LOCUS       NM_177532               5882 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens Ras association domain family member 6 (RASSF6),
            transcript variant 1, mRNA.
ACCESSION   NM_177532
VERSION     NM_177532.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5882)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 5882)
  AUTHORS   Kuleape,J.A., Hossain,S., Sinclear,C.K., Shimizu,T., Iwasa,H.,
            Maruyama,J., Arimoto-Matsuzaki,K., Nishina,H. and Hata,Y.
  TITLE     DNA Damage Triggers the Nuclear Accumulation of RASSF6 Tumor
            Suppressor Protein via CDK9 and BAF53 To Regulate p53 Target Gene
            Transcription
  JOURNAL   Mol Cell Biol 42 (2), e0031021 (2022)
   PUBMED   34898277
  REMARK    GeneRIF: DNA Damage Triggers the Nuclear Accumulation of RASSF6
            Tumor Suppressor Protein via CDK9 and BAF53 To Regulate p53 Target
            Gene Transcription.
REFERENCE   3  (bases 1 to 5882)
  AUTHORS   Zhou,W., Liu,Y. and Wu,X.
  TITLE     Down-regulation of circITCH promotes osteosarcoma development and
            resistance to doxorubicin via the miR-524/RASSF6 axis
  JOURNAL   J Gene Med 23 (10), e3373 (2021)
   PUBMED   34151476
  REMARK    GeneRIF: Down-regulation of circITCH promotes osteosarcoma
            development and resistance to doxorubicin via the miR-524/RASSF6
            axis.
REFERENCE   4  (bases 1 to 5882)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 5882)
  AUTHORS   Bozdogan,O., Guresci,S., Ocalan,D. and Bozdogan,N.
  TITLE     Kindlin-3 and RASSF6 are probable biomarkers for predicting
            metastasis in cutaneous melanoma
  JOURNAL   Pol J Pathol 72 (3), 237-244 (2021)
   PUBMED   35048636
  REMARK    GeneRIF: Kindlin-3 and RASSF6 are probable biomarkers for
            predicting metastasis in cutaneous melanoma.
REFERENCE   6  (bases 1 to 5882)
  AUTHORS   Hesson,L.B., Dunwell,T.L., Cooper,W.N., Catchpoole,D., Brini,A.T.,
            Chiaramonte,R., Griffiths,M., Chalmers,A.D., Maher,E.R. and
            Latif,F.
  TITLE     The novel RASSF6 and RASSF10 candidate tumour suppressor genes are
            frequently epigenetically inactivated in childhood leukaemias
  JOURNAL   Mol Cancer 8, 42 (2009)
   PUBMED   19570220
  REMARK    GeneRIF: Sequencing revealed RASSF6 and RASSF10 were the only RASSF
            members with a high frequency of leukaemia-specific methylation.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5882)
  AUTHORS   Hillian,A.D., Londono,D., Dunn,J.M., Goddard,K.A., Pace,R.G.,
            Knowles,M.R. and Drumm,M.L.
  CONSRTM   CF Gene Modifier Study Group
  TITLE     Modulation of cystic fibrosis lung disease by variants in
            interleukin-8
  JOURNAL   Genes Immun 9 (6), 501-508 (2008)
   PUBMED   18563170
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 5882)
  AUTHORS   Allen,N.P., Donninger,H., Vos,M.D., Eckfeld,K., Hesson,L.,
            Gordon,L., Birrer,M.J., Latif,F. and Clark,G.J.
  TITLE     RASSF6 is a novel member of the RASSF family of tumor suppressors
  JOURNAL   Oncogene 26 (42), 6203-6211 (2007)
   PUBMED   17404571
  REMARK    GeneRIF: Demonstrates properties of a Ras effector and tumor
            suppressor but exhibits biological properties that are unique and
            distinct from those of other family members.
REFERENCE   9  (bases 1 to 5882)
  AUTHORS   Ikeda,M., Hirabayashi,S., Fujiwara,N., Mori,H., Kawata,A., Iida,J.,
            Bao,Y., Sato,Y., Iida,T., Sugimura,H. and Hata,Y.
  TITLE     Ras-association domain family protein 6 induces apoptosis via both
            caspase-dependent and caspase-independent pathways
  JOURNAL   Exp Cell Res 313 (7), 1484-1495 (2007)
   PUBMED   17367779
  REMARK    GeneRIF: These findings indicate that RASSF6 is implicated in
            apoptosis in HeLa cells and that it triggers both caspase-dependent
            and caspase-independent pathways.
REFERENCE   10 (bases 1 to 5882)
  AUTHORS   Hull,J., Rowlands,K., Lockhart,E., Sharland,M., Moore,C.,
            Hanchard,N. and Kwiatkowski,D.P.
  TITLE     Haplotype mapping of the bronchiolitis susceptibility locus near
            IL8
  JOURNAL   Hum Genet 114 (3), 272-279 (2004)
   PUBMED   14605870
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC074250.6.
            
            On Nov 23, 2018 this sequence version replaced NM_177532.4.
            
            Summary: This gene encodes a member of the Ras-association domain
            family (RASSF). Members of this family form the core of a highly
            conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH)
            pathway. The protein encoded by this gene is a Ras effector protein
            that induces apoptosis. A genomic region containing this gene has
            been linked to susceptibility to viral bronchiolitis. Alternative
            splicing results in multiple transcript variants and protein
            isoforms. [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. It encodes isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR749283.1, AY217664.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307439.10/ ENSP00000303877.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               AC074250.6         113792-113940       c
            150-248             AC074250.6         105235-105333       c
            249-327             AC074250.6         92144-92222         c
            328-470             AC074250.6         86955-87097         c
            471-565             AC074250.6         81344-81438         c
            566-750             AC074250.6         78684-78868         c
            751-852             AC074250.6         75693-75794         c
            853-904             AC074250.6         75321-75372         c
            905-1023            AC074250.6         70117-70235         c
            1024-1121           AC074250.6         69914-70011         c
            1122-5882           AC074250.6         65054-69814         c
FEATURES             Location/Qualifiers
     source          1..5882
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     gene            1..5882
                     /gene="RASSF6"
                     /note="Ras association domain family member 6"
                     /db_xref="GeneID:166824"
                     /db_xref="HGNC:HGNC:20796"
                     /db_xref="MIM:612620"
     exon            1..149
                     /gene="RASSF6"
                     /inference="alignment:Splign:2.1.0"
     exon            150..248
                     /gene="RASSF6"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..1197
                     /gene="RASSF6"
                     /note="isoform a is encoded by transcript variant 1; Ras
                     association (RalGDS/AF-6) domain family 6; putative RAS
                     binding protein; ras association domain-containing protein
                     6; Ras association (RalGDS/AF-6) domain family member 6"
                     /codon_start=1
                     /product="ras association domain-containing protein 6
                     isoform a"
                     /protein_id="NP_803876.1"
                     /db_xref="CCDS:CCDS3559.1"
                     /db_xref="GeneID:166824"
                     /db_xref="HGNC:HGNC:20796"
                     /db_xref="MIM:612620"
                     /translation="MTMMAHQYPSWIFINEKTFITREQLNSLLKTYNIFYENQKNLHI
                     LYGETEDGKLIVEGMLDIFWGVKRPIQLKIQDEKPFSSFTSMKSSDVFSSKGMTRWGE
                     FDDLYRISELDRTQIPMSEKRNSQEDYLSYHSNTLKPHAKDEPDSPVLYRTMSEAALV
                     RKRMKPLMMDRKERQKNRASINGHFYNHETSIFIPAFESETKVRVNSNMRTEEVIKQL
                     LQKFKIENSPQDFALHIIFATGEQRRLKKTDIPLLQRLLQGPSEKNARIFLMDKDAEE
                     ISSDVAQYINFHFSLLESILQRLNEEEKREIQRIVTKFNKEKAIILKCLQNKLVIKTE
                     TTV"
     exon            249..327
                     /gene="RASSF6"
                     /inference="alignment:Splign:2.1.0"
     exon            328..470
                     /gene="RASSF6"
                     /inference="alignment:Splign:2.1.0"
     exon            471..565
                     /gene="RASSF6"
                     /inference="alignment:Splign:2.1.0"
     exon            566..750
                     /gene="RASSF6"
                     /inference="alignment:Splign:2.1.0"
     exon            751..852
                     /gene="RASSF6"
                     /inference="alignment:Splign:2.1.0"
     exon            853..904
                     /gene="RASSF6"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1023
                     /gene="RASSF6"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1121
                     /gene="RASSF6"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..5882
                     /gene="RASSF6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5747..5752
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASSF6"
                     /note="hexamer: AATAAG"
     regulatory      5767..5772
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASSF6"
                     /note="hexamer: AATGAA"
     polyA_site      5768
                     /gene="RASSF6"
                     /note="major polyA site"
     polyA_site      5784
                     /gene="RASSF6"
     regulatory      5862..5867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASSF6"
                     /note="hexamer: ATTAAA"
     polyA_site      5882
                     /gene="RASSF6"
ORIGIN      
        1 gagtgactcg cggagtccca gcccggcaga gacagggcac tggtttccct ctaccagagt
       61 tcctgaccca gccgagaaca aaccgcgaag caagttcagc cgaacaacga tggtgaaaag
      121 ggtcctcctg ctcacagtgt gaataacagg atatcctcag accatctcaa aaaggaggaa
      181 aagatgacta tgatggctca ccagtacccc tcttggatct tcattaatga gaagacattc
      241 ataaccaggg aacaacttaa ttctttattg aagacctata acatttttta tgagaaccag
      301 aaaaatctgc atattttata tggagagact gaagatggca aactaattgt tgaaggaatg
      361 ctggacattt tctggggagt aaaacgacct atacagctaa aaatacaaga tgagaagcca
      421 ttctcttctt ttactagtat gaagtcatca gacgtcttct ccagcaaagg aatgacacgc
      481 tggggggaat ttgacgatct ctatcgtatt agtgagctgg acaggaccca gattcctatg
      541 tctgaaaaaa ggaattccca ggaagactat ttatcttatc acagcaacac cctgaagcca
      601 catgcaaagg atgaaccaga ctccccagtg ctctatagaa ccatgagtga agcagctctg
      661 gtgagaaaaa ggatgaagcc tctgatgatg gacagaaaag aaagacagaa aaatagagcc
      721 tctattaatg gacacttcta taaccatgaa acatcaattt tcattccagc ctttgaatca
      781 gaaactaagg tcagagtaaa cagtaacatg agaactgaag aagtaataaa gcaacttctc
      841 caaaaattta agattgaaaa tagtccccag gattttgctc ttcacattat ttttgcaaca
      901 ggagaacaaa gacgactaaa gaagacagac attccgctac tgcagaggct cctacaggga
      961 ccttctgaaa agaatgctcg cattttcctc atggataaag atgcagaaga aattagcagt
     1021 gatgtggctc agtacattaa ctttcacttt tctctcttgg aatccattct tcaaagatta
     1081 aatgaagaag agaaaagaga gattcaaaga atagtaacaa aattcaataa agaaaaggcg
     1141 attatactga aatgtcttca aaataaacta gtaataaaaa cagagacaac agtttagcag
     1201 tacaagcttc tattgctaaa acatttcaaa aaactcagag atattactct ttgatgaatg
     1261 cataagttct gtacttgcat ttatacgaac atatatgaga cttgaatcgt agaaaattga
     1321 atgtcaaaaa aagctcattt ctttttgaag tgatgaggtt aattagggtt cacagttgga
     1381 caaaatgagt ttgagtttag tttcagtaac tgaaataagc ttgaatactg catatgccaa
     1441 atagctttta tagtaaacca tgtaatgaac tcaaatttaa atggtgtctt cagataagca
     1501 gtttaaactt catttagctt ggactctcaa gagaactgaa acataatcaa tggattcaga
     1561 aatgactcag aaaaaagaag ctgccagttc ttggaatgaa aaagaaatac agtcttacac
     1621 catcaaggaa tctacctgat agtgacagta gcttcttgaa aactctggca ttttcataaa
     1681 atctaggact atcttaaatg gcctgttgac ttctgactat ctgtaacatc agagctgtct
     1741 ggcctttgga aaggaaaaat tatggactct gttaagaaat cctaattgaa attttctgaa
     1801 cctcccccca gcccttttat tctctctctt ctgctgatga aagacctttc atcagttcaa
     1861 agcttttctt aagctctttt ttaagttaat tgaacttttt ctttatttat ttttcaaaaa
     1921 aatgtttata tcacatagac atattacatc ggctaaagta agacttggcc cacaaatacc
     1981 tatttgttgc tgaatgaata caatggataa agcaaggctg ttgtagctga agttacatag
     2041 ggaatcccaa actctgccct cttagcatct tattctacat gacaactctc aaggtactca
     2101 cagatctgtt taacccactt gaaaaaaaaa cactaaaaat gaagaaatgc tataagtata
     2161 aactatgatt ttatttataa attctgtatt aaaatggaat tatatgcaac attctttcat
     2221 tctgtaaact aattccattt gcattcctca taagcattgt agtaaattga tcatattaca
     2281 tgtactaagg aatgagatta tatgcagtaa acccaactgg aagattaaca atattaaaat
     2341 atgaaacatt tttaagacaa aggcattact tctcagtatt accaaaccta aactggttga
     2401 aggtgaaagt gtgctatggc cttttcaagc ctaagaagtc tctcttactg agtaaaccag
     2461 aggcttgcat cgctattctt tcacctgtca atattaataa gaaaatagtc tcatctcact
     2521 taaatgaggc aaatgtaata gttaaaattc aacatactta taaaaaacta gtgtcatgta
     2581 cctgccatga acatgacaaa aggttagtct tcaatagact gaaatgtata agagaagaac
     2641 caagtcttac atagaaaaaa aaggtagata tgaaaagaaa aatcacagaa gagagaatgc
     2701 aaatggccac taagtatatg aaaaaagtcg tatcttaaca gtgaacaact gtgttagtct
     2761 gtatcaatca gaagacagaa acaaggtagt aatttaaaca gggaaagttt aatataaata
     2821 ataattaagc tatgatagga gaataataat aaagatgaaa agagaaggta ccctaaggct
     2881 gagggaaaga atcctaacaa ggaaaggcag gaatgagggt ttcagaattc actggagaag
     2941 gtgtggttgc agcccactgg agagaagttt gctggcttgc ccaggccaga gcaggaccac
     3001 agatactgga caagctggta cagccaaccc cctaggtgtg gaccagctga ggcaggtggg
     3061 cagatatgca gagggacttg gggctttgcc aaagggtaag cacaaagaag gagtcacggg
     3121 ttctgttcga ggcactgttg ggattaggag ccggagggac ctactttgca ggaacctagc
     3181 ataactttgt gtgacgagac tgcacaagac aaagctcagg caagtggctc agtagttggc
     3241 cagcccagca gggtcctctg tatgagtgtg cacccagctg aagagaagaa atggagagca
     3301 gcaattggag cttcaggacc ggcttgcact gtggctccag gttataccac cactgcccaa
     3361 agcaaaagct agagaagcaa gtggagaaat gctggagaaa gctgcaccct acaggcaacc
     3421 agcactgcag aaaccactcc aggcaaagta gtgaaggaaa aaagcctgct ctccagtagc
     3481 ctggcctgtc agcctggagg aatcaggaaa gaccccttcc tcttgcagtg tgtctccagc
     3541 gccctctact gacaaagtat gccatcatgc aagctgcaaa ggaaacattt caagagtcta
     3601 tatctatttt cacggagcgg gcaaccaaca gtgaatgtgg agctgagaga cagtaaaata
     3661 ataactgaca tgccaccgaa gtacaaagta aaataaataa ataaatacac attttggcct
     3721 attagcaaag attaagaaat gataacatta aatactcaat aaatcaccat gagatgggga
     3781 ctcaaacttc tggtaaaaat acaaatagat ataatttttc ttgaaggcaa tttagtagtc
     3841 tgtttatcct ataattctac ttgtaagatc ctatcatatg aaaataacca gagatacaaa
     3901 gacattctgc aaagatatgt tttatattgt tatttattgt gacaaaagga aataaaaagc
     3961 ctaaatgttc agaaaattat tttaaaagat gaaagaggga aataggccat ggacggtggc
     4021 tcacgcctgt aatcccagca ctttaggagg ccaaggtagg tggatcactt gaggttggga
     4081 tttcgagacc agcctggcca acatggtgaa accctgcctc tactaaaaat acaaaaaatg
     4141 agccgggtgc aatggcaggc acctataatg ccagctactc gggaggctga ggcaggagaa
     4201 tcgcttgaac ccgggaggcg gaggttgcat gagccgagat ggcgccactg ctctccagcc
     4261 tggacgacag agcaagactc cgtctctaaa aaaaaaaaaa gagggaaata aacatttatt
     4321 tgtatattgt tatgtagcca ttaaaattct gtttccaagt aattttaatt acaggggtaa
     4381 attcttatat atctaaataa gaatatacac atacacatgt tccaaaatat ttattatgta
     4441 cttaaggcat atatattata tatgtatgtg tgtgtatata tatatgtatt tgtgtgtgtg
     4501 aacactaata tttgcatata tatacacaca agaaataaaa acatgttaaa aatggctata
     4561 tctgcattgt agaattatga gtgattcatg tttttctaac ttccctatct gtattaagtg
     4621 ttctatagtt tatatttgtt actttttaca tcaggaaata gtaaagttat tatttaaaac
     4681 ttatgaacaa aaaagtaaca agcacatgca agcacagagt tctaccaaat gcaaaaaatt
     4741 tcaaatcaat tattcaaatg agacattaac atcacttctg tggtagtttt atatccataa
     4801 agtctgattc ttctcctttg aagagatgaa gcttaatctt cctcatcctg aaaatgggct
     4861 ggacttagtg acttacgtct ttttatttta tttttaattg acaaataata attgtatgta
     4921 tttatggggt acaatattat attattatat atgtatacat tatggaatta ttaaatcaag
     4981 ctaattaaca tatccataac ctcttataat ttctttgtgg tgagaacatt taaaaatgta
     5041 ctcttttagc aattagggac ttacttttaa tacaggaaaa tggaagagac tgtgagactt
     5101 tgaagtaggt cataaaagtc actgtggctt cctccttgct ctctcttgga ccacttgctc
     5161 tgggggaagt caactgccat gtcctgagca gccctggaaa gacctacatg atgaagaact
     5221 gagaccttct atcaaatgcc agcagggaat tgaggcctcc tgtcaacagc cattttagaa
     5281 gtagatcttc cagcctcagt caagccttca gatgactgca gccctgtcta atagcttgac
     5341 cgtaatttca tgagagacct tcagccagaa aacccaagga aaccattctg gattcctcat
     5401 cctcagaaac tgtatgagat aagaagtgtt tgttgtagta cgccgctaaa tttggggcaa
     5461 tttgttacat agcaatgtat agctcataca atttctggga aaaaaatagt ttattttcga
     5521 atcatttttg cataatgcaa gaatataaac ttgtcacaga ataatttatc cttgttttag
     5581 gtggtccaaa tatttcattg tcagttatat attagctcaa attaaatttt agataatata
     5641 tattattatt aatggtaaag aatgtgtcac atttatcttt atagcttttc tgtacctaat
     5701 attgtgtctt gtgcgtagga tgtgctcaat aaaaattgat tgaataaata agtgaatgaa
     5761 agaataaatg aatgagtgaa ggaattatct gaaatatttt tataaaattc cccatatgta
     5821 tgtattactt attacaagtc tggtcccata gctgaaaaaa tattaaacat tatatatata
     5881 ta
//
