LOCUS       NM_003475               2017 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens Ras association domain family member 7 (RASSF7),
            transcript variant 1, mRNA.
ACCESSION   NM_003475
VERSION     NM_003475.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2017)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2017)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2017)
  AUTHORS   Kumaraswamy,A., Mamidi,A., Desai,P., Sivagnanam,A.,
            Perumalsamy,L.R., Ramakrishnan,C., Gromiha,M., Rajalingam,K. and
            Mahalingam,S.
  TITLE     The non-enzymatic RAS effector RASSF7 inhibits oncogenic c-Myc
            function
  JOURNAL   J Biol Chem 293 (40), 15691-15705 (2018)
   PUBMED   30139745
  REMARK    GeneRIF: RASSF7 competed with MAX in the formation of a
            heterodimeric complex with c-Myc and attenuated its occupancy on
            target gene promoters to regulate transcription.
REFERENCE   4  (bases 1 to 2017)
  AUTHORS   Zhang,M., Li,Q., Zhang,L., Wang,Y., Wang,L., Li,Q., He,T., Wan,B.
            and Wang,X.
  TITLE     RASSF7 promotes cell proliferation through activating MEK1/2-ERK1/2
            signaling pathway in hepatocellular carcinoma
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 64 (5), 73-79 (2018)
   PUBMED   29729697
  REMARK    GeneRIF: RASSF7 promotes cell proliferation through activating
            MEK1/MEK2-ERK1/ERK2 signaling pathway in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2017)
  AUTHORS   Liu,Z.H., Huo,J.L., Wu,Z.G., Sun,Z., Bai,F., Samartzis,D.,
            Gantenbein,B., Fan,S.D. and Wang,H.Q.
  TITLE     RASSF7 expression and its regulatory roles on apoptosis in human
            intervertebral disc degeneration
  JOURNAL   Int J Clin Exp Pathol 8 (12), 16097-16103 (2015)
   PUBMED   26884887
  REMARK    GeneRIF: Suggest that loss of RASSF7 expression results in
            apoptosis in nucleus pulposus cells in human intervertebral disc
            degeneration.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2017)
  AUTHORS   Sherwood,V., Manbodh,R., Sheppard,C. and Chalmers,A.D.
  TITLE     RASSF7 is a member of a new family of RAS association
            domain-containing proteins and is required for completing mitosis
  JOURNAL   Mol Biol Cell 19 (4), 1772-1782 (2008)
   PUBMED   18272789
REFERENCE   7  (bases 1 to 2017)
  AUTHORS   Tsang,H.T., Connell,J.W., Brown,S.E., Thompson,A., Reid,E. and
            Sanderson,C.M.
  TITLE     A systematic analysis of human CHMP protein interactions:
            additional MIT domain-containing proteins bind to multiple
            components of the human ESCRT III complex
  JOURNAL   Genomics 88 (3), 333-346 (2006)
   PUBMED   16730941
REFERENCE   8  (bases 1 to 2017)
  AUTHORS   Iarmolinskii,D.G., Kartel,N.A., Ermak,G., Demidchik,Iu.E. and
            Figge,J.
  TITLE     [Study of HRas1 minisatellite frequencies in children with thyroid
            papillary cancer]
  JOURNAL   Tsitol Genet 38 (1), 9-14 (2004)
   PUBMED   15098441
  REMARK    GeneRIF: 'rare' alleles of HRas1 minisatellite are associated with
            increased risk of papillary thyroid cancer formation in children
            and adolescents after Chernobyl accident
REFERENCE   9  (bases 1 to 2017)
  AUTHORS   Morris,J.A., Kandpal,G., Ma,L. and Austin,C.P.
  TITLE     DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated
            protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL:
            regulation and loss of interaction with mutation
  JOURNAL   Hum Mol Genet 12 (13), 1591-1608 (2003)
   PUBMED   12812986
REFERENCE   10 (bases 1 to 2017)
  AUTHORS   Weitzel,J.N., Kasperczyk,A., Mohan,C. and Krontiris,T.G.
  TITLE     The HRAS1 gene cluster: two upstream regions recognizing
            transcripts and a third encoding a gene with a leucine zipper
            domain
  JOURNAL   Genomics 14 (2), 309-319 (1992)
   PUBMED   1339391
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP006284.2, BC106921.1 and CA315057.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003475.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M91083.1, BC106921.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397583.8/ ENSP00000380713.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-480               AP006284.2         19687-20166
            481-1956            BC106921.1         9-1484
            1957-2017           CA315057.1         18-78               c
FEATURES             Location/Qualifiers
     source          1..2017
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..2017
                     /gene="RASSF7"
                     /gene_synonym="C11orf13; CFAP88; FAP88; HRAS1; HRC1"
                     /note="Ras association domain family member 7"
                     /db_xref="GeneID:8045"
                     /db_xref="HGNC:HGNC:1166"
                     /db_xref="MIM:143023"
     exon            1..508
                     /gene="RASSF7"
                     /gene_synonym="C11orf13; CFAP88; FAP88; HRAS1; HRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            509..639
                     /gene="RASSF7"
                     /gene_synonym="C11orf13; CFAP88; FAP88; HRAS1; HRC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             516..1637
                     /gene="RASSF7"
                     /gene_synonym="C11orf13; CFAP88; FAP88; HRAS1; HRC1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     HRAS1-related cluster-1; Ras association (RalGDS/AF-6)
                     domain family (N-terminal) member 7; Ras association
                     (RalGDS/AF-6) domain family 7; ras association
                     domain-containing protein 7; HRAS1-related cluster protein
                     1"
                     /codon_start=1
                     /product="ras association domain-containing protein 7
                     isoform 1"
                     /protein_id="NP_003466.1"
                     /db_xref="CCDS:CCDS7702.1"
                     /db_xref="GeneID:8045"
                     /db_xref="HGNC:HGNC:1166"
                     /db_xref="MIM:143023"
                     /translation="MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQT
                     GRFVLVQRLREKERQLLPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPP
                     PERCLIRASLPVKPRAALGCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLEL
                     RVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALE
                     AELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQ
                     AQELEELNRELRQCNLQQFIQQTGAALPPPPRPDRGPPGTQGPLPPAREESLLGAPSE
                     SHAGAQPRPRGGPHDAELLEVAAAPAPEWCPLAAQPQAL"
     exon            640..1337
                     /gene="RASSF7"
                     /gene_synonym="C11orf13; CFAP88; FAP88; HRAS1; HRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1466
                     /gene="RASSF7"
                     /gene_synonym="C11orf13; CFAP88; FAP88; HRAS1; HRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1549
                     /gene="RASSF7"
                     /gene_synonym="C11orf13; CFAP88; FAP88; HRAS1; HRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..2017
                     /gene="RASSF7"
                     /gene_synonym="C11orf13; CFAP88; FAP88; HRAS1; HRC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1994..1999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASSF7"
                     /gene_synonym="C11orf13; CFAP88; FAP88; HRAS1; HRC1"
                     /note="hexamer: AATAAA"
     polyA_site      2017
                     /gene="RASSF7"
                     /gene_synonym="C11orf13; CFAP88; FAP88; HRAS1; HRC1"
                     /note="major polyA site"
ORIGIN      
        1 gcggcgctgg gggcggcagg ttgcggcggc gccggagcgg gtctccaggc tggcgagcgc
       61 ccaggtgagc cgcgccgggt ccccggtact tgggagcgcg gggcgcgcct cgagccggcc
      121 ggacgccgac tccaactggg gagagttttc cgcgatgccc ggacggagag cgggggcggc
      181 gccgcacctg cgcccgccct gcggaacggg gacgccctgg ctcccgccag gctggggtcg
      241 cggcgcgggc ttcggtgccc gcggcgggga ccgggacttt cggggcgagc gcagcgatta
      301 ggcggcagcg gcggggctcc ccgggctggc gggggctgct cagacccgga gtctgctcca
      361 tctgcagggt cgaggtctgg gttgcgaccc cgagcgcctc tgcggcctga gcaggtcggg
      421 gtggggcgtt cccatgccgg cggccgcggg gcctggcgtg cgggcgcctc cgcgccgccc
      481 ggggaggggg cagtgtcctc cgagccagga caggcatgtt gttgggactg gcggccatgg
      541 agctgaaggt gtgggtggat ggcatccagc gtgtggtctg tggggtctca gagcagacca
      601 cctgccagga agtggtcatc gcactagccc aagcaatagg ccagactggc cgctttgtgc
      661 ttgtgcagcg gcttcgggag aaggagcggc agttgctgcc acaagagtgt ccagtgggcg
      721 cccaggccac ctgcggacag tttgccagcg atgtccagtt tgtcctgagg cgcacagggc
      781 ccagcctagc tgggaggccc tcctcagaca gctgtccacc cccggaacgc tgcctaattc
      841 gtgccagcct ccctgtaaag ccacgggctg cgctgggctg tgagccccgc aaaacactga
      901 cccccgagcc agcccccagc ctctcacgcc ctgggcctgc ggcccctgtg acacccacac
      961 caggctgctg cacagacctg cggggcctgg agctcagggt gcagaggaat gctgaggagc
     1021 tgggccatga ggccttctgg gagcaagagc tgcgccggga gcaggcccgg gagcgagagg
     1081 gacaggcacg cctgcaggca ctaagtgcgg ccactgctga gcatgccgcc cggctgcagg
     1141 ccctggacgc tcaggcccgt gccctggagg ctgagctgca gctggcagcg gaggcccctg
     1201 ggcccccctc acctatggca tctgccactg agcgcctgca ccaggacctg gctgttcagg
     1261 agcggcagag tgcggaggtg cagggcagcc tggctctggt gagccgggcc ctggaggcag
     1321 cagagcgagc cttgcaggct caggctcagg agctggagga gctgaaccga gagctccgtc
     1381 agtgcaacct gcagcagttc atccagcaga ccggggctgc gctgccaccg cccccacggc
     1441 ctgacagggg ccctcctggc actcagggcc ctctgcctcc agccagagag gagtccctcc
     1501 tgggcgctcc ctctgagtcc catgctggtg cccagcctag gccccgaggt ggcccccatg
     1561 acgcagaact cctggaggta gcagcagctc ctgccccaga gtggtgtcct ctggcagccc
     1621 agccccaggc tctgtgacag cctagtgagg gctgcaagac catcctgccc ggaccacaga
     1681 aggagagttg gcggtcacag agggctcctc tgccaggcag tgggaagccc tgggtttggc
     1741 ctcaggagct gggggtgcag tgggggactg ccctagtcct tgccaggtcg ccagcaccct
     1801 ggagaagcat ggggcgtagc cagctcggaa cttgccaggc cccaaaggcc acgactgcct
     1861 gttggggaca ggagatgcat ggacagtgtg ctcaagctgt gggcatgtgc ttgcctgcgg
     1921 gagaggtcct tcactgtgtg tacacagcaa gagcatgtgt gtgccacttc ccctacccca
     1981 acgtgaaaac ctcaataaac tgcccgaagc agcttga
//
