LOCUS       NM_001135256            7845 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens RB binding protein 4, chromatin remodeling factor
            (RBBP4), transcript variant 3, mRNA.
ACCESSION   NM_001135256
VERSION     NM_001135256.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7845)
  AUTHORS   Zhan,Y., Zhang,Z., Yin,A., Su,X., Tang,N., Chen,Y., Zhang,Z.,
            Chen,W., Wang,J. and Wang,W.
  TITLE     RBBP4: A novel diagnostic and prognostic biomarker for
            non-small-cell lung cancer correlated with autophagic cell death
  JOURNAL   Cancer Med 13 (15), e70090 (2024)
   PUBMED   39109577
  REMARK    GeneRIF: RBBP4: A novel diagnostic and prognostic biomarker for
            non-small-cell lung cancer correlated with autophagic cell death.
REFERENCE   2  (bases 1 to 7845)
  AUTHORS   Zhan,Y., Yin,A., Su,X., Tang,N., Zhang,Z., Chen,Y., Wang,W. and
            Wang,J.
  TITLE     Interpreting the molecular mechanisms of RBBP4/7 and their roles in
            human diseases (Review)
  JOURNAL   Int J Mol Med 53 (5) (2024)
   PUBMED   38577935
  REMARK    GeneRIF: Interpreting the molecular mechanisms of RBBP4/7 and their
            roles in human diseases (Review).
            Review article
REFERENCE   3  (bases 1 to 7845)
  AUTHORS   Li,J., Song,C., Gu,J., Li,C., Zang,W., Shi,L., Chen,L., Zhu,L.,
            Zhou,M., Wang,T., Li,H., Qi,S. and Lu,Y.
  TITLE     RBBP4 regulates the expression of the Mre11-Rad50-NBS1 (MRN)
            complex and promotes DNA double-strand break repair to mediate
            glioblastoma chemoradiotherapy resistance
  JOURNAL   Cancer Lett 557, 216078 (2023)
   PUBMED   36736531
  REMARK    GeneRIF: RBBP4 regulates the expression of the Mre11-Rad50-NBS1
            (MRN) complex and promotes DNA double-strand break repair to
            mediate glioblastoma chemoradiotherapy resistance.
REFERENCE   4  (bases 1 to 7845)
  AUTHORS   Zhu,X., Luo,X., Long,X., Jiang,S., Xie,X., Zhang,Q. and Wang,H.
  TITLE     CircAGO2 promotes colorectal cancer progression by inhibiting heat
            shock protein family B (small) member 8 via miR-1-3p/retinoblastoma
            binding protein 4 axis
  JOURNAL   Funct Integr Genomics 23 (2), 78 (2023)
   PUBMED   36881338
  REMARK    GeneRIF: CircAGO2 promotes colorectal cancer progression by
            inhibiting heat shock protein family B (small) member 8 via
            miR-1-3p/retinoblastoma binding protein 4 axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7845)
  AUTHORS   Hao,D., Li,Y., Shi,J. and Jiang,J.
  TITLE     Circ_0110498 facilitates the cisplatin resistance of non-small cell
            lung cancer by mediating the miR-1287-5p/RBBP4 axis
  JOURNAL   Thorac Cancer 14 (7), 662-672 (2023)
   PUBMED   36691322
  REMARK    GeneRIF: Circ_0110498 facilitates the cisplatin resistance of
            non-small cell lung cancer by mediating the miR-1287-5p/RBBP4 axis.
REFERENCE   6  (bases 1 to 7845)
  AUTHORS   Taunton,J., Hassig,C.A. and Schreiber,S.L.
  TITLE     A mammalian histone deacetylase related to the yeast
            transcriptional regulator Rpd3p
  JOURNAL   Science 272 (5260), 408-411 (1996)
   PUBMED   8602529
REFERENCE   7  (bases 1 to 7845)
  AUTHORS   Qian,Y.W. and Lee,E.Y.
  TITLE     Dual retinoblastoma-binding proteins with properties related to a
            negative regulator of ras in yeast
  JOURNAL   J Biol Chem 270 (43), 25507-25513 (1995)
   PUBMED   7503932
REFERENCE   8  (bases 1 to 7845)
  AUTHORS   Qian,Y.W., Wang,Y.C., Hollingsworth,R.E. Jr., Jones,D., Ling,N. and
            Lee,E.Y.
  TITLE     A retinoblastoma-binding protein related to a negative regulator of
            Ras in yeast
  JOURNAL   Nature 364 (6438), 648-652 (1993)
   PUBMED   8350924
REFERENCE   9  (bases 1 to 7845)
  AUTHORS   Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
            Vandekerckhove,J.
  TITLE     Microsequences of 145 proteins recorded in the two-dimensional gel
            protein database of normal human epidermal keratinocytes
  JOURNAL   Electrophoresis 13 (12), 960-969 (1992)
   PUBMED   1286667
REFERENCE   10 (bases 1 to 7845)
  AUTHORS   Bauw,G., Rasmussen,H.H., van den Bulcke,M., van Damme,J., Puype,M.,
            Gesser,B., Celis,J.E. and Vandekerckhove,J.
  TITLE     Two-dimensional gel electrophoresis, protein electroblotting and
            microsequencing: a direct link between proteins and genes
  JOURNAL   Electrophoresis 11 (7), 528-536 (1990)
   PUBMED   1699755
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC114489.2, AK299251.1 and
            AK222779.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001135256.1.
            
            Summary: This gene encodes a ubiquitously expressed nuclear protein
            which belongs to a highly conserved subfamily of WD-repeat
            proteins. It is present in protein complexes involved in histone
            acetylation and chromatin assembly. It is part of the Mi-2 complex
            which has been implicated in chromatin remodeling and
            transcriptional repression associated with histone deacetylation.
            This encoded protein is also part of co-repressor complexes, which
            is an integral component of transcriptional silencing. It is found
            among several cellular proteins that bind directly to
            retinoblastoma protein to regulate cell proliferation. This protein
            also seems to be involved in transcriptional repression of
            E2F-responsive genes. Three transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Sep
            2008].
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (c) is
            shorter at the N-terminus compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK299251.1, SRR14038196.1498702.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC114489.2         15553-15554
            3-513               AK299251.1         1-511
            514-514             AC114489.2         32564-32564
            515-1687            AK222779.1         516-1688
            1688-7845           AC114489.2         44251-50408
FEATURES             Location/Qualifiers
     source          1..7845
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.1"
     gene            1..7845
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /note="RB binding protein 4, chromatin remodeling factor"
                     /db_xref="GeneID:5928"
                     /db_xref="HGNC:HGNC:9887"
                     /db_xref="MIM:602923"
     exon            1..77
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     exon            78..225
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1339
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /note="isoform c is encoded by transcript variant 3; MSI1
                     protein homolog; retinoblastoma-binding protein 4;
                     chromatin assembly factor/CAF-1 p48 subunit;
                     retinoblastoma-binding protein p48; histone-binding
                     protein RBBP4; RBBP-4; CAF-I p48; CAF-1 subunit C; CAF-I
                     48 kDa subunit; chromatin assembly factor 1 subunit C;
                     chromatin assembly factor I p48 subunit;
                     nucleosome-remodeling factor subunit RBAP48"
                     /codon_start=1
                     /product="histone-binding protein RBBP4 isoform c"
                     /protein_id="NP_001128728.1"
                     /db_xref="CCDS:CCDS44106.1"
                     /db_xref="GeneID:5928"
                     /db_xref="HGNC:HGNC:9887"
                     /db_xref="MIM:602923"
                     /translation="MTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHL
                     VIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNP
                     CIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLS
                     ASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLM
                     IWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH
                     SFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFI
                     HGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS"
     exon            226..371
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     exon            372..545
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     exon            546..661
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     exon            662..822
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     exon            823..949
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1027
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1104
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1162
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1273
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..7845
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2266..2271
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /note="hexamer: AATAAA"
     polyA_site      2287
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /note="major polyA site"
     regulatory      7825..7830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
                     /note="hexamer: AATAAA"
     polyA_site      7845
                     /gene="RBBP4"
                     /gene_synonym="lin-53; NURF55; RBAP48"
ORIGIN      
        1 gggtgcctgg gctgagccgc ggcctcgaca tggcctaaca gtgagggcag gcccgagttt
       61 gccgagtgca gtccccgcag ccttcgacga cgcagtggaa gaacgagtga tcaacgagga
      121 atacaaaata tggaaaaaga acaccccttt tctttatgat ttggtgatga cccatgctct
      181 ggagtggccc agcctaactg cccagtggct tccagatgta accagaccag aagggaaaga
      241 tttcagcatt catcgacttg tcctggggac acacacatcg gatgaacaaa accatcttgt
      301 tatagccagt gtgcagctcc ctaatgatga tgctcagttt gatgcgtcac actacgacag
      361 tgagaaagga gaatttggag gttttggttc agttagtgga aaaattgaaa tagaaatcaa
      421 gatcaaccat gaaggagaag taaacagggc ccgttatatg ccccagaacc cttgtatcat
      481 cgcaacaaag actccttcca gtgatgttct tgtttttgac tatacaaaac atccttctaa
      541 accagatcct tctggagagt gcaacccaga cttgcgtctc cgtggacatc agaaggaagg
      601 ctatgggctt tcttggaacc caaatctcag tgggcactta cttagtgctt cagatgacca
      661 taccatctgc ctgtgggaca tcagtgccgt tccaaaggag ggaaaagtgg tagatgcgaa
      721 gaccatcttt acagggcata cggcagtagt agaagatgtt tcctggcatc tactccatga
      781 gtctctgttt gggtcagttg ctgatgatca gaaacttatg atttgggata ctcgttcaaa
      841 caatacttcc aaaccaagcc actcagttga tgctcacact gctgaagtga actgcctttc
      901 tttcaatcct tatagtgagt tcattcttgc cacaggatca gctgacaaga ctgttgcctt
      961 gtgggatctg agaaatctga aacttaagtt gcattccttt gagtcacata aggatgaaat
     1021 attccaggtt cagtggtcac ctcacaatga gactatttta gcttccagtg gtactgatcg
     1081 cagactgaat gtctgggatt taagtaaaat tggagaggaa caatccccag aagatgcaga
     1141 agacgggcca ccagagttgt tgtttattca tggtggtcat actgccaaga tatctgattt
     1201 ctcctggaat cccaatgaac cttgggtgat ttgttctgta tcagaagaca atatcatgca
     1261 agtgtggcaa atggcagaga acatttataa tgatgaagac cctgaaggaa gcgtggatcc
     1321 agaaggacaa gggtcctaga tatgtcttta cttgttgtga ttttagactc cccttttttc
     1381 ttctcaaccc tgagagtgat ttaacactgg ttttgagaca gactttattc agctatccct
     1441 ctatataata ggtaccaccg ataatgctat tagcccaaac cgtgggtgtt ttctaaatat
     1501 taataggggg gcttgattca acaaagccac agacttaacg ttgaaatttt cttcaggaat
     1561 tttctagtaa cccaggtcta aagtagctac agaaagggga atattatgtg tgattatttt
     1621 tcttcttatg ctatatcccc aagtttttca gactcattta agtaaaggct agagtgagta
     1681 aggaatagag ccaaatgagg taggtgtctg agccatgaag tataaatact gaaagatgtc
     1741 acttttattc aggaaatagg gggagattca agtcatatag attcctactc gaaaatcttg
     1801 acacctgact ttccaggatg cacattttca tacgtagacc agtttcctct tggtttcttc
     1861 agttaagtca aaacaacacg ttcctctttc cccatatatt catatatttt tgctcgttag
     1921 tgtatttctt gagctgtttt catgttgttt atttcctgtc tgtgaaatgg tgtttttttt
     1981 tttgttgttg gttttttttt tttttttttt aacttgggac caccaagttg taaagatgta
     2041 tgtttttacc tgacagttat accacaggta gactgtcaag ttgagaagag tgaatcaata
     2101 acttgtattt gttttaaaaa ttaaattaat ccttgataag agttgctttt tttttttagg
     2161 agttagtcct tgaccactag tttgatgcca tctccatttt gggtgacctg tttcaccagc
     2221 aggcctgtta ctctccatga ctaactgtgt aagtgcttaa aatggaataa attgcttttc
     2281 tacataaccc catgctgatg ggttttattt agtataaaac atccatcaaa caccagtctc
     2341 tggcttctag aagagtcctt cagatgacag ttgttgtcca tggtctttga ctatcaagag
     2401 cagaattaaa tgtaatagtc ccagagctgt agaaaagaac tttactcctt cccagggaaa
     2461 gtgaaagaca taaaacactg aatcagaggt ggcacagatt agtctttgat aaggtaacgt
     2521 ttctttgaag tctatctgta gagaactaca tggacttcca agagtgtcaa aggcagtgtg
     2581 gtagagagaa tttaaggcaa gatttaaatt tggaaaaggt gcttgaacct tttctcagag
     2641 gttttatttc cccagtatgt ttttcactgg ggcctttact taggttagaa ataataggct
     2701 ttgaaggcct ctatcaccag atgcaataac cagataaaat tcctgttttt tcccaatcgc
     2761 ttagtttttt gttgttgttg ttttttaact gagtagatca ttctgaccca gaactacttt
     2821 catgaggtaa gatctttggg aaaatctgaa tagcgttaac cattagattc aaatctcaaa
     2881 tggtttcttt tcaagtctag ttgttttaga gtatagtgag aaataccttg acacaatttt
     2941 aagagtaaac tatatgggtc agcatatcct tgaacaaaaa gtagactttg taaaagtatt
     3001 catttaaatt ctaacactcg tggcacaaaa gaatggaaat tgtaaaccca tgtaatggaa
     3061 attggctatc tttttgaccc cacatgtgcc cctcaaaaat gtttttggtt tgggtcaaca
     3121 caaggcaaga tacattcttt aaaatactcc cagatgtgtc catacattca tccttcactc
     3181 agtgcatatg tgagggttgt tgctggaaga caggaggctc atctttcctt tccttggtgc
     3241 attgagatca gtatcaacag cagatgaaat agaatccagc aaagagttga catgttctgc
     3301 ctccggccaa ctctagaatc tttttaagca ggtcagccag tatttgcaac ttccacagga
     3361 tgaattgctt gccaagtttc tggcactctt gtctggttgg aagagtacat ccaaagggta
     3421 cttagtgatc ctttgctaag aagttttttg ctgtttccgg gttacagatt tggccatata
     3481 tttctaaaca gcccctgtaa agttgaaaga aaaagtttat aacagtgaac ttctgaggtt
     3541 tagttactgc aggctttgtt gagaagagat tgttacagtg tgatttatgg atgatcaggg
     3601 atgactttcc cctagcaaat atttggatgc ctcctgtttg tcaaatagaa tgaatggtga
     3661 tggtgatggg agggatagtt aaacgttttc tctgctaggt taacttctta caggtataat
     3721 tacaatgcct gaaattctgt agtttcattt ctttggatta gtcgttgtct tttccagatt
     3781 gtacacaatc tgatcaacac aaaggtagtt agtagatcat taacctcaat tgcaaggtta
     3841 taatttctca aacattaagc atattatcag tcatgtggat tcaaacacag tataagaaaa
     3901 tcctcaaggc tgggtgtgat ggcttatgcc tgtaatccca gctacttagc aggctgaggc
     3961 aggagtattg tttgaaccca ggaggcagag ttgcagtgag ccaagatcgt gccactactc
     4021 cagcctgggc aaaatagcaa gacccgaccc cccatctcta ctaaaaagaa atttaaaaaa
     4081 ataaaatcct agaaaattag aaaaagcaac aatagttact tgtgggccag gcgcggtggt
     4141 tcacgcctgt aatcccagca ctttgagagg ctgaggcacg tggatcacaa ggtcaggagt
     4201 tcaagaccag cctggccaag atggtgaaac cccgtttcta ctaaaaatac aaaaactagc
     4261 tggccgtggt ggcatgctcc tgtagtccca gctactcagg aggctgaggc aggaaaatca
     4321 cttgaaccca ggaggtggag gttgcagtga actgagaccg tgccactgca ctccagcctg
     4381 ggtggcagag cgagactgtc tcaaaaaaaa aagaaagttg tgaatttgat gtaagcttag
     4441 gaaatgaata aaatttatag gcatctgtat aatgtacaac ttgacacgga ctttctttta
     4501 tccttagttt ctttcacgga ctctagaact tttatcagaa tatactggta aaacattggg
     4561 ggagggatcc tgagtaggtg attggtcaga aagatgcctt cagttttgtc agtgtctaaa
     4621 agttaagtct gtttaggcca agcatggtgg ctcacacctg aaatcccagc actctgggag
     4681 gccgaggcaa gtggatcaca aggtcaggag atgagaccat cttagccaac atggtgaaac
     4741 cccgtctcta ctaaaataca aaaaaattag ccaggcgtgg tggtgcgtgc ctataatccc
     4801 agctacttgg gaggctgagg caggggaatc gcttgaaccc gggaggcaga ggtcacgcca
     4861 ctgcactcca gcctggcaac agagcaagac tccgtctcaa aaaaaaaaaa aaaaaaaaag
     4921 agtaagtctg tgtaacatga acatctctgc ttccacccaa aaccacagcc tttgaatatt
     4981 atataaggaa cttaatggat agatatgttt attatttttg atagcacaac tgctttctct
     5041 gctattataa ggaaaactga gaatagcagg tgggtagggt aggatgagga aacaagatgc
     5101 ccaaagccta gatgccacag aattcatggt gataatcagg gcatattttg agtcctacta
     5161 gaaacaaaca ttccaaatga actctgaatg cctgactcag gcgttttgga ggtttgggtt
     5221 atccccttgt cattaggcac acaagggttt tttgttgttt ttgttttttg ggtttttgtt
     5281 ttgttttgag gcagtctcac tctgttgtac aagctggagt gctgtattgt gatcttgact
     5341 cactgcaacc tctgcctcct ggttcaagcg attctcctgc cttggcctcc tgagtagctg
     5401 ggattataag tgcctgccac tatgcccggc taatttttgt atttttagtg gagatggagt
     5461 tttgccatgt tggccaggct ggtcttgaac tcctgactcc aggtgatcca ccctcctcag
     5521 cctcccaaag tgctaggatt acaggcgtga gccaccccgt ccggcctgtt tttaaggcat
     5581 taattagtat tgttaggaaa gcagtaacaa tgcaaacacc actcttctct tcacaaagat
     5641 caccttgaga ctgtgtctcc attccacctg cctgagaagt gggagcatca gcctgttcca
     5701 ggctcttggg tagtagcata gccctttaaa aagagagagc cattttccat gtgtttttgg
     5761 ataagcacaa tttgaaaatc atttcccaaa tcctcttttt gtttttgatt ctaaggtaaa
     5821 attttcccta agccctccca ccatcccctc agccagtatt agatgagatt tgtatagcag
     5881 cagaaactga cttataagta gagagctctt cagcaagact gagccttagc tgttccatct
     5941 ctttgttctt ctgttgctgg agttgcaccc catttcttaa ctgcctctgg cgttcttcca
     6001 tttcctccag ctgttcctgc atgagatggc caagaacatt tctaatgagc caaacaataa
     6061 aaactcacat tgtccactct tacttataaa acactttttt gttcattgtt taatcttgat
     6121 agcagtattg aggctggtat ttatatgata ggttatgaaa caggttcaaa gaagttgtgt
     6181 cttggaaaaa aagtgacaat gcttttgaaa atgatgacga aaaaggcatc ttgtctgtta
     6241 accacagctt gctttaatag aatcctggga gggtgattgg gactttttag tattacaacc
     6301 ttagtgtcat tgaggaggat tttggtctag ttagtgggct gagtttcata tacctctccc
     6361 tccatgtgca ggtttgttaa gataattggt agtttttaat aatataaaat acttaagttg
     6421 aaatacaaaa gtgtggcaac aattattaaa tattggctag aattctagga gagttacaca
     6481 actagtggaa gtccatgttt agaaaataaa tggcttgttt aaggaaaagt ttttgtgtcc
     6541 aaagctcctt aaagtcagag agatttctac ctggtactta acatcatatg gaaattgatg
     6601 ctttagtgag ggtgttggct atcctattgc taatttcctg catccttttt tcttctttat
     6661 ttttgtatag agacagggtc tcgctatgtt gcccaggctg gtcttgttcc tgggctcaag
     6721 cagtcctccc gcctcggtct cccaaagtgc tgggattaca ggtgtgagcc actgtgccca
     6781 gcttatcctt ttttcattac acaaaaagac tgaatttggt tagttctaag ttggaagata
     6841 aagatggtat gcacaggagg cccttgggag ccctcagata actttctcat tcttccagaa
     6901 tcaggctggg atgcattctg taaattttcc ctgcctagga tgtatacctg aggaataagg
     6961 taaggaagat gtcagcaagt cagtctctgg tttacctgct agctggcatg gatccttaag
     7021 gaagcaggag ggagttggga agagaggaag gggtgaagtt ggtatctttt aaagcgagag
     7081 tgattttacc tcagattttg aagaatacta aggaatccag ttgttggggt acatgctatt
     7141 attagaagga tctagataat ttgtcctctg agtcatactt gacattgtac ctgtggcaca
     7201 tcaatccgca ctgtttgata ctctggctga atctcagctt tcaccaacat tgtcaaagga
     7261 ccttttttag tgcccagcca tgcctaagag tgtgtcatct gaagagggaa gcatctgcat
     7321 actgctgtcc tgattgctca gtcctcacta cctaccagac ccgttggtaa ggtacaaaag
     7381 tacatgcttg gaaaagcagt ctgcaccacc agtgataagc tgtgacagag tggaacagcc
     7441 tcaatgaaat gaaggaagga ttgctacagt ggcattaagg atggtctctt aatcctgtgt
     7501 taaccactag attaacttta caatcaactc aaaatccttc aaaggctttc cactttcttt
     7561 agtggcattc agaccccctc tagtttgacc cctacctcca acttgaacct ctgttactct
     7621 tccgtatgaa cattttcctc tagccctgga ctactagtac cgaagtcact agtcacatag
     7681 gactcatttg aaatatgact agtctcaatt gagatgtaat gtaagtgtaa aatacacagc
     7741 agatttctaa gacagcacac aaaatgtaaa atatgtcaaa aatatttgat actgattaca
     7801 tgttgaaata tatgtgttgg gttaaataaa atgcattaaa gttaa
//
