LOCUS       NM_001394096            5581 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens Ras association domain family member 8 (RASSF8),
            transcript variant 7, mRNA.
ACCESSION   NM_001394096
VERSION     NM_001394096.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5581)
  AUTHORS   Lin,Y., Guo,R., R,G. and Xu,B.
  TITLE     Tailored modulation of S100A1 and RASSF8 expression by
            butanediamide augments healing of rotator cuff tears
  JOURNAL   PeerJ 11, e15791 (2023)
   PUBMED   37601265
  REMARK    GeneRIF: Tailored modulation of S100A1 and RASSF8 expression by
            butanediamide augments healing of rotator cuff tears.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5581)
  AUTHORS   Li,X., Jiang,X., Lu,J., Lin,Y., Jiang,L., Li,Y., Wan,F. and Wang,C.
  TITLE     CircCERS6 Suppresses the Development of Epithelial Ovarian Cancer
            Through Mediating miR-630/RASSF8
  JOURNAL   Biochem Genet 60 (6), 2611-2629 (2022)
   PUBMED   35676548
  REMARK    GeneRIF: CircCERS6 Suppresses the Development of Epithelial Ovarian
            Cancer Through Mediating miR-630/RASSF8.
REFERENCE   3  (bases 1 to 5581)
  AUTHORS   Zhang,X., Sun,P., Yang,W., Li,S., Jia,H., Wang,W., Jiang,S.,
            Wang,L., Liu,X., Liang,L. and Zi,W.
  TITLE     RASSF8-AS1 displays low expression in colorectal cancer and
            up-regulates RASSF8 to suppress cell invasion and migration
  JOURNAL   Pathol Res Pract 237, 153996 (2022)
   PUBMED   35839610
  REMARK    GeneRIF: RASSF8-AS1 displays low expression in colorectal cancer
            and up-regulates RASSF8 to suppress cell invasion and migration.
REFERENCE   4  (bases 1 to 5581)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 5581)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 5581)
  AUTHORS   Falvella,F.S., Manenti,G., Spinola,M., Pignatiello,C., Conti,B.,
            Pastorino,U. and Dragani,T.A.
  TITLE     Identification of RASSF8 as a candidate lung tumor suppressor gene
  JOURNAL   Oncogene 25 (28), 3934-3938 (2006)
   PUBMED   16462760
  REMARK    GeneRIF: Expression of RASSF8 protein by transfected lung cancer
            cells led to inhibition of anchorage-independent growth in soft
            agar in A549 cells and reduction of clonogenic activity in NCI-H520
            cells
REFERENCE   7  (bases 1 to 5581)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
REFERENCE   8  (bases 1 to 5581)
  AUTHORS   Debeer,P., Schoenmakers,E.F., Twal,W.O., Argraves,W.S., De Smet,L.,
            Fryns,J.P. and Van De Ven,W.J.
  TITLE     The fibulin-1 gene (FBLN1) is disrupted in a t(12;22) associated
            with a complex type of synpolydactyly
  JOURNAL   J Med Genet 39 (2), 98-104 (2002)
   PUBMED   11836357
REFERENCE   9  (bases 1 to 5581)
  AUTHORS   Gonzalez,P., Epstein,D.L. and Borras,T.
  TITLE     Characterization of gene expression in human trabecular meshwork
            using single-pass sequencing of 1060 clones
  JOURNAL   Invest Ophthalmol Vis Sci 41 (12), 3678-3693 (2000)
   PUBMED   11053263
REFERENCE   10 (bases 1 to 5581)
  AUTHORS   Debeer,P., Schoenmakers,E.F., Thoelen,R., Holvoet,M., Kuittinen,T.,
            Fabry,G., Fryns,J.P., Goodman,F.R. and Van de Ven,W.J.
  TITLE     Physical map of a 1.5 mb region on 12p11.2 harbouring a
            synpolydactyly associated chromosomal breakpoint
  JOURNAL   Eur J Hum Genet 8 (8), 561-570 (2000)
   PUBMED   10951517
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC055707.33.
            
            Summary: This gene encodes a member of the Ras-assocation domain
            family (RASSF) of tumor suppressor proteins. This gene is essential
            for maintaining adherens junction function in epithelial cells and
            has a role in epithelial cell migration. It is a lung tumor
            suppressor gene candidate. A chromosomal translocation
            t(12;22)(p11.2;q13.3) leading to the fusion of this gene and the
            FBLN1 gene is found in a complex type of synpolydactyly. Multiple
            alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, May
            2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.624035.1,
                                           SRR14038196.1740679.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145774, SAMEA2149178
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AC055707.33        121838-121948       c
            112-205             AC055707.33        85050-85143         c
            206-373             AC055707.33        24734-24901         c
            374-1263            AC055707.33        14793-15682         c
            1264-1408           AC055707.33        12467-12611         c
            1409-5581           AC055707.33        7311-11483          c
FEATURES             Location/Qualifiers
     source          1..5581
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.1"
     gene            1..5581
                     /gene="RASSF8"
                     /gene_synonym="C12orf2; HOJ1"
                     /note="Ras association domain family member 8"
                     /db_xref="GeneID:11228"
                     /db_xref="HGNC:HGNC:13232"
                     /db_xref="MIM:608231"
     exon            1..111
                     /gene="RASSF8"
                     /gene_synonym="C12orf2; HOJ1"
                     /inference="alignment:Splign:2.1.0"
     exon            112..205
                     /gene="RASSF8"
                     /gene_synonym="C12orf2; HOJ1"
                     /inference="alignment:Splign:2.1.0"
     exon            206..373
                     /gene="RASSF8"
                     /gene_synonym="C12orf2; HOJ1"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..1530
                     /gene="RASSF8"
                     /gene_synonym="C12orf2; HOJ1"
                     /note="isoform a is encoded by transcript variant 7; ras
                     association domain-containing protein 8; Ras association
                     (RalGDS/AF-6) domain family (N-terminal) member 8;
                     carcinoma-associated protein HOJ-1"
                     /codon_start=1
                     /product="ras association domain-containing protein 8
                     isoform a"
                     /protein_id="NP_001381025.1"
                     /db_xref="CCDS:CCDS53765.1"
                     /db_xref="GeneID:11228"
                     /db_xref="HGNC:HGNC:13232"
                     /db_xref="MIM:608231"
                     /translation="MELKVWVDGVQRIVCGVTEVTTCQEVVIALAQAIGRTGRYTLIE
                     KWRDTERHLAPHENPIISLNKWGQYASDVQLILRRTGPSLSERPTSDSVARIPERTLY
                     RQSLPPLAKLRPQIDKSIKRREPKRKSLTFTGGAKGLMDIFGKGKETEFKQKVLNNCK
                     TTADELKKLIRLQTEKLQSIEKQLESNEIEIRFWEQKYNSNLEEEIVRLEQKIKRNDV
                     EIEEEEFWENELQIEQENEKQLKDQLQEIRQKITECENKLKDYLAQIRTMESGLEAEK
                     LQREVQEAQVNEEEVKGKIGKVKGEIDIQGQQSLRLENGIKAVERSLGQATKRLQDKE
                     QELEQLTKELRQVNLQQFIQQTGTKVTVLPAEPIEIEASHADIEREAPFQSGSLKRPG
                     SSRQLPSNLRILQNPISSGFNPEGIYV"
     exon            374..1263
                     /gene="RASSF8"
                     /gene_synonym="C12orf2; HOJ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1408
                     /gene="RASSF8"
                     /gene_synonym="C12orf2; HOJ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..5581
                     /gene="RASSF8"
                     /gene_synonym="C12orf2; HOJ1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5555..5560
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASSF8"
                     /gene_synonym="C12orf2; HOJ1"
                     /note="hexamer: AATAAA"
     polyA_site      5581
                     /gene="RASSF8"
                     /gene_synonym="C12orf2; HOJ1"
                     /note="major polyA site"
ORIGIN      
        1 agagggcagt ttgacaagtc tcagccccgg gcgatggaag attttgcccg tgggaccgtc
       61 acgagccacc ggtcatctcc ccgcgcccgg ctttcgggtc ctcaggcctc ggtgcctgtg
      121 tagatcatcc tagaatacct gtgtggtgct gtccttcctc aagactacct cattctcact
      181 ggctcggaga ctcctgcctg ctgagctaga gacatgacct aacaccctga tgaccactct
      241 cagggacctt gagtgactgg ccggtgcacc atggaactta aagtatgggt ggatggagtt
      301 cagaggattg tttgtggagt cactgaagtc acaacttgcc aggaggttgt catagcctta
      361 gctcaagcaa taggtcgaac tggaaggtac acccttatag agaaatggag agatactgaa
      421 agacacttag cacctcatga aaatcctatc atatccttaa acaaatgggg gcagtatgct
      481 agtgatgtgc agctcattct acgacgaact gggccgtctc tcagtgagcg acccacttca
      541 gacagtgtgg ctcgaattcc tgaaagaact ttatacaggc agagtctgcc ccccttagct
      601 aaactgaggc ctcagattga caaatcaatc aaaaggaggg aaccgaaaag gaaatcactg
      661 acatttacag gaggtgccaa aggattaatg gacatttttg gaaaaggtaa agaaactgag
      721 tttaagcaaa aggtgctgaa taactgcaaa acaacagcag atgagttgaa gaagctaatc
      781 cgtctgcaga cagagaagct tcaatccatt gagaaacagc tggaatctaa tgaaatagaa
      841 ataagatttt gggagcaaaa gtataattcc aaccttgaag aggaaattgt ccgtctagag
      901 caaaagatca aaagaaacga tgtagaaatt gaggaggaag aattctggga aaatgaatta
      961 cagattgaac aggaaaatga aaaacagctg aaggatcaac ttcaagaaat aagacagaaa
     1021 ataacagaat gtgaaaacaa attaaaggac tatttggcac agatccggac tatggaaagt
     1081 ggtcttgaag cagaaaaatt gcaacgggaa gttcaagagg cacaggtcaa tgaggaagag
     1141 gttaaaggaa agatcggtaa ggtcaaaggg gagattgaca ttcaaggcca gcagagtctg
     1201 aggttggaaa atggcatcaa agctgtggaa agatctcttg gacaagccac caaacgctta
     1261 caggacaaag aacaggaact ggagcagttg actaaggagt tgcggcaagt caatctccag
     1321 cagttcatcc agcagacagg gacaaaagtt accgttttgc cagcggagcc cattgaaata
     1381 gaggcctcac atgcagacat tgaaagggag gcaccattcc agtctgggtc cctgaagcga
     1441 cctggttcat ctcggcagct ccccagtaat ctccgcattc tgcagaatcc tatctcatct
     1501 ggttttaatc ctgaaggcat atatgtatga cattatctgt ctttagggag gagacccaac
     1561 agaggtacca aggacagtaa acttcctttt tgatttgtgc caatgatgaa cagaggatct
     1621 attccacaag acgctgtatg ttttttctct cctaaattgc ataccacttg gagccatacc
     1681 ctgtgcactg atgctaaaga acaaagaaac tgtgttttca cacatcaaca gtgttgatat
     1741 ttttgtccag cagctataat gcaaagcctt cgtttttatt tgtagcattt tgagagcttt
     1801 aggaaagtat tatatagtgt gtatacataa ataagccgtg acttaagtaa gagtgaagag
     1861 aaatttgtga ctggcttagt ttaatttatt tcatgtaatc aatgtgtgaa tgttgatgtt
     1921 ttaatatttt tattgactta tcctgtgact gacttacgtt acatattgtg tgattatgac
     1981 cgtgtgcatg ttgccagact ccatccatgc attgctgatt tacactacac aagtgtccta
     2041 gggtgctcca ccatcgaagc taactccaca ggaagccact tgcatttgtt ttgtgaaact
     2101 gtcctagcca ttgcttaatt aggtgaaata attcagggtt ttttaaatct ggaatttagt
     2161 cgttccttta caatatttcc aaatatacgt gtggccacag agcataacag atatttttca
     2221 taagctaaat tgtatgtata aaacatttgc agtgtttcag acactgttga acaaaaatgt
     2281 aattggtaag tatgtatcca aacaggcatg gggtttcctg atacattatg tgttttgttt
     2341 ctgccctgtc ttatcattta cactcatgga tcttcagaat taatctaaca tggaagttat
     2401 agatacctga aagctgggtt ggtctacttc aggaacattg ctttaagtga tgtattttaa
     2461 aataacccgc ttcatatgta tgatctgttg gtgtacacac catgggtaag gtattgcttg
     2521 cacataattt gctctgcata ttatggacca ttgtggtttc ttccagtcac ttagatggaa
     2581 aggaggttaa acctaggtac tttttagcaa ggatataaag tcaaattcag catatgtttt
     2641 tatttttagg cttgactttt acaagacatt aatctccatt tgtacatatg ttattttatt
     2701 tgtaaaacca aatatgactc aacacctttt tgatgagtag tgacttaact aagatttaca
     2761 agtaatattt agacagattc agtcagacac cacttagcca tttttacatt ccctctggtt
     2821 agatttggta cagtataatt aagactttaa tctgaaattt aaagtagttt taattctgaa
     2881 gaagttacat cctctgtatt atttacatgc aacaaaataa aagtggatta atatagtaat
     2941 gccatggtaa caatagagct atgtcttatg catgaaggca actttggatg ttttaacaca
     3001 tttgactgac tttggtttag tgaatgctga caatgctgct ctacttaggt ttcctatgaa
     3061 atttttaaga atggctatga gactgtatag aagcttctag agaactgaaa gtcataatgc
     3121 agagttgcct tttctagtgc agctaagtgg cggacctcaa ctgaagatat gagtttcttt
     3181 gggttcttgg agttatcaaa ttgatcttgc cattatgtta ctttgcaaat aactgaagta
     3241 aatgattctt acctaaataa ccacaacctg tacacatttg ctcacaattt atagtagtta
     3301 ttttctatct acctatattt aaaattagga tgattaaaaa ataatttata gattttgtga
     3361 cagtaatgat ttacatatgc ccaatatatg ccttattttt aaataagtca ttctgtataa
     3421 agtcattttg ttgttgttca gagaaatcaa gatcttattc acaaagaaaa acattttata
     3481 aattgatcgc attttcttta agtcaaaatg ttaaactgga ggcagtatta aactttgcaa
     3541 ttaggagttt cagagatgcc ttggcatacc acgaaaaaca ctgtcaatat ccaactcatt
     3601 ataaattgtt atcagaatta acctaataac tttaagtaag gacaagcagc atcctagcaa
     3661 cttgtagtag tcttgggttc ccagcagagt atcacagtta acctctctga caacttcatc
     3721 agaatttcca agctgccaaa taatcttcat agacctaatt acagatttaa aaaaatttcc
     3781 taggcgacga aagtatagaa atgtgaatat gttgaataca ttgagaagct gtacttttta
     3841 attagttata ttacttctgg aagcacatat ctaaggaata ttttctaaga ctcagaggga
     3901 aaaaaactcg ttttcatagg atcatctgaa gatactttag tatatttgtg atcattttta
     3961 tctattgcaa atacaaatga attagataag tgccacatcc tggatacatt tcggaggggt
     4021 agtgggcaat ggtatacaaa aataccaaat ataaaatttt catctggggg aatgttcagg
     4081 ttctaaatac taaattagat ttcaatgttt tgtgtttttt ttaaaaaaat catattgcaa
     4141 cttgttttat tgtgattttc tacaagtatt aaatacattt aaagatcttt ttatcttacc
     4201 aagaaataat ttggaatagc attggtatat ttgacctttt gagtgtctgt catcctcaga
     4261 gaatggccca tagtgtgttg cctgtggaca tagtgtccat agtccctttc ttgtccttct
     4321 gagatatttt ggtttgataa cattttgttt tttgtcttga tgcacaggga cttttttata
     4381 atatgagact tcagttggta ttaataggag ttacctattt aattctccca gtcatcaatg
     4441 aggtaatcat caattcctat agttcaaatt agtcataaac aagagctaca gcaagactga
     4501 tagagtaaaa actatataaa tacagtaaaa aaaaaataga atttatggtg tgaaatatga
     4561 agtatagcaa tatataacaa gaacatgtaa gcacttgctt ccacagcata aatgtaattt
     4621 acatctgcat taaaggataa ttttctctgt gaataagagc aaaatggtct tcagagaaac
     4681 agactgttca tttgaagcca tttctgtaaa catcttccaa gatagaactg taatggattg
     4741 aggaaataac acagaaaaga caaaaacttt tgatttcagg catgcaaagt gcttgggcag
     4801 atggacagtt cccattgtgc attgcctttg ataaatttgg ccttaattta tataacgatg
     4861 ctgtgttcac atccctctcc tacctaaagt tgtctttatt ggtttatatt gtgttaaaat
     4921 tagcttataa ttattacttt tgtattgtgt tcagtttttt aagttgcatg tttatactat
     4981 ttgctacagt atttttaagt ttggggtgaa ggccatcagc tgtatcaaaa agacaaaaca
     5041 atcactattt attcagtatt gctgctttac atctccagaa taagctttcg atgccaggac
     5101 agtgactgcc tgaaagctgc aggagctctt ttcaatgcat tttatatatt tttagaaacc
     5161 aaataaatgc agaaaactat ttcgtatact aattatatta aaccagcaga aatataaagg
     5221 caataaagta tatacatata tatgggggga ggggaaagat taaaaaatag atttacagcc
     5281 agacatggtg atagccctaa atgtatttct caatatgttt ttctttattg accctaggag
     5341 gatttgagtt gctgcagctt taaacagaaa attgccatgt tcactaattg tgagcacata
     5401 aatatgcttt tagtactgct ttgcttatgt acaaataaat ctgtaatatg tattatatgt
     5461 aattatcctt ttctttgact ttcattttaa atgtatattt tctgatcatt atgagctgta
     5521 aaacaaagaa tcaatattgg atattctccc aaataataaa ttttcaggat tcattggggc
     5581 a
//
