LOCUS       NM_000321               4768 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens RB transcriptional corepressor 1 (RB1), transcript
            variant 1, mRNA.
ACCESSION   NM_000321
VERSION     NM_000321.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4768)
  AUTHORS   Zhang,S., Valenzuela,L.F., Zatulovskiy,E., Mangiante,L., Curtis,C.
            and Skotheim,J.M.
  TITLE     The G1-S transition is promoted by Rb degradation via the E3 ligase
            UBR5
  JOURNAL   Sci Adv 10 (43), eadq6858 (2024)
   PUBMED   39441926
  REMARK    GeneRIF: The G1-S transition is promoted by Rb degradation via the
            E3 ligase UBR5.
REFERENCE   2  (bases 1 to 4768)
  AUTHORS   Schwartz,C.J., Marra,A., Selenica,P., Gazzo,A., Tan,K., Ross,D.,
            Razavi,P., Chandarlapaty,S., Weigelt,B., Reis-Filho,J.S., Brogi,E.,
            Pareja,F. and Wen,H.Y.
  TITLE     RB1 Genetic Alterations in Estrogen Receptor-Positive Breast
            Carcinomas: Correlation With Neuroendocrine Differentiation
  JOURNAL   Mod Pathol 37 (8), 100541 (2024)
   PUBMED   38897452
  REMARK    GeneRIF: RB1 Genetic Alterations in Estrogen Receptor-Positive
            Breast Carcinomas: Correlation With Neuroendocrine Differentiation.
REFERENCE   3  (bases 1 to 4768)
  AUTHORS   Gregersen,P.A., Jensen,P.S., Christensen,R., Lohmann,D., Racher,H.,
            Gallie,B. and Urbak,S.F.
  TITLE     Retinoblastoma caused by an RB1 variant with unusually low
            penetrance in a Danish family
  JOURNAL   Eur J Med Genet 70, 104956 (2024)
   PUBMED   38897371
  REMARK    GeneRIF: Retinoblastoma caused by an RB1 variant with unusually low
            penetrance in a Danish family.
REFERENCE   4  (bases 1 to 4768)
  AUTHORS   Konagaya,Y., Rosenthal,D., Ratnayeke,N., Fan,Y. and Meyer,T.
  TITLE     An intermediate Rb-E2F activity state safeguards proliferation
            commitment
  JOURNAL   Nature 631 (8020), 424-431 (2024)
   PUBMED   38926571
  REMARK    GeneRIF: An intermediate Rb-E2F activity state safeguards
            proliferation commitment.
REFERENCE   5  (bases 1 to 4768)
  AUTHORS   Queiroz,L.F., Silva,M.S.D.M.E., Rosman,F.C., Rosas,S.L.B.,
            Souza,H.S.P. and Carvalho,M.D.G.D.C.
  TITLE     Molecular monitoring by CDKN2A/p16INK4A and RB1 gene methylation in
            breast cancer
  JOURNAL   Rev Assoc Med Bras (1992) 70 (4), e20231358 (2024)
   PUBMED   38716944
  REMARK    GeneRIF: Molecular monitoring by CDKN2A/p16INK4A and RB1 gene
            methylation in breast cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4768)
  AUTHORS   Lohmann,D.R. and Gallie,B.L.
  TITLE     Retinoblastoma
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301625
REFERENCE   7  (bases 1 to 4768)
  AUTHORS   Dyson,N., Guida,P., Munger,K. and Harlow,E.
  TITLE     Homologous sequences in adenovirus E1A and human papillomavirus E7
            proteins mediate interaction with the same set of cellular proteins
  JOURNAL   J Virol 66 (12), 6893-6902 (1992)
   PUBMED   1331501
REFERENCE   8  (bases 1 to 4768)
  AUTHORS   Huang,S., Shin,E., Sheppard,K.A., Chokroverty,L., Shan,B.,
            Qian,Y.W., Lee,E.Y. and Yee,A.S.
  TITLE     The retinoblastoma protein region required for interaction with the
            E2F transcription factor includes the T/E1A binding and
            carboxy-terminal sequences
  JOURNAL   DNA Cell Biol 11 (7), 539-548 (1992)
   PUBMED   1388726
REFERENCE   9  (bases 1 to 4768)
  AUTHORS   Onadim,Z., Hogg,A., Baird,P.N. and Cowell,J.K.
  TITLE     Oncogenic point mutations in exon 20 of the RB1 gene in families
            showing incomplete penetrance and mild expression of the
            retinoblastoma phenotype
  JOURNAL   Proc Natl Acad Sci U S A 89 (13), 6177-6181 (1992)
   PUBMED   1352883
REFERENCE   10 (bases 1 to 4768)
  AUTHORS   Hogg,A., Onadim,Z., Baird,P.N. and Cowell,J.K.
  TITLE     Detection of heterozygous mutations in the RB1 gene in
            retinoblastoma patients using single-strand conformation
            polymorphism analysis and polymerase chain reaction sequencing
  JOURNAL   Oncogene 7 (7), 1445-1451 (1992)
   PUBMED   1352398
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL392048.9, BC040540.1 and
            L41870.1.
            
            On Feb 26, 2020 this sequence version replaced NM_000321.2.
            
            Summary: The protein encoded by this gene is a negative regulator
            of the cell cycle and was the first tumor suppressor gene found.
            The encoded protein also stabilizes constitutive heterochromatin to
            maintain the overall chromatin structure. The active,
            hypophosphorylated form of the protein binds transcription factor
            E2F1. Defects in this gene are a cause of childhood cancer
            retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040540.1, L41870.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267163.6/ ENSP00000267163.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AL392048.9         15309-15309
            2-4765              BC040540.1         2-4765
            4766-4768           L41870.1           4741-4743
FEATURES             Location/Qualifiers
     source          1..4768
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.2"
     gene            1..4768
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /note="RB transcriptional corepressor 1"
                     /db_xref="GeneID:5925"
                     /db_xref="HGNC:HGNC:9884"
                     /db_xref="MIM:614041"
     exon            1..299
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..2949
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /note="isoform 1 is encoded by transcript variant 1;
                     retinoblastoma-associated protein;
                     prepro-retinoblastoma-associated protein; protein
                     phosphatase 1, regulatory subunit 130; retinoblastoma
                     suspectibility protein; retinoblastoma 1"
                     /codon_start=1
                     /product="retinoblastoma-associated protein isoform 1"
                     /protein_id="NP_000312.2"
                     /db_xref="CCDS:CCDS31973.1"
                     /db_xref="GeneID:5925"
                     /db_xref="HGNC:HGNC:9884"
                     /db_xref="MIM:614041"
                     /translation="MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPL
                     VRLEFEETEEPDFTALCQKLKIPDHVRERAWLTWEKVSSVDGVLGGYIQKKKELWGIC
                     IFIAAVDLDEMSFTFTELQKNIEISVHKFFNLLKEIDTSTKVDNAMSRLLKKYDVLFA
                     LFSKLERTCELIYLTQPSSSISTEINSALVLKVSWITFLLAKGEVLQMEDDLVISFQL
                     MLCVLDYFIKLSPPMLLKEPYKTAVIPINGSPRTPRRGQNRSARIAKQLENDTRIIEV
                     LCKEHECNIDEVKNVYFKNFIPFMNSLGLVTSNGLPEVENLSKRYEEIYLKNKDLDAR
                     LFLDHDKTLQTDSIDSFETQRTPRKSNLDEEVNVIPPHTPVRTVMNTIQQLMMILNSA
                     SDQPSENLISYFNNCTVNPKESILKRVKDIGYIFKEKFAKAVGQGCVEIGSQRYKLGV
                     RLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLLACALEVVMATYSRSTSQNLDS
                     GTDLSFPWILNVLNLKAFDFYKVIESFIKAEGNLTREMIKHLERCEHRIMESLAWLSD
                     SPLFDLIKQSKDREGPTDHLESACPLNLPLQNNHTAADMYLSPVRSPKKKGSTTRVNS
                     TANAETQATSAFQTQKPLKSTSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWT
                     LFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLKFKIIVTAYKDLPHAVQETFK
                     RVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLR
                     IPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSD
                     RVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQKLAEMTSTRTRMQKQ
                     KMNDSMDTSNKEEK"
     exon            300..426
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /inference="alignment:Splign:2.1.0"
     exon            427..542
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /inference="alignment:Splign:2.1.0"
     exon            543..662
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /inference="alignment:Splign:2.1.0"
     exon            663..701
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /inference="alignment:Splign:2.1.0"
     exon            702..769
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /inference="alignment:Splign:2.1.0"
     exon            770..880
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1023
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1101
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1211
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1289
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1377
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1494
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1551
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1583
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1660
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1857
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..1976
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2122
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2268
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2373
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2487
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /inference="alignment:Splign:2.1.0"
     exon            2488..2651
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..2682
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..2825
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /inference="alignment:Splign:2.1.0"
     exon            2826..2875
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /inference="alignment:Splign:2.1.0"
     exon            2876..4768
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4743..4748
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /note="hexamer: AATAAA"
     polyA_site      4768
                     /gene="RB1"
                     /gene_synonym="OSRC; p105-Rb; p110-RB1; pp110; PPP1R130;
                     pRb; RB"
                     /note="major polyA site"
ORIGIN      
        1 agttgccggg cgggggaggg cgcgtccggt ttttctcagg ggacgttgaa attatttttg
       61 taacgggagt cgggagagga cggggcgtgc cccgacgtgc gcgcgcgtcg tcctccccgg
      121 cgctcctcca cagctcgctg gctcccgccg cggaaaggcg tcatgccgcc caaaaccccc
      181 cgaaaaacgg ccgccaccgc cgccgctgcc gccgcggaac ccccggcacc gccgccgccg
      241 ccccctcctg aggaggaccc agagcaggac agcggcccgg aggacctgcc tctcgtcagg
      301 cttgagtttg aagaaacaga agaacctgat tttactgcat tatgtcagaa attaaagata
      361 ccagatcatg tcagagagag agcttggtta acttgggaga aagtttcatc tgtggatgga
      421 gtattgggag gttatattca aaagaaaaag gaactgtggg gaatctgtat ctttattgca
      481 gcagttgacc tagatgagat gtcgttcact tttactgagc tacagaaaaa catagaaatc
      541 agtgtccata aattctttaa cttactaaaa gaaattgata ccagtaccaa agttgataat
      601 gctatgtcaa gactgttgaa gaagtatgat gtattgtttg cactcttcag caaattggaa
      661 aggacatgtg aacttatata tttgacacaa cccagcagtt cgatatctac tgaaataaat
      721 tctgcattgg tgctaaaagt ttcttggatc acatttttat tagctaaagg ggaagtatta
      781 caaatggaag atgatctggt gatttcattt cagttaatgc tatgtgtcct tgactatttt
      841 attaaactct cacctcccat gttgctcaaa gaaccatata aaacagctgt tatacccatt
      901 aatggttcac ctcgaacacc caggcgaggt cagaacagga gtgcacggat agcaaaacaa
      961 ctagaaaatg atacaagaat tattgaagtt ctctgtaaag aacatgaatg taatatagat
     1021 gaggtgaaaa atgtttattt caaaaatttt atacctttta tgaattctct tggacttgta
     1081 acatctaatg gacttccaga ggttgaaaat ctttctaaac gatacgaaga aatttatctt
     1141 aaaaataaag atctagatgc aagattattt ttggatcatg ataaaactct tcagactgat
     1201 tctatagaca gttttgaaac acagagaaca ccacgaaaaa gtaaccttga tgaagaggtg
     1261 aatgtaattc ctccacacac tccagttagg actgttatga acactatcca acaattaatg
     1321 atgattttaa attcagcaag tgatcaacct tcagaaaatc tgatttccta ttttaacaac
     1381 tgcacagtga atccaaaaga aagtatactg aaaagagtga aggatatagg atacatcttt
     1441 aaagagaaat ttgctaaagc tgtgggacag ggttgtgtcg aaattggatc acagcgatac
     1501 aaacttggag ttcgcttgta ttaccgagta atggaatcca tgcttaaatc agaagaagaa
     1561 cgattatcca ttcaaaattt tagcaaactt ctgaatgaca acatttttca tatgtcttta
     1621 ttggcgtgcg ctcttgaggt tgtaatggcc acatatagca gaagtacatc tcagaatctt
     1681 gattctggaa cagatttgtc tttcccatgg attctgaatg tgcttaattt aaaagccttt
     1741 gatttttaca aagtgatcga aagttttatc aaagcagaag gcaacttgac aagagaaatg
     1801 ataaaacatt tagaacgatg tgaacatcga atcatggaat cccttgcatg gctctcagat
     1861 tcacctttat ttgatcttat taaacaatca aaggaccgag aaggaccaac tgatcacctt
     1921 gaatctgctt gtcctcttaa tcttcctctc cagaataatc acactgcagc agatatgtat
     1981 ctttctcctg taagatctcc aaagaaaaaa ggttcaacta cgcgtgtaaa ttctactgca
     2041 aatgcagaga cacaagcaac ctcagccttc cagacccaga agccattgaa atctacctct
     2101 ctttcactgt tttataaaaa agtgtatcgg ctagcctatc tccggctaaa tacactttgt
     2161 gaacgccttc tgtctgagca cccagaatta gaacatatca tctggaccct tttccagcac
     2221 accctgcaga atgagtatga actcatgaga gacaggcatt tggaccaaat tatgatgtgt
     2281 tccatgtatg gcatatgcaa agtgaagaat atagacctta aattcaaaat cattgtaaca
     2341 gcatacaagg atcttcctca tgctgttcag gagacattca aacgtgtttt gatcaaagaa
     2401 gaggagtatg attctattat agtattctat aactcggtct tcatgcagag actgaaaaca
     2461 aatattttgc agtatgcttc caccaggccc cctaccttgt caccaatacc tcacattcct
     2521 cgaagccctt acaagtttcc tagttcaccc ttacggattc ctggagggaa catctatatt
     2581 tcacccctga agagtccata taaaatttca gaaggtctgc caacaccaac aaaaatgact
     2641 ccaagatcaa gaatcttagt atcaattggt gaatcattcg ggacttctga gaagttccag
     2701 aaaataaatc agatggtatg taacagcgac cgtgtgctca aaagaagtgc tgaaggaagc
     2761 aaccctccta aaccactgaa aaaactacgc tttgatattg aaggatcaga tgaagcagat
     2821 ggaagtaaac atctcccagg agagtccaaa tttcagcaga aactggcaga aatgacttct
     2881 actcgaacac gaatgcaaaa gcagaaaatg aatgatagca tggatacctc aaacaaggaa
     2941 gagaaatgag gatctcagga ccttggtgga cactgtgtac acctctggat tcattgtctc
     3001 tcacagatgt gactgtataa ctttcccagg ttctgtttat ggccacattt aatatcttca
     3061 gctctttttg tggatataaa atgtgcagat gcaattgttt gggtgattcc taagccactt
     3121 gaaatgttag tcattgttat ttatacaaga ttgaaaatct tgtgtaaatc ctgccattta
     3181 aaaagttgta gcagattgtt tcctcttcca aagtaaaatt gctgtgcttt atggatagta
     3241 agaatggccc tagagtggga gtcctgataa cccaggcctg tctgactact ttgccttctt
     3301 ttgtagcata taggtgatgt ttgctcttgt ttttattaat ttatatgtat atttttttaa
     3361 tttaacatga acacccttag aaaatgtgtc ctatctatct tccaaatgca atttgattga
     3421 ctgcccattc accaaaatta tcctgaactc ttctgcaaaa atggatatta ttagaaatta
     3481 gaaaaaaatt actaatttta cacattagat tttattttac tattggaatc tgatatactg
     3541 tgtgcttgtt ttataaaatt ttgcttttaa ttaaataaaa gctggaagca aagtataacc
     3601 atatgatact atcatactac tgaaacagat ttcatacctc agaatgtaaa agaacttact
     3661 gattattttc ttcatccaac ttatgttttt aaatgaggat tattgatagt actcttggtt
     3721 tttataccat tcagatcact gaatttataa agtacccatc tagtacttga aaaagtaaag
     3781 tgttctgcca gatcttaggt atagaggacc ctaacacagt atatcccaag tgcactttct
     3841 aatgtttctg ggtcctgaag aattaagata caaattaatt ttactccata aacagactgt
     3901 taattatagg agccttaatt tttttttcat agagatttgt ctaattgcat ctcaaaatta
     3961 ttctgccctc cttaatttgg gaaggtttgt gttttctctg gaatggtaca tgtcttccat
     4021 gtatcttttg aactggcaat tgtctattta tcttttattt ttttaagtca gtatggtcta
     4081 acactggcat gttcaaagcc acattatttc tagtccaaaa ttacaagtaa tcaagggtca
     4141 ttatgggtta ggcattaatg tttctatctg attttgtgca aaagcttcaa attaaaacag
     4201 ctgcattaga aaaagaggcg cttctcccct cccctacacc taaaggtgta tttaaactat
     4261 cttgtgtgat taacttattt agagatgctg taacttaaaa taggggatat ttaaggtagc
     4321 ttcagctagc ttttaggaaa atcactttgt ctaactcaga attattttta aaaagaaatc
     4381 tggtcttgtt agaaaacaaa attttatttt gtgctcattt aagtttcaaa cttactattt
     4441 tgacagttat tttgataaca atgacactag aaaacttgac tccatttcat cattgtttct
     4501 gcatgaatat catacaaatc agttagtttt taggtcaagg gcttactatt tctgggtctt
     4561 ttgctactaa gttcacatta gaattagtgc cagaatttta ggaacttcag agatcgtgta
     4621 ttgagatttc ttaaataatg cttcagatat tattgcttta ttgctttttt gtattggtta
     4681 aaactgtaca tttaaaattg ctatgttact attttctaca attaatagtt tgtctatttt
     4741 aaaataaatt agttgttaag agtcttaa
//
