LOCUS       NM_014737               5390 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens Ras association domain family member 2 (RASSF2),
            transcript variant 1, mRNA.
ACCESSION   NM_014737
VERSION     NM_014737.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5390)
  AUTHORS   Aykanli,E., Arisan,S., Arisan,E.D. and Yavuzsan,A.H.
  TITLE     Diagnostic Value of GSTP1, RASSF1, AND RASSF2 Methylation in Serum
            of Prostate Cancer Patients
  JOURNAL   Urol J 21 (3), 182-188 (2024)
   PUBMED   38493315
  REMARK    GeneRIF: Diagnostic Value of GSTP1, RASSF1, AND RASSF2 Methylation
            in Serum of Prostate Cancer Patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5390)
  AUTHORS   Liu,Z., Feng,G., Chen,Y., Fan,J., Liang,Z., Bi,J. and Dai,X.
  TITLE     Hyperhomocysteinemia may aggravate abdominal aortic aneurysm
            formation by up-regulating RASSF2
  JOURNAL   Gene 898, 148036 (2024)
   PUBMED   38036076
  REMARK    GeneRIF: Hyperhomocysteinemia may aggravate abdominal aortic
            aneurysm formation by up-regulating RASSF2.
REFERENCE   3  (bases 1 to 5390)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 5390)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 5390)
  AUTHORS   Dhanaraman,T., Singh,S., Killoran,R.C., Singh,A., Xu,X.,
            Shifman,J.M. and Smith,M.J.
  TITLE     RASSF effectors couple diverse RAS subfamily GTPases to the Hippo
            pathway
  JOURNAL   Sci Signal 13 (653) (2020)
   PUBMED   33051258
  REMARK    GeneRIF: RASSF effectors couple diverse RAS subfamily GTPases to
            the Hippo pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5390)
  AUTHORS   Hesson,L.B., Wilson,R., Morton,D., Adams,C., Walker,M., Maher,E.R.
            and Latif,F.
  TITLE     CpG island promoter hypermethylation of a novel Ras-effector gene
            RASSF2A is an early event in colon carcinogenesis and correlates
            inversely with K-ras mutations
  JOURNAL   Oncogene 24 (24), 3987-3994 (2005)
   PUBMED   15806169
  REMARK    GeneRIF: In colonic neoplsms epigenetic (RASSF2A) and genetic
            (K-ras) changes are mutually exclusive and provide alternative
            pathways for affecting Ras signalling.
REFERENCE   7  (bases 1 to 5390)
  AUTHORS   Fujita,H., Fukuhara,S., Sakurai,A., Yamagishi,A., Kamioka,Y.,
            Nakaoka,Y., Masuda,M. and Mochizuki,N.
  TITLE     Local activation of Rap1 contributes to directional vascular
            endothelial cell migration accompanied by extension of microtubules
            on which RAPL, a Rap1-associating molecule, localizes
  JOURNAL   J Biol Chem 280 (6), 5022-5031 (2005)
   PUBMED   15569673
REFERENCE   8  (bases 1 to 5390)
  AUTHORS   Vos,M.D., Ellis,C.A., Elam,C., Ulku,A.S., Taylor,B.J. and
            Clark,G.J.
  TITLE     RASSF2 is a novel K-Ras-specific effector and potential tumor
            suppressor
  JOURNAL   J Biol Chem 278 (30), 28045-28051 (2003)
   PUBMED   12732644
  REMARK    GeneRIF: RASSF2 is a new member of the RASSF1 family of Ras
            effectors/tumor suppressors that exhibits a specificity for
            interacting with K-Ras
REFERENCE   9  (bases 1 to 5390)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   10 (bases 1 to 5390)
  AUTHORS   Comincini,S., Castiglioni,B.M., Foti,G.M., Del Vecchio,I. and
            Ferretti,L.
  TITLE     Isolation and molecular characterization of rasfadin, a novel gene
            in the vicinity of the bovine prion gene
  JOURNAL   Mamm Genome 12 (2), 150-156 (2001)
   PUBMED   11210185
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from D79990.1, DA333367.1 and
            AL133354.14.
            
            On Nov 22, 2018 this sequence version replaced NM_014737.2.
            
            Summary: This gene encodes a protein that contains a Ras
            association domain. Similar to its cattle and sheep counterparts,
            this gene is located near the prion gene. Two alternatively spliced
            transcripts encoding the same isoform have been reported. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY154470.1, SRR1803613.260208.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2157437 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379400.8/ ENSP00000368710.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               D79990.1           38-152
            116-592             DA333367.1         116-592
            593-5389            D79990.1           630-5426
            5390-5390           AL133354.14        2023-2023           c
FEATURES             Location/Qualifiers
     source          1..5390
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..5390
                     /gene="RASSF2"
                     /gene_synonym="CENP-34; RASFADIN"
                     /note="Ras association domain family member 2"
                     /db_xref="GeneID:9770"
                     /db_xref="HGNC:HGNC:9883"
                     /db_xref="MIM:609492"
     exon            1..52
                     /gene="RASSF2"
                     /gene_synonym="CENP-34; RASFADIN"
                     /inference="alignment:Splign:2.1.0"
     exon            53..127
                     /gene="RASSF2"
                     /gene_synonym="CENP-34; RASFADIN"
                     /inference="alignment:Splign:2.1.0"
     exon            128..218
                     /gene="RASSF2"
                     /gene_synonym="CENP-34; RASFADIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..1140
                     /gene="RASSF2"
                     /gene_synonym="CENP-34; RASFADIN"
                     /note="Ras association (RalGDS/AF-6) domain family 2; Ras
                     association (RalGDS/AF-6) domain family member 2;
                     centromere protein 34"
                     /codon_start=1
                     /product="ras association domain-containing protein 2"
                     /protein_id="NP_055552.1"
                     /db_xref="CCDS:CCDS13083.1"
                     /db_xref="GeneID:9770"
                     /db_xref="HGNC:HGNC:9883"
                     /db_xref="MIM:609492"
                     /translation="MDYSHQTSLVPCGQDKYISKNELLLHLKTYNLYYEGQNLQLRHR
                     EEEDEFIVEGLLNISWGLRRPIRLQMQDDNERIRPPPSSSSWHSGCNLGAQGTTLKPL
                     TVPKVQISEVDAPPEGDQMPSSTDSRGLKPLQEDTPQLMRTRSDVGVRRRGNVRTPSD
                     QRRIRRHRFSINGHFYNHKTSVFTPAYGSVTNVRINSTMTTPQVLKLLLNKFKIENSA
                     EEFALYVVHTSGEKQKLKATDYPLIARILQGPCEQISKVFLMEKDQVEEVTYDVAQYI
                     KFEMPVLKSFIQKLQEEEDREVKKLMRKYTVLRLMIRQRLEEIAETPATI"
     exon            219..294
                     /gene="RASSF2"
                     /gene_synonym="CENP-34; RASFADIN"
                     /inference="alignment:Splign:2.1.0"
     exon            295..446
                     /gene="RASSF2"
                     /gene_synonym="CENP-34; RASFADIN"
                     /inference="alignment:Splign:2.1.0"
     exon            447..535
                     /gene="RASSF2"
                     /gene_synonym="CENP-34; RASFADIN"
                     /inference="alignment:Splign:2.1.0"
     exon            536..696
                     /gene="RASSF2"
                     /gene_synonym="CENP-34; RASFADIN"
                     /inference="alignment:Splign:2.1.0"
     exon            697..798
                     /gene="RASSF2"
                     /gene_synonym="CENP-34; RASFADIN"
                     /inference="alignment:Splign:2.1.0"
     exon            799..850
                     /gene="RASSF2"
                     /gene_synonym="CENP-34; RASFADIN"
                     /inference="alignment:Splign:2.1.0"
     exon            851..972
                     /gene="RASSF2"
                     /gene_synonym="CENP-34; RASFADIN"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1070
                     /gene="RASSF2"
                     /gene_synonym="CENP-34; RASFADIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..5390
                     /gene="RASSF2"
                     /gene_synonym="CENP-34; RASFADIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5369..5374
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASSF2"
                     /gene_synonym="CENP-34; RASFADIN"
                     /note="hexamer: AATAAA"
     polyA_site      5390
                     /gene="RASSF2"
                     /gene_synonym="CENP-34; RASFADIN"
                     /note="major polyA site"
ORIGIN      
        1 agagtgatat gaagagcgag agaaaagaga ggacagcgga cgagcagatc cggtatctgg
       61 aatcccggcg cctagaacgt gtttttcggg agagcaaagg ctgtgtctac ggcagcctgg
      121 ggatatagcc tctccttccg atgaaaagag aaaggaagaa tggactacag ccaccaaacg
      181 tccctagtcc catgtggaca agataaatac atttccaaaa atgaacttct cttgcatctg
      241 aagacctaca acttgtacta tgaaggccag aatttacagc tccggcaccg ggaggaagaa
      301 gacgagttca ttgtggaggg gctcctgaac atctcctggg gcctgcgccg gcccattcgc
      361 ctgcagatgc aggatgacaa cgaacgcatt cgaccccctc catcctcctc ctcctggcac
      421 tctggctgta acctgggggc tcagggaacc actctgaagc ccctgactgt gcccaaagtt
      481 cagatctcag aggtggatgc cccgccggag ggtgaccaga tgccaagctc cacagactcc
      541 aggggcctga agcccctgca ggaggacacc ccacagctga tgcgcacacg cagtgatgtt
      601 ggggtgcgtc gccgtggcaa tgtgaggacg cctagtgacc agcggcgaat cagacgccac
      661 cgcttctcca tcaacggcca tttctacaac cataagacat ccgtgttcac accagcctat
      721 ggctctgtca ccaacgtccg catcaacagc accatgacca ccccacaggt cctgaagctg
      781 ctgctcaaca aatttaagat tgagaattca gcagaggagt ttgccttgta cgtggtccat
      841 acgagtggtg agaaacagaa gctgaaggcc accgattacc cgctgattgc ccgaatcctc
      901 cagggcccat gtgagcagat ctccaaagtg ttcctaatgg agaaggacca ggtggaggaa
      961 gtcacctacg acgtggccca gtatataaag ttcgagatgc cggtacttaa aagcttcatt
     1021 cagaagctcc aggaggaaga agatcgggaa gtaaagaagc tgatgcgcaa gtacaccgtg
     1081 ctccggctaa tgattcgaca gaggctggag gagatagccg agaccccagc aacaatctga
     1141 gccatgagaa cgaggggatc tgggcacccc aggaaccgcc attgcccata agacccccag
     1201 gaagctaggc actttctttc catggaaaca tttagacaca aacctcccca gctccggcca
     1261 agccatcatt tgctacctgg agctggatgt agaagtcagc agacagctcc ctatccctgg
     1321 acccctgccc tccttttttc tgctcacaag gacttttgat tttagttata aggaggaccc
     1381 aaaatgtgtg tgtgtacatg tgtgtgcaca catggtacgt gtccatgtgc ctacctgata
     1441 ctttcacatg taattaaatt ccaggcaacc agcacaagag ccgtgagctt ggcacatgtg
     1501 ctgctcgtga gcaggaaaat cagaggagcc actgatctga gtggtattta ggttgaagga
     1561 aagatttctc ctctcaagtg ccagggagca gccacacgtc tgtctgtgtt tagagaggga
     1621 agagggttct ccaggttcac catttgggtt gtttatatgt tggtagaaat tctccctgta
     1681 tgcctagaag gatcagtgaa tgtaagagcc ttggaaatta acaaaataac agccacataa
     1741 ccttgcggca agtctgatgg aaagaaaaag ataaaccatc cgtggggtag atgcaataag
     1801 cccacgtatt tttacactgg aaacgttgat tgttttaaat gacaaagaca tatgtgatgt
     1861 tctatgtgga aacctgtgaa gagtggattc tgcctccatc tctgcctcca tggctacctt
     1921 taggagacag agaagatcct gtgtgtttct ctgtacccag ctgacagcct gtctctatgg
     1981 cgcttccttg agtggaagga aatgtctcaa gaaacaaaga tctcgctggt gcgtacacag
     2041 tgctgaccag ctagtgtggc cagggcctgg tggcctggtg gccaggaagt ttcaggttga
     2101 agggaaatgt cgaggctacc tgcagatatg acaggtgcct tgaacgcagc ccatcttcat
     2161 gtcatcaaag gtcttcctgc acttgaagct ggggcgatgt ttgcagtcaa gaccattctt
     2221 tccaacctct gggttcttgc aagttgccct caccttgtgt gtggagatgc attccaagaa
     2281 tgaagcctca tcttgctact gagtgtgggg ttcagggaag ctctttaggc cacctggtga
     2341 aggtgcatgg ggaggatgga gcttctcctc agctcctctg agcagccacc tatgtgatct
     2401 ttaaatccaa ccccaatggg agaaaagggc aagaacagtc tgtgccctgg gactcctatc
     2461 aggaagcttg acaggcagct gggcatcagt gcagctgata tcgtttgagg agggagacag
     2521 atgcttggac ctgggtgcct ggctatggag attgaccaag caagatcagg agctcctgat
     2581 agcaggcgtc tttgagccta gctggggtag aggcactgcc catctcttct ccaccttctc
     2641 tccacagaat gtttgcagag ctgggcagtt gaggaaagga cagcccctgg ttggtgcctc
     2701 caaaggaagg tggacttttt tggtggagac gtttctgccc tgggcaccct cctgcccccg
     2761 attcatacct atggcttctt gagaaggctc acagctgtgg tcttaacgta gactgcagaa
     2821 agatggcatg cggcccctgg catttcgcca agggttttat agcaagtctc cttcctccat
     2881 agggacagca gcaccagccc tgtggggcat ggagtggaag cccagaaggg cttctgcaag
     2941 ctgcacagaa ctggggtaag aagacaaaga gtagccaccg ggagaggctt cctttgttac
     3001 agctgggaaa gaacagttct gtgaatgcaa acacctcctg agttttgcaa ttgagaaaat
     3061 gatttggaga acttctcttc tggtaatttt tattttgaat gttcagggcc ttagttggcc
     3121 ccagtaattc tccttggagg acttgggaga agaatttcca caaagcaaac tactaaccac
     3181 tagctcttac tggacagcga tttctggctt ataagagttc tctttgattt gcactagcac
     3241 tacgatagtg ttagatgggg aaatactgca acatgtccag ttggccagat cactttccaa
     3301 gggagcgata ctaaggcaga ctcagctttt taaagatggg aggtcaggag gtggaagtga
     3361 gaggagatcc catctcacac aacacacttc cacgtaatgc agaccacact tttccatttt
     3421 gtcctgccct cttgagaggt catttctcac gtcctaagaa cctgatcaga aattttggaa
     3481 gggttctttg aaatagcagc agttgaaaca gagacacttt gccacagtgt ggagcagatt
     3541 ttctcactgg tatcacatgg tcttgcagtt ttgaactctt cgaccgattt gtgggagttt
     3601 atgtaattgc gtgcaatgaa cctgaaattg tgtaaaggac aaaagaccag tttatagggt
     3661 tgggtttttt ttccaacttg tgaaaagcag tttagctgca tctgtctccc caccaccccc
     3721 accccgggag gggcttatgt tacaaggtga tcaagtgaag gaaaaacctg agcctatctg
     3781 gctgggatgg tggaattaag cacaaggtca cattctctgt gatcacatga gagggaaggt
     3841 gatgacttaa atggcagggg gtggggatta tcttggggag aggctgaaaa gcacaaaaga
     3901 tagtcttccc tgtacgtatt ggtgaagaac gtgcacaagg ctggatggac ttcaacttgg
     3961 agttgagttg aggcaagagg atttctggat attagtcacc catctgcaag aaaaatgctg
     4021 aggcctcggg tcaagatttt gatctgagac atgctgatgc ttcaaggaga aatattttca
     4081 caatcctctc ttccctcacc agaagagaac agtactctct cctagaaacc tctaggtaaa
     4141 cacattttat cctaatatcg gtagcatata atgccccccc caaaatatct gttttccatg
     4201 caaaaaagtc tcaacaagaa gtctgtggag ttgagtggtt acttcaaagt gtcaggagag
     4261 tgaagaaatt ggccacagaa gagcaagaag ctctcttaag aaaagggaat tctctttaaa
     4321 gaaaccacca ccaacaacaa aacaaccaaa aaccatgttt tatgtcaaag ctctgtagca
     4381 cagagaatgt ggtgtcacag atacatcgcc gagagaggtt tctttctttc tttttttttt
     4441 ttttgagaca gagtctggtt ctgtttccca ggctggagtg cagtggtggg atctcagctc
     4501 actgcaacat ccgcctctgg ggttcaagtg attctcctgt ctcagcctcc caagtagctg
     4561 gaattacagg gacccgccac cacgcccggc taattttttt gtgtggtttt agtagaggtg
     4621 gggtttcacc atcttggcca ggctggtctt gaactcctga cctcgtgatc cacccgccta
     4681 ggcctcccaa agtgttggga ttacaggcgt gagccactgt gcccagccaa aagagaaatt
     4741 tctacatgaa caaggcaatt tcagtgtctt acagcggcca aaccatgacg tgaagaatga
     4801 gataggagac aggagatcac cataagcgtc cctgatatag cagcacacat tttcacgttt
     4861 ccacttaaat cgttttgcac aaagtcttgc ttcgctcaga tgagatgaga tatgatttcc
     4921 tagagatgta aaaataagaa tgaatgtggc gcccccttct tccagatgta atagaaagct
     4981 ctgccctatc acaagggggg tgttgaagcg ccccttgtgt tttaactgta tttaactgag
     5041 cacaagatgc acaagctgtg gtgggaaacc ctcagtttac ctttggagtc ttccctgcag
     5101 atcgcagacc tgtttccagg ctgatgtttc tggtgtgtaa ttgctagcgt ttctgaaggg
     5161 ttttcccaat tgttttagcc ttgtgaagta ttcttaatta taacttgcct ttcagcgatg
     5221 gtacatgact tgattcaacg tttggttctg aacttacaca ctgatgcgtt tactcatcta
     5281 acataatctg acagggcctc agcaagggag ccatacattt ttgtaacatt ttgatatgtt
     5341 ttaatgcatc tgacttagat cttactgaaa taaagcactt ttcaaagaga
//
