LOCUS       NM_001394094            5624 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens Ras association domain family member 8 (RASSF8),
            transcript variant 5, mRNA.
ACCESSION   NM_001394094 XM_024448819
VERSION     NM_001394094.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5624)
  AUTHORS   Lin,Y., Guo,R., R,G. and Xu,B.
  TITLE     Tailored modulation of S100A1 and RASSF8 expression by
            butanediamide augments healing of rotator cuff tears
  JOURNAL   PeerJ 11, e15791 (2023)
   PUBMED   37601265
  REMARK    GeneRIF: Tailored modulation of S100A1 and RASSF8 expression by
            butanediamide augments healing of rotator cuff tears.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5624)
  AUTHORS   Li,X., Jiang,X., Lu,J., Lin,Y., Jiang,L., Li,Y., Wan,F. and Wang,C.
  TITLE     CircCERS6 Suppresses the Development of Epithelial Ovarian Cancer
            Through Mediating miR-630/RASSF8
  JOURNAL   Biochem Genet 60 (6), 2611-2629 (2022)
   PUBMED   35676548
  REMARK    GeneRIF: CircCERS6 Suppresses the Development of Epithelial Ovarian
            Cancer Through Mediating miR-630/RASSF8.
REFERENCE   3  (bases 1 to 5624)
  AUTHORS   Zhang,X., Sun,P., Yang,W., Li,S., Jia,H., Wang,W., Jiang,S.,
            Wang,L., Liu,X., Liang,L. and Zi,W.
  TITLE     RASSF8-AS1 displays low expression in colorectal cancer and
            up-regulates RASSF8 to suppress cell invasion and migration
  JOURNAL   Pathol Res Pract 237, 153996 (2022)
   PUBMED   35839610
  REMARK    GeneRIF: RASSF8-AS1 displays low expression in colorectal cancer
            and up-regulates RASSF8 to suppress cell invasion and migration.
REFERENCE   4  (bases 1 to 5624)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 5624)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 5624)
  AUTHORS   Falvella,F.S., Manenti,G., Spinola,M., Pignatiello,C., Conti,B.,
            Pastorino,U. and Dragani,T.A.
  TITLE     Identification of RASSF8 as a candidate lung tumor suppressor gene
  JOURNAL   Oncogene 25 (28), 3934-3938 (2006)
   PUBMED   16462760
  REMARK    GeneRIF: Expression of RASSF8 protein by transfected lung cancer
            cells led to inhibition of anchorage-independent growth in soft
            agar in A549 cells and reduction of clonogenic activity in NCI-H520
            cells
REFERENCE   7  (bases 1 to 5624)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
REFERENCE   8  (bases 1 to 5624)
  AUTHORS   Debeer,P., Schoenmakers,E.F., Twal,W.O., Argraves,W.S., De Smet,L.,
            Fryns,J.P. and Van De Ven,W.J.
  TITLE     The fibulin-1 gene (FBLN1) is disrupted in a t(12;22) associated
            with a complex type of synpolydactyly
  JOURNAL   J Med Genet 39 (2), 98-104 (2002)
   PUBMED   11836357
REFERENCE   9  (bases 1 to 5624)
  AUTHORS   Gonzalez,P., Epstein,D.L. and Borras,T.
  TITLE     Characterization of gene expression in human trabecular meshwork
            using single-pass sequencing of 1060 clones
  JOURNAL   Invest Ophthalmol Vis Sci 41 (12), 3678-3693 (2000)
   PUBMED   11053263
REFERENCE   10 (bases 1 to 5624)
  AUTHORS   Debeer,P., Schoenmakers,E.F., Thoelen,R., Holvoet,M., Kuittinen,T.,
            Fabry,G., Fryns,J.P., Goodman,F.R. and Van de Ven,W.J.
  TITLE     Physical map of a 1.5 mb region on 12p11.2 harbouring a
            synpolydactyly associated chromosomal breakpoint
  JOURNAL   Eur J Hum Genet 8 (8), 561-570 (2000)
   PUBMED   10951517
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC055707.33.
            
            On Apr 1, 2021 this sequence version replaced XM_024448819.1.
            
            Summary: This gene encodes a member of the Ras-assocation domain
            family (RASSF) of tumor suppressor proteins. This gene is essential
            for maintaining adherens junction function in epithelial cells and
            has a role in epithelial cell migration. It is a lung tumor
            suppressor gene candidate. A chromosomal translocation
            t(12;22)(p11.2;q13.3) leading to the fusion of this gene and the
            FBLN1 gene is found in a complex type of synpolydactyly. Multiple
            alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, May
            2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.53661.1,
                                           SRR14038192.1718728.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2149178
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AC055707.33        121838-121948       c
            112-205             AC055707.33        85050-85143         c
            206-416             AC055707.33        24734-24944         c
            417-1306            AC055707.33        14793-15682         c
            1307-1451           AC055707.33        12467-12611         c
            1452-5624           AC055707.33        7311-11483          c
FEATURES             Location/Qualifiers
     source          1..5624
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.1"
     gene            1..5624
                     /gene="RASSF8"
                     /gene_synonym="C12orf2; HOJ1"
                     /note="Ras association domain family member 8"
                     /db_xref="GeneID:11228"
                     /db_xref="HGNC:HGNC:13232"
                     /db_xref="MIM:608231"
     exon            1..111
                     /gene="RASSF8"
                     /gene_synonym="C12orf2; HOJ1"
                     /inference="alignment:Splign:2.1.0"
     exon            112..205
                     /gene="RASSF8"
                     /gene_synonym="C12orf2; HOJ1"
                     /inference="alignment:Splign:2.1.0"
     exon            206..416
                     /gene="RASSF8"
                     /gene_synonym="C12orf2; HOJ1"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..1573
                     /gene="RASSF8"
                     /gene_synonym="C12orf2; HOJ1"
                     /note="isoform a is encoded by transcript variant 5; ras
                     association domain-containing protein 8; Ras association
                     (RalGDS/AF-6) domain family (N-terminal) member 8;
                     carcinoma-associated protein HOJ-1"
                     /codon_start=1
                     /product="ras association domain-containing protein 8
                     isoform a"
                     /protein_id="NP_001381023.1"
                     /db_xref="CCDS:CCDS53765.1"
                     /db_xref="GeneID:11228"
                     /db_xref="HGNC:HGNC:13232"
                     /db_xref="MIM:608231"
                     /translation="MELKVWVDGVQRIVCGVTEVTTCQEVVIALAQAIGRTGRYTLIE
                     KWRDTERHLAPHENPIISLNKWGQYASDVQLILRRTGPSLSERPTSDSVARIPERTLY
                     RQSLPPLAKLRPQIDKSIKRREPKRKSLTFTGGAKGLMDIFGKGKETEFKQKVLNNCK
                     TTADELKKLIRLQTEKLQSIEKQLESNEIEIRFWEQKYNSNLEEEIVRLEQKIKRNDV
                     EIEEEEFWENELQIEQENEKQLKDQLQEIRQKITECENKLKDYLAQIRTMESGLEAEK
                     LQREVQEAQVNEEEVKGKIGKVKGEIDIQGQQSLRLENGIKAVERSLGQATKRLQDKE
                     QELEQLTKELRQVNLQQFIQQTGTKVTVLPAEPIEIEASHADIEREAPFQSGSLKRPG
                     SSRQLPSNLRILQNPISSGFNPEGIYV"
     exon            417..1306
                     /gene="RASSF8"
                     /gene_synonym="C12orf2; HOJ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1451
                     /gene="RASSF8"
                     /gene_synonym="C12orf2; HOJ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..5624
                     /gene="RASSF8"
                     /gene_synonym="C12orf2; HOJ1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5598..5603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASSF8"
                     /gene_synonym="C12orf2; HOJ1"
                     /note="hexamer: AATAAA"
     polyA_site      5624
                     /gene="RASSF8"
                     /gene_synonym="C12orf2; HOJ1"
                     /note="major polyA site"
ORIGIN      
        1 agagggcagt ttgacaagtc tcagccccgg gcgatggaag attttgcccg tgggaccgtc
       61 acgagccacc ggtcatctcc ccgcgcccgg ctttcgggtc ctcaggcctc ggtgcctgtg
      121 tagatcatcc tagaatacct gtgtggtgct gtccttcctc aagactacct cattctcact
      181 ggctcggaga ctcctgcctg ctgagctgac tacacagact tagtcttctc cactccgtgt
      241 tcctgcagct agagacatga cctaacaccc tgatgaccac tctcagggac cttgagtgac
      301 tggccggtgc accatggaac ttaaagtatg ggtggatgga gttcagagga ttgtttgtgg
      361 agtcactgaa gtcacaactt gccaggaggt tgtcatagcc ttagctcaag caataggtcg
      421 aactggaagg tacaccctta tagagaaatg gagagatact gaaagacact tagcacctca
      481 tgaaaatcct atcatatcct taaacaaatg ggggcagtat gctagtgatg tgcagctcat
      541 tctacgacga actgggccgt ctctcagtga gcgacccact tcagacagtg tggctcgaat
      601 tcctgaaaga actttataca ggcagagtct gcccccctta gctaaactga ggcctcagat
      661 tgacaaatca atcaaaagga gggaaccgaa aaggaaatca ctgacattta caggaggtgc
      721 caaaggatta atggacattt ttggaaaagg taaagaaact gagtttaagc aaaaggtgct
      781 gaataactgc aaaacaacag cagatgagtt gaagaagcta atccgtctgc agacagagaa
      841 gcttcaatcc attgagaaac agctggaatc taatgaaata gaaataagat tttgggagca
      901 aaagtataat tccaaccttg aagaggaaat tgtccgtcta gagcaaaaga tcaaaagaaa
      961 cgatgtagaa attgaggagg aagaattctg ggaaaatgaa ttacagattg aacaggaaaa
     1021 tgaaaaacag ctgaaggatc aacttcaaga aataagacag aaaataacag aatgtgaaaa
     1081 caaattaaag gactatttgg cacagatccg gactatggaa agtggtcttg aagcagaaaa
     1141 attgcaacgg gaagttcaag aggcacaggt caatgaggaa gaggttaaag gaaagatcgg
     1201 taaggtcaaa ggggagattg acattcaagg ccagcagagt ctgaggttgg aaaatggcat
     1261 caaagctgtg gaaagatctc ttggacaagc caccaaacgc ttacaggaca aagaacagga
     1321 actggagcag ttgactaagg agttgcggca agtcaatctc cagcagttca tccagcagac
     1381 agggacaaaa gttaccgttt tgccagcgga gcccattgaa atagaggcct cacatgcaga
     1441 cattgaaagg gaggcaccat tccagtctgg gtccctgaag cgacctggtt catctcggca
     1501 gctccccagt aatctccgca ttctgcagaa tcctatctca tctggtttta atcctgaagg
     1561 catatatgta tgacattatc tgtctttagg gaggagaccc aacagaggta ccaaggacag
     1621 taaacttcct ttttgatttg tgccaatgat gaacagagga tctattccac aagacgctgt
     1681 atgttttttc tctcctaaat tgcataccac ttggagccat accctgtgca ctgatgctaa
     1741 agaacaaaga aactgtgttt tcacacatca acagtgttga tatttttgtc cagcagctat
     1801 aatgcaaagc cttcgttttt atttgtagca ttttgagagc tttaggaaag tattatatag
     1861 tgtgtataca taaataagcc gtgacttaag taagagtgaa gagaaatttg tgactggctt
     1921 agtttaattt atttcatgta atcaatgtgt gaatgttgat gttttaatat ttttattgac
     1981 ttatcctgtg actgacttac gttacatatt gtgtgattat gaccgtgtgc atgttgccag
     2041 actccatcca tgcattgctg atttacacta cacaagtgtc ctagggtgct ccaccatcga
     2101 agctaactcc acaggaagcc acttgcattt gttttgtgaa actgtcctag ccattgctta
     2161 attaggtgaa ataattcagg gttttttaaa tctggaattt agtcgttcct ttacaatatt
     2221 tccaaatata cgtgtggcca cagagcataa cagatatttt tcataagcta aattgtatgt
     2281 ataaaacatt tgcagtgttt cagacactgt tgaacaaaaa tgtaattggt aagtatgtat
     2341 ccaaacaggc atggggtttc ctgatacatt atgtgttttg tttctgccct gtcttatcat
     2401 ttacactcat ggatcttcag aattaatcta acatggaagt tatagatacc tgaaagctgg
     2461 gttggtctac ttcaggaaca ttgctttaag tgatgtattt taaaataacc cgcttcatat
     2521 gtatgatctg ttggtgtaca caccatgggt aaggtattgc ttgcacataa tttgctctgc
     2581 atattatgga ccattgtggt ttcttccagt cacttagatg gaaaggaggt taaacctagg
     2641 tactttttag caaggatata aagtcaaatt cagcatatgt ttttattttt aggcttgact
     2701 tttacaagac attaatctcc atttgtacat atgttatttt atttgtaaaa ccaaatatga
     2761 ctcaacacct ttttgatgag tagtgactta actaagattt acaagtaata tttagacaga
     2821 ttcagtcaga caccacttag ccatttttac attccctctg gttagatttg gtacagtata
     2881 attaagactt taatctgaaa tttaaagtag ttttaattct gaagaagtta catcctctgt
     2941 attatttaca tgcaacaaaa taaaagtgga ttaatatagt aatgccatgg taacaataga
     3001 gctatgtctt atgcatgaag gcaactttgg atgttttaac acatttgact gactttggtt
     3061 tagtgaatgc tgacaatgct gctctactta ggtttcctat gaaattttta agaatggcta
     3121 tgagactgta tagaagcttc tagagaactg aaagtcataa tgcagagttg ccttttctag
     3181 tgcagctaag tggcggacct caactgaaga tatgagtttc tttgggttct tggagttatc
     3241 aaattgatct tgccattatg ttactttgca aataactgaa gtaaatgatt cttacctaaa
     3301 taaccacaac ctgtacacat ttgctcacaa tttatagtag ttattttcta tctacctata
     3361 tttaaaatta ggatgattaa aaaataattt atagattttg tgacagtaat gatttacata
     3421 tgcccaatat atgccttatt tttaaataag tcattctgta taaagtcatt ttgttgttgt
     3481 tcagagaaat caagatctta ttcacaaaga aaaacatttt ataaattgat cgcattttct
     3541 ttaagtcaaa atgttaaact ggaggcagta ttaaactttg caattaggag tttcagagat
     3601 gccttggcat accacgaaaa acactgtcaa tatccaactc attataaatt gttatcagaa
     3661 ttaacctaat aactttaagt aaggacaagc agcatcctag caacttgtag tagtcttggg
     3721 ttcccagcag agtatcacag ttaacctctc tgacaacttc atcagaattt ccaagctgcc
     3781 aaataatctt catagaccta attacagatt taaaaaaatt tcctaggcga cgaaagtata
     3841 gaaatgtgaa tatgttgaat acattgagaa gctgtacttt ttaattagtt atattacttc
     3901 tggaagcaca tatctaagga atattttcta agactcagag ggaaaaaaac tcgttttcat
     3961 aggatcatct gaagatactt tagtatattt gtgatcattt ttatctattg caaatacaaa
     4021 tgaattagat aagtgccaca tcctggatac atttcggagg ggtagtgggc aatggtatac
     4081 aaaaatacca aatataaaat tttcatctgg gggaatgttc aggttctaaa tactaaatta
     4141 gatttcaatg ttttgtgttt tttttaaaaa aatcatattg caacttgttt tattgtgatt
     4201 ttctacaagt attaaataca tttaaagatc tttttatctt accaagaaat aatttggaat
     4261 agcattggta tatttgacct tttgagtgtc tgtcatcctc agagaatggc ccatagtgtg
     4321 ttgcctgtgg acatagtgtc catagtccct ttcttgtcct tctgagatat tttggtttga
     4381 taacattttg ttttttgtct tgatgcacag ggactttttt ataatatgag acttcagttg
     4441 gtattaatag gagttaccta tttaattctc ccagtcatca atgaggtaat catcaattcc
     4501 tatagttcaa attagtcata aacaagagct acagcaagac tgatagagta aaaactatat
     4561 aaatacagta aaaaaaaaat agaatttatg gtgtgaaata tgaagtatag caatatataa
     4621 caagaacatg taagcacttg cttccacagc ataaatgtaa tttacatctg cattaaagga
     4681 taattttctc tgtgaataag agcaaaatgg tcttcagaga aacagactgt tcatttgaag
     4741 ccatttctgt aaacatcttc caagatagaa ctgtaatgga ttgaggaaat aacacagaaa
     4801 agacaaaaac ttttgatttc aggcatgcaa agtgcttggg cagatggaca gttcccattg
     4861 tgcattgcct ttgataaatt tggccttaat ttatataacg atgctgtgtt cacatccctc
     4921 tcctacctaa agttgtcttt attggtttat attgtgttaa aattagctta taattattac
     4981 ttttgtattg tgttcagttt tttaagttgc atgtttatac tatttgctac agtattttta
     5041 agtttggggt gaaggccatc agctgtatca aaaagacaaa acaatcacta tttattcagt
     5101 attgctgctt tacatctcca gaataagctt tcgatgccag gacagtgact gcctgaaagc
     5161 tgcaggagct cttttcaatg cattttatat atttttagaa accaaataaa tgcagaaaac
     5221 tatttcgtat actaattata ttaaaccagc agaaatataa aggcaataaa gtatatacat
     5281 atatatgggg ggaggggaaa gattaaaaaa tagatttaca gccagacatg gtgatagccc
     5341 taaatgtatt tctcaatatg tttttcttta ttgaccctag gaggatttga gttgctgcag
     5401 ctttaaacag aaaattgcca tgttcactaa ttgtgagcac ataaatatgc ttttagtact
     5461 gctttgctta tgtacaaata aatctgtaat atgtattata tgtaattatc cttttctttg
     5521 actttcattt taaatgtata ttttctgatc attatgagct gtaaaacaaa gaatcaatat
     5581 tggatattct cccaaataat aaattttcag gattcattgg ggca
//
