LOCUS       NM_001080521            2804 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens Ras association domain family member 10 (RASSF10),
            mRNA.
ACCESSION   NM_001080521 XM_928030
VERSION     NM_001080521.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2804)
  AUTHORS   Liu,Y., Zhu,X., Zhang,W., Bian,T., Wu,Z., Zhang,J., Qiu,H., Hu,Y.,
            Feng,J. and Shi,J.
  TITLE     RASSF10 exhibits tumor-suppressing potential involving tumor
            proliferation, metastasis and epithelial-mesenchymal transition in
            esophageal squamous cell carcinoma
  JOURNAL   Oncol Rep 47 (4) (2022)
   PUBMED   35211758
  REMARK    GeneRIF: RASSF10 exhibits tumorsuppressing potential involving
            tumor proliferation, metastasis and epithelialmesenchymal
            transition in esophageal squamous cell carcinoma.
REFERENCE   2  (bases 1 to 2804)
  AUTHORS   Lakshmi Ch,N.P., Sivagnanam,A., Raja,S. and Mahalingam,S.
  TITLE     Molecular basis for RASSF10/NPM/RNF2 feedback cascade-mediated
            regulation of gastric cancer cell proliferation
  JOURNAL   J Biol Chem 297 (2), 100935 (2021)
   PUBMED   34224728
  REMARK    GeneRIF: Molecular basis for RASSF10/NPM/RNF2 feedback
            cascade-mediated regulation of gastric cancer cell proliferation.
REFERENCE   3  (bases 1 to 2804)
  AUTHORS   Gao,Y., Fu,Y., Wang,J., Zheng,X., Zhou,J. and Ma,J.
  TITLE     EBV as a high infection risk factor promotes RASSF10 methylation
            and induces cell proliferation in EBV-associated gastric cancer
  JOURNAL   Biochem Biophys Res Commun 547, 1-8 (2021)
   PUBMED   33588233
  REMARK    GeneRIF: EBV as a high infection risk factor promotes RASSF10
            methylation and induces cell proliferation in EBV-associated
            gastric cancer.
REFERENCE   4  (bases 1 to 2804)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2804)
  AUTHORS   Dansranjavin,T., Wagenlehner,F., Gattenloehner,S., Steger,K.,
            Weidner,W., Dammann,R. and Schagdarsurengin,U.
  TITLE     Epigenetic down regulation of RASSF10 and its possible clinical
            implication in prostate carcinoma
  JOURNAL   Prostate 72 (14), 1550-1558 (2012)
   PUBMED   22415519
  REMARK    GeneRIF: The study demonstrates the frequent epigenetic
            inactivation of RASSF10 in PCa and its implication in clinical
            symptoms of PCa.
REFERENCE   6  (bases 1 to 2804)
  AUTHORS   Helmbold,P., Richter,A.M., Walesch,S., Skorokhod,A., Marsch,W.Ch.,
            Enk,A. and Dammann,R.H.
  TITLE     RASSF10 promoter hypermethylation is frequent in malignant melanoma
            of the skin but uncommon in nevus cell nevi
  JOURNAL   J Invest Dermatol 132 (3 Pt 1), 687-694 (2012)
   PUBMED   22113481
  REMARK    GeneRIF: The RASSF10 promoter was hypermethylated in all malignant
            melanoma (MM) cell lines, 19/28 of the primary MM, 30/33 of the MM
            metastases, 2/18 of the dysplastic nevus cell nevi, and 0/29 of the
            non-dysplastic nevus cell nevi.
REFERENCE   7  (bases 1 to 2804)
  AUTHORS   Hill,V.K., Underhill-Day,N., Krex,D., Robel,K., Sangan,C.B.,
            Summersgill,H.R., Morris,M., Gentle,D., Chalmers,A.D., Maher,E.R.
            and Latif,F.
  TITLE     Epigenetic inactivation of the RASSF10 candidate tumor suppressor
            gene is a frequent and an early event in gliomagenesis
  JOURNAL   Oncogene 30 (8), 978-989 (2011)
   PUBMED   20956940
  REMARK    GeneRIF: This is the first report demonstrating that RASSF10 can
            act as a tumor suppressor gene and is frequently methylated in
            gliomas
REFERENCE   8  (bases 1 to 2804)
  AUTHORS   Schagdarsurengin,U., Richter,A.M., Wohler,C. and Dammann,R.H.
  TITLE     Frequent epigenetic inactivation of RASSF10 in thyroid cancer
  JOURNAL   Epigenetics 4 (8), 571-576 (2009)
   PUBMED   19934646
  REMARK    GeneRIF: RASSF10 may encode a novel epigenetically inactivated
            candidate tumor suppressor gene in thyroid carcinogenesis.
REFERENCE   9  (bases 1 to 2804)
  AUTHORS   Hesson,L.B., Dunwell,T.L., Cooper,W.N., Catchpoole,D., Brini,A.T.,
            Chiaramonte,R., Griffiths,M., Chalmers,A.D., Maher,E.R. and
            Latif,F.
  TITLE     The novel RASSF6 and RASSF10 candidate tumour suppressor genes are
            frequently epigenetically inactivated in childhood leukaemias
  JOURNAL   Mol Cancer 8, 42 (2009)
   PUBMED   19570220
  REMARK    GeneRIF: Sequencing revealed RASSF6 and RASSF10 were the only RASSF
            members with a high frequency of leukaemia-specific methylation.
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2804)
  AUTHORS   Sherwood,V., Manbodh,R., Sheppard,C. and Chalmers,A.D.
  TITLE     RASSF7 is a member of a new family of RAS association
            domain-containing proteins and is required for completing mitosis
  JOURNAL   Mol Biol Cell 19 (4), 1772-1782 (2008)
   PUBMED   18272789
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084859.7 and BX098487.1.
            
            On May 17, 2019 this sequence version replaced NM_001080521.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: DRR138518.292968.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000529419.3/ ENSP00000485526.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2638              AC084859.7         89714-92351
            2639-2791           BX098487.1         15-167              c
            2792-2804           AC084859.7         92505-92517
FEATURES             Location/Qualifiers
     source          1..2804
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.3"
     gene            1..2804
                     /gene="RASSF10"
                     /note="Ras association domain family member 10"
                     /db_xref="GeneID:644943"
                     /db_xref="HGNC:HGNC:33984"
                     /db_xref="MIM:614713"
     exon            1..2804
                     /gene="RASSF10"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..1785
                     /gene="RASSF10"
                     /note="Ras association (RalGDS/AF-6) domain family
                     (N-terminal) member 10"
                     /codon_start=1
                     /product="ras association domain-containing protein 10"
                     /protein_id="NP_001073990.2"
                     /db_xref="CCDS:CCDS44542.2"
                     /db_xref="GeneID:644943"
                     /db_xref="HGNC:HGNC:33984"
                     /db_xref="MIM:614713"
                     /translation="MDPSEKKISVWICQEEKLVSGLSRRTTCSDVVRVLLEDGCRRRR
                     RQRRSRRLGSAGDPHGPGELPEPPNEDDEDDDEALPQGMLCGPPQCYCIVEKWRGFER
                     ILPNKTRILRLWAAWGEEQENVRFVLVRSEASLPNAGPRSAEARVVLSRERPCPARGA
                     PARPSLAMTQEKQRRVVRKAFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHE
                     SASVERMETLVHLVLSQDHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDT
                     YLVGAGIELDGSRPGEEPEEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQE
                     QRVQQEELLERLSAEIQEELNQRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRT
                     QLSTSLYIGLRLNTDLEAVKSDLDYSQQQWDSKKRELQGLLQTLHTLELTVAPDGAPG
                     SGSPSREPGPQACADMWVDQARGLAKSGPGNDEDSDTGLSSMHSQDSDSLPMCESLV"
     polyA_site      2262
                     /gene="RASSF10"
                     /note="major polyA site"
     regulatory      2299..2304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASSF10"
                     /note="hexamer: GATAAA"
     polyA_site      2321
                     /gene="RASSF10"
                     /note="major polyA site"
     regulatory      2520..2525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASSF10"
                     /note="hexamer: TATAAA"
     polyA_site      2541
                     /gene="RASSF10"
     regulatory      2656..2661
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASSF10"
                     /note="hexamer: AATAAA"
     polyA_site      2696
                     /gene="RASSF10"
     regulatory      2767..2772
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASSF10"
                     /note="hexamer: ATTAAA"
     polyA_site      2804
                     /gene="RASSF10"
ORIGIN      
        1 agagccagag cggcgggagc cggtcctggg cgcgttgccc cgggagcgcc cgtcgtccgg
       61 gcagagcgca gccgcaaccg cgaccacagc cgcagtcgct ttccagcctg ccttcggtgc
      121 gcagcggggg aacagggcta gtgcagccgc cggagggggg cacgggctcc tctcccatcc
      181 cagagctact gggctgccct tgctgtcctc gccgccccag cagaccccgg ccggacctgc
      241 cacctgcgcc ctggttgcgc catggatcct tcggaaaaga agatatcggt gtggatctgc
      301 caggaagaga agctggtgtc cggcctctcc cgccgcacca cttgctccga cgttgtgcga
      361 gtgcttttgg aggacggctg ccggcggcga cggagacagc ggcggagccg gcggctgggg
      421 tcggccggcg acccgcatgg cccgggagag ctgcccgaac ccccgaacga ggacgacgag
      481 gacgacgacg aggcgctgcc gcagggcatg ctgtgcgggc ccccgcagtg ctattgcatc
      541 gtggagaagt ggcgcggctt tgagcgcatc ctccccaaca agacgcgcat cttgcgcctc
      601 tgggctgcct ggggcgaaga gcaagagaat gtgcgcttcg tgctagtgcg cagcgaggca
      661 tcgctgccta acgccggccc ccgcagcgcc gaggcgcgcg tagtgctgag ccgagagcgc
      721 ccctgtccgg cccgcggggc cccggcgcgg cccagcctgg ccatgaccca ggagaaacag
      781 cggcgagtgg tgcgcaaggc ctttcgcaaa ctggccaagc tcaaccggcg gcgccagcag
      841 cagacaccgt cgtcctgttc gtccacttcg tcgtccactg cctcgtcctg ctcttcgtcg
      901 ccgcggaccc acgagagcgc gtcggtggag cgcatggaga cgctggtgca tctggtgctt
      961 tcccaggacc acacaattcg ccagcaggtg cagcggctcc acgagctgga ccgcgagatc
     1021 gatcactacg aggccaaggt gcacctggac cgcatgcggc gtcacggggt caactacgtg
     1081 caggacactt acttggttgg ggcaggcatc gagctcgacg ggtccagacc gggagaggag
     1141 ccagaagagg tggcggcgga ggcggaggag gcggcggcgg cgccccctct agccggcgag
     1201 gcgcaggcgg cggcgctgga ggagctggcc cggcgctgcg acgacttgct gcggcttcag
     1261 gagcaacggg ttcagcagga ggagttgctg gagcgccttt cagccgagat tcaggaggaa
     1321 ctcaaccaga ggtggatgcg acggcgccag gaggagctgg cggcgcggga ggagcccctg
     1381 gagcccgacg gtggccccga cggcgagctg ctgctggagc aggaacgggt caggacgcag
     1441 ctcagtacca gcctttacat tgggctgcgg ctcaacacgg acctagaggc cgtcaagtcg
     1501 gacttggatt acagccagca gcaatgggac agcaagaagc gcgagctaca gggccttctg
     1561 caaactttgc acactttgga gctgacggtg gcaccggatg gggctcctgg ctctggcagt
     1621 ccctcgcggg aacctgggcc tcaagcctgc gccgacatgt gggtggacca ggcccgtgga
     1681 ctggccaaga gcggtcctgg caacgacgaa gactcggata cgggactgag ctctatgcat
     1741 agccaagact cggactcctt gcccatgtgc gaatcccttg tgtaggggtg gggggcgggg
     1801 ggcggggggc gggaacaggg ggattctttt ttcttgcaga atgcagtggg ccagccggct
     1861 cgcggacttg aaaccaggct gttgcgagcc cagagctccg gctgggcagc agcgctctgc
     1921 gcagcctcgc gctcatctgg ctccggggtg agtgcagagc agggtgaggg tagaagaagt
     1981 aggatcctca atacaagctc attaaagaga gggaaggagg gaggaggcaa gaacccccta
     2041 tactggaaaa caaacaaccc aaggaaattg acgtggtccg agcccatttt caaagtaagg
     2101 aagtataatg gagatttcgc tactcttctg tatgggaagg actgatggca gctagaactt
     2161 tagtttgtgg tatgaagtgc tttaaaagaa acacttggat gaaaaggaaa ttccttgaat
     2221 gttaattgtg actgtaaacg tgttaaaact agccaaagag gacgcactgg tgtcggtctc
     2281 tgcctttctt acctctttga taaaacccat aggcaccaaa atcctggctg tttacatttc
     2341 tgcagatttg ggaattaccc atctgctaaa tcatttgtct tttattttct ttcaaaggct
     2401 aaactgtatc gaagtctaac cctgtatttc ctcctagtaa acacaataga tgttaaaagg
     2461 gaattctttt cccaaaataa ccttttatta ttacaaaagc caaacataat catttgagat
     2521 ataaaatcct ggcaaacata atcgtggtta aaatttaatc tgggcccttt gggatctgtc
     2581 ccttcaaagg caggtgagtt gccctttaat tcgtattgcc acttcattga ctcaatcact
     2641 gttatttcag aaaaaaataa aaggaagtag cagaattcaa gttacgcaaa acaaaacttg
     2701 ctgtctaaca agcactcttt gaaagcaaag atgttttagt gttcagcttt taaattgagc
     2761 tatgtgatta aaaccaacca tgaccttaac ggattttacc caaa
//
