LOCUS       NM_023940               1968 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens RAS like family 11 member B (RASL11B), mRNA.
ACCESSION   NM_023940
VERSION     NM_023940.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1968)
  AUTHORS   Luo,Y., Wang,A.T., Zhang,Q.F., Liu,R.M. and Xiao,J.H.
  TITLE     RASL11B gene enhances hyaluronic acid-mediated chondrogenic
            differentiation in human amniotic mesenchymal stem cells via the
            activation of Sox9/ERK/smad signals
  JOURNAL   Exp Biol Med (Maywood) 245 (18), 1708-1721 (2020)
   PUBMED   32878463
  REMARK    GeneRIF: RASL11B gene enhances hyaluronic acid-mediated
            chondrogenic differentiation in human amniotic mesenchymal stem
            cells via the activation of Sox9/ERK/smad signals.
REFERENCE   2  (bases 1 to 1968)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1968)
  AUTHORS   Liu,J. and Li,Y.
  TITLE     Upregulation of MAPK10, TUBB2B and RASL11B may contribute to the
            development of neuroblastoma
  JOURNAL   Mol Med Rep 20 (4), 3475-3486 (2019)
   PUBMED   31432180
  REMARK    GeneRIF: the present study identified a novel significant
            association between the increased expression levels of MAPK10,
            TUBB2B and RASL11B, and neuroblastoma cells.
REFERENCE   4  (bases 1 to 1968)
  AUTHORS   He,H., Dai,J., Zhuo,R., Zhao,J., Wang,H., Sun,F., Zhu,Y. and Xu,D.
  TITLE     Study on the mechanism behind lncRNA MEG3 affecting clear cell
            renal cell carcinoma by regulating miR-7/RASL11B signaling
  JOURNAL   J Cell Physiol 233 (12), 9503-9515 (2018)
   PUBMED   29968912
  REMARK    GeneRIF: MEG3 could up-regulate RASL11B to inhibit the cell
            proliferation, invasion, and migration; induce G0/G1 cell cycle
            arrest; and promote cell apoptosis by suppressing miR-7 in clear
            cell renal cell carcinoma.
REFERENCE   5  (bases 1 to 1968)
  AUTHORS   Stolle,K., Schnoor,M., Fuellen,G., Spitzer,M., Cullen,P. and
            Lorkowski,S.
  TITLE     Cloning, genomic organization, and tissue-specific expression of
            the RASL11B gene
  JOURNAL   Biochim Biophys Acta 1769 (7-8), 514-524 (2007)
   PUBMED   17628721
  REMARK    GeneRIF: RASL11B gene is expressed in all tissues investigated,
            with highest levels in placenta & primary macrophages. RASL11B may
            play a role in TGF-beta1-mediated developmental processes & in
            pathophysiologies such as inflammation, cancer, and
            arteriosclerosis.
REFERENCE   6  (bases 1 to 1968)
  AUTHORS   Louro,R., Nakaya,H.I., Paquola,A.C., Martins,E.A., da Silva,A.M.,
            Verjovski-Almeida,S. and Reis,E.M.
  TITLE     RASL11A, member of a novel small monomeric GTPase gene family, is
            down-regulated in prostate tumors
  JOURNAL   Biochem Biophys Res Commun 316 (3), 618-627 (2004)
   PUBMED   15033445
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC023154.5 and BC001087.2.
            
            On Nov 23, 2018 this sequence version replaced NM_023940.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.602430.1,
                                           SRR3476690.442080.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000248706.5/ ENSP00000248706.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC023154.5         71499-71509
            12-1968             BC001087.2         1-1957
FEATURES             Location/Qualifiers
     source          1..1968
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q12"
     gene            1..1968
                     /gene="RASL11B"
                     /note="RAS like family 11 member B"
                     /db_xref="GeneID:65997"
                     /db_xref="HGNC:HGNC:23804"
                     /db_xref="MIM:612404"
     exon            1..333
                     /gene="RASL11B"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..938
                     /gene="RASL11B"
                     /EC_number="3.6.5.2"
                     /codon_start=1
                     /product="ras-like protein family member 11B"
                     /protein_id="NP_076429.1"
                     /db_xref="CCDS:CCDS3490.1"
                     /db_xref="GeneID:65997"
                     /db_xref="HGNC:HGNC:23804"
                     /db_xref="MIM:612404"
                     /translation="MRLIQNMCTIAEYPAPGNAAASDCCVGAAGRRLVKIAVVGASGV
                     GKTALVVRFLTKRFIGDYERNAGNLYTRQVQIEGETLALQVQDTPGIQVHENSLSCSE
                     QLNRCIRWADAVVIVFSITDYKSYELISQLHQHVQQLHLGTRLPVVVVANKADLLHIK
                     QVDPQLGLQLASMLGCSFYEVSVSENYNDVYSAFHVLCKEVSHKQQPSSTPEKRRTSL
                     IPRPKSPNMQDLKRRFKQALSAKVRTVTSV"
     exon            334..390
                     /gene="RASL11B"
                     /inference="alignment:Splign:2.1.0"
     exon            391..467
                     /gene="RASL11B"
                     /inference="alignment:Splign:2.1.0"
     exon            468..1968
                     /gene="RASL11B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1947..1952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASL11B"
                     /note="hexamer: AATAAA"
     polyA_site      1968
                     /gene="RASL11B"
                     /note="major polyA site"
ORIGIN      
        1 agtctgggtc tggagcctga gccctgcgga acctcggcgc tcggccccac cccgcccgta
       61 cctgcactta tttattgttg ttatttctta ccgcggagcc ccgcagtcgg gtcctcccgc
      121 ccgctcccgc gcagcgctag cattctccag tccctcagtc ccttcccgcg cggtgcgccg
      181 cagccgaggc gatgcgcctc attcagaaca tgtgcaccat cgccgagtac cccgcgccgg
      241 gcaacgccgc ggcctccgac tgctgtgtgg gcgccgccgg ccgccgcctg gtcaagatcg
      301 ccgtggtggg cgccagcggc gtgggcaaga ccgcactggt ggtccggttc ctcaccaaac
      361 gattcatcgg tgactatgaa agaaatgcag gtaatctcta tactagacaa gttcagatag
      421 aaggtgaaac cctggctctt caggttcaag acactccagg tattcaggtc catgagaaca
      481 gcctgagctg cagtgaacag ctgaataggt gcattcgctg ggcagatgct gtggtgatcg
      541 ttttctccat cactgactac aagagctatg aactcatcag ccagctccac cagcacgtgc
      601 agcagctaca cctgggcacc cggctgcctg tggtggtcgt ggccaacaaa gctgacctgt
      661 tgcacatcaa acaggttgac cctcagcttg gactgcagct agccagcatg ctaggctgct
      721 cattctatga agtgtctgtc agtgaaaatt ataatgatgt ctacagcgcc ttccacgtcc
      781 tctgtaaaga ggtcagtcac aaacagcagc ctagcagtac acccgagaag cgaagaacct
      841 ccctcattcc caggcccaag tcacccaaca tgcaggacct gaagaggagg tttaagcaag
      901 ccctctctgc caaagtgagg actgtcacct ccgtctgaag caggaggagc actcaagggg
      961 gtttggtctt cccaggaaga gggcctgagg ttctcctagt gcaggaacgt tgaatattgg
     1021 caatgattcc tggttccaga aagggctgga gcagaagggc caagagggcc tgtggaactg
     1081 ctacagaaaa ggaagtgttg ttctgagcag ggggacagga ttgatgaggc ttgaaagagc
     1141 ccactgagcc actctctgaa tatgtgaaat gtactctgtg tcttttcctt tagagtgggg
     1201 agggggcata atcgtttcgg tttctgcatt caactacctt gtaaatggtg gtccgttgca
     1261 gtttcaccaa atgtattgat gtgatttaca gtgggaatga aagaacagat taagcattga
     1321 taggctttct tttttccccc ttttttcttt tttctctttt cttctttctt ttcctctttt
     1381 tccccaagag gaagaattgc ttttctctta ccagtatgat ttgtaactct ggaacactat
     1441 tcttacagaa tgcctttcta acctgaagga tacccagatt tctttcttta tgtacaagat
     1501 ggaaaatccc ctacccctca aaaacaggtt gagtttatgg gccagaatat tttgtatacc
     1561 agacattggt aagctctcat ggtttacagg aaggctctgg ttccccctca caggatgagc
     1621 atgctcagtt gggcgtgtgt ggaggagctg tgaacttcac gctcttcaac cccagacttt
     1681 gactgtatag ttttttgttt ttttaactgt tccatcagga aaaaaatgtg tcagttgatt
     1741 ttggtgtgac ttgtgtaaat ggttcatggc aatgacgttg ggttgcttcc taggcctggc
     1801 tgagttgtgc ctaagggtgg ctgaaatact aaaacactta tcttacagca agtgaacagg
     1861 ggctacctgc cacatcccct ccacagatgc actttaaaaa gccactcatg ctttggctta
     1921 aactgtaatt aatttatttt atgtacaata aatcgcattt gaaaaaga
//
