LOCUS       NP_005048                538 aa            linear   PRI 20-FEB-2025
DEFINITION  retinoblastoma-binding protein 5 isoform 1 [Homo sapiens].
ACCESSION   NP_005048
VERSION     NP_005048.2
DBSOURCE    REFSEQ: accession NM_005057.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 538)
  AUTHORS   Chen,Y., Su,H., Zhao,J., Na,Z., Jiang,K., Bacchiocchi,A., Loh,K.H.,
            Halaban,R., Wang,Z., Cao,X. and Slavoff,S.A.
  TITLE     Unannotated microprotein EMBOW regulates the interactome and
            chromatin and mitotic functions of WDR5
  JOURNAL   Cell Rep 42 (9), 113145 (2023)
   PUBMED   37725512
REFERENCE   2  (residues 1 to 538)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (residues 1 to 538)
  AUTHORS   Xie,H., Zhao,J., Wan,J., Zhao,J., Wang,Q., Yang,X., Yang,W., Lin,P.
            and Yu,X.
  TITLE     Long non-coding RNA AC245100.4 promotes prostate cancer
            tumorigenesis via the microRNA-145-5p/RBBP5 axis
  JOURNAL   Oncol Rep 45 (2), 619-629 (2021)
   PUBMED   33416179
  REMARK    GeneRIF: Long noncoding RNA AC245100.4 promotes prostate cancer
            tumorigenesis via the microRNA1455p/RBBP5 axis.
            Erratum:[Oncol Rep. 2023 Mar;49(3):62. doi: 10.3892/or.2023.8499..
            PMID: 36799194]
REFERENCE   4  (residues 1 to 538)
  AUTHORS   Patel,A., Dharmarajan,V., Vought,V.E. and Cosgrove,M.S.
  TITLE     On the mechanism of multiple lysine methylation by the human mixed
            lineage leukemia protein-1 (MLL1) core complex
  JOURNAL   J Biol Chem 284 (36), 24242-24256 (2009)
   PUBMED   19556245
REFERENCE   5  (residues 1 to 538)
  AUTHORS   Southall,S.M., Wong,P.S., Odho,Z., Roe,S.M. and Wilson,J.R.
  TITLE     Structural basis for the requirement of additional factors for MLL1
            SET domain activity and recognition of epigenetic marks
  JOURNAL   Mol Cell 33 (2), 181-191 (2009)
   PUBMED   19187761
REFERENCE   6  (residues 1 to 538)
  AUTHORS   Lee,J.H., Tate,C.M., You,J.S. and Skalnik,D.G.
  TITLE     Identification and characterization of the human Set1B histone
            H3-Lys4 methyltransferase complex
  JOURNAL   J Biol Chem 282 (18), 13419-13428 (2007)
   PUBMED   17355966
REFERENCE   7  (residues 1 to 538)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   8  (residues 1 to 538)
  AUTHORS   Scacheri,P.C., Davis,S., Odom,D.T., Crawford,G.E., Perkins,S.,
            Halawi,M.J., Agarwal,S.K., Marx,S.J., Spiegel,A.M., Meltzer,P.S.
            and Collins,F.S.
  TITLE     Genome-wide analysis of menin binding provides insights into MEN1
            tumorigenesis
  JOURNAL   PLoS Genet 2 (4), e51 (2006)
   PUBMED   16604156
  REMARK    GeneRIF: analysis of menin's role as a tumor suppressor and binding
            sites of Rbbp5 and MLL1
REFERENCE   9  (residues 1 to 538)
  AUTHORS   Goo,Y.H., Sohn,Y.C., Kim,D.H., Kim,S.W., Kang,M.J., Jung,D.J.,
            Kwak,E., Barlev,N.A., Berger,S.L., Chow,V.T., Roeder,R.G.,
            Azorsa,D.O., Meltzer,P.S., Suh,P.G., Song,E.J., Lee,K.J., Lee,Y.C.
            and Lee,J.W.
  TITLE     Activating signal cointegrator 2 belongs to a novel steady-state
            complex that contains a subset of trithorax group proteins
  JOURNAL   Mol Cell Biol 23 (1), 140-149 (2003)
   PUBMED   12482968
REFERENCE   10 (residues 1 to 538)
  AUTHORS   Saijo,M., Sakai,Y., Kishino,T., Niikawa,N., Matsuura,Y., Morino,K.,
            Tamai,K. and Taya,Y.
  TITLE     Molecular cloning of a human protein that binds to the
            retinoblastoma protein and chromosomal mapping
  JOURNAL   Genomics 27 (3), 511-519 (1995)
   PUBMED   7558034
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA797022.1, BC075059.2,
            AL583832.14 and BQ020418.1.
            
            On Oct 4, 2004 this sequence version replaced NP_005048.1.
            
            Summary: This gene encodes a ubiquitously expressed nuclear protein
            which belongs to a highly conserved subfamily of WD-repeat
            proteins. The encoded protein binds directly to retinoblastoma
            protein, which regulates cell proliferation. It interacts
            preferentially with the underphosphorylated retinoblastoma protein
            via the E1A-binding pocket B. Three alternatively spliced
            transcript variants that encode different protein isoforms have
            been described for this gene. [provided by RefSeq, Jul 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053856.1, X85134.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264515.11/ ENSP00000264515.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     Protein         1..538
                     /product="retinoblastoma-binding protein 5 isoform 1"
                     /note="SWD1, Set1c WD40 repeat protein, homolog; RBBP-5;
                     retinoblastoma-binding protein RBQ-3;
                     retinoblastoma-binding protein 5"
                     /calculated_mol_wt=59022
     Region          22..63
                     /region_name="WD 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15291.2)"
     Region          29..64
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <31..321
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          64..103
                     /region_name="WD 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15291.2)"
     Region          70..106
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          148..188
                     /region_name="WD 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15291.2)"
     Region          154..190
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          196..235
                     /region_name="WD 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15291.2)"
     Region          201..246
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          249..291
                     /region_name="WD 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15291.2)"
     Site            252
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by CDK1.
                     /evidence=ECO:0000269|PubMed:7558034; propagated from
                     UniProtKB/Swiss-Prot (Q15291.2)"
     Region          254..291
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          293..331
                     /region_name="WD 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15291.2)"
     Region          298..321
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          330..366
                     /region_name="Interaction with ASH2L.
                     /evidence=ECO:0000269|PubMed:21220120"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15291.2)"
     Region          344..377
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15291.2)"
     Site            350
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17081983; propagated from
                     UniProtKB/Swiss-Prot (Q15291.2)"
     Region          371..380
                     /region_name="Interaction with WDR5.
                     /evidence=ECO:0000269|PubMed:21220120"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15291.2)"
     Site            388
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231; propagated from
                     UniProtKB/Swiss-Prot (Q15291.2)"
     Site            389
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231; propagated from
                     UniProtKB/Swiss-Prot (Q15291.2)"
     Region          408..538
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15291.2)"
     Site            497
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CDK1.
                     /evidence=ECO:0000269|PubMed:7558034; propagated from
                     UniProtKB/Swiss-Prot (Q15291.2)"
     Site            525
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (Q15291.2)"
     CDS             1..538
                     /gene="RBBP5"
                     /gene_synonym="RBQ3; SWD1"
                     /coded_by="NM_005057.4:106..1722"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS30983.1"
                     /db_xref="GeneID:5929"
                     /db_xref="HGNC:HGNC:9888"
                     /db_xref="MIM:600697"
ORIGIN      
        1 mnlellesfg qnypeeadgt ldcismaltc tfnrwgtlla vgcndgrivi wdfltrgiak
       61 iisahihpvc slcwsrdghk lvsastdniv sqwdvlsgdc dqrfrfpspi lkvqyhprdq
      121 nkvlvcpmks apvmltlsds khvvlpvddd sdlnvvasfd rrgeyiytgn akgkilvlkt
      181 dsqdlvasfr vttgtsntta iksiefarkg scflintadr iirvydgrei ltcgrdgepe
      241 pmqklqdlvn rtpwkkccfs gdgeyivags arqhalyiwe ksignlvkil hgtrgellld
      301 vawhpvrpii asissgvvsi waqnqvenws afapdfkeld enveyeeres efdiededks
      361 epeqtgadaa edeevdvtsv dpiaafcssd eeledskall ylpiapeved peenpygppp
      421 davqtslmde gassekkrqs sadgsqppkk kpkttnielq gvpndevhpl lgvkgdgksk
      481 kkqagrpkgs kgkekdspfk pklykgdrgl plegsakgkv qaelsqplta ggaisell
//
