LOCUS       NM_032023               3631 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens Ras association domain family member 4 (RASSF4), mRNA.
ACCESSION   NM_032023
VERSION     NM_032023.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3631)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3631)
  AUTHORS   Cui,S.H., Hu,X.D. and Yan,Y.
  TITLE     Wnt/beta-catenin signaling pathway participates in the effect of
            miR-626 on oral squamous cell carcinoma by targeting RASSF4
  JOURNAL   J Oral Pathol Med 50 (10), 1005-1017 (2021)
   PUBMED   34121238
  REMARK    GeneRIF: Wnt/beta-catenin signaling pathway participates in the
            effect of miR-626 on oral squamous cell carcinoma by targeting
            RASSF4.
REFERENCE   3  (bases 1 to 3631)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3631)
  AUTHORS   Lin,Y.T., Deel,M.D. and Linardic,C.M.
  TITLE     RASSF4 is required for skeletal muscle differentiation
  JOURNAL   Cell Biol Int 44 (2), 381-390 (2020)
   PUBMED   31508857
  REMARK    GeneRIF: RASSF4 is required for skeletal muscle differentiation.
REFERENCE   5  (bases 1 to 3631)
  AUTHORS   De Smedt,E., Maes,K., Verhulst,S., Lui,H., Kassambara,A., Maes,A.,
            Robert,N., Heirman,C., Cakana,A., Hose,D., Breckpot,K., van
            Grunsven,L.A., De Veirman,K., Menu,E., Vanderkerken,K., Moreaux,J.
            and De Bruyne,E.
  TITLE     Loss of RASSF4 Expression in Multiple Myeloma Promotes RAS-Driven
            Malignant Progression
  JOURNAL   Cancer Res 78 (5), 1155-1168 (2018)
   PUBMED   29259009
  REMARK    GeneRIF: Loss of RASSF4 Expression in Multiple Myeloma Promotes
            RAS-Driven Malignant Progression.
REFERENCE   6  (bases 1 to 3631)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3631)
  AUTHORS   Eckfeld,K., Hesson,L., Vos,M.D., Bieche,I., Latif,F. and Clark,G.J.
  TITLE     RASSF4/AD037 is a potential ras effector/tumor suppressor of the
            RASSF family
  JOURNAL   Cancer Res 64 (23), 8688-8693 (2004)
   PUBMED   15574778
REFERENCE   8  (bases 1 to 3631)
  AUTHORS   Chow,L.S., Lo,K.W., Kwong,J., Wong,A.Y. and Huang,D.P.
  TITLE     Aberrant methylation of RASSF4/AD037 in nasopharyngeal carcinoma
  JOURNAL   Oncol Rep 12 (4), 781-787 (2004)
   PUBMED   15375500
REFERENCE   9  (bases 1 to 3631)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   10 (bases 1 to 3631)
  AUTHORS   Dintilhac,A. and Bernues,J.
  TITLE     HMGB1 interacts with many apparently unrelated proteins by
            recognizing short amino acid sequences
  JOURNAL   J Biol Chem 277 (9), 7021-7028 (2002)
   PUBMED   11748221
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI601296.1, BC032593.1 and
            AL353801.13.
            
            On Nov 22, 2018 this sequence version replaced NM_032023.3.
            
            Summary: The function of this gene has not yet been determined but
            may involve a role in tumor suppression. Alternative splicing of
            this gene results in several transcript variants; however, most of
            the variants have not been fully described. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.178619.1,
                                           SRR1803613.234755.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340258.10/ ENSP00000339692.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-364               BI601296.1         35-398
            365-2464            BC032593.1         378-2477
            2465-3631           AL353801.13        170092-171258
FEATURES             Location/Qualifiers
     source          1..3631
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.21"
     gene            1..3631
                     /gene="RASSF4"
                     /gene_synonym="AD037"
                     /note="Ras association domain family member 4"
                     /db_xref="GeneID:83937"
                     /db_xref="HGNC:HGNC:20793"
                     /db_xref="MIM:610559"
     exon            1..65
                     /gene="RASSF4"
                     /gene_synonym="AD037"
                     /inference="alignment:Splign:2.1.0"
     exon            66..165
                     /gene="RASSF4"
                     /gene_synonym="AD037"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1069
                     /gene="RASSF4"
                     /gene_synonym="AD037"
                     /note="Ras association (RalGDS/AF-6) domain family 4;
                     tumor suppressor RASSF4; Ras association domain family 4;
                     Ras association (RalGDS/AF-6) domain family member 4"
                     /codon_start=1
                     /product="ras association domain-containing protein 4"
                     /protein_id="NP_114412.2"
                     /db_xref="CCDS:CCDS7208.1"
                     /db_xref="GeneID:83937"
                     /db_xref="HGNC:HGNC:20793"
                     /db_xref="MIM:610559"
                     /translation="MKEDCLPSSHVPISDSKSIQKSELLGLLKTYNCYHEGKSFQLRH
                     REEEGTLIIEGLLNIAWGLRRPIRLQMQDDREQVHLPSTSWMPRRPSCPLKEPSPQNG
                     NITAQGPSIQPVHKAESSTDSSGPLEEAEEAPQLMRTKSDASCMSQRRPKCRAPGEAQ
                     RIRRHRFSINGHFYNHKTSVFTPAYGSVTNVRVNSTMTTLQVLTLLLNKFRVEDGPSE
                     FALYIVHESGERTKLKDCEYPLISRILHGPCEKIARIFLMEADLGVEVPHEVAQYIKF
                     EMPVLDSFVEKLKEEEEREIIKLTMKFQALRLTMLQRLEQLVEAK"
     exon            166..241
                     /gene="RASSF4"
                     /gene_synonym="AD037"
                     /inference="alignment:Splign:2.1.0"
     exon            242..384
                     /gene="RASSF4"
                     /gene_synonym="AD037"
                     /inference="alignment:Splign:2.1.0"
     exon            385..476
                     /gene="RASSF4"
                     /gene_synonym="AD037"
                     /inference="alignment:Splign:2.1.0"
     exon            477..634
                     /gene="RASSF4"
                     /gene_synonym="AD037"
                     /inference="alignment:Splign:2.1.0"
     exon            635..736
                     /gene="RASSF4"
                     /gene_synonym="AD037"
                     /inference="alignment:Splign:2.1.0"
     exon            737..788
                     /gene="RASSF4"
                     /gene_synonym="AD037"
                     /inference="alignment:Splign:2.1.0"
     exon            789..910
                     /gene="RASSF4"
                     /gene_synonym="AD037"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1008
                     /gene="RASSF4"
                     /gene_synonym="AD037"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..3631
                     /gene="RASSF4"
                     /gene_synonym="AD037"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2428..2433
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASSF4"
                     /gene_synonym="AD037"
                     /note="hexamer: AATAAA"
     polyA_site      2454
                     /gene="RASSF4"
                     /gene_synonym="AD037"
                     /note="major polyA site"
     regulatory      3605..3610
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASSF4"
                     /gene_synonym="AD037"
                     /note="hexamer: AATAAA"
     polyA_site      3631
                     /gene="RASSF4"
                     /gene_synonym="AD037"
ORIGIN      
        1 gcagctccgg tgcaagcgag gacacgacac atgcagtggc ttctggactg cgcgatgact
       61 ggacgcaagt aacttctagg tctgcagaca agaggaagag aagatgaagg aagactgtct
      121 gccgagttct cacgtgccca tcagtgacag caagtccatt cagaagtcgg agctcttagg
      181 cctgctgaaa acctacaact gctaccatga gggcaagagc ttccagctga gacaccgtga
      241 ggaagaaggg actctgatca tcgaggggct cctcaacatt gcctgggggc tgaggcggcc
      301 catccggctg cagatgcagg atgaccggga gcaggtgcac ctcccctcca cctcatggat
      361 gcccagacgg cctagctgcc ctctaaagga gccatcgccc cagaacggga acatcacagc
      421 ccaggggcca agcattcagc cagtgcacaa ggctgagagt tccacagaca gctcggggcc
      481 cctggaggag gcagaggagg ccccccagct gatgcggacc aagagcgacg ccagttgcat
      541 gagccagagg aggcccaagt gccgcgcccc cggtgaggcc cagcgcatcc ggcgacaccg
      601 gttctctatc aacggccact tctacaatca taagacctcc gtgtttactc cagcctatgg
      661 atccgtgacc aatgtgaggg tcaacagcac catgacaacc ctgcaggtgc tcaccctgct
      721 gctgaacaaa tttagggtgg aagatggccc cagtgagttc gcactctaca tcgttcacga
      781 gtctggggag cggacaaaat taaaagactg cgagtacccg ctgatttcca gaatcctgca
      841 tgggccatgt gagaagatcg ccaggatctt cctgatggaa gctgacttgg gcgtggaagt
      901 cccccatgaa gtcgctcagt acattaagtt tgaaatgccg gtgctggaca gttttgttga
      961 aaaattaaaa gaagaggaag aaagagaaat aatcaaactg accatgaagt tccaagccct
     1021 gcgtctgacg atgctgcagc gcctggagca gctggtggag gccaagtaac tggccaacac
     1081 ctgcctcttc caaagtcccc agcagtggca ggtgtacact gagccctggt tgctggcccc
     1141 ggccggtcac attgactgat ggccaccgcc tgacgaatcg agtgcctgtg tgtctacctc
     1201 tctgaagcct gagcaccatg attcccacag ccagctcttg gctccaagat gagcacccac
     1261 aggaagccga cccaggcctg aggggccagg aacttgctgg gtcagatctg tgtggccagc
     1321 cctgtccaca ccatgcctct cctgcactgg agagcagtgc tggcccagcc cctgcggctt
     1381 aggcttcatc tgcttgcaca ttgcctgtcc cagagcccct gtgggtccac aagcccctgt
     1441 cctcttcctt catatgagat tcttgtctgc cctcatatca cgctgcccca caggaatgct
     1501 gctgggaaaa gcagggcctg ccagcaggta tgagatctag cctgctttca gccatcacct
     1561 tgccacagtg tccccggctt ctaagcctcc aatatcaccc tgtgagcctc gcacagctca
     1621 gccccaacac agaggtgaga ccaggaataa ggccacaagt atctcacttt ctctgcagaa
     1681 atcaatcttt acttcatcag agagacctaa agcgattctt acaaggagct tgctgcaaga
     1741 aacacggtca ttcaatcaca ttgaggaggg tccacatggc attgagaggg tgctgcccgc
     1801 tcaatgccca gcagcagctc tggaaggcag tgctcagccc catcaccact gtcccgtgga
     1861 tgcctgtgta cctcttgcct tttctgggct tgcgtttctc tcctctagtg ggtggggatg
     1921 actttcaatg actttcaata cttcccctga aggaagaatg ataaggagaa atgtctgttt
     1981 tgaggaaagg gctttgaatt ccccagatac tgaacaattt gtgtttgtga ctgatggaga
     2041 atttcaggaa tgaatgagaa agcctttgcg aaactatgca acagtttaca tcagtcatgt
     2101 gaagtatttg tctaaaacag agcaaactga agaccaaatt attctcctgt tgaggtccgt
     2161 ggatggcaga tttaaaggga agaaccacaa aggcttgcaa agataggaga ggctccatct
     2221 ctaatgcatg tagaagctcc ttacgggtgc ccatcaagag catagcttgg aagccaccat
     2281 gctgtgcgga actgcgtcag ggcaaatgtc acagcaggat ttccccaacc cagctccatc
     2341 atcacagaca cagagagctg caggggaggc ctgcccactg ttttgtcgac tctgccctcc
     2401 tctggcagca tagatcctta ggtgctcaat aaaggtgtgc tgtattgaac tgaagaagtg
     2461 agaaccaagc tttttttttt ttttttgctt tctgtgcatc caccctgacc cccggctcta
     2521 acttctgaaa ctcttatcct aaaggatgtg tggccatgtt tggcagaaga gccacaactc
     2581 gctgctctag gagccgacat gactccttca tttctgtgca tgccctgggg actagggtgg
     2641 agcctgagga gaggctgcca tggaacacgc aggcgtcact ggtgggagcc tagaggtgac
     2701 ctggatgatg agcaatagag tcaccccgag tcacagaatc ttagcatcag gagggcccca
     2761 agaatcttcc aggccagggg ctcaggtggg atggaagcag ggcctaggag agggtacaaa
     2821 acaaatcaaa caggagctcc caggtaattg tactcccaag ctattattta caatctcagg
     2881 tggaggacag ctcctgtccc attgttcagc tgtaactgag tgactgcctt gtgccaggcc
     2941 tgtgctcagc cctggaggca caaagatgga gccagtctgt cctgtgtcta ggggtcttct
     3001 catcaggaga agaaggccag acactggaag ggtcaagaga tcagctgagc aacgaaccgg
     3061 caaagctcct gggagtgagg tggaggccaa ggcagagttg gctaagaagt gcatgtggcg
     3121 tcacaggcca agatgcacct gccagctagg agcaggccag gtcctggcac acaggaagcc
     3181 agtggagcag gagaccctcc ctaagtacca gcctgtttgg ttggttggtt tgcttttgaa
     3241 agttattaca atattattta aggccttttc ggataagttc acttttaaag taggtgttat
     3301 caatctaatt tctgaacgtt atgggtcaga aaaatcacta gcaagtggct cagaaaaagg
     3361 gaaaaggtac acttctgcaa tcagctgagg agttcacacc tttttttcta aatcaacatc
     3421 atatttgctg ttcagaggca atctgaaaag ctgcaaattc agctcacctc aaccccataa
     3481 tttcaaacgt tagaggctgg tctctgtggt ttcctactgg ttcctgtggg gagctcccgc
     3541 tttctttcta catagagctt agggtatttc tcatatgccc cattggctac ctagtgtctc
     3601 aggtaataaa cgtatccgaa gataaagcaa a
//
