LOCUS       NM_001394098            5980 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens Ras association domain family member 8 (RASSF8),
            transcript variant 9, mRNA.
ACCESSION   NM_001394098 XM_024448818
VERSION     NM_001394098.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5980)
  AUTHORS   Lin,Y., Guo,R., R,G. and Xu,B.
  TITLE     Tailored modulation of S100A1 and RASSF8 expression by
            butanediamide augments healing of rotator cuff tears
  JOURNAL   PeerJ 11, e15791 (2023)
   PUBMED   37601265
  REMARK    GeneRIF: Tailored modulation of S100A1 and RASSF8 expression by
            butanediamide augments healing of rotator cuff tears.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5980)
  AUTHORS   Li,X., Jiang,X., Lu,J., Lin,Y., Jiang,L., Li,Y., Wan,F. and Wang,C.
  TITLE     CircCERS6 Suppresses the Development of Epithelial Ovarian Cancer
            Through Mediating miR-630/RASSF8
  JOURNAL   Biochem Genet 60 (6), 2611-2629 (2022)
   PUBMED   35676548
  REMARK    GeneRIF: CircCERS6 Suppresses the Development of Epithelial Ovarian
            Cancer Through Mediating miR-630/RASSF8.
REFERENCE   3  (bases 1 to 5980)
  AUTHORS   Zhang,X., Sun,P., Yang,W., Li,S., Jia,H., Wang,W., Jiang,S.,
            Wang,L., Liu,X., Liang,L. and Zi,W.
  TITLE     RASSF8-AS1 displays low expression in colorectal cancer and
            up-regulates RASSF8 to suppress cell invasion and migration
  JOURNAL   Pathol Res Pract 237, 153996 (2022)
   PUBMED   35839610
  REMARK    GeneRIF: RASSF8-AS1 displays low expression in colorectal cancer
            and up-regulates RASSF8 to suppress cell invasion and migration.
REFERENCE   4  (bases 1 to 5980)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 5980)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 5980)
  AUTHORS   Falvella,F.S., Manenti,G., Spinola,M., Pignatiello,C., Conti,B.,
            Pastorino,U. and Dragani,T.A.
  TITLE     Identification of RASSF8 as a candidate lung tumor suppressor gene
  JOURNAL   Oncogene 25 (28), 3934-3938 (2006)
   PUBMED   16462760
  REMARK    GeneRIF: Expression of RASSF8 protein by transfected lung cancer
            cells led to inhibition of anchorage-independent growth in soft
            agar in A549 cells and reduction of clonogenic activity in NCI-H520
            cells
REFERENCE   7  (bases 1 to 5980)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
REFERENCE   8  (bases 1 to 5980)
  AUTHORS   Debeer,P., Schoenmakers,E.F., Twal,W.O., Argraves,W.S., De Smet,L.,
            Fryns,J.P. and Van De Ven,W.J.
  TITLE     The fibulin-1 gene (FBLN1) is disrupted in a t(12;22) associated
            with a complex type of synpolydactyly
  JOURNAL   J Med Genet 39 (2), 98-104 (2002)
   PUBMED   11836357
REFERENCE   9  (bases 1 to 5980)
  AUTHORS   Gonzalez,P., Epstein,D.L. and Borras,T.
  TITLE     Characterization of gene expression in human trabecular meshwork
            using single-pass sequencing of 1060 clones
  JOURNAL   Invest Ophthalmol Vis Sci 41 (12), 3678-3693 (2000)
   PUBMED   11053263
REFERENCE   10 (bases 1 to 5980)
  AUTHORS   Debeer,P., Schoenmakers,E.F., Thoelen,R., Holvoet,M., Kuittinen,T.,
            Fabry,G., Fryns,J.P., Goodman,F.R. and Van de Ven,W.J.
  TITLE     Physical map of a 1.5 mb region on 12p11.2 harbouring a
            synpolydactyly associated chromosomal breakpoint
  JOURNAL   Eur J Hum Genet 8 (8), 561-570 (2000)
   PUBMED   10951517
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC055707.33.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Mar 31, 2021 this sequence version replaced XM_024448818.1.
            
            Summary: This gene encodes a member of the Ras-assocation domain
            family (RASSF) of tumor suppressor proteins. This gene is essential
            for maintaining adherens junction function in epithelial cells and
            has a role in epithelial cell migration. It is a lung tumor
            suppressor gene candidate. A chromosomal translocation
            t(12;22)(p11.2;q13.3) leading to the fusion of this gene and the
            FBLN1 gene is found in a complex type of synpolydactyly. Multiple
            alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, May
            2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.1592624.1,
                                           ERR4352444.318968.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000689635.1/ ENSP00000510086.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-467               AC055707.33        121032-121498       c
            468-561             AC055707.33        85050-85143         c
            562-772             AC055707.33        24734-24944         c
            773-1662            AC055707.33        14793-15682         c
            1663-1807           AC055707.33        12467-12611         c
            1808-5980           AC055707.33        7311-11483          c
FEATURES             Location/Qualifiers
     source          1..5980
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.1"
     gene            1..5980
                     /gene="RASSF8"
                     /gene_synonym="C12orf2; HOJ1"
                     /note="Ras association domain family member 8"
                     /db_xref="GeneID:11228"
                     /db_xref="HGNC:HGNC:13232"
                     /db_xref="MIM:608231"
     exon            1..467
                     /gene="RASSF8"
                     /gene_synonym="C12orf2; HOJ1"
                     /inference="alignment:Splign:2.1.0"
     exon            468..561
                     /gene="RASSF8"
                     /gene_synonym="C12orf2; HOJ1"
                     /inference="alignment:Splign:2.1.0"
     exon            562..772
                     /gene="RASSF8"
                     /gene_synonym="C12orf2; HOJ1"
                     /inference="alignment:Splign:2.1.0"
     CDS             670..1929
                     /gene="RASSF8"
                     /gene_synonym="C12orf2; HOJ1"
                     /note="isoform a is encoded by transcript variant 9; ras
                     association domain-containing protein 8; Ras association
                     (RalGDS/AF-6) domain family (N-terminal) member 8;
                     carcinoma-associated protein HOJ-1"
                     /codon_start=1
                     /product="ras association domain-containing protein 8
                     isoform a"
                     /protein_id="NP_001381027.1"
                     /db_xref="CCDS:CCDS53765.1"
                     /db_xref="GeneID:11228"
                     /db_xref="HGNC:HGNC:13232"
                     /db_xref="MIM:608231"
                     /translation="MELKVWVDGVQRIVCGVTEVTTCQEVVIALAQAIGRTGRYTLIE
                     KWRDTERHLAPHENPIISLNKWGQYASDVQLILRRTGPSLSERPTSDSVARIPERTLY
                     RQSLPPLAKLRPQIDKSIKRREPKRKSLTFTGGAKGLMDIFGKGKETEFKQKVLNNCK
                     TTADELKKLIRLQTEKLQSIEKQLESNEIEIRFWEQKYNSNLEEEIVRLEQKIKRNDV
                     EIEEEEFWENELQIEQENEKQLKDQLQEIRQKITECENKLKDYLAQIRTMESGLEAEK
                     LQREVQEAQVNEEEVKGKIGKVKGEIDIQGQQSLRLENGIKAVERSLGQATKRLQDKE
                     QELEQLTKELRQVNLQQFIQQTGTKVTVLPAEPIEIEASHADIEREAPFQSGSLKRPG
                     SSRQLPSNLRILQNPISSGFNPEGIYV"
     exon            773..1662
                     /gene="RASSF8"
                     /gene_synonym="C12orf2; HOJ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1807
                     /gene="RASSF8"
                     /gene_synonym="C12orf2; HOJ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..5980
                     /gene="RASSF8"
                     /gene_synonym="C12orf2; HOJ1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5954..5959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASSF8"
                     /gene_synonym="C12orf2; HOJ1"
                     /note="hexamer: AATAAA"
     polyA_site      5980
                     /gene="RASSF8"
                     /gene_synonym="C12orf2; HOJ1"
                     /note="major polyA site"
ORIGIN      
        1 agaggcaccg gccgcgggag cgagcgggtc gccgactcct acgcccgcgc tcctcctacg
       61 cccgcgctcg tccggcgccc cgcgccgcgc cccgctcagc gtctgccgcc cagctcctcg
      121 cccagcctcg ccgagcctcg cccttcccgc ccgcggcggc gttggcgctg ggggcggctc
      181 ccgcggcgtc tctgccgctg gccgagcgct cgcgcaccgc ggcacccccg ccagtggcgt
      241 ccacactcac ctagcgcggg ccgggaggtg cgcggagagg gaacgccggg gggccggggc
      301 ctccagccgg tgcggggcgc gcggcgcggg gagcgccggg gagtgccggg gagtgcggcg
      361 cggggacggg cgctgggcgg ccgcggagct ccgggtgccg ccgcgtcccc agcgccccgg
      421 ccggcccctc tgggcggcct gcgggggcgg cgcagttgcg aaactgagtg cctgtgtaga
      481 tcatcctaga atacctgtgt ggtgctgtcc ttcctcaaga ctacctcatt ctcactggct
      541 cggagactcc tgcctgctga gctgactaca cagacttagt cttctccact ccgtgttcct
      601 gcagctagag acatgaccta acaccctgat gaccactctc agggaccttg agtgactggc
      661 cggtgcacca tggaacttaa agtatgggtg gatggagttc agaggattgt ttgtggagtc
      721 actgaagtca caacttgcca ggaggttgtc atagccttag ctcaagcaat aggtcgaact
      781 ggaaggtaca cccttataga gaaatggaga gatactgaaa gacacttagc acctcatgaa
      841 aatcctatca tatccttaaa caaatggggg cagtatgcta gtgatgtgca gctcattcta
      901 cgacgaactg ggccgtctct cagtgagcga cccacttcag acagtgtggc tcgaattcct
      961 gaaagaactt tatacaggca gagtctgccc cccttagcta aactgaggcc tcagattgac
     1021 aaatcaatca aaaggaggga accgaaaagg aaatcactga catttacagg aggtgccaaa
     1081 ggattaatgg acatttttgg aaaaggtaaa gaaactgagt ttaagcaaaa ggtgctgaat
     1141 aactgcaaaa caacagcaga tgagttgaag aagctaatcc gtctgcagac agagaagctt
     1201 caatccattg agaaacagct ggaatctaat gaaatagaaa taagattttg ggagcaaaag
     1261 tataattcca accttgaaga ggaaattgtc cgtctagagc aaaagatcaa aagaaacgat
     1321 gtagaaattg aggaggaaga attctgggaa aatgaattac agattgaaca ggaaaatgaa
     1381 aaacagctga aggatcaact tcaagaaata agacagaaaa taacagaatg tgaaaacaaa
     1441 ttaaaggact atttggcaca gatccggact atggaaagtg gtcttgaagc agaaaaattg
     1501 caacgggaag ttcaagaggc acaggtcaat gaggaagagg ttaaaggaaa gatcggtaag
     1561 gtcaaagggg agattgacat tcaaggccag cagagtctga ggttggaaaa tggcatcaaa
     1621 gctgtggaaa gatctcttgg acaagccacc aaacgcttac aggacaaaga acaggaactg
     1681 gagcagttga ctaaggagtt gcggcaagtc aatctccagc agttcatcca gcagacaggg
     1741 acaaaagtta ccgttttgcc agcggagccc attgaaatag aggcctcaca tgcagacatt
     1801 gaaagggagg caccattcca gtctgggtcc ctgaagcgac ctggttcatc tcggcagctc
     1861 cccagtaatc tccgcattct gcagaatcct atctcatctg gttttaatcc tgaaggcata
     1921 tatgtatgac attatctgtc tttagggagg agacccaaca gaggtaccaa ggacagtaaa
     1981 cttccttttt gatttgtgcc aatgatgaac agaggatcta ttccacaaga cgctgtatgt
     2041 tttttctctc ctaaattgca taccacttgg agccataccc tgtgcactga tgctaaagaa
     2101 caaagaaact gtgttttcac acatcaacag tgttgatatt tttgtccagc agctataatg
     2161 caaagccttc gtttttattt gtagcatttt gagagcttta ggaaagtatt atatagtgtg
     2221 tatacataaa taagccgtga cttaagtaag agtgaagaga aatttgtgac tggcttagtt
     2281 taatttattt catgtaatca atgtgtgaat gttgatgttt taatattttt attgacttat
     2341 cctgtgactg acttacgtta catattgtgt gattatgacc gtgtgcatgt tgccagactc
     2401 catccatgca ttgctgattt acactacaca agtgtcctag ggtgctccac catcgaagct
     2461 aactccacag gaagccactt gcatttgttt tgtgaaactg tcctagccat tgcttaatta
     2521 ggtgaaataa ttcagggttt tttaaatctg gaatttagtc gttcctttac aatatttcca
     2581 aatatacgtg tggccacaga gcataacaga tatttttcat aagctaaatt gtatgtataa
     2641 aacatttgca gtgtttcaga cactgttgaa caaaaatgta attggtaagt atgtatccaa
     2701 acaggcatgg ggtttcctga tacattatgt gttttgtttc tgccctgtct tatcatttac
     2761 actcatggat cttcagaatt aatctaacat ggaagttata gatacctgaa agctgggttg
     2821 gtctacttca ggaacattgc tttaagtgat gtattttaaa ataacccgct tcatatgtat
     2881 gatctgttgg tgtacacacc atgggtaagg tattgcttgc acataatttg ctctgcatat
     2941 tatggaccat tgtggtttct tccagtcact tagatggaaa ggaggttaaa cctaggtact
     3001 ttttagcaag gatataaagt caaattcagc atatgttttt atttttaggc ttgactttta
     3061 caagacatta atctccattt gtacatatgt tattttattt gtaaaaccaa atatgactca
     3121 acaccttttt gatgagtagt gacttaacta agatttacaa gtaatattta gacagattca
     3181 gtcagacacc acttagccat ttttacattc cctctggtta gatttggtac agtataatta
     3241 agactttaat ctgaaattta aagtagtttt aattctgaag aagttacatc ctctgtatta
     3301 tttacatgca acaaaataaa agtggattaa tatagtaatg ccatggtaac aatagagcta
     3361 tgtcttatgc atgaaggcaa ctttggatgt tttaacacat ttgactgact ttggtttagt
     3421 gaatgctgac aatgctgctc tacttaggtt tcctatgaaa tttttaagaa tggctatgag
     3481 actgtataga agcttctaga gaactgaaag tcataatgca gagttgcctt ttctagtgca
     3541 gctaagtggc ggacctcaac tgaagatatg agtttctttg ggttcttgga gttatcaaat
     3601 tgatcttgcc attatgttac tttgcaaata actgaagtaa atgattctta cctaaataac
     3661 cacaacctgt acacatttgc tcacaattta tagtagttat tttctatcta cctatattta
     3721 aaattaggat gattaaaaaa taatttatag attttgtgac agtaatgatt tacatatgcc
     3781 caatatatgc cttattttta aataagtcat tctgtataaa gtcattttgt tgttgttcag
     3841 agaaatcaag atcttattca caaagaaaaa cattttataa attgatcgca ttttctttaa
     3901 gtcaaaatgt taaactggag gcagtattaa actttgcaat taggagtttc agagatgcct
     3961 tggcatacca cgaaaaacac tgtcaatatc caactcatta taaattgtta tcagaattaa
     4021 cctaataact ttaagtaagg acaagcagca tcctagcaac ttgtagtagt cttgggttcc
     4081 cagcagagta tcacagttaa cctctctgac aacttcatca gaatttccaa gctgccaaat
     4141 aatcttcata gacctaatta cagatttaaa aaaatttcct aggcgacgaa agtatagaaa
     4201 tgtgaatatg ttgaatacat tgagaagctg tactttttaa ttagttatat tacttctgga
     4261 agcacatatc taaggaatat tttctaagac tcagagggaa aaaaactcgt tttcatagga
     4321 tcatctgaag atactttagt atatttgtga tcatttttat ctattgcaaa tacaaatgaa
     4381 ttagataagt gccacatcct ggatacattt cggaggggta gtgggcaatg gtatacaaaa
     4441 ataccaaata taaaattttc atctggggga atgttcaggt tctaaatact aaattagatt
     4501 tcaatgtttt gtgttttttt taaaaaaatc atattgcaac ttgttttatt gtgattttct
     4561 acaagtatta aatacattta aagatctttt tatcttacca agaaataatt tggaatagca
     4621 ttggtatatt tgaccttttg agtgtctgtc atcctcagag aatggcccat agtgtgttgc
     4681 ctgtggacat agtgtccata gtccctttct tgtccttctg agatattttg gtttgataac
     4741 attttgtttt ttgtcttgat gcacagggac ttttttataa tatgagactt cagttggtat
     4801 taataggagt tacctattta attctcccag tcatcaatga ggtaatcatc aattcctata
     4861 gttcaaatta gtcataaaca agagctacag caagactgat agagtaaaaa ctatataaat
     4921 acagtaaaaa aaaaatagaa tttatggtgt gaaatatgaa gtatagcaat atataacaag
     4981 aacatgtaag cacttgcttc cacagcataa atgtaattta catctgcatt aaaggataat
     5041 tttctctgtg aataagagca aaatggtctt cagagaaaca gactgttcat ttgaagccat
     5101 ttctgtaaac atcttccaag atagaactgt aatggattga ggaaataaca cagaaaagac
     5161 aaaaactttt gatttcaggc atgcaaagtg cttgggcaga tggacagttc ccattgtgca
     5221 ttgcctttga taaatttggc cttaatttat ataacgatgc tgtgttcaca tccctctcct
     5281 acctaaagtt gtctttattg gtttatattg tgttaaaatt agcttataat tattactttt
     5341 gtattgtgtt cagtttttta agttgcatgt ttatactatt tgctacagta tttttaagtt
     5401 tggggtgaag gccatcagct gtatcaaaaa gacaaaacaa tcactattta ttcagtattg
     5461 ctgctttaca tctccagaat aagctttcga tgccaggaca gtgactgcct gaaagctgca
     5521 ggagctcttt tcaatgcatt ttatatattt ttagaaacca aataaatgca gaaaactatt
     5581 tcgtatacta attatattaa accagcagaa atataaaggc aataaagtat atacatatat
     5641 atggggggag gggaaagatt aaaaaataga tttacagcca gacatggtga tagccctaaa
     5701 tgtatttctc aatatgtttt tctttattga ccctaggagg atttgagttg ctgcagcttt
     5761 aaacagaaaa ttgccatgtt cactaattgt gagcacataa atatgctttt agtactgctt
     5821 tgcttatgta caaataaatc tgtaatatgt attatatgta attatccttt tctttgactt
     5881 tcattttaaa tgtatatttt ctgatcatta tgagctgtaa aacaaagaat caatattgga
     5941 tattctccca aataataaat tttcaggatt cattggggca
//
