LOCUS       NM_014781               6636 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens RB1 inducible coiled-coil 1 (RB1CC1), transcript
            variant 1, mRNA.
ACCESSION   NM_014781
VERSION     NM_014781.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6636)
  AUTHORS   Eickhorst,C., Babic,R., Rush-Kittle,J., Lucya,L., Imam,F.L.,
            Sanchez-Martin,P., Hollenstein,D.M., Michaelis,J., Munch,C.,
            Meisinger,C., Slade,D., Gamez-Diaz,L. and Kraft,C.
  TITLE     FIP200 Phosphorylation Regulates Late Steps in Mitophagy
  JOURNAL   J Mol Biol 436 (15), 168631 (2024)
   PUBMED   38821350
  REMARK    GeneRIF: FIP200 Phosphorylation Regulates Late Steps in Mitophagy.
REFERENCE   2  (bases 1 to 6636)
  AUTHORS   Liang,J., Cai,H., Hou,C., Song,F., Jiang,Y., Wang,Z., Qiu,D.,
            Zhu,Y., Wang,F., Yu,D. and Hou,J.
  TITLE     METTL14 inhibits malignant progression of oral squamous cell
            carcinoma by targeting the autophagy-related gene RB1CC1 in an
            m6A-IGF2BP2-dependent manner
  JOURNAL   Clin Sci (Lond) 137 (17), 1373-1389 (2023)
   PUBMED   37615536
  REMARK    GeneRIF: METTL14 inhibits malignant progression of oral squamous
            cell carcinoma by targeting the autophagy-related gene RB1CC1 in an
            m6A-IGF2BP2-dependent manner.
REFERENCE   3  (bases 1 to 6636)
  AUTHORS   Yang,Y. and Klionsky,D.J.
  TITLE     A novel role of ATG9A and RB1CC1/FIP200 in mediating cell-death
            checkpoints to repress TNF cytotoxicity
  JOURNAL   Autophagy 19 (6), 1617-1618 (2023)
   PUBMED   36892222
  REMARK    GeneRIF: A novel role of ATG9A and RB1CC1/FIP200 in mediating
            cell-death checkpoints to repress TNF cytotoxicity.
REFERENCE   4  (bases 1 to 6636)
  AUTHORS   Yi,F., Cai,C., Ruan,B., Hao,M., Yeo,S.K., Haas,M., Yang,F.,
            Zhang,X. and Guan,J.L.
  TITLE     Regulation of RB1CC1/FIP200 stability and autophagy function by
            CREBBP-mediated acetylation in an intrinsically disordered region
  JOURNAL   Autophagy 19 (6), 1662-1677 (2023)
   PUBMED   36394358
  REMARK    GeneRIF: Regulation of RB1CC1/FIP200 stability and autophagy
            function by CREBBP-mediated acetylation in an intrinsically
            disordered region.
REFERENCE   5  (bases 1 to 6636)
  AUTHORS   Wen,J., Zellner,A., Braun,N.C., Bajaj,T., Gassen,N.C., Peitz,M. and
            Brustle,O.
  TITLE     Loss of function of FIP200 in human pluripotent stem cell-derived
            neurons leads to axonal pathology and hyperactivity
  JOURNAL   Transl Psychiatry 13 (1), 143 (2023)
   PUBMED   37137886
  REMARK    GeneRIF: Loss of function of FIP200 in human pluripotent stem
            cell-derived neurons leads to axonal pathology and hyperactivity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6636)
  AUTHORS   Chano,T., Kontani,K., Teramoto,K., Okabe,H. and Ikegawa,S.
  TITLE     Truncating mutations of RB1CC1 in human breast cancer
  JOURNAL   Nat Genet 31 (3), 285-288 (2002)
   PUBMED   12068296
  REMARK    GeneRIF: RB1CC1 is frequently mutated in breast cancer and shows
            characteristics of a classical tumor-suppressor gene.
REFERENCE   7  (bases 1 to 6636)
  AUTHORS   Chano,T., Ikegawa,S., Saito-Ohara,F., Inazawa,J., Mabuchi,A.,
            Saeki,Y. and Okabe,H.
  TITLE     Isolation, characterization and mapping of the mouse and human
            RB1CC1 genes
  JOURNAL   Gene 291 (1-2), 29-34 (2002)
   PUBMED   12095676
REFERENCE   8  (bases 1 to 6636)
  AUTHORS   Chano,T., Ikegawa,S., Kontani,K., Okabe,H., Baldini,N. and Saeki,Y.
  TITLE     Identification of RB1CC1, a novel human gene that can induce RB1 in
            various human cells
  JOURNAL   Oncogene 21 (8), 1295-1298 (2002)
   PUBMED   11850849
REFERENCE   9  (bases 1 to 6636)
  AUTHORS   Ueda,H., Abbi,S., Zheng,C. and Guan,J.L.
  TITLE     Suppression of Pyk2 kinase and cellular activities by FIP200
  JOURNAL   J Cell Biol 149 (2), 423-430 (2000)
   PUBMED   10769033
REFERENCE   10 (bases 1 to 6636)
  AUTHORS   Maucuer,A., Camonis,J.H. and Sobel,A.
  TITLE     Stathmin interaction with a putative kinase and coiled-coil-forming
            protein domains
  JOURNAL   Proc Natl Acad Sci U S A 92 (8), 3100-3104 (1995)
   PUBMED   7724523
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA326842.1, BC017556.1,
            AC113139.2, AC090814.2 and AB059622.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_014781.4.
            
            Summary: The protein encoded by this gene interacts with signaling
            pathways to coordinately regulate cell growth, cell proliferation,
            apoptosis, autophagy, and cell migration. This tumor suppressor
            also enhances retinoblastoma 1 gene expression in cancer cells.
            Alternative splicing results in multiple transcript variants
            encoding distinct isoforms. [provided by RefSeq, Nov 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript matching the
            genomic sequence was available for the full length of the gene. The
            extent of this transcript is supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB059622.1, SRR1803611.125219.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000025008.10/ ENSP00000025008.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-405               DA326842.1         32-436
            406-1227            BC017556.1         1-822
            1228-1228           AC113139.2         136991-136991
            1229-4705           BC017556.1         824-4300
            4706-4706           AC090814.2         141790-141790       c
            4707-5194           BC017556.1         4302-4789
            5195-6636           AB059622.1         5192-6633
FEATURES             Location/Qualifiers
     source          1..6636
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q11.23"
     gene            1..6636
                     /gene="RB1CC1"
                     /gene_synonym="ATG17; CC1; FIP200; PPP1R131"
                     /note="RB1 inducible coiled-coil 1"
                     /db_xref="GeneID:9821"
                     /db_xref="HGNC:HGNC:15574"
                     /db_xref="MIM:606837"
     exon            1..361
                     /gene="RB1CC1"
                     /gene_synonym="ATG17; CC1; FIP200; PPP1R131"
                     /inference="alignment:Splign:2.1.0"
     exon            362..476
                     /gene="RB1CC1"
                     /gene_synonym="ATG17; CC1; FIP200; PPP1R131"
                     /inference="alignment:Splign:2.1.0"
     exon            477..598
                     /gene="RB1CC1"
                     /gene_synonym="ATG17; CC1; FIP200; PPP1R131"
                     /inference="alignment:Splign:2.1.0"
     CDS             528..5312
                     /gene="RB1CC1"
                     /gene_synonym="ATG17; CC1; FIP200; PPP1R131"
                     /note="isoform 1 is encoded by transcript variant 1; 200
                     kDa FAK family kinase-interacting protein; RB1-inducible
                     coiled-coil protein 1; FAK family kinase-interacting
                     protein of 200 kDa; phosphatase 1, regulatory subunit 131"
                     /codon_start=1
                     /product="RB1-inducible coiled-coil protein 1 isoform 1"
                     /protein_id="NP_055596.3"
                     /db_xref="CCDS:CCDS34892.1"
                     /db_xref="GeneID:9821"
                     /db_xref="HGNC:HGNC:15574"
                     /db_xref="MIM:606837"
                     /translation="MKLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQV
                     LVVNGGECMAADRRVCTYSAGTDTNPIFLFNKEMILCDRPPAIPKTTFSTENDMEIKV
                     EESLMMPAVFHTVASRTQLALEMYEVAKKLCSFCEGLVHDEHLQHQGWAAIMANLEDC
                     SNSYQKLLFKFESIYSNYLQSIEDIKLKLTHLGTAVSVMAKIPLLECLTRHSYRECLG
                     RLDSLPEHEDSEKAEMKRSTELVLSPDMPRTTNESLLTSFPKSVEHVSPDTADAESGK
                     EIRESCQSTVHQQDETTIDTKDGDLPFFNVSLLDWINVQDRPNDVESLVRKCFDSMSR
                     LDPRIIRPFIAECRQTIAKLDNQNMKAIKGLEDRLYALDQMIASCGRLVNEQKELAQG
                     FLANQKRAENLKDASVLPDLCLSHANQLMIMLQNHRKLLDIKQKCTTAKQELANNLHV
                     RLKWCCFVMLHADQDGEKLQALLRLVIELLERVKIVEALSTVPQMYCLAVVEVVRRKM
                     FIKHYREWAGALVKDGKRLYEAEKSKRESFGKLFRKSFLRNRLFRGLDSWPPSFCTQK
                     PRKFDCELPDISLKDLQFLQSFCPSEVQPFLRVPLLCDFEPLHQHVLALHNLVKAAQS
                     LDEMSQTITDLLSEQKASVSQTSPQSASSPRMESTAGITTTTSPRTPPPLTVQDPLCP
                     AVCPLEELSPDSIDAHTFDFETIPHPNIEQTIHQVSLDLDSLAESPESDFMSAVNEFV
                     IEENLSSPNPISDPQSPEMMVESLYSSVINAIDSRRMQDTNVCGKEDFGDHTSLNVQL
                     ERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVKCSLE
                     ITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFA
                     LVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEK
                     LQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQE
                     SHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKET
                     LKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEE
                     ESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEK
                     YEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLE
                     KVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNV
                     RTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARL
                     LEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVETADEGRVDS
                     AMETSMMSVQENIHMLSEEKQRIMLLERTLQLKEEENKRLNQRLMSQSMSSVSSRHSE
                     KIAIRDFQVGDLVLIILDERHDNYVLFTVSPTLYFLHSESLPALDLKPGEGASGASRR
                     PWVLGKVMEKEYCQAKKAQNRFKVPLGTKFYRVKAVSWNKKV"
     exon            599..725
                     /gene="RB1CC1"
                     /gene_synonym="ATG17; CC1; FIP200; PPP1R131"
                     /inference="alignment:Splign:2.1.0"
     exon            726..896
                     /gene="RB1CC1"
                     /gene_synonym="ATG17; CC1; FIP200; PPP1R131"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1099
                     /gene="RB1CC1"
                     /gene_synonym="ATG17; CC1; FIP200; PPP1R131"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1529
                     /gene="RB1CC1"
                     /gene_synonym="ATG17; CC1; FIP200; PPP1R131"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1700
                     /gene="RB1CC1"
                     /gene_synonym="ATG17; CC1; FIP200; PPP1R131"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1885
                     /gene="RB1CC1"
                     /gene_synonym="ATG17; CC1; FIP200; PPP1R131"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2072
                     /gene="RB1CC1"
                     /gene_synonym="ATG17; CC1; FIP200; PPP1R131"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2154
                     /gene="RB1CC1"
                     /gene_synonym="ATG17; CC1; FIP200; PPP1R131"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2216
                     /gene="RB1CC1"
                     /gene_synonym="ATG17; CC1; FIP200; PPP1R131"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2320
                     /gene="RB1CC1"
                     /gene_synonym="ATG17; CC1; FIP200; PPP1R131"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2447
                     /gene="RB1CC1"
                     /gene_synonym="ATG17; CC1; FIP200; PPP1R131"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..4348
                     /gene="RB1CC1"
                     /gene_synonym="ATG17; CC1; FIP200; PPP1R131"
                     /inference="alignment:Splign:2.1.0"
     exon            4349..4514
                     /gene="RB1CC1"
                     /gene_synonym="ATG17; CC1; FIP200; PPP1R131"
                     /inference="alignment:Splign:2.1.0"
     exon            4515..4623
                     /gene="RB1CC1"
                     /gene_synonym="ATG17; CC1; FIP200; PPP1R131"
                     /inference="alignment:Splign:2.1.0"
     exon            4624..4864
                     /gene="RB1CC1"
                     /gene_synonym="ATG17; CC1; FIP200; PPP1R131"
                     /inference="alignment:Splign:2.1.0"
     exon            4865..4919
                     /gene="RB1CC1"
                     /gene_synonym="ATG17; CC1; FIP200; PPP1R131"
                     /inference="alignment:Splign:2.1.0"
     exon            4920..4967
                     /gene="RB1CC1"
                     /gene_synonym="ATG17; CC1; FIP200; PPP1R131"
                     /inference="alignment:Splign:2.1.0"
     exon            4968..5026
                     /gene="RB1CC1"
                     /gene_synonym="ATG17; CC1; FIP200; PPP1R131"
                     /inference="alignment:Splign:2.1.0"
     exon            5027..5163
                     /gene="RB1CC1"
                     /gene_synonym="ATG17; CC1; FIP200; PPP1R131"
                     /inference="alignment:Splign:2.1.0"
     exon            5164..5234
                     /gene="RB1CC1"
                     /gene_synonym="ATG17; CC1; FIP200; PPP1R131"
                     /inference="alignment:Splign:2.1.0"
     exon            5235..6636
                     /gene="RB1CC1"
                     /gene_synonym="ATG17; CC1; FIP200; PPP1R131"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6186..6191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RB1CC1"
                     /gene_synonym="ATG17; CC1; FIP200; PPP1R131"
                     /note="hexamer: AATAAA"
     polyA_site      6207
                     /gene="RB1CC1"
                     /gene_synonym="ATG17; CC1; FIP200; PPP1R131"
                     /note="major polyA site"
     regulatory      6615..6620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RB1CC1"
                     /gene_synonym="ATG17; CC1; FIP200; PPP1R131"
                     /note="hexamer: AATAAA"
     polyA_site      6636
                     /gene="RB1CC1"
                     /gene_synonym="ATG17; CC1; FIP200; PPP1R131"
                     /note="major polyA site"
ORIGIN      
        1 ggagtcgaca ataacaaacc aagccgcggc ggtgtccgcg gccctgccga gccctcggcg
       61 ttgcctcaga atcccccagt cgcctgggcc cctcggctct gacaggccgc ggccttctgt
      121 cccccggccc cagacccaga gccgaggggc ctgctcgcgt ccttgtccgc ccggacccct
      181 ccctgcctcc tagagttcgg ggccgcggcg ggcgggcgcc cgggacgccg gcggttgtgt
      241 cggcttagcg gtgccgaatg ggcggttggt aaccgctgcc gaggactagg cggcggcgga
      301 agatggtgcc gggggtcgct ggctctgctg ctgccgccgg cgaaggagga ggcgttgccg
      361 gttttctgag tttaaccagt aatgccattc agttgccaat ctcaagcaaa gcaaacataa
      421 gccagtttta atctactttt taagaaaagt ggtagtcctt ttcacagtgc ctgacgtaac
      481 tgtatcagag ggtgaggtat aagctcacag aattcagata aatcatcatg aagttatatg
      541 tatttctggt taacactgga actactctaa catttgacac tgaacttaca gtgcaaactg
      601 tggcagacct taagcatgcc attcaaagca aatacaagat tgctattcaa caccaggtgc
      661 tggtggtcaa tggaggagaa tgcatggctg cagatcgaag agtgtgtacc tacagtgctg
      721 ggacggatac aaatccaatt tttcttttta acaaagaaat gatcttatgt gatcgtccac
      781 ctgctattcc taaaactacc ttttcgacag aaaatgacat ggaaataaaa gttgaagaat
      841 ctcttatgat gcctgcagtt tttcatactg ttgcttcaag gacacagctt gcattggaaa
      901 tgtatgaagt tgccaagaaa ctttgttctt tttgtgaagg tcttgtacat gatgaacatc
      961 ttcaacacca aggctgggct gcaatcatgg ccaacctgga ggactgttca aattcatacc
     1021 aaaagctact tttcaagttt gaaagtattt attcaaatta tctgcagtcc atagaagaca
     1081 tcaagttaaa acttactcat ttaggaactg cagtttcagt aatggccaag attccactgt
     1141 tggagtgcct aaccagacat agttacagag aatgtttggg aagactggat tctttacctg
     1201 aacatgaaga ctcagaaaaa gctgagatga aaagatccac tgaactggtg ctctctcctg
     1261 atatgcctag aacaactaac gaatctttgt taacctcatt tcccaagtca gtggaacatg
     1321 tgtccccaga taccgcagat gctgaaagtg gcaaagaaat tagggaatct tgtcaaagta
     1381 ctgttcatca gcaagatgaa actacgattg acactaaaga tggtgatctg ccctttttta
     1441 atgtctcttt gttagactgg ataaatgttc aagatagacc taatgatgtg gaatctttgg
     1501 tcaggaagtg ctttgattct atgagcaggc ttgatccaag gattattcga ccatttatag
     1561 cagaatgccg tcaaactatt gccaaacttg ataatcagaa tatgaaagcc attaaaggac
     1621 ttgaagatcg gctctacgcc ctggaccaga tgattgctag ctgtggccga ctggtgaatg
     1681 aacagaaaga gcttgctcag ggatttttag ctaatcagaa gagagctgaa aacttaaagg
     1741 atgcatctgt attacctgat ttatgcctga gtcacgcaaa tcagttgatg attatgttgc
     1801 aaaatcatag aaaactgtta gatattaagc agaagtgtac cactgccaaa caagaactag
     1861 caaataacct acatgtcaga ctgaagtggt gttgctttgt aatgcttcat gctgatcaag
     1921 atggagagaa gttacaagct ttgctccgcc tcgtaataga gctgttagaa agagtcaaaa
     1981 ttgttgaagc tcttagtaca gttcctcaga tgtactgctt agctgttgtt gaggttgtaa
     2041 gaagaaaaat gttcataaaa cactacaggg agtgggctgg tgctttagtc aaagatggaa
     2101 agagattata tgaagcagaa aaatcaaaaa gggaatcctt tgggaaatta tttaggaagt
     2161 cttttttaag aaatcgtctg tttaggggac tggactcctg gcccccttcc ttttgtactc
     2221 aaaagcctcg aaagtttgac tgtgaacttc cagatatttc attaaaagat ttacagtttc
     2281 tgcaatcatt ttgtccttcg gaagttcagc cattcctcag ggttccctta ctttgtgact
     2341 ttgaacctct acaccagcat gtacttgctc tacataattt ggtaaaagca gcacaaagtt
     2401 tggatgaaat gtcacagacc attacagatc tactgagtga acaaaaggca tctgtgagtc
     2461 agacatcccc acagtctgct tcttcaccaa ggatggaaag tacagcagga attacaacta
     2521 ctacctcacc gagaactcct ccaccactga ctgttcagga tcccttatgt cctgcagttt
     2581 gtcccttaga agaattatct ccagatagta ttgatgcaca tacgtttgat tttgaaacta
     2641 ttccccatcc aaacatagaa cagactattc accaagtttc tttagacttg gattcattag
     2701 cagaaagtcc tgaatcagat tttatgtctg ctgtgaatga gtttgtaata gaagaaaatt
     2761 tgtcgtctcc taatcctata agtgatccac aaagcccaga aatgatggtg gaatcacttt
     2821 attcatcagt tatcaatgcg atagacagta gacgaatgca ggatacaaat gtatgtggta
     2881 aggaggattt tggagatcat acttctctga atgtccagtt ggaaagatgt agagttgttg
     2941 cccaagactc tcacttcagt atacaaacca ttaaggaaga cctttgccac tttagaacat
     3001 ttgtacaaaa agaacagtgt gacttctcaa attcattaaa atgtacagca gtagaaataa
     3061 gaaacattat tgaaaaagta aaatgttctc tggaaataac actaaaagaa aaacatcaaa
     3121 aagaactact gtctttaaaa aatgaatatg aaggtaaact tgacggacta ataaaggaaa
     3181 ctgaagagaa tgaaaacaaa attaaaaaat tgaagggaga gttagtatgc cttgaggagg
     3241 ttttacaaaa taaagataat gaatttgctt tggttaaaca tgaaaaagaa gctgtaatct
     3301 gcctgcagaa tgaaaaggat cagaagttgt tagagatgga aaatataatg cactctcaaa
     3361 attgtgaaat taaagaactg aagcagtcac gagaaatagt gttagaagac ttaaaaaagc
     3421 tccatgttga aaatgatgag aagttacagt tattgagggc agaacttcag tccttggagc
     3481 aaagtcatct aaaggaatta gaggacacac ttcaggttag gcacatacaa gagtttgaga
     3541 aggttatgac agaccacaga gtttctttgg aggaattaaa aaaggaaaac caacaaataa
     3601 ttaatcaaat acaagaatct catgctgaaa ttatccagga aaaagaaaaa cagttacagg
     3661 aattaaaact caaggtttct gatttgtcag acacgagatg caagttagag gttgaacttg
     3721 cgttgaagga agcagaaact gatgaaataa aaattttgct ggaagaaagc agagcccagc
     3781 agaaggagac cttgaaatct cttcttgaac aagagacaga aaatttgaga acagaaatta
     3841 gtaaactcaa ccaaaagatt caggataata atgaaaatta tcaggtgggc ttagcagagc
     3901 taagaacttt aatgacaatt gaaaaagatc agtgtatttc cgagttaatt agtagacatg
     3961 aagaagaatc taatatactt aaagctgaat taaacaaagt aacatctttg cataaccaag
     4021 catttgaaat agaaaaaaac ctaaaagaac aaataattga actgcagagt aaattggatt
     4081 cagaattgag tgctcttgaa agacaaaaag atgaaaaaat tacccaacaa gaagagaaat
     4141 acgaagctat tatccagaac cttgagaaag acagacaaaa attggtcagc agccaggagc
     4201 aagacagaga acagttaatt cagaagctta attgtgaaaa agatgaagct attcagactg
     4261 ccctaaaaga atttaaattg gagagagaag ttgttgagaa agagttatta gaaaaagtta
     4321 aacatcttga gaatcaaata gcaaaaagtc ctgccattga ctctaccaga ggagattctt
     4381 caagcttagt tgctgaactt caagaaaagc ttcaggaaga aaaagctaag tttctagaac
     4441 aacttgaaga gcaagaaaaa agaaagaatg aagaaatgca aaatgttcga acatctttga
     4501 ttgcggaaca acagaccaat tttaacactg ttttaacaag agagaaaatg agaaaagaaa
     4561 acataataaa tgatcttagt gataagttga aaagtacaat gcagcaacaa gaacgggata
     4621 aagatttgat agagtcactt tctgaagatc gagctcgttt gcttgaggaa aagaaaaagc
     4681 ttgaagaaga agtcagtaag ttgcgtagta gcagttttgt tccttcacca tatgtagcta
     4741 cagccccaga actttatgga gcttgtgcac ctgaactccc aggtgaatca gatagatccg
     4801 ctgtggaaac agcagatgaa ggaagagtgg attcagcaat ggagacaagc atgatgtctg
     4861 tacaagaaaa tattcatatg ttgtctgaag aaaaacagcg gataatgctg ttagaacgaa
     4921 cattgcaatt gaaagaagaa gaaaataaac ggttaaatca aagactgatg tctcagagca
     4981 tgtcttcagt atcttcaagg cattctgaaa agatagctat tagagatttt caggtgggag
     5041 atttggtact catcatccta gacgaacgcc atgacaatta tgtgttattt actgttagtc
     5101 ctactttata ttttctacat tcagagtctc tacctgccct ggatctcaaa ccaggtgagg
     5161 gtgcttcagg tgcatctaga agaccctggg tacttggaaa agtaatggaa aaagaatact
     5221 gtcaagccaa aaaggcacaa aacagattta aagttccttt ggggacaaag ttttacagag
     5281 tgaaagccgt atcatggaat aagaaagtat aacttatgga caaaattaat acattctatg
     5341 acattttttt ctgatttgtc ctgcagtgct cattcatcac tccaaaaaca gcaggccatc
     5401 tttttatgca aaagtcagcg tgacaatata cttcactggt gtacatcgtt tactttttaa
     5461 ctggcttcat tttaggaata ataaattcat cagaatcctt ggctgaatta aaatggtttt
     5521 tgttttttgg tttttttttt tacccagaca actctagaaa tgcggaccaa actacttcat
     5581 tttctcaaag ggcatacctt gtgcattgtg gcttatgatg agccatatta attgcctgtt
     5641 aaatatacac tagcttgaac ttagatgtta aatgttatta ttaccagcat ttgtcctttt
     5701 gtgaaatcag tatcagaata cttgcactct ttaacacatt ctttataaaa tgtataaatt
     5761 attcagaact atttaaaata aagaggagtg ttattgcatg ctgataatca ttttgagttt
     5821 gcctcagtag atactaaagc aaattgtttc agttttttta aatgcccttt gatgtttcaa
     5881 aaaaaaaaag gaactgtaat ttgattgact gattttaaga tcagccataa gtaatcagca
     5941 atcttcaaaa gcactttcag tggattggtc atctgggttc taaagggaag agtctgtgct
     6001 actaaccatt tcaaatgcag actcaaacct tcccaacatc tttatgactc tagaataatc
     6061 atattgatga aatcgtaatt catggttgag tttcagaaca aaagatattc attgcacatt
     6121 aaccatttag aggtcattta aataacaaaa tattgtattg taaaagaact gtacaatttt
     6181 aaaacaataa agatttgaac ctgtaaatgt gtgtgccttt taaagaagga tacattttta
     6241 atatatttga gtgattgctg ggaagtgtga aaatattgtt atgtatcata tcaaagagaa
     6301 acatgtttat tacaaaaatg ttctttaact atatactatg taacagggta aacagtgtta
     6361 tgtagaatag aattgtgtaa actagatctt tagagaagtt gccattgagc aaagttattt
     6421 aaatgagtta gttgagttgg atgagaattg tttgaggttt gttgctagag aacaataata
     6481 aaataattct ttttcagaaa atatttaatt tcttcataaa aataagttaa atattttttt
     6541 aaatatgtat atctaatagt acaaaatgga ataaacatca tagtgtatag aaaactgaat
     6601 ttgacaagtt aatgaataaa tgaacaaatg atttca
//
