LOCUS       NM_016563               2519 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens RAS like family 12 (RASL12), transcript variant 1,
            mRNA.
ACCESSION   NM_016563
VERSION     NM_016563.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2519)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2519)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2519)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 2519)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   5  (bases 1 to 2519)
  AUTHORS   Wistow,G., Bernstein,S.L., Ray,S., Wyatt,M.K., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human iris for the NEIBank
            Project: steroid-response factors and similarities with retinal
            pigment epithelium
  JOURNAL   Mol Vis 8, 185-195 (2002)
   PUBMED   12107412
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI489884.1, AF233588.1 and AC013553.14.
            
            On Nov 22, 2018 this sequence version replaced NM_016563.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.776896.1,
                                           SRR3476690.26196.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000220062.9/ ENSP00000220062.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                BI489884.1         122-161
            41-1417             AF233588.1         1-1377
            1418-1506           AC013553.14        63485-63573         c
            1507-2519           AF233588.1         1465-2477
FEATURES             Location/Qualifiers
     source          1..2519
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.31"
     gene            1..2519
                     /gene="RASL12"
                     /gene_synonym="RIS"
                     /note="RAS like family 12"
                     /db_xref="GeneID:51285"
                     /db_xref="HGNC:HGNC:30289"
     exon            1..259
                     /gene="RASL12"
                     /gene_synonym="RIS"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..957
                     /gene="RASL12"
                     /gene_synonym="RIS"
                     /EC_number="3.6.5.2"
                     /note="isoform 1 is encoded by transcript variant 1; Ras
                     family member Ris; ras-like protein family member 12;
                     ras-like protein Ris"
                     /codon_start=1
                     /product="ras-like protein family member 12 isoform 1"
                     /protein_id="NP_057647.1"
                     /db_xref="CCDS:CCDS10200.1"
                     /db_xref="GeneID:51285"
                     /db_xref="HGNC:HGNC:30289"
                     /translation="MSSVFGKPRAGSGPQSAPLEVNLAILGRRGAGKSALTVKFLTKR
                     FISEYDPNLEDTYSSEETVDHQPVHLRVMDTADLDTPRNCERYLNWAHAFLVVYSVDS
                     RQSFDSSSSYLELLALHAKETQRSIPALLLGNKLDMAQYRQVTKAEGVALAGRFGCLF
                     FEVSACLDFEHVQHVFHEAVREARRELEKSPLTRPLFISEERALPHQAPLTARHGLAS
                     CTFNTLSTINLKEMPTVAQAKLVTVKSSRAQSKRKAPTLTLLKGFKIF"
     exon            260..316
                     /gene="RASL12"
                     /gene_synonym="RIS"
                     /inference="alignment:Splign:2.1.0"
     exon            317..390
                     /gene="RASL12"
                     /gene_synonym="RIS"
                     /inference="alignment:Splign:2.1.0"
     exon            391..581
                     /gene="RASL12"
                     /gene_synonym="RIS"
                     /inference="alignment:Splign:2.1.0"
     exon            582..2519
                     /gene="RASL12"
                     /gene_synonym="RIS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2493..2498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASL12"
                     /gene_synonym="RIS"
                     /note="hexamer: AATAAA"
     polyA_site      2519
                     /gene="RASL12"
                     /gene_synonym="RIS"
                     /note="major polyA site"
ORIGIN      
        1 agcccgctgg acgcggggcc gagggcgcgg acgccgacgg gtccggggcc gcgcgctcca
       61 gggaagcctg catcccgctc ccctgggccc cgacgggcgg gcgcactgcg cggggcccac
      121 cggccgcaga cctgcgtggc cgtccagggc gtcgccatgt cctcggtgtt tggaaaaccc
      181 cgcgcgggca gcgggcctca gagcgcgccc ctcgaggtca acctggccat cctggggcgc
      241 cgcggggctg gcaagtctgc cctgaccgtg aagtttctga ccaagaggtt tatcagtgaa
      301 tatgacccca acttggagga cacctacagc tccgaggaga ctgtggacca ccagcctgtc
      361 cacctgaggg tcatggacac tgcagacctg gacaccccca ggaactgcga gcgctacctg
      421 aactgggccc atgccttcct ggtggtgtac agcgtcgaca gccgccagag ctttgatagc
      481 agcagcagct acctggagct gcttgccttg cacgcgaagg agacacagcg cagcatccct
      541 gccctgctgc tgggcaacaa gctggacatg gctcagtaca ggcaagtcac caaggcagag
      601 ggtgtggctt tggcaggcag gtttgggtgc ctgtttttcg aggtctctgc ctgtctggac
      661 tttgagcacg tgcagcatgt cttccacgag gcagtgcgag aggcacggcg ggagctggag
      721 aagagccccc tgacccggcc cctcttcatc tccgaggaga gggccctgcc ccaccaggcc
      781 ccgctcaccg cgcggcatgg gctggccagc tgcaccttca acacgctctc caccatcaac
      841 ctgaaggaga tgcccactgt ggcccaggcc aagctggtca ccgtgaagtc atcccgggcc
      901 cagagcaagc gcaaggcgcc taccctgact ctcctgaagg gcttcaagat cttctgaggc
      961 cccctcccca ggaagcctag gctcggtggc tggacaggac tgcagcagga cagggactgg
     1021 cttctcacca ccagcctttc cgtctgatgg acagcagacc ccgcctccag caccaagcag
     1081 tgtccctaca ctcaattcac tgtgtgagct ggagtggcag gcagggatgc tgcttctgtt
     1141 ccctccaggc cttggtcttc atggtaacca ccgcgtctgt ggccgtagag ggaaacagcc
     1201 actgtgacaa cccagagacc tggggtcagc cttaagtagg aagaaattgc agtgtctatc
     1261 ctgctgccat cagcccttcc tgctccagct acagttgggc cagctgtggc cttagtggat
     1321 ggtctgggtg gatggctctg tcaatgtcag gcccgagaac agcctgcgga atgacagcct
     1381 ggggtccttg tgccacctgg tggacgggaa aggcagggcg gctgcagttt cagaggccag
     1441 agcctggccc tcctgtcatc tgctgacttc acagaaggcc caggctacaa accccacagt
     1501 ttatccaagg aaaatctagt taaaataatc caatggacag aagccccagg aaggggtatt
     1561 tccaacactt ggcgtctcaa tgaggataaa agggagggac tgtaggttgt ccagcataag
     1621 gagccccaga gttctttcac cagcagacag attctccatg tgttttccca ctgttaagga
     1681 ctctgtccaa agaacctcag catcagctcc ctcaagctta atgatccagg ctgcagaaga
     1741 aagttgtcac tccagtgagt tacccagggc tccagggagc ccacagcagc atcagaccca
     1801 tccaggggct acagggcctg cccccctgca ggtagaaaca cagtataccc gtttgtcatc
     1861 tggtttggca ggacccagga ccctcagcaa tgagtctgag tgttcaaagc ccactttaga
     1921 acctaaagca ttttgggtta ataaagcaaa attttgctta tgttatttgg tggtgtcacc
     1981 gcagcttata ccaagacacc atggctcaga catgggatca ggacacacct ttgagatccc
     2041 actgttagca agaaaaggct gtccaaggca ggcagtgtgg tagttgtctg attttgttta
     2101 ccacacgcca ggtcccaggg aagtcttgca cagactctta gcagacaagc agggaaaaga
     2161 gagggtcctg gtgggtggaa ggattgggaa ggggattctg ggcctggaag cctgctcctt
     2221 cccctctcag ccgtctcagg actactgttg gattgcaaac agcatctctg acccagtctt
     2281 cggactcatt ctgtaaatgg aggagctgag gtcagagggg ggctgtgaac tactcaagac
     2341 cacatgcttg cagtcctaca ggcttcccga cccacaggcc agctacggat tttgcacttt
     2401 tgctccaggc cacttgtgtg tgtatgtgtg tgtgtaccac tgccatctga acaaactatg
     2461 caataccacc tgctcccttc caggagcatt ttaataaaag atttttttta ataacagaa
//
