LOCUS       NM_005610               7883 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens RB binding protein 4, chromatin remodeling factor
            (RBBP4), transcript variant 1, mRNA.
ACCESSION   NM_005610
VERSION     NM_005610.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7883)
  AUTHORS   Zhan,Y., Zhang,Z., Yin,A., Su,X., Tang,N., Chen,Y., Zhang,Z.,
            Chen,W., Wang,J. and Wang,W.
  TITLE     RBBP4: A novel diagnostic and prognostic biomarker for
            non-small-cell lung cancer correlated with autophagic cell death
  JOURNAL   Cancer Med 13 (15), e70090 (2024)
   PUBMED   39109577
  REMARK    GeneRIF: RBBP4: A novel diagnostic and prognostic biomarker for
            non-small-cell lung cancer correlated with autophagic cell death.
REFERENCE   2  (bases 1 to 7883)
  AUTHORS   Zhan,Y., Yin,A., Su,X., Tang,N., Zhang,Z., Chen,Y., Wang,W. and
            Wang,J.
  TITLE     Interpreting the molecular mechanisms of RBBP4/7 and their roles in
            human diseases (Review)
  JOURNAL   Int J Mol Med 53 (5) (2024)
   PUBMED   38577935
  REMARK    GeneRIF: Interpreting the molecular mechanisms of RBBP4/7 and their
            roles in human diseases (Review).
            Review article
REFERENCE   3  (bases 1 to 7883)
  AUTHORS   Li,J., Song,C., Gu,J., Li,C., Zang,W., Shi,L., Chen,L., Zhu,L.,
            Zhou,M., Wang,T., Li,H., Qi,S. and Lu,Y.
  TITLE     RBBP4 regulates the expression of the Mre11-Rad50-NBS1 (MRN)
            complex and promotes DNA double-strand break repair to mediate
            glioblastoma chemoradiotherapy resistance
  JOURNAL   Cancer Lett 557, 216078 (2023)
   PUBMED   36736531
  REMARK    GeneRIF: RBBP4 regulates the expression of the Mre11-Rad50-NBS1
            (MRN) complex and promotes DNA double-strand break repair to
            mediate glioblastoma chemoradiotherapy resistance.
REFERENCE   4  (bases 1 to 7883)
  AUTHORS   Zhu,X., Luo,X., Long,X., Jiang,S., Xie,X., Zhang,Q. and Wang,H.
  TITLE     CircAGO2 promotes colorectal cancer progression by inhibiting heat
            shock protein family B (small) member 8 via miR-1-3p/retinoblastoma
            binding protein 4 axis
  JOURNAL   Funct Integr Genomics 23 (2), 78 (2023)
   PUBMED   36881338
  REMARK    GeneRIF: CircAGO2 promotes colorectal cancer progression by
            inhibiting heat shock protein family B (small) member 8 via
            miR-1-3p/retinoblastoma binding protein 4 axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7883)
  AUTHORS   Hao,D., Li,Y., Shi,J. and Jiang,J.
  TITLE     Circ_0110498 facilitates the cisplatin resistance of non-small cell
            lung cancer by mediating the miR-1287-5p/RBBP4 axis
  JOURNAL   Thorac Cancer 14 (7), 662-672 (2023)
   PUBMED   36691322
  REMARK    GeneRIF: Circ_0110498 facilitates the cisplatin resistance of
            non-small cell lung cancer by mediating the miR-1287-5p/RBBP4 axis.
REFERENCE   6  (bases 1 to 7883)
  AUTHORS   Taunton,J., Hassig,C.A. and Schreiber,S.L.
  TITLE     A mammalian histone deacetylase related to the yeast
            transcriptional regulator Rpd3p
  JOURNAL   Science 272 (5260), 408-411 (1996)
   PUBMED   8602529
REFERENCE   7  (bases 1 to 7883)
  AUTHORS   Qian,Y.W. and Lee,E.Y.
  TITLE     Dual retinoblastoma-binding proteins with properties related to a
            negative regulator of ras in yeast
  JOURNAL   J Biol Chem 270 (43), 25507-25513 (1995)
   PUBMED   7503932
REFERENCE   8  (bases 1 to 7883)
  AUTHORS   Qian,Y.W., Wang,Y.C., Hollingsworth,R.E. Jr., Jones,D., Ling,N. and
            Lee,E.Y.
  TITLE     A retinoblastoma-binding protein related to a negative regulator of
            Ras in yeast
  JOURNAL   Nature 364 (6438), 648-652 (1993)
   PUBMED   8350924
REFERENCE   9  (bases 1 to 7883)
  AUTHORS   Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
            Vandekerckhove,J.
  TITLE     Microsequences of 145 proteins recorded in the two-dimensional gel
            protein database of normal human epidermal keratinocytes
  JOURNAL   Electrophoresis 13 (12), 960-969 (1992)
   PUBMED   1286667
REFERENCE   10 (bases 1 to 7883)
  AUTHORS   Bauw,G., Rasmussen,H.H., van den Bulcke,M., van Damme,J., Puype,M.,
            Gesser,B., Celis,J.E. and Vandekerckhove,J.
  TITLE     Two-dimensional gel electrophoresis, protein electroblotting and
            microsequencing: a direct link between proteins and genes
  JOURNAL   Electrophoresis 11 (7), 528-536 (1990)
   PUBMED   1699755
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC315298.1, AK312571.1 and
            AC114489.2.
            
            On Nov 22, 2018 this sequence version replaced NM_005610.2.
            
            Summary: This gene encodes a ubiquitously expressed nuclear protein
            which belongs to a highly conserved subfamily of WD-repeat
            proteins. It is present in protein complexes involved in histone
            acetylation and chromatin assembly. It is part of the Mi-2 complex
            which has been implicated in chromatin remodeling and
            transcriptional repression associated with histone deacetylation.
            This encoded protein is also part of co-repressor complexes, which
            is an integral component of transcriptional silencing. It is found
            among several cellular proteins that bind directly to
            retinoblastoma protein to regulate cell proliferation. This protein
            also seems to be involved in transcriptional repression of
            E2F-responsive genes. Three transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Sep
            2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.35501.1,
                                           SRR3476690.340079.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373493.10/ ENSP00000362592.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 DC315298.1         61-64
            5-551               AK312571.1         3-549
            552-552             AC114489.2         32564-32564
            553-1377            AK312571.1         551-1375
            1378-7883           AC114489.2         43903-50408
FEATURES             Location/Qualifiers
     source          1..7883
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.1"
     gene            1..7883
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /note="RB binding protein 4, chromatin remodeling factor"
                     /db_xref="GeneID:5928"
                     /db_xref="HGNC:HGNC:9887"
                     /db_xref="MIM:602923"
     exon            1..115
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1377
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /note="isoform a is encoded by transcript variant 1; MSI1
                     protein homolog; retinoblastoma-binding protein 4;
                     chromatin assembly factor/CAF-1 p48 subunit;
                     retinoblastoma-binding protein p48; histone-binding
                     protein RBBP4; RBBP-4; CAF-I p48; CAF-1 subunit C; CAF-I
                     48 kDa subunit; chromatin assembly factor 1 subunit C;
                     chromatin assembly factor I p48 subunit;
                     nucleosome-remodeling factor subunit RBAP48"
                     /codon_start=1
                     /product="histone-binding protein RBBP4 isoform a"
                     /protein_id="NP_005601.1"
                     /db_xref="CCDS:CCDS366.1"
                     /db_xref="GeneID:5928"
                     /db_xref="HGNC:HGNC:9887"
                     /db_xref="MIM:602923"
                     /translation="MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPS
                     LTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEK
                     GEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSK
                     PDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVD
                     AKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEV
                     NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILA
                     SSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICS
                     VSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS"
     exon            116..263
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     exon            264..409
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     exon            410..583
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     exon            584..699
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     exon            700..860
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     exon            861..987
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1065
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1142
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1200
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1311
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..7883
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2304..2309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /note="hexamer: AATAAA"
     polyA_site      2325
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /note="major polyA site"
     regulatory      7863..7868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /note="hexamer: AATAAA"
     polyA_site      7883
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
ORIGIN      
        1 ggaaacaata gaggccgcgc gcacagagcg agctcttgca gcctccccgc ccctcccgca
       61 acgctcgacc ccaggattcc cccggctcgc ctgcccgcca tggccgacaa ggaagcagcc
      121 ttcgacgacg cagtggaaga acgagtgatc aacgaggaat acaaaatatg gaaaaagaac
      181 accccttttc tttatgattt ggtgatgacc catgctctgg agtggcccag cctaactgcc
      241 cagtggcttc cagatgtaac cagaccagaa gggaaagatt tcagcattca tcgacttgtc
      301 ctggggacac acacatcgga tgaacaaaac catcttgtta tagccagtgt gcagctccct
      361 aatgatgatg ctcagtttga tgcgtcacac tacgacagtg agaaaggaga atttggaggt
      421 tttggttcag ttagtggaaa aattgaaata gaaatcaaga tcaaccatga aggagaagta
      481 aacagggccc gttatatgcc ccagaaccct tgtatcatcg caacaaagac tccttccagt
      541 gatgttcttg tttttgacta tacaaaacat ccttctaaac cagatccttc tggagagtgc
      601 aacccagact tgcgtctccg tggacatcag aaggaaggct atgggctttc ttggaaccca
      661 aatctcagtg ggcacttact tagtgcttca gatgaccata ccatctgcct gtgggacatc
      721 agtgccgttc caaaggaggg aaaagtggta gatgcgaaga ccatctttac agggcatacg
      781 gcagtagtag aagatgtttc ctggcatcta ctccatgagt ctctgtttgg gtcagttgct
      841 gatgatcaga aacttatgat ttgggatact cgttcaaaca atacttccaa accaagccac
      901 tcagttgatg ctcacactgc tgaagtgaac tgcctttctt tcaatcctta tagtgagttc
      961 attcttgcca caggatcagc tgacaagact gttgccttgt gggatctgag aaatctgaaa
     1021 cttaagttgc attcctttga gtcacataag gatgaaatat tccaggttca gtggtcacct
     1081 cacaatgaga ctattttagc ttccagtggt actgatcgca gactgaatgt ctgggattta
     1141 agtaaaattg gagaggaaca atccccagaa gatgcagaag acgggccacc agagttgttg
     1201 tttattcatg gtggtcatac tgccaagata tctgatttct cctggaatcc caatgaacct
     1261 tgggtgattt gttctgtatc agaagacaat atcatgcaag tgtggcaaat ggcagagaac
     1321 atttataatg atgaagaccc tgaaggaagc gtggatccag aaggacaagg gtcctagata
     1381 tgtctttact tgttgtgatt ttagactccc cttttttctt ctcaaccctg agagtgattt
     1441 aacactggtt ttgagacaga ctttattcag ctatccctct atataatagg taccaccgat
     1501 aatgctatta gcccaaaccg tgggtgtttt ctaaatatta ataggggggc ttgattcaac
     1561 aaagccacag acttaacgtt gaaattttct tcaggaattt tctagtaacc caggtctaaa
     1621 gtagctacag aaaggggaat attatgtgtg attatttttc ttcttatgct atatccccaa
     1681 gtttttcaga ctcatttaag taaaggctag agtgagtaag gaatagagcc aaatgaggta
     1741 ggtgtctgag ccatgaagta taaatactga aagatgtcac ttttattcag gaaatagggg
     1801 gagattcaag tcatatagat tcctactcga aaatcttgac acctgacttt ccaggatgca
     1861 cattttcata cgtagaccag tttcctcttg gtttcttcag ttaagtcaaa acaacacgtt
     1921 cctctttccc catatattca tatatttttg ctcgttagtg tatttcttga gctgttttca
     1981 tgttgtttat ttcctgtctg tgaaatggtg tttttttttt tgttgttggt tttttttttt
     2041 ttttttttaa cttgggacca ccaagttgta aagatgtatg tttttacctg acagttatac
     2101 cacaggtaga ctgtcaagtt gagaagagtg aatcaataac ttgtatttgt tttaaaaatt
     2161 aaattaatcc ttgataagag ttgctttttt tttttaggag ttagtccttg accactagtt
     2221 tgatgccatc tccattttgg gtgacctgtt tcaccagcag gcctgttact ctccatgact
     2281 aactgtgtaa gtgcttaaaa tggaataaat tgcttttcta cataacccca tgctgatggg
     2341 ttttatttag tataaaacat ccatcaaaca ccagtctctg gcttctagaa gagtccttca
     2401 gatgacagtt gttgtccatg gtctttgact atcaagagca gaattaaatg taatagtccc
     2461 agagctgtag aaaagaactt tactccttcc cagggaaagt gaaagacata aaacactgaa
     2521 tcagaggtgg cacagattag tctttgataa ggtaacgttt ctttgaagtc tatctgtaga
     2581 gaactacatg gacttccaag agtgtcaaag gcagtgtggt agagagaatt taaggcaaga
     2641 tttaaatttg gaaaaggtgc ttgaaccttt tctcagaggt tttatttccc cagtatgttt
     2701 ttcactgggg cctttactta ggttagaaat aataggcttt gaaggcctct atcaccagat
     2761 gcaataacca gataaaattc ctgttttttc ccaatcgctt agttttttgt tgttgttgtt
     2821 ttttaactga gtagatcatt ctgacccaga actactttca tgaggtaaga tctttgggaa
     2881 aatctgaata gcgttaacca ttagattcaa atctcaaatg gtttcttttc aagtctagtt
     2941 gttttagagt atagtgagaa ataccttgac acaattttaa gagtaaacta tatgggtcag
     3001 catatccttg aacaaaaagt agactttgta aaagtattca tttaaattct aacactcgtg
     3061 gcacaaaaga atggaaattg taaacccatg taatggaaat tggctatctt tttgacccca
     3121 catgtgcccc tcaaaaatgt ttttggtttg ggtcaacaca aggcaagata cattctttaa
     3181 aatactccca gatgtgtcca tacattcatc cttcactcag tgcatatgtg agggttgttg
     3241 ctggaagaca ggaggctcat ctttcctttc cttggtgcat tgagatcagt atcaacagca
     3301 gatgaaatag aatccagcaa agagttgaca tgttctgcct ccggccaact ctagaatctt
     3361 tttaagcagg tcagccagta tttgcaactt ccacaggatg aattgcttgc caagtttctg
     3421 gcactcttgt ctggttggaa gagtacatcc aaagggtact tagtgatcct ttgctaagaa
     3481 gttttttgct gtttccgggt tacagatttg gccatatatt tctaaacagc ccctgtaaag
     3541 ttgaaagaaa aagtttataa cagtgaactt ctgaggttta gttactgcag gctttgttga
     3601 gaagagattg ttacagtgtg atttatggat gatcagggat gactttcccc tagcaaatat
     3661 ttggatgcct cctgtttgtc aaatagaatg aatggtgatg gtgatgggag ggatagttaa
     3721 acgttttctc tgctaggtta acttcttaca ggtataatta caatgcctga aattctgtag
     3781 tttcatttct ttggattagt cgttgtcttt tccagattgt acacaatctg atcaacacaa
     3841 aggtagttag tagatcatta acctcaattg caaggttata atttctcaaa cattaagcat
     3901 attatcagtc atgtggattc aaacacagta taagaaaatc ctcaaggctg ggtgtgatgg
     3961 cttatgcctg taatcccagc tacttagcag gctgaggcag gagtattgtt tgaacccagg
     4021 aggcagagtt gcagtgagcc aagatcgtgc cactactcca gcctgggcaa aatagcaaga
     4081 cccgaccccc catctctact aaaaagaaat ttaaaaaaat aaaatcctag aaaattagaa
     4141 aaagcaacaa tagttacttg tgggccaggc gcggtggttc acgcctgtaa tcccagcact
     4201 ttgagaggct gaggcacgtg gatcacaagg tcaggagttc aagaccagcc tggccaagat
     4261 ggtgaaaccc cgtttctact aaaaatacaa aaactagctg gccgtggtgg catgctcctg
     4321 tagtcccagc tactcaggag gctgaggcag gaaaatcact tgaacccagg aggtggaggt
     4381 tgcagtgaac tgagaccgtg ccactgcact ccagcctggg tggcagagcg agactgtctc
     4441 aaaaaaaaaa gaaagttgtg aatttgatgt aagcttagga aatgaataaa atttataggc
     4501 atctgtataa tgtacaactt gacacggact ttcttttatc cttagtttct ttcacggact
     4561 ctagaacttt tatcagaata tactggtaaa acattggggg agggatcctg agtaggtgat
     4621 tggtcagaaa gatgccttca gttttgtcag tgtctaaaag ttaagtctgt ttaggccaag
     4681 catggtggct cacacctgaa atcccagcac tctgggaggc cgaggcaagt ggatcacaag
     4741 gtcaggagat gagaccatct tagccaacat ggtgaaaccc cgtctctact aaaatacaaa
     4801 aaaattagcc aggcgtggtg gtgcgtgcct ataatcccag ctacttggga ggctgaggca
     4861 ggggaatcgc ttgaacccgg gaggcagagg tcacgccact gcactccagc ctggcaacag
     4921 agcaagactc cgtctcaaaa aaaaaaaaaa aaaaaaagag taagtctgtg taacatgaac
     4981 atctctgctt ccacccaaaa ccacagcctt tgaatattat ataaggaact taatggatag
     5041 atatgtttat tatttttgat agcacaactg ctttctctgc tattataagg aaaactgaga
     5101 atagcaggtg ggtagggtag gatgaggaaa caagatgccc aaagcctaga tgccacagaa
     5161 ttcatggtga taatcagggc atattttgag tcctactaga aacaaacatt ccaaatgaac
     5221 tctgaatgcc tgactcaggc gttttggagg tttgggttat ccccttgtca ttaggcacac
     5281 aagggttttt tgttgttttt gttttttggg tttttgtttt gttttgaggc agtctcactc
     5341 tgttgtacaa gctggagtgc tgtattgtga tcttgactca ctgcaacctc tgcctcctgg
     5401 ttcaagcgat tctcctgcct tggcctcctg agtagctggg attataagtg cctgccacta
     5461 tgcccggcta atttttgtat ttttagtgga gatggagttt tgccatgttg gccaggctgg
     5521 tcttgaactc ctgactccag gtgatccacc ctcctcagcc tcccaaagtg ctaggattac
     5581 aggcgtgagc caccccgtcc ggcctgtttt taaggcatta attagtattg ttaggaaagc
     5641 agtaacaatg caaacaccac tcttctcttc acaaagatca ccttgagact gtgtctccat
     5701 tccacctgcc tgagaagtgg gagcatcagc ctgttccagg ctcttgggta gtagcatagc
     5761 cctttaaaaa gagagagcca ttttccatgt gtttttggat aagcacaatt tgaaaatcat
     5821 ttcccaaatc ctctttttgt ttttgattct aaggtaaaat tttccctaag ccctcccacc
     5881 atcccctcag ccagtattag atgagatttg tatagcagca gaaactgact tataagtaga
     5941 gagctcttca gcaagactga gccttagctg ttccatctct ttgttcttct gttgctggag
     6001 ttgcacccca tttcttaact gcctctggcg ttcttccatt tcctccagct gttcctgcat
     6061 gagatggcca agaacatttc taatgagcca aacaataaaa actcacattg tccactctta
     6121 cttataaaac acttttttgt tcattgttta atcttgatag cagtattgag gctggtattt
     6181 atatgatagg ttatgaaaca ggttcaaaga agttgtgtct tggaaaaaaa gtgacaatgc
     6241 ttttgaaaat gatgacgaaa aaggcatctt gtctgttaac cacagcttgc tttaatagaa
     6301 tcctgggagg gtgattggga ctttttagta ttacaacctt agtgtcattg aggaggattt
     6361 tggtctagtt agtgggctga gtttcatata cctctccctc catgtgcagg tttgttaaga
     6421 taattggtag tttttaataa tataaaatac ttaagttgaa atacaaaagt gtggcaacaa
     6481 ttattaaata ttggctagaa ttctaggaga gttacacaac tagtggaagt ccatgtttag
     6541 aaaataaatg gcttgtttaa ggaaaagttt ttgtgtccaa agctccttaa agtcagagag
     6601 atttctacct ggtacttaac atcatatgga aattgatgct ttagtgaggg tgttggctat
     6661 cctattgcta atttcctgca tccttttttc ttctttattt ttgtatagag acagggtctc
     6721 gctatgttgc ccaggctggt cttgttcctg ggctcaagca gtcctcccgc ctcggtctcc
     6781 caaagtgctg ggattacagg tgtgagccac tgtgcccagc ttatcctttt ttcattacac
     6841 aaaaagactg aatttggtta gttctaagtt ggaagataaa gatggtatgc acaggaggcc
     6901 cttgggagcc ctcagataac tttctcattc ttccagaatc aggctgggat gcattctgta
     6961 aattttccct gcctaggatg tatacctgag gaataaggta aggaagatgt cagcaagtca
     7021 gtctctggtt tacctgctag ctggcatgga tccttaagga agcaggaggg agttgggaag
     7081 agaggaaggg gtgaagttgg tatcttttaa agcgagagtg attttacctc agattttgaa
     7141 gaatactaag gaatccagtt gttggggtac atgctattat tagaaggatc tagataattt
     7201 gtcctctgag tcatacttga cattgtacct gtggcacatc aatccgcact gtttgatact
     7261 ctggctgaat ctcagctttc accaacattg tcaaaggacc ttttttagtg cccagccatg
     7321 cctaagagtg tgtcatctga agagggaagc atctgcatac tgctgtcctg attgctcagt
     7381 cctcactacc taccagaccc gttggtaagg tacaaaagta catgcttgga aaagcagtct
     7441 gcaccaccag tgataagctg tgacagagtg gaacagcctc aatgaaatga aggaaggatt
     7501 gctacagtgg cattaaggat ggtctcttaa tcctgtgtta accactagat taactttaca
     7561 atcaactcaa aatccttcaa aggctttcca ctttctttag tggcattcag accccctcta
     7621 gtttgacccc tacctccaac ttgaacctct gttactcttc cgtatgaaca ttttcctcta
     7681 gccctggact actagtaccg aagtcactag tcacatagga ctcatttgaa atatgactag
     7741 tctcaattga gatgtaatgt aagtgtaaaa tacacagcag atttctaaga cagcacacaa
     7801 aatgtaaaat atgtcaaaaa tatttgatac tgattacatg ttgaaatata tgtgttgggt
     7861 taaataaaat gcattaaagt taa
//
