LOCUS       NM_182663               3799 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens Ras association domain family member 5 (RASSF5),
            transcript variant 1, mRNA.
ACCESSION   NM_182663
VERSION     NM_182663.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3799)
  AUTHORS   Ren,S., Li,C., Xiong,H., Wu,Q., Wu,X., Xiong,Z., Dong,L., Shu,B.,
            Wei,W., Ma,C., Li,X. and Chen,J.
  TITLE     The Rejuvenation and Functional Restoration of Aged Adipose Stem
            Cells by DUXAP10 Knockdown via the Regulation of the
            miR-214-3p/RASSF5 Axis
  JOURNAL   Stem Cells Transl Med 13 (5), 462-476 (2024)
   PUBMED   38459853
  REMARK    GeneRIF: The Rejuvenation and Functional Restoration of Aged
            Adipose Stem Cells by DUXAP10 Knockdown via the Regulation of the
            miR-214-3p/RASSF5 Axis.
REFERENCE   2  (bases 1 to 3799)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 3799)
  AUTHORS   Singh,A., Erijman,A., Noronha,A., Kumar,H., Peleg,Y., Yarden,Y. and
            Shifman,J.M.
  TITLE     Engineered variants of the Ras effector protein RASSF5 (NORE1A)
            promote anticancer activities in lung adenocarcinoma
  JOURNAL   J Biol Chem 297 (6), 101353 (2021)
   PUBMED   34717958
  REMARK    GeneRIF: Engineered variants of the Ras effector protein RASSF5
            (NORE1A) promote anticancer activities in lung adenocarcinoma.
REFERENCE   4  (bases 1 to 3799)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 3799)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   6  (bases 1 to 3799)
  AUTHORS   Tommasi,S., Dammann,R., Jin,S.G., Zhang,X.F., Avruch,J. and
            Pfeifer,G.P.
  TITLE     RASSF3 and NORE1: identification and cloning of two human
            homologues of the putative tumor suppressor gene RASSF1
  JOURNAL   Oncogene 21 (17), 2713-2720 (2002)
   PUBMED   11965544
REFERENCE   7  (bases 1 to 3799)
  AUTHORS   Ortiz-Vega,S., Khokhlatchev,A., Nedwidek,M., Zhang,X.F.,
            Dammann,R., Pfeifer,G.P. and Avruch,J.
  TITLE     The putative tumor suppressor RASSF1A homodimerizes and
            heterodimerizes with the Ras-GTP binding protein Nore1
  JOURNAL   Oncogene 21 (9), 1381-1390 (2002)
   PUBMED   11857081
  REMARK    Erratum:[Oncogene 2002 Mar 14;21(12):1943]
REFERENCE   8  (bases 1 to 3799)
  AUTHORS   Khokhlatchev,A., Rabizadeh,S., Xavier,R., Nedwidek,M., Chen,T.,
            Zhang,X.F., Seed,B. and Avruch,J.
  TITLE     Identification of a novel Ras-regulated proapoptotic pathway
  JOURNAL   Curr Biol 12 (4), 253-265 (2002)
   PUBMED   11864565
REFERENCE   9  (bases 1 to 3799)
  AUTHORS   Yao,R., Wang,Y. and You,M.
  TITLE     Chromosome mapping and sequence variation of the murine Ras
            effector gene Nore1
  JOURNAL   Cytogenet Cell Genet 95 (1-2), 126-128 (2001)
   PUBMED   11978988
REFERENCE   10 (bases 1 to 3799)
  AUTHORS   Vavvas,D., Li,X., Avruch,J. and Zhang,X.F.
  TITLE     Identification of Nore1 as a potential Ras effector
  JOURNAL   J Biol Chem 273 (10), 5439-5442 (1998)
   PUBMED   9488663
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK289861.1, AK291268.1,
            BC004270.1, CD367770.1 and AC244034.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_182663.3.
            
            Summary: This gene is a member of the Ras association domain
            family. It functions as a tumor suppressor, and is inactivated in a
            variety of cancers. The encoded protein localizes to centrosomes
            and microtubules, and associates with the GTP-activated forms of
            Ras, Rap1, and several other Ras-like small GTPases. The protein
            regulates lymphocyte adhesion and suppresses cell growth in
            response to activated Rap1 or Ras. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1), also known as transcript A,
            represents the longest transcript and encodes the longest isoform
            (A), also known as NORE1A.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.262070.1,
                                           SRR1803615.122634.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000579436.7/ ENSP00000462099.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               AK289861.1         2-120
            120-1212            AK291268.1         119-1211
            1213-1630           AK289861.1         1214-1631
            1631-3626           BC004270.1         1486-3481
            3627-3635           CD367770.1         18-26               c
            3636-3799           AC244034.4         24479-24642         c
FEATURES             Location/Qualifiers
     source          1..3799
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..3799
                     /gene="RASSF5"
                     /gene_synonym="Maxp1; NORE1; NORE1A; NORE1B; RAPL; RASSF3"
                     /note="Ras association domain family member 5"
                     /db_xref="GeneID:83593"
                     /db_xref="HGNC:HGNC:17609"
                     /db_xref="MIM:607020"
     exon            1..529
                     /gene="RASSF5"
                     /gene_synonym="Maxp1; NORE1; NORE1A; NORE1B; RAPL; RASSF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1329
                     /gene="RASSF5"
                     /gene_synonym="Maxp1; NORE1; NORE1A; NORE1B; RAPL; RASSF3"
                     /note="isoform A is encoded by transcript variant 1; Ras
                     association (RalGDS/AF-6) domain family 5; tumor
                     suppressor RASSF3; Ras effector-like protein; novel Ras
                     effector 1; regulator for cell adhesion and polarization
                     enriched in lymphoid tissue; ras association
                     domain-containing protein 5; Rap1-binding protein; new ras
                     effector 1; Ras association (RalGDS/AF-6) domain family
                     member 5"
                     /codon_start=1
                     /product="ras association domain-containing protein 5
                     isoform A"
                     /protein_id="NP_872604.1"
                     /db_xref="CCDS:CCDS30998.1"
                     /db_xref="GeneID:83593"
                     /db_xref="HGNC:HGNC:17609"
                     /db_xref="MIM:607020"
                     /translation="MAMASPAIGQRPYPLLLDPEPPRYLQSLSGPELPPPPPDRSSRL
                     CVPAPLSTAPGAREGRSARRAARGNLEPPPRASRPARPLRPGLQQRLRRRPGAPRPRD
                     VRSIFEQPQDPRVPAERGEGHCFAELVLPGGPGWCDLCGREVLRQALRCTNCKFTCHP
                     ECRSLIQLDCSQQEGLSRDRPSPESTLTVTFSQNVCKPVEETQRPPTLQEIKQKIDSY
                     NTREKNCLGMKLSEDGTYTGFIKVHLKLRRPVTVPAGIRPQSIYDAIKEVNLAATTDK
                     RTSFYLPLDAIKQLHISSTTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQK
                     LSIADRPLYLRLLAGPDTEVLSFVLKENETGEVEWDAFSIPELQNFLTILEKEEQDKI
                     QQVQKKYDKFRQKLEEALRESQGKPG"
     exon            530..651
                     /gene="RASSF5"
                     /gene_synonym="Maxp1; NORE1; NORE1A; NORE1B; RAPL; RASSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            652..762
                     /gene="RASSF5"
                     /gene_synonym="Maxp1; NORE1; NORE1A; NORE1B; RAPL; RASSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            763..1060
                     /gene="RASSF5"
                     /gene_synonym="Maxp1; NORE1; NORE1A; NORE1B; RAPL; RASSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1176
                     /gene="RASSF5"
                     /gene_synonym="Maxp1; NORE1; NORE1A; NORE1B; RAPL; RASSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..3799
                     /gene="RASSF5"
                     /gene_synonym="Maxp1; NORE1; NORE1A; NORE1B; RAPL; RASSF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3603..3608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASSF5"
                     /gene_synonym="Maxp1; NORE1; NORE1A; NORE1B; RAPL; RASSF3"
                     /note="hexamer: AATAAA"
     polyA_site      3626
                     /gene="RASSF5"
                     /gene_synonym="Maxp1; NORE1; NORE1A; NORE1B; RAPL; RASSF3"
                     /note="major polyA site"
ORIGIN      
        1 ctctcggggc tggctcggga gtagcgcagt cgccaaagcc gccgctgcca aagctgccgc
       61 cactagccgg gcatggccat ggcgtccccg gccatcgggc agcgcccgta cccgctacta
      121 ttggaccccg agccgccgcg ctatctacag agcctgagcg gccccgagct accgccgccg
      181 ccccccgacc ggtcctcgcg cctctgtgtc ccggcgcccc tctccactgc gcccggggcg
      241 cgcgaggggc gcagcgcccg gagggctgcc cgggggaacc tggagccccc gccccgggcc
      301 tcccgacccg ctcgcccgct ccggcctggt ctgcagcaga gactgcggcg gcggcctgga
      361 gcgccccgac cccgcgacgt gcggagcatc ttcgagcagc cgcaggatcc cagagtcccg
      421 gcggagcgag gcgaggggca ctgcttcgcc gagttggtgc tgccgggcgg ccccggctgg
      481 tgtgacctgt gcggacgaga ggtgctgcgg caggcgctgc gctgcactaa ctgtaaattc
      541 acctgtcacc cagaatgccg cagcctgatc cagttggact gcagtcagca ggagggttta
      601 tcccgggaca gaccctctcc agaaagcacc ctcaccgtga ccttcagcca gaatgtctgt
      661 aaacctgtgg aggagacaca gcgcccgccc acactgcagg agatcaagca gaagatcgac
      721 agctacaaca cgcgagagaa gaactgcctg ggcatgaaac tgagtgaaga cggcacctac
      781 acgggtttca tcaaagtgca tctgaaactc cggcggcctg tgacggtgcc tgctgggatc
      841 cggccccagt ccatctatga tgccatcaag gaggtgaacc tggcggctac cacggacaag
      901 cggacatcct tctacctgcc cctagatgcc atcaagcagc tgcacatcag cagcaccacc
      961 accgtcagtg aggtcatcca ggggctgctc aagaagttca tggttgtgga caatccccag
     1021 aagtttgcac tttttaagcg gatacacaag gacggacaag tgctcttcca gaaactctcc
     1081 attgctgacc gccccctcta cctgcgcctg cttgctgggc ctgacacgga ggtcctcagc
     1141 tttgtgctaa aggagaatga aactggagag gtagagtggg atgccttctc catccctgaa
     1201 cttcagaact tcctaacaat cctggaaaaa gaggagcagg acaaaatcca acaagtgcaa
     1261 aagaagtatg acaagtttag gcagaaactg gaggaggcct taagagaatc ccagggcaaa
     1321 cctgggtaac cggtcctgct tcctctcctc ctggtgcatt cagatttatt tgtattatta
     1381 attattattt tgcaacagac actttttctc aggacatctc tggcaggtgc atttgtgcct
     1441 gcccagcagt tccagctgtg gcaaaagtct cttccatgga caagtgtttg cacgagggtt
     1501 cagctgtgcc cgcccccagg ctgtgcccca ccacagattc tgccaaggat cagaactcat
     1561 gtgaaacaaa cagctgacgt cctctctcga tctgcaagcc tttcaccaac caaatagttg
     1621 cctctctcgt caccaaactg gaacctcaca ccagccggca aaggaaggaa gaaaggtttt
     1681 agagctgtgt gttctttctc tggcattgat tcctctttga gttctcttac ttgccacgta
     1741 caggaccatt atttatgagt gaaaagttgt agcacattcc ttttgcaggt ctgagctaag
     1801 cccctgaaag cagggtaatg ctcataaaag gactgttccc gcggccccaa ggtgcctgtt
     1861 gttcacactt aagggaagtt tataaagcta ctggccccag atgctcaggg taaggagcac
     1921 caaagctgag gctggctcag agatctccag agaagctgca gcctgccctg gccctggctc
     1981 tggccctggc ccacattgca catggaaacc caaaggcata tatctgcgta tgtgtggtac
     2041 ttagtcacat ctttgtcaac aaactgttcg tttttaagtt acaaatttga atttaatgtt
     2101 gtcatcatcg tcatgtgttt ccccaaaggg aagccagtca ttgaccattt aaaaagtctc
     2161 ctgctaagta tggaaatcag acagtaagag aaagccaaaa agcaatgcag agaaaggtgt
     2221 ccaagctgtc ttcagccttc cccagctaaa gagcagagga gggcctgggc tacttgggtt
     2281 ccccatcggc ctccagcact gcctccctcc tcccactgcg actctgggat ctccaggtgc
     2341 tgcccaagga gttgccttga ttacagagag gggagcctcc aattcggcca acttggagtc
     2401 ctttctgttt tgaagcatgg gccagacccg gcactgcgct cggagagccg gtgggcctgg
     2461 cctccccgtc gacctcagtg cctttttgtt ttcagagaga aataggagta gggcgagttt
     2521 gcctgaagct ctgctgctgg cttctcctgc caggaagtga acaatggcgg cggtgtggga
     2581 gacaaggcca ggagagcccg cgttcagtat gggttgaggg tcacagacct ccctcccatc
     2641 tgggtgcctg agttttgact ccaatcagtg ataccagacc acattgacag ggaggatcaa
     2701 attcctgact tacatttgca ctggcttctt gtttaggctg aatcctaaaa taaattagtc
     2761 aaaaaattcc aacaagtagc caggactgca gagacactcc agtgcagagg gagaaggact
     2821 tgtaattttc aaagcagggc tggttttcca acccagcctc tgagaaacca tttctttgct
     2881 atcctctgcc ttcccaagtc cctcttgggt cggttcaagc ccaagcttgt tcgtgtagct
     2941 tcagaagttc cctctctgac ccaggctgag tccatactgc ccctgatccc agaaggaatg
     3001 ctgacccctc gtcgtatgaa ctgtgcatag tctccagagc ttcaaaggca acacaagctc
     3061 gcaactctaa gattttttta aaccacaaaa accctggtta gccatctcat gctcagcctt
     3121 atcacttccc tccctttaga aactctctcc ctgctgtata ttaaagggag caggtggaga
     3181 gtcattttcc ttcgtcctgc atgtctctaa cattaataga aggcatggct cctgctgcaa
     3241 ccgctgtgaa tgctgctgag aacctccctc tatggggatg gctattttat ttttgagaag
     3301 gaaaaaaaaa gtcatgtata tatacacata aaggcatata gctatatata aagagataag
     3361 ggtgtttatg aaatgagaaa attattggac aattcagact ttactaaagc acagttagac
     3421 ccaaggccta tgctgaggtc taaacctctg aaaaaagtat agtatcgagt acccgttccc
     3481 tcccagaggt gggagtaact gctggtagtg ccttctttgg ttgtgttgct cagtgtgtaa
     3541 gtgtttgttt ccaggatatt ttctttttaa atgtctttct tatatgggtt ttaaaaaaaa
     3601 gtaataaaag cctgttgcaa aaatgactca tgttagaaac gtctcccttg aacttcacca
     3661 tcttacggac actgggagcg ggggagagag ggtgagaatg gacatgatca catgcttcct
     3721 ggtggagtca gattttcttt tgccagtgag cagagaaatg aaggctactg ttcaaataat
     3781 ttgggaaaaa ttgtccaaa
//
