LOCUS       NM_133452               3484 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens ribonucleoprotein, PTB binding 1 (RAVER1), transcript
            variant 1, mRNA.
ACCESSION   NM_133452 XM_058946
VERSION     NM_133452.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3484)
  AUTHORS   Wedler,A., Bley,N., Glass,M., Muller,S., Rausch,A., Lederer,M.,
            Urbainski,J., Schian,L., Obika,K.B., Simon,T., Peters,L.M.,
            Misiak,C., Fuchs,T., Kohn,M., Jacob,R., Gutschner,T., Ihling,C.,
            Sinz,A. and Huttelmaier,S.
  TITLE     RAVER1 hinders lethal EMT and modulates miR/RISC activity by the
            control of alternative splicing
  JOURNAL   Nucleic Acids Res 52 (7), 3971-3988 (2024)
   PUBMED   38300787
  REMARK    GeneRIF: RAVER1 hinders lethal EMT and modulates miR/RISC activity
            by the control of alternative splicing.
REFERENCE   2  (bases 1 to 3484)
  AUTHORS   Fink-Baldauf,I.M., Stuart,W.D., Brewington,J.J., Guo,M. and
            Maeda,Y.
  TITLE     CRISPRi links COVID-19 GWAS loci to LZTFL1 and RAVER1
  JOURNAL   EBioMedicine 75, 103806 (2022)
   PUBMED   34998241
  REMARK    GeneRIF: CRISPRi links COVID-19 GWAS loci to LZTFL1 and RAVER1.
REFERENCE   3  (bases 1 to 3484)
  AUTHORS   Qin,Y., Huttlin,E.L., Winsnes,C.F., Gosztyla,M.L., Wacheul,L.,
            Kelly,M.R., Blue,S.M., Zheng,F., Chen,M., Schaffer,L.V., Licon,K.,
            Backstrom,A., Vaites,L.P., Lee,J.J., Ouyang,W., Liu,S.N., Zhang,T.,
            Silva,E., Park,J., Pitea,A., Kreisberg,J.F., Gygi,S.P., Ma,J.,
            Harper,J.W., Yeo,G.W., Lafontaine,D.L.J., Lundberg,E. and Ideker,T.
  TITLE     A multi-scale map of cell structure fusing protein images and
            interactions
  JOURNAL   Nature 600 (7889), 536-542 (2021)
   PUBMED   34819669
REFERENCE   4  (bases 1 to 3484)
  CONSRTM   COVID-19 Host Genetics Initiative
  TITLE     Mapping the human genetic architecture of COVID-19
  JOURNAL   Nature 600 (7889), 472-477 (2021)
   PUBMED   34237774
REFERENCE   5  (bases 1 to 3484)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 3484)
  AUTHORS   Miyasaka,T., Morita,M., Ito,K., Suzuki,T., Fukuda,H., Takeda,S.,
            Inoue,J., Semba,K. and Yamamoto,T.
  TITLE     Interaction of antiproliferative protein Tob with the CCR4-NOT
            deadenylase complex
  JOURNAL   Cancer Sci 99 (4), 755-761 (2008)
   PUBMED   18377426
REFERENCE   7  (bases 1 to 3484)
  AUTHORS   Romanelli,M.G., Lorenzi,P., Avesani,F. and Morandi,C.
  TITLE     Functional characterization of the ribonucleoprotein, PTB-binding
            1/Raver1 promoter region
  JOURNAL   Gene 405 (1-2), 79-87 (2007)
   PUBMED   17931803
  REMARK    GeneRIF: Raver1 gene promoter region shares common features of
            ubiquitously expressed gene with the interacting splicing regulator
            PTB
REFERENCE   8  (bases 1 to 3484)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   9  (bases 1 to 3484)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   10 (bases 1 to 3484)
  AUTHORS   Huttelmaier,S., Illenberger,S., Grosheva,I., Rudiger,M.,
            Singer,R.H. and Jockusch,B.M.
  TITLE     Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and
            microfilament attachment proteins
  JOURNAL   J Cell Biol 155 (5), 775-786 (2001)
   PUBMED   11724819
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB446023.1, BX401103.2, BC037565.1 and CR746909.1.
            
            On Sep 25, 2018 this sequence version replaced NM_133452.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.2099020.1,
                                           SRR7346977.1448016.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: locus in the vicinity of
                                      disease-associated variant(s)
            MANE Ensembl match     :: ENST00000617231.5/ ENSP00000482277.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               DB446023.1         112-241
            131-985             BX401103.2         136-990
            986-1649            BC037565.1         432-1095
            1650-2103           CR746909.1         63-516
            2104-3484           BC037565.1         1550-2930
FEATURES             Location/Qualifiers
     source          1..3484
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..3484
                     /gene="RAVER1"
                     /note="ribonucleoprotein, PTB binding 1"
                     /db_xref="GeneID:125950"
                     /db_xref="HGNC:HGNC:30296"
                     /db_xref="MIM:609950"
     exon            1..241
                     /gene="RAVER1"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..2242
                     /gene="RAVER1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein raver-1"
                     /codon_start=1
                     /product="ribonucleoprotein PTB-binding 1 isoform 1"
                     /protein_id="NP_597709.3"
                     /db_xref="CCDS:CCDS45960.2"
                     /db_xref="GeneID:125950"
                     /db_xref="HGNC:HGNC:30296"
                     /db_xref="MIM:609950"
                     /translation="MAADVSVTHRPPLSPKSGAEVEAGDAAERRAPEEELPPLDPEEI
                     RKRLEHTERQFRNRRKILIRGLPGDVTNQEVHDLLSDYELKYCFVDKYKGTAFVTLLN
                     GEQAEAAINAFHQSRLRERELSVQLQPTDALLCVANLPPSLTQQQFEELVRPFGSLER
                     CFLVYSERTGQSKGYGFAEYMKKDSAARAKSDLLGKPLGPRTLYVHWTDAGQLTPALL
                     HSRCLCVDRLPPGFNDVDALCRALSAVHSPTFCQLACGQDGQLKGFAVLEYETAEMAE
                     EAQQQADGLSLGGSHLRVSFCAPGPPGRSMLAALIAAQATALNRGKGLLPEPNILQLL
                     NNLGPSASLQLLLNPLLHGSAGGKQGLLGAPPAMPLLNGPALSTALLQLALQTQGQKK
                     PGILGDSPLGALQPGAQPANPLLGELPAGGGLPPELPPRRGKPPPLLPSVLGPAGGDR
                     EALGLGPPAAQLTPPPAPVGLRGSGLRGLQKDSGPLPTPPGVSLLGEPPKDYRIPLNP
                     YLNLHSLLPASNLAGKEARGWGGAGRSRRPAEGPPTNPPAPGGGSSSSKAFQLKSRLL
                     SPLSSARLPPEPGLSDSYSFDYPSDMGPRRLFSHPREPALGPHGPSRHKMSPPPSGFG
                     ERSSGGSGGGPLSHFYSGSPTSYFTSGLQAGLKQSHLSKAIGSSPLGSGEGLLGLSPG
                     PNGHSHLLKTPLGGQKRSFAHLLPSPEPSPEGSYVGQHSQGLGGHYADSYLKRKRIF"
     exon            242..308
                     /gene="RAVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            309..778
                     /gene="RAVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            779..970
                     /gene="RAVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1100
                     /gene="RAVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1195
                     /gene="RAVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1283
                     /gene="RAVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1495
                     /gene="RAVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1792
                     /gene="RAVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1867
                     /gene="RAVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2011
                     /gene="RAVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2095
                     /gene="RAVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..3484
                     /gene="RAVER1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3452..3457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAVER1"
                     /note="hexamer: ATTAAA"
     regulatory      3465..3470
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAVER1"
                     /note="hexamer: AGTAAA"
     polyA_site      3480
                     /gene="RAVER1"
     polyA_site      3484
                     /gene="RAVER1"
                     /note="major polyA site"
ORIGIN      
        1 agaaggcgcc gggtttccca agatggcggc ggacgtgtcc gttactcacc ggcccccgct
       61 gagccctaag tctggggccg aagtcgaagc cggcgatgcc gcggagcgcc gggcgccgga
      121 agaagagctg ccgcctctag atccagaaga gatccggaaa cgcctggaac acaccgagcg
      181 ccagttccgt aaccgccgca agatactgat ccggggcctc ccgggggacg tgaccaacca
      241 ggaagtacat gacctgctca gtgactatga gctcaaatac tgttttgtgg acaaatacaa
      301 agggacagcc ttcgtgaccc tgctgaatgg ggagcaggcc gaggccgcaa tcaatgcttt
      361 ccaccagagc cgcctgcggg agcgtgaact gtcggtgcag ctgcagccca cggatgccct
      421 gctgtgtgtg gccaacctgc cccccagcct cacacagcag cagttcgagg agctggtgcg
      481 gcccttcggc agcctggagc gctgcttcct ggtctacagt gagcgcactg gccaatccaa
      541 gggctatggc tttgctgagt acatgaagaa ggactcggct gcccgtgcca agtcggacct
      601 gctgggcaag ccgctgggac cacgcaccct ctacgtgcac tggacggatg ccgggcaact
      661 gacgcctgcc cttctccact cccgctgcct ctgtgtggac cgcctgccac ctggcttcaa
      721 cgatgtggac gctctgtgcc gggcgctgtc agctgtccac agccccacct tctgccagct
      781 ggcgtgcggc caggatgggc agctgaaggg cttcgcggtg ctggagtatg agacggctga
      841 gatggcggag gaggcacagc agcaggcgga cggcctgtcc ctggggggca gccacctgcg
      901 agtctccttc tgcgcccctg ggccccccgg ccgcagtatg ctggccgctc tcatcgctgc
      961 ccaggccacg gccctcaatc gggggaaggg actcctcccc gagcccaaca tcctgcagct
     1021 gctcaacaac ctgggcccat ccgcgtccct ccagctgctg ctcaaccccc tgctccatgg
     1081 cagtgcgggg gggaagcagg gcctcctggg tgccccccca gccatgccgc tgctcaatgg
     1141 gccagccctg tccacggcgc tgttgcagct cgccctgcag acccagggcc agaagaagcc
     1201 cggcatcctg ggagactcac ccctgggcgc cctccagcct ggggcccagc cagccaaccc
     1261 cctcctcggg gagctgcctg caggaggggg cctgcccccg gagctgccgc cccggcgagg
     1321 gaagccacca cccctgctgc catccgtgct tggccctgct gggggtgacc gggaggccct
     1381 gggcttgggt cccccagcgg cccagctcac tcctcccccc gcccctgtgg ggctccgagg
     1441 ctctggcctc agaggcctcc agaaagacag tgggcctctg ccgacgcccc ctggggtctc
     1501 actgctgggg gagcccccca aggactaccg gattcccctg aatccctacc tgaacctaca
     1561 cagcctgctc ccggccagca acctggcggg taaggaggcc cggggctggg gaggcgccgg
     1621 gagaagccgc cgcccagctg agggcccccc aactaacccc ccagcccctg gaggtggcag
     1681 cagcagcagc aaagccttcc agctcaagtc ccgcctgctc agccccctca gcagcgcccg
     1741 cctgcccccc gaaccaggac tgtctgacag ctacagcttc gactacccct cggacatggg
     1801 acctcggcgg ctcttctccc acccacggga accagccctt gggcctcacg gacccagccg
     1861 acacaagatg tcccccccgc ccagtggctt cggcgaacgg agcagcggtg ggagtggcgg
     1921 gggccccctg tctcacttct attcaggctc gcccacttcc tacttcacca gcggcctgca
     1981 ggctggcctc aagcagagcc acctcagtaa ggcaatcggc tcttccccgc tggggtccgg
     2041 agaagggctc ctgggcctca gccccgggcc taatggtcac agccacctgc tgaagacccc
     2101 actgggcggc cagaaacgca gctttgccca cctgctgccc tcgcccgagc ccagcccaga
     2161 aggcagctat gtgggccagc actcccaggg cctcggcggc cactacgcgg actcctacct
     2221 gaagcggaag aggattttct aagtggctgg caccagagat aactcaaggg cctgcaccaa
     2281 atcgcttttg ggttttctga tgttttgttt tgtgtttttt ttaaaccatt ttctctcttt
     2341 cggtaataga aaaatctctg aaagacttta ctgaccaatc agccggagcc ccaggagccc
     2401 aaggggtgtg ggggagtctg gaggcctcat tatgtctctg gcttgctccc cacgctgaaa
     2461 ccctgcagcc ttaagagaga ggggccccgg cctgctctcc ctccctcccc ccatctcctc
     2521 ctccgctgtg cccgtctctc cggagccctc ctgcctcatt gctcctgtaa ttttggcctt
     2581 tcgagtgcct tggaggtttc cctgacctcc cgtgaagata cagagactgt ctcctttttt
     2641 tttaactttg acaactgact tctgtttcct tttctaagtt ttatttttca aaccaccccg
     2701 gacagccccc agctctgatt ccttcaaggc ccggcctgtc cgggccacca ttccacacct
     2761 tgcggtttga aacagctgtt tttcccacat ttgctgcagg catggctgtc tcctgcccct
     2821 gcctgcccat ctggcctata ccccagccgt ggggcccggg gtccctgccg cagccccctc
     2881 cccttctgat gccttaaaag ctgggcccca ggccctgctg gccagagcca cagatgccaa
     2941 gctctgggag cttgactatg gaccaaacag ctctggccta gggattgggc caccctaccc
     3001 aggatctcca ccctggggac agtagaaggg gaaagccttc atcttggcga accggcccca
     3061 ccaccccctc ctacccgggc ctccgtgcag agatgggctt tctctgccag tcccctgctg
     3121 tctgtctgtg ggagtcggac attgtgccca tctcccggag cctctgctgt cactcgcttg
     3181 ttgaagatga attcttgaat tctgcctgcc cacccccggc cagatccctg gagctggcct
     3241 ccttccagcc cagtgccaga aaccagcact ccatgaagat aaactctggg cccgcccacc
     3301 agcaggacct gtcgacctga ggtgaccctg ggccttgccc ccagccaact gggccaccag
     3361 cttccctccc ttgactctgg gggtccacat ccactccaag gggactattc ccccgacccc
     3421 accccagtct ccccacacgg acctttgctg aattaaagtt tgtaagtaaa tggttttaaa
     3481 gaaa
//
