LOCUS       NM_178169               3507 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens Ras association domain family member 3 (RASSF3),
            transcript variant 1, mRNA.
ACCESSION   NM_178169
VERSION     NM_178169.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3507)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3507)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3507)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   4  (bases 1 to 3507)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3507)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 3507)
  AUTHORS   Schagdarsurengin,U., Richter,A.M., Hornung,J., Lange,C.,
            Steinmann,K. and Dammann,R.H.
  TITLE     Frequent epigenetic inactivation of RASSF2 in thyroid cancer and
            functional consequences
  JOURNAL   Mol Cancer 9, 264 (2010)
   PUBMED   20920251
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3507)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 3507)
  AUTHORS   Jacquemart,I.C., Springs,A.E. and Chen,W.Y.
  TITLE     Rassf3 is responsible in part for resistance to mammary tumor
            development in neu transgenic mice
  JOURNAL   Int J Oncol 34 (2), 517-528 (2009)
   PUBMED   19148488
  REMARK    GeneRIF: Mammary tumor incidence in bi-transgenic mice is delayed,
            suggesting that transgenic Rassf3 may influence mammary tumor
            incidence in transgenic mice
REFERENCE   9  (bases 1 to 3507)
  AUTHORS   Fujita,H., Fukuhara,S., Sakurai,A., Yamagishi,A., Kamioka,Y.,
            Nakaoka,Y., Masuda,M. and Mochizuki,N.
  TITLE     Local activation of Rap1 contributes to directional vascular
            endothelial cell migration accompanied by extension of microtubules
            on which RAPL, a Rap1-associating molecule, localizes
  JOURNAL   J Biol Chem 280 (6), 5022-5031 (2005)
   PUBMED   15569673
REFERENCE   10 (bases 1 to 3507)
  AUTHORS   Tommasi,S., Dammann,R., Jin,S.G., Zhang,X.F., Avruch,J. and
            Pfeifer,G.P.
  TITLE     RASSF3 and NORE1: identification and cloning of two human
            homologues of the putative tumor suppressor gene RASSF1
  JOURNAL   Oncogene 21 (17), 2713-2720 (2002)
   PUBMED   11965544
  REMARK    GeneRIF: The presence of a Ras association domain common to
            NORE1,RASSF1, and RASSF3 suggests their possible involvement
            inRas-like signaling pathways.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC078962.30, AY217662.1 and AC025262.27.
            
            On Nov 22, 2018 this sequence version replaced NM_178169.3.
            
            Summary: The RAS oncogene (MIM 190020) is mutated in nearly
            one-third of all human cancers. Members of the RAS superfamily are
            plasma membrane GTP-binding proteins that modulate intracellular
            signal transduction pathways. A subfamily of RAS effectors,
            including RASSF3, share a RAS association (RA) domain.[supplied by
            OMIM, Jul 2003].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the supported protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.231312.1,
                                           SRR1163655.100080.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000542104.6/ ENSP00000443021.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AC078962.30        95001-95018
            19-1355             AY217662.1         1-1337
            1356-3507           AC025262.27        145850-148001       c
FEATURES             Location/Qualifiers
     source          1..3507
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q14.2"
     gene            1..3507
                     /gene="RASSF3"
                     /gene_synonym="RASSF5"
                     /note="Ras association domain family member 3"
                     /db_xref="GeneID:283349"
                     /db_xref="HGNC:HGNC:14271"
                     /db_xref="MIM:607019"
     exon            1..249
                     /gene="RASSF3"
                     /gene_synonym="RASSF5"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..855
                     /gene="RASSF3"
                     /gene_synonym="RASSF5"
                     /note="Ras association (RalGDS/AF-6) domain family 3; Ras
                     association (RalGDS/AF-6) domain family member 3"
                     /codon_start=1
                     /product="ras association domain-containing protein 3"
                     /protein_id="NP_835463.1"
                     /db_xref="CCDS:CCDS8969.1"
                     /db_xref="GeneID:283349"
                     /db_xref="HGNC:HGNC:14271"
                     /db_xref="MIM:607019"
                     /translation="MSSGYSSLEEDAEDFFFTARTSFFRRAPQGKPRSGQQDVEKEKE
                     THSYLSKEEIKEKVHKYNLAVTDKLKMTLNSNGIYTGFIKVQMELCKPPQTSPNSGKL
                     SPSSNGCMNTLHISSTNTVGEVIEALLKKFLVTESPAKFALYKRCHREDQVYACKLSD
                     REHPLYLRLVAGPRTDTLSFVLREHEIGEWEAFSLPELQNFLRILDKEEDEQLQNLKR
                     RYTAYRQKLEEALREVWKPD"
     exon            250..357
                     /gene="RASSF3"
                     /gene_synonym="RASSF5"
                     /inference="alignment:Splign:2.1.0"
     exon            358..595
                     /gene="RASSF3"
                     /gene_synonym="RASSF5"
                     /inference="alignment:Splign:2.1.0"
     exon            596..705
                     /gene="RASSF3"
                     /gene_synonym="RASSF5"
                     /inference="alignment:Splign:2.1.0"
     exon            706..3507
                     /gene="RASSF3"
                     /gene_synonym="RASSF5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3488..3493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASSF3"
                     /gene_synonym="RASSF5"
                     /note="hexamer: ATTAAA"
     polyA_site      3507
                     /gene="RASSF3"
                     /gene_synonym="RASSF5"
                     /note="major polyA site"
ORIGIN      
        1 gattgagcgg cggccgcagc tgcataagga ctgcccgggg ctgcgcgccg ggaacctcgc
       61 ggggctggcg ggcgccgcac cccctccctg gccgcctgcg ccccggggag gccgcccgcg
      121 cgcgacggga ccggcagcat gagcagcggc tacagcagcc tggaggagga cgccgaggac
      181 ttcttcttca ccgccaggac ctccttcttc aggagagcgc cccagggcaa gccccgctcc
      241 ggccaacaag atgttgagaa agagaaggaa acccacagtt acctcagcaa agaggagatc
      301 aaagagaaag ttcataaata caacttagca gtcacagaca agttgaagat gaccttgaat
      361 tcaaatggga tttacactgg cttcattaaa gtacagatgg aactctgcaa acctccacag
      421 acttctccaa attctggaaa actctctccc agtagcaatg gctgtatgaa tacacttcat
      481 atcagcagca caaacactgt cggggaagtg atcgaggccc tgctcaaaaa gtttctcgtg
      541 actgagagcc ctgccaagtt tgcactttat aagcgttgtc acagggaaga ccaagtctac
      601 gcctgcaagc tctcagaccg ggaacatcca ctctacctgc gtttggtagc agggcccaga
      661 acagacacac ttagttttgt tcttcgtgaa catgaaattg gagagtggga agccttcagc
      721 cttccagaac tacagaattt cttgcgcatc ttggacaagg aagaagatga acagctgcag
      781 aacctgaaga ggcgctacac agcctacagg cagaagctgg aagaagccct ccgtgaggtg
      841 tggaagcctg attaaagcgg ggctccctgc ccgtgaggcc cggtgcagga ccgatgtaca
      901 aaacagcagc aagtgcctct cttctcagag ggctgctgtc ttgccccact atgctagggt
      961 cttcgccttt ctatctgtag attttgttcc ccaaacctgg tcacacagca tcctgcacct
     1021 tagcgtccca tgtaagggac tctgcaagct tgttgttcag caccgcagtg ttacctcttg
     1081 gcaagctgtg aacctgtcgc ctcatcagga gcattcgagg gtgcttggaa gcatgaactc
     1141 tgggggtgtt tttttttttg gttattttaa ttatgtgatg atgctgttaa gcttacagat
     1201 atgcagttga ttttttaaaa agcttaacta ggaatctttc tgaatacttg tcctattttg
     1261 aaactacctg tctggttttt tgtttggttt tgttttcttt ttttaatgtc agaggaatct
     1321 atccatgtga atcgaaaggc acaggaatct aggaactctg aggaatttat tgtgaaggat
     1381 tttgttaggg ggttgacaga gaaagcaaag tgtaagtttg gaagaaggca tgtgcggtgg
     1441 tggcgagtgc tgcgggctat ggaaggtgac ttggcttttc agttaggggt agtggagaaa
     1501 ggggtagttg cttgtaaacg agttaaaagc attcagtgtg gaggtgttaa acccatttta
     1561 ggatcgcttg gtttcctggt gggtagaata tgggaacaga gccagaggca ggagctaaac
     1621 caaaaggagg gacccatgaa ctctgcagct gaccaatcag agaatcaggc aggtgtagcc
     1681 tactgacctg ggcagaggtg ggcctcacgc agctggatcc gaccctttaa ttctgccctt
     1741 ttggagtgga aggtctgatt ggtgtagctg ctctgcatag gcaggacagt gacagttcac
     1801 taactcttgt taagttacat agtgtatagc tttcccccca caggtggttt tcaaagttga
     1861 gacggaattt gggtaggggc agctgttttt cccttgattg ttagctagga tatttgtcaa
     1921 gtaaactttg gtgacaatca ctctcttccc ttttattcct cctttccttt tcctttcttc
     1981 ccttttttct ttccttccct gctgtctccc accctacctt gttcttttcc tccctccctc
     2041 cctccctccc tccctccctc cctccttccc tccctctctc tccctctccc tttcttttct
     2101 acattgaaat ctgttcttac ataatagaga acagggctat tgaataaaga cccaatccta
     2161 ccagatcttt agttctaaag ggcaacttga ctgtgagtag gagggccccc aagaaaggga
     2221 ggaaagtcca cacccagcta accacacaac agggcttcat tatggaaata ttttaacaaa
     2281 agtacatgtt attaccaacc aaagagatgc atgtgcaata gaagccttcc ttaaaaacag
     2341 gctaaataac ctcattttat gcagcagttt aatctgagaa cagagggaaa ggtgtgcagt
     2401 ggttccagag gggccttata ttctattttt agtctagata ttttttgttt ataaattccc
     2461 aaggaattgt taacactttg gtgacaccta atggattctt tttgaaattc caaggtgctt
     2521 cagttctttg cccaagtgaa ctgtgccttt tattgcattt ctgttcgtct cttggtggct
     2581 cttctgactt tttggagaat acccatcttg ttggaggcag acttaagttg ttatgctgtg
     2641 ccacacaatt tactgagaca atcatatctt cctaagcatt taaggaaagt tgaaaaaaat
     2701 agaattagct ataaaatatg tatggcacat cttgtttaat tttgcatgta acttctcttt
     2761 tgtacattga tgaggtttta gtgacattgt catccaacac tttaccttta ttgttcaggg
     2821 aatgccttcg tgattttttg tactggtttt attattcaga ctatggcctg gatttgagta
     2881 tattgttatt accacctggt tttttaatta ttcatcccag taaacttata ttttgtgaag
     2941 catttgtttc tcagattaag acactgttag aacctaaagt agtagctgat gggtatctgt
     3001 gaattttttt tttttttttt tttttacttg aagtagattg tctgaatagg catcctcatc
     3061 tatatttacc caaaacctcg cttactgtca tgtgcactac aaattgcaat ttggaaacct
     3121 actgtattga aattctgtca gtttatggtt cttgaagact gatgtccttt cccaaacact
     3181 ggttactgca gcagcatttt taatgtgtaa gtgaagaaaa aaggccacta aggccaaaga
     3241 ttttttaaga atcattgtac aaatcattat gttaaactat ctaagctttg ctgtaatact
     3301 gttttctctt caatatgtga tggtacagga aggatgttaa atgaaggggt ggtattgcag
     3361 gagagcattt taaatggcag aagtaaaaag ttataatatt tataattttg atgggtttaa
     3421 gtttattttt gtagggaaga tttttctccc ctaaaatagt ttctagaatg gcaaaattgt
     3481 ttccattatt aaaaattgaa gttatta
//
