LOCUS       NM_005447               5515 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens Ras association domain family member 9 (RASSF9), mRNA.
ACCESSION   NM_005447
VERSION     NM_005447.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5515)
  AUTHORS   Dhanaraman,T., Singh,S., Killoran,R.C., Singh,A., Xu,X.,
            Shifman,J.M. and Smith,M.J.
  TITLE     RASSF effectors couple diverse RAS subfamily GTPases to the Hippo
            pathway
  JOURNAL   Sci Signal 13 (653) (2020)
   PUBMED   33051258
  REMARK    GeneRIF: RASSF effectors couple diverse RAS subfamily GTPases to
            the Hippo pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5515)
  AUTHORS   Li,B., Chen,P., Wang,J., Wang,L., Ren,M., Zhang,R. and He,J.
  TITLE     MicroRNA-1254 exerts oncogenic effects by directly targeting RASSF9
            in human breast cancer
  JOURNAL   Int J Oncol 53 (5), 2145-2156 (2018)
   PUBMED   30132526
  REMARK    GeneRIF: RASSF9 is a direct target of miR-1254 in breast cancer.
REFERENCE   3  (bases 1 to 5515)
  AUTHORS   Kita,R. and Fraser,H.B.
  TITLE     Local Adaptation of Sun-Exposure-Dependent Gene Expression
            Regulation in Human Skin
  JOURNAL   PLoS Genet 12 (10), e1006382 (2016)
   PUBMED   27760139
  REMARK    GeneRIF: Our analysis revealed 10 sun-exposure-dependent gene
            expression quantitative trait loci (se-eQTLs), including genes
            involved in skin pigmentation (SLC45A2) and epidermal
            differentiation (RASSF9).
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5515)
  AUTHORS   Kang,D., Oh,S., Ahn,S.M., Lee,B.H. and Moon,M.H.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
REFERENCE   5  (bases 1 to 5515)
  AUTHORS   Sherwood,V., Manbodh,R., Sheppard,C. and Chalmers,A.D.
  TITLE     RASSF7 is a member of a new family of RAS association
            domain-containing proteins and is required for completing mitosis
  JOURNAL   Mol Biol Cell 19 (4), 1772-1782 (2008)
   PUBMED   18272789
REFERENCE   6  (bases 1 to 5515)
  AUTHORS   Chen,L., Johnson,R.C. and Milgram,S.L.
  TITLE     P-CIP1, a novel protein that interacts with the cytosolic domain of
            peptidylglycine alpha-amidating monooxygenase, is associated with
            endosomes
  JOURNAL   J Biol Chem 273 (50), 33524-33532 (1998)
   PUBMED   9837933
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC016993.4, AK022089.1 and
            AC137768.2.
            
            On Nov 23, 2018 this sequence version replaced NM_005447.3.
            
            Summary: The protein encoded by this gene localizes to perinuclear
            endosomes. This protein associates with peptidylglycine
            alpha-amidating monooxygenase, and may be involved with the
            trafficking of this enzyme through secretory or endosomal pathways.
            [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.37432.1,
                                           SRR1803616.229450.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361228.5/ ENSP00000354884.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC016993.4         29197-29224         c
            29-1665             AK022089.1         1-1637
            1666-5515           AC137768.2         25043-28892         c
FEATURES             Location/Qualifiers
     source          1..5515
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.31"
     gene            1..5515
                     /gene="RASSF9"
                     /gene_synonym="P-CIP1; PAMCI; PCIP1"
                     /note="Ras association domain family member 9"
                     /db_xref="GeneID:9182"
                     /db_xref="HGNC:HGNC:15739"
                     /db_xref="MIM:610383"
     exon            1..255
                     /gene="RASSF9"
                     /gene_synonym="P-CIP1; PAMCI; PCIP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..1516
                     /gene="RASSF9"
                     /gene_synonym="P-CIP1; PAMCI; PCIP1"
                     /note="peptidylglycine alpha-amidating monooxygenase
                     COOH-terminal interactor protein-1; PAM COOH-terminal
                     interactor protein 1; Ras association (RalGDS/AF-6) domain
                     family (N-terminal) member 9"
                     /codon_start=1
                     /product="ras association domain-containing protein 9"
                     /protein_id="NP_005438.2"
                     /db_xref="CCDS:CCDS44950.1"
                     /db_xref="GeneID:9182"
                     /db_xref="HGNC:HGNC:15739"
                     /db_xref="MIM:610383"
                     /translation="MAPFGRNLLKTRHKNRSPTKDMDSEEKEIVVWVCQEEKLVCGLT
                     KRTTSADVIQALLEEHEATFGEKRFLLGKPSDYCIIEKWRGSERVLPPLTRILKLWKA
                     WGDEQPNMQFVLVKADAFLPVPLWRTAEAKLVQNTEKLWELSPANYMKTLPPDKQKRI
                     VRKTFRKLAKIKQDTVSHDRDNMETLVHLIISQDHTIHQQVKRMKELDLEIEKCEAKF
                     HLDRVENDGENYVQDAYLMPSFSEVEQNLDLQYEENQTLEDLSESDGIEQLEERLKYY
                     RILIDKLSAEIEKEVKSVCIDINEDAEGEAASELESSNLESVKCDLEKSMKAGLKIHS
                     HLSGIQKEIKYSDSLLQMKAKEYELLAKEFNSLHISNKDGCQLKENRAKESEVPSSNG
                     EIPPFTQRVFSNYTNDTDSDTGISSNHSQDSETTVGDVVLLST"
     exon            256..5515
                     /gene="RASSF9"
                     /gene_synonym="P-CIP1; PAMCI; PCIP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1636..1641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASSF9"
                     /gene_synonym="P-CIP1; PAMCI; PCIP1"
                     /note="hexamer: AATAAA"
     polyA_site      1666
                     /gene="RASSF9"
                     /gene_synonym="P-CIP1; PAMCI; PCIP1"
                     /note="major polyA site"
     regulatory      5492..5497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASSF9"
                     /gene_synonym="P-CIP1; PAMCI; PCIP1"
                     /note="hexamer: AATAAA"
     regulatory      5497..5502
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASSF9"
                     /gene_synonym="P-CIP1; PAMCI; PCIP1"
                     /note="hexamer: AAGAAA"
     polyA_site      5510
                     /gene="RASSF9"
                     /gene_synonym="P-CIP1; PAMCI; PCIP1"
     polyA_site      5515
                     /gene="RASSF9"
                     /gene_synonym="P-CIP1; PAMCI; PCIP1"
ORIGIN      
        1 acaacaatcc cgcagttcaa agttaagcag cagttgcaca acttccagca actttctcag
       61 ccggctacta atgagctgaa agccaggaac atccgaggag aagagaaagc ttccagccct
      121 cctcccttca ccctggaaat ccagacaccc ccacccccac cctcagatca ctttaagata
      181 atttctttat tcgtttgccc gacagaccat ggctcccttt ggaagaaact tgctaaagac
      241 tcggcataaa aacagatctc caactaaaga catggattca gaagagaagg aaattgtggt
      301 ttgggtttgc caagaagaga agcttgtctg tgggctgact aaacgcacca cctctgctga
      361 tgtcatccag gctttgcttg aggaacatga ggctacgttt ggagagaaac gatttcttct
      421 ggggaagccc agtgattact gcatcataga gaagtggaga ggctccgaaa gggttcttcc
      481 tccactaact agaatcctga agctttggaa agcgtgggga gatgagcagc ccaatatgca
      541 atttgttttg gttaaagcag atgcttttct tccagttcct ttgtggcgga cagctgaagc
      601 caaattagtg caaaacacag aaaaattgtg ggagctcagc ccagcaaact acatgaagac
      661 tttaccacca gataaacaaa aaagaatagt caggaaaact ttccggaaac tggctaaaat
      721 taagcaggac acagtttctc atgatcgaga taatatggag acattagttc atctgatcat
      781 ttcccaggac catactattc atcagcaagt caagagaatg aaagagctgg atctggaaat
      841 tgaaaagtgt gaagctaagt tccatcttga tcgagtagaa aatgatggag aaaactatgt
      901 tcaggatgca tatttaatgc ccagtttcag tgaagttgag caaaatctag acttgcagta
      961 tgaggaaaac cagactctgg aggacctgag cgaaagtgat ggaattgaac agctggaaga
     1021 acgactgaaa tattaccgaa tactcattga taagctctct gctgaaatag aaaaagaggt
     1081 aaaaagtgtt tgcattgata taaatgaaga tgcggaaggg gaagctgcaa gtgaactgga
     1141 aagctctaat ttagagagtg ttaagtgtga tttggagaaa agcatgaaag ctggtttgaa
     1201 aattcactct catttgagtg gcatccagaa agagattaaa tacagtgact cattgcttca
     1261 gatgaaagca aaagaatatg aactcctggc caaggaattc aattcacttc acattagcaa
     1321 caaagatggg tgccagttaa aggaaaacag agcgaaggaa tctgaggttc ccagtagcaa
     1381 tggggagatt cctcccttta ctcaaagagt atttagcaat tacacaaatg acacagactc
     1441 ggacactggt atcagttcta accacagtca ggactccgaa acaacagtag gagatgtggt
     1501 gctgttgtca acatagttcc aatggctcct ttctgacctg ctttcatgtt ttaatgtttg
     1561 tttaatttaa taggaaacct cattttaaat ataacactca aaaaaatgta aatcatattg
     1621 tagtattcaa tagttaataa aaactcgaga aatgtgttgt ttctgatgtg aaatttccaa
     1681 aggaacttta attattgcaa gttcaagcaa tgaactattt atcacgaatg cagcacaaat
     1741 agcttgtcgt tgtagaacac agaaataatt tgatgggaat catatgataa tcttccttag
     1801 cgtctgtgga aaacgattta cataaacttt aaaagcaatc ctcaatatta gacagtccaa
     1861 atattcaaac atgaagaagt agaattaaaa tgtgctgtaa tatatatttt tccaacactg
     1921 tataattgga atttttaaat ctgtaaagta tatgggagct actgtgttgt aactgcatta
     1981 attcaaagtt tggttctttt aattgatcct tgataataca acgtatcatg tatatcactt
     2041 cctgaaccct tctacctgtt gaggcctatg aaacaggctg ctgttgggac atgtataaat
     2101 actggcaggg aatcagacac gtatagggta cagatgaggc agggccaagt gctgcataca
     2161 aacagcaatt tttataaaga agcctcaatt tattaagagc tatgtgtgga tgtttgctat
     2221 ctggcaattc agatctcctg accaaaccca tgttcattca ctgagtgagg tatagtgtgg
     2281 gttacagaga aaatcagtca tagtgttatt tgtttatgtc ctatctacaa aagttgcaat
     2341 gatggaattt ggaacccttc tgtggataaa atagaatctg ctataattat tagcattttg
     2401 tctctgaacc tacagagagg agaccacatg gacaaaagac ttattctgct atgctataac
     2461 tcagattgtc ttatttcttc atctaaagtg cttaaaagag acttagttcc taaaaaagta
     2521 ccagcaaaat ccccaacaca ctagtaagaa ttcaagaaat tgaagggatt atttaggtct
     2581 tatcttgact gacaatcatt attatggcct actatgcttg tgttttaatt agaaatgtgc
     2641 tttcttctct ctcccttctt tgcttacttt cttcttattt gccttcctgt ctgccttact
     2701 tcctctcttt tcctgccttc atctctcctt ctcccgtctt ctttttttcc tttgcttcct
     2761 tcctgccaat gaacacatga tgcaatcata atgaaataat tattttttat tgtactgtta
     2821 actgagtact gctgcagttt atttttattt agctgatatc tttcctgtgt gtcactgcac
     2881 atgtaagtag aaatattatt ttacttagtt ttaatatgtg gacattggtt aagggtccca
     2941 atccttctca tttcttctct tttattcttt tgcatacttt tagtgcaggt tttaactcag
     3001 ttttcttatt gttttacttt caaaatttga aaagtattta attttttaaa gcaactttat
     3061 tgttaactca tttaaaaaaa tatattgctc cttaaatctt cttaacatat ttgttcctgc
     3121 cttctcctgt cttttaactc atctttggga agacatttag aattttctga ttgtttcagt
     3181 ttcgtgagca tttatactat catttcttgt accaaaatag atattttcag gtcttatttc
     3241 aagttggctg gtaagaaaaa tagaaatttc cattctatgg aaaaatacag tgataaagag
     3301 taataattct ggcatcggtt acattttttt aaaaaagata aaattgaata gtcatctgtg
     3361 aaaggaaagt tcacctgact aagagtccat aaaattattc aacaatataa gccactgaca
     3421 tattcattgt tcactaatgg ggatcaaatt cagaagatca tcgtaaatga taaacccatt
     3481 gtatcatttt cctacagtgg aagtcatctc tttgaattat tcttatcttt agtgagaaaa
     3541 tactgaaaga acatgcttat ctatttgact aattatctga attcaagagg ttctgataag
     3601 aagtaggcct ggagagataa tttcatctta gaaactttga attaacttct gcttttatac
     3661 agttaagcac agtaatgcat ttaaggctca attcttctac attttacagt aaataatgtt
     3721 tgtaagtctc agaaagcagt accattgctt tttaaattca tttcagaatt tccatttgct
     3781 cattagttat acaaatgtat ttgtgcgttt gatcactaca atcattaagt tttaatcctt
     3841 catcagctac catggtgaac ctcttaattt acagttacat gttaatatat taacacaaat
     3901 agaagtactg aaatacaatg ccctcatgtc tggatactga actatttgtt attaaattaa
     3961 gtgagaattg gaattataag tatagaactt gatagaaagt gtaatgttat tatctataga
     4021 aatgttaaag tataaattct tgagtaatct gacaggttaa ctatgaaatt gctatatgca
     4081 gctagaagaa acaaaccaaa gctgactatt cttaatttct gtaacaggac ctagattcat
     4141 ccttggtcat ccttccactt ggaattctcc tttttatcct tctgcaatgc tctgaaatct
     4201 taccctttcc acagtctttt taatgtgcta gctcttctat gatatacgtt tgttccattc
     4261 aattagttgg aatctcatct ctgaacccag aaatatttta gaggtacttc tcataagaag
     4321 catttttatt ctggcttacg ctatatatat ttatgcactt acctaattcc cctccttcaa
     4381 tgaattctat tttttttttc cttgagacgg agtctcactc tgtcgcccag gctggagtgc
     4441 agtggcgcga tcttggctca ctgcaagctc cgcctcccgg cttcacgcca ttttcctgcc
     4501 tcagcctcct gagtagctgg gactacaggc gcccgccacc acgccaggct aatttttttg
     4561 tattttttta gtagagacgg ggtttcaccg tgttagccag gatggtctcg atgtcctgac
     4621 cttgtgatcc acccgtcttg gcctcccaaa gtgctgggat tacaggcgtg agccaccgtg
     4681 cccgaccaat gaattcttat taaattactt tatcatctgt cttgttagcc ttactctttc
     4741 ctattaactt ctttgccccc tgctcccttt ttgaattgag tggctaaatt ttagaggttt
     4801 gtagcttttg tgtgtgtgtg tgtgtgtttt atagatggta aatgatgctt gtacattttg
     4861 tacatgaatg aatacgtatt ttagcagact taaaacatta acagtaattg accttataca
     4921 ttttgggaaa gaaaaattaa atcttcatgc tactacgatt tttttaaatg tggcatcaat
     4981 gtttattttt aataatagta ttactgactt aataaacccc aaatgtctct ttaagctgat
     5041 ttaatggtta tattatagaa ttttttattt cattgtgtgc ttatgagaaa aaacatattt
     5101 tagagttggg ttttaaatgg tagacacaga aagtaacttt aaaatatcct aaacaaaata
     5161 tctatttcat ttttcttctt aagtaaaata acaacacctc attagtgtgt agaagctatt
     5221 ctaatccatt aaaattttat ttttatattt atttaaatat ctactgtaca tgacaaaata
     5281 tatttctgtg gctgcctttt ataattattt tccaagtaga cataatctat ttaaaacata
     5341 tttttctagt gacaaagaaa tacattttat cctgatatat agtttttaaa tactaggcta
     5401 tttcttttca tactgcctga ttggtttaat aaacatgatg tgacaaatat taagtatata
     5461 tcattttatc atgttgtaac tgatccaaaa taataaaaga aataattata ccttt
//
