856.1, X85134.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264515.11/ ENSP00000264515.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                DA797022.1         45-102
            59-1767             BC075059.2         1-1709
            1768-4275           AL583832.14        61728-64235         c
            4276-4367           BQ020418.1         13-104              c
FEATURES             Location/Qualifiers
     source          1..4367
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..4367
                     /gene="RBBP5"
                     /gene_synonym="RBQ3; SWD1"
                     /note="RB binding protein 5, histone lysine
                     methyltransferase complex subunit"
                     /db_xref="GeneID:5929"
                     /db_xref="HGNC:HGNC:9888"
                     /db_xref="MIM:600697"
     exon            1..124
                     /gene="RBBP5"
                     /gene_synonym="RBQ3; SWD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1722
                     /gene="RBBP5"
                     /gene_synonym="RBQ3; SWD1"
                     /note="isoform 1 is encoded by transcript variant 1; SWD1,
                     Set1c WD40 repeat protein, homolog; RBBP-5;
                     retinoblastoma-binding protein RBQ-3;
                     retinoblastoma-binding protein 5"
                     /codon_start=1
                     /product="retinoblastoma-binding protein 5 isoform 1"
                     /protein_id="NP_005048.2"
                     /db_xref="CCDS:CCDS30983.1"
                     /db_xref="GeneID:5929"
                     /db_xref="HGNC:HGNC:9888"
                     /db_xref="MIM:600697"
                     /translation="MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCN
                     DGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQ
                     RFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFD
                     RRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTA
                     DRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHAL
                     YIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAP
                     DFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEE
                     LEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKK
                     KPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDR
                     GLPLEGSAKGKVQAELSQPLTAGGAISELL"
     exon            125..150
                     /gene="RBBP5"
                     /gene_synonym="RBQ3; SWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            151..323
                     /gene="RBBP5"
                     /gene_synonym="RBQ3; SWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            324..464
                     /gene="RBBP5"
                     /gene_synonym="RBQ3; SWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            465..627
                     /gene="RBBP5"
                     /gene_synonym="RBQ3; SWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            628..737
                     /gene="RBBP5"
                     /gene_synonym="RBQ3; SWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            738..857
                     /gene="RBBP5"
                     /gene_synonym="RBQ3; SWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1011
                     /gene="RBBP5"
                     /gene_synonym="RBQ3; SWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1083
                     /gene="RBBP5"
                     /gene_synonym="RBQ3; SWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1201
                     /gene="RBBP5"
                     /gene_synonym="RBQ3; SWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1271
                     /gene="RBBP5"
                     /gene_synonym="RBQ3; SWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1501
                     /gene="RBBP5"
                     /gene_synonym="RBQ3; SWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1693
                     /gene="RBBP5"
                     /gene_synonym="RBQ3; SWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..4367
                     /gene="RBBP5"
                     /gene_synonym="RBQ3; SWD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4342..4347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBBP5"
                     /gene_synonym="RBQ3; SWD1"
                     /note="hexamer: AATAAA"
     polyA_site      4367
                     /gene="RBBP5"
                     /gene_synonym="RBQ3; SWD1"
                     /note="major polyA site"
ORIGIN      
        1 gccagtctct tcgcggcgtc caccacttag acgcaagttg ctgaagccgg ccggggagaa
       61 ggtgttgttg ccggagctga gaccgggcgg ccacagtccg cagggatgaa cctcgagttg
      121 ctggagtcct ttgggcagaa ctatccagag gaagctgatg gaactttgga ttgtatcagc
      181 atggctttga cttgcacctt taacaggtgg ggcacactgc ttgcagttgg ctgtaatgat
      241 ggccgaattg tcatctggga tttcttgaca agaggcattg ctaaaataat tagtgcacac
      301 atccatccag tgtgttcttt atgctggagc cgagatggtc ataaactcgt gagtgcttcc
      361 actgataaca tagtgtcaca gtgggatgtt ctttcaggcg actgtgacca gaggtttcga
      421 ttcccttcac ccatcttaaa agtccaatat catccacgag atcagaacaa ggttctcgtg
      481 tgtcccatga aatctgctcc tgtcatgttg accctttcag attccaaaca tgttgttctg
      541 ccggtggacg atgactccga tttgaacgtt gtggcatctt ttgataggcg aggggaatat
      601 atttatacgg gaaacgcaaa aggcaagatt ttggtcctaa aaacagattc tcaggatctt
      661 gttgcttcct tcagagtgac aactggaaca agcaatacca cagccattaa gtcaattgag
      721 tttgcccgga aggggagttg ctttttaatt aacacggcag atcgaataat cagagtttat
      781 gatggcagag aaatcttaac atgtggaaga gatggagagc ctgaacctat gcagaaattg
      841 caggatttgg tgaataggac cccatggaag aaatgttgtt tctctgggga tggggaatac
      901 atcgtggcag gttctgcccg gcagcatgcc ctgtacatct gggagaagag cattggcaac
      961 ctggtgaaga ttctccatgg gacgagagga gaactcctct tggatgtagc ttggcatcct
     1021 gttcgaccca tcatagcatc catttccagt ggagtggtat ctatctgggc acagaatcaa
     1081 gtagaaaact ggagtgcatt tgcaccagac ttcaaagaat tggatgaaaa tgtagaatac
     1141 gaagaaaggg aatcagagtt tgatattgaa gatgaagata agagtgagcc tgagcagaca
     1201 ggggctgatg ctgcagaaga tgaggaagtg gatgtcacca gcgtggaccc tattgctgcc
     1261 ttctgtagca gtgatgaaga gctggaagat tcaaaggctc tattgtattt acccattgcc
     1321 cctgaggtag aagacccaga agaaaatcct tacggccccc caccggatgc agtccaaacc
     1381 tccttgatgg atgaaggggc tagttcagag aagaagaggc agtcctcagc agatgggtcc
     1441 cagccaccta agaagaaacc caaaacaacc aatatagaac ttcaaggagt accaaatgat
     1501 gaagtccatc cactactggg tgtgaagggg gatggcaaat ccaagaagaa gcaagcaggc
     1561 cggcctaaag gatcaaaagg taaagagaaa gattctccat ttaaaccgaa actctacaaa
     1621 ggggacagag gtttacctct ggaaggatca gcgaagggta aagtgcaggc ggaactcagc
     1681 cagcccttga cagcaggagg agcaatctca gaactgttat gaagaccttc gaagttcttc
     1741 attctttctc actttgccat catgtggcct ctggacactg tggtcagtca tttgaaaatt
     1801 gactttaatt taaaacaaag gcctgtgcct cccacccagg aggtgggagg gtgaatttta
     1861 tgtttaaatg aagaagtgaa ttatggaaga agagtatacg accttccctt ccctttcaag
     1921 cataagtcca aatagactct caggaatgaa gatttgtgaa gacatcagat aggaattttg
     1981 actcatttaa actttgatgc ttagttatgt tgctggagaa aagatactta tgttttgctc
     2041 atctaacttc attgtaccca gcgtcatttt gacatgtcat ttcctatctc ccatttgcct
     2101 tcggtcctca atgcatgtct ttgagtgact tcttatctga aattttgcta ctggtatcct
     2161 aggaaagctt ttgttggata ctctcatttt aaacttctcc tctccccaga tacctcctat
     2221 atttccatat tgtgtgcaaa ggatgggcag aaaagaaagt gcttgaaaga tttcaaattt
     2281 tcagaaaggg aacaacgaag gccctctctt cctctcatac cacgttttgc tcaagaagct
     2341 gggctgtaac aattcagggt tttcccttgt tttcctctca ttgcatgttt ccctccaata
     2401 ttggttcatt gtcatcaatc atggtttttg aagatagcta gttttatcca tctccagcaa
     2461 agaatcatca atagtttata ttgctttacc tgtgctggct tccagagatg gaaacaaacc
     2521 caggtgtctc tcaacaagct acttttttac tggggtgggg gaatctatgc aaggagtaaa
     2581 gtaaaaccat ccagaatcaa agcagcaacc acatagttca aatcaaagat caaggtgaat
     2641 tttttgtatc actgcctgtg gaaatctatc ctcatcagtc attgcatttt tccctgccta
     2701 tacctgtgct cctttttctt actgtgtttt cagtcacttc ctttctgtga aaggttgctt
     2761 agcttttttt ttgacatttg ttgttcttta taaaaataac agattggata gatgtgtaca
     2821 tttggtgttt gaaattctct gaaaatccca ttaggaaacc aggtgtgaaa agggctcagt
     2881 agcttctctg agtggcgttt ttagctgact ggaagtgctt aatctggatc gtcttttttt
     2941 tttttttttt tttttcaata ttttaaaagg agaatttaaa tactgtgctt actgtgaaat
     3001 atatcagttg gtgagccggg cgtggtgggt cacgcctgta atcccagcac tttgggaggc
     3061 caaggcgggt tgatcacccg aggtcaggag ttcaagacca gcctggccaa cgtggtgaaa
     3121 gcctgtatct attaaaagac aaaaattagc tgggcgtggt agtacatgcc tgtaatccca
     3181 gctacactgg aggctgagtc aggagaatca cttgaacgtg ggaggcagag gttgcagtga
     3241 gtggagatcg caccactgcc ctccagccta ggtgacagaa tgagactcta tctcaaaaaa
     3301 aaaaaaaaaa tgatatcagt tggtggatgc tcctataggt agccaaacac attgattacc
     3361 tgttagattt taggatagaa atcaaagtag agcacgtcag caagagcctc tttgtctcac
     3421 tccatcattt aaaaccagta tattcagtag ttgaagaaag agctctccct gagtcagttg
     3481 caaaacgtct atatttttag atgccactac ttttttctta aatattcatt ttgagactgt
     3541 catgagttag accagtggtt gagattagta gatggctcac tagacatgtt tttgttttgc
     3601 agacattata tccattccag tcctctgcac tgtacactgc agcagtgtgc aaactatggg
     3661 acttagaggg tttctgccat ctttccacgt gtgaagtagc ttggtttcct ctgcctgtgc
     3721 atttggatgt ttgtgctatg tccacctcct aaactggcta ctgagaaaat catcttcagc
     3781 cctgtcagat tgtctctggc agtagctcct aataattatt tatgtttttg gaattttttt
     3841 ttcaactttt aaaaaacctt ctatccattt caatttgaat tatttgattt gtacaatata
     3901 tgtatattct cttcttcctt tttgtcatcc ctgccctgcc acccccaaaa ttttgttttt
     3961 aaaaatattc tgggctgggc atggtggctc acacctgtaa tcccagcact tggggaggcc
     4021 gaggctggtg gatcatctga ggtcaggtgt ttgagaccag cctggtcaac atggtgaaac
     4081 cccgtctcta ctaaaaatac aaaaattagc tgggcgtggt ggcgggcacc tgtaatccta
     4141 gctactcggg aggctgaggc aggagaattg cttgaatcca ggaggcagag gttgcagtga
     4201 gctgagattg cgccactgca ctccagcctg ggtgacagag caagactcca tctcaaaaaa
     4261 aaaaaaaaaa aaaaatctgt agttttgtac aagatgagac ttagccttgg gtacttcttg
     4321 ctgaagcttt aatgctttgt aaataaaatc ggatgtttat taaagaa
//
