LOCUS       NM_206827               2542 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens RAS like family 11 member A (RASL11A), transcript
            variant 1, mRNA.
ACCESSION   NM_206827 XM_172905
VERSION     NM_206827.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2542)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2542)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2542)
  AUTHORS   Wangsa,D., Braun,R., Stuelten,C.H., Brown,M., Bauer,K.M., Emons,G.,
            Weston,L.A., Hu,Y., Yang,H.H., Vila-Casadesus,M., Lee,M.P.,
            Brauer,P., Warner,L., Upender,M., Hummon,A.B., Camps,J. and Ried,T.
  TITLE     Induced Chromosomal Aneuploidy Results in Global and Consistent
            Deregulation of the Transcriptome of Cancer Cells
  JOURNAL   Neoplasia 21 (7), 721-729 (2019)
   PUBMED   31174021
  REMARK    GeneRIF: One gene, RASL11A, localized on chromosome band 13q12.2,
            escaped the copy number-induced overexpression and was reproducibly
            and significantly down-regulated on the mRNA and protein level
            (P=.0001, FDR=0.002). RASL11A expression levels were also lower in
            primary colorectal tumors as compared to matched normal mucosa
            (P=.0001, FDR=0.0001
REFERENCE   4  (bases 1 to 2542)
  AUTHORS   Pistoni,M., Verrecchia,A., Doni,M., Guccione,E. and Amati,B.
  TITLE     Chromatin association and regulation of rDNA transcription by the
            Ras-family protein RasL11a
  JOURNAL   EMBO J 29 (7), 1215-1224 (2010)
   PUBMED   20168301
  REMARK    GeneRIF: In transient transfection experiments, RasL11a enhanced
            the transcriptional activity of an RNA polymerase I-specific
            reporter controlled by the rDNA enhancer/promoter region.
REFERENCE   5  (bases 1 to 2542)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   6  (bases 1 to 2542)
  AUTHORS   Louro,R., Nakaya,H.I., Paquola,A.C., Martins,E.A., da Silva,A.M.,
            Verjovski-Almeida,S. and Reis,E.M.
  TITLE     RASL11A, member of a novel small monomeric GTPase gene family, is
            down-regulated in prostate tumors
  JOURNAL   Biochem Biophys Res Commun 316 (3), 618-627 (2004)
   PUBMED   15033445
  REMARK    GeneRIF: RASL11A is down-regulated in prostate tumors as measured
            by quantitative real-time PCR. This result suggests that this gene
            may have a tumor suppressor role in prostate cancer.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL159977.10.
            
            On Aug 7, 2019 this sequence version replaced NM_206827.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY439004.1, BC136761.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000241463.5/ ENSP00000241463.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               AL159977.10        97596-97834
            240-296             AL159977.10        98250-98306
            297-376             AL159977.10        98405-98484
            377-2542            AL159977.10        99793-101958
FEATURES             Location/Qualifiers
     source          1..2542
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.2"
     gene            1..2542
                     /gene="RASL11A"
                     /note="RAS like family 11 member A"
                     /db_xref="GeneID:387496"
                     /db_xref="HGNC:HGNC:23802"
                     /db_xref="MIM:612403"
     exon            1..239
                     /gene="RASL11A"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..844
                     /gene="RASL11A"
                     /EC_number="3.6.5.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ras-like protein family member 11A"
                     /codon_start=1
                     /product="ras-like protein family member 11A isoform 1"
                     /protein_id="NP_996563.1"
                     /db_xref="CCDS:CCDS9321.1"
                     /db_xref="GeneID:387496"
                     /db_xref="HGNC:HGNC:23802"
                     /db_xref="MIM:612403"
                     /translation="MRPLSMSGHFLLAPIPESSSDYLLPKDIKLAVLGAGRVGKSAMI
                     VRFLTKRFIGDYEPNTGKLYSRLVYVEGDQLSLQIQDTPGGVQIQDSLPQVVDSLSKC
                     VQWAEGFLLVYSITDYDSYLSIRPLYQHIRKVHPDSKAPVIIVGNKGDLLHARQVQTQ
                     DGIQLANELGSLFLEISTSENYEDVCDVFQHLCKEVSKMHGLSGERRRASIIPRPRSP
                     NMQDLKRRFKQALSPKVKAPSALG"
     exon            240..296
                     /gene="RASL11A"
                     /inference="alignment:Splign:2.1.0"
     exon            297..376
                     /gene="RASL11A"
                     /inference="alignment:Splign:2.1.0"
     exon            377..2542
                     /gene="RASL11A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1009..1014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASL11A"
                     /note="hexamer: GATAAA"
     polyA_site      1036
                     /gene="RASL11A"
                     /note="major polyA site"
     regulatory      1095..1100
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASL11A"
                     /note="hexamer: ATTAAA"
     polyA_site      1118
                     /gene="RASL11A"
                     /note="major polyA site"
     regulatory      1441..1446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASL11A"
                     /note="hexamer: ATTAAA"
     polyA_site      1466
                     /gene="RASL11A"
     regulatory      2507..2512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASL11A"
                     /note="hexamer: AATAAA"
     polyA_site      2542
                     /gene="RASL11A"
ORIGIN      
        1 aggcagccgc cgcggtcccg gacctctagt cccgcactcc cagctggcga gccggctccg
       61 ggtgcggcga ggcccagccc tctcggattg cgcgccggac cccgggacgc gctccatgcg
      121 gccgctcagc atgtccgggc actttctgct cgcacccatc cccgagtcct cctcggacta
      181 cctactgccc aaggacatca aactggcggt gctgggcgcc ggccgcgtgg gcaagagcgc
      241 aatgatcgtg cgcttcctga ccaagagatt cattggagac tatgaaccga atacaggcaa
      301 gctgtattca cggctggtct atgtcgaggg ggaccagctc tccctgcaga tccaggatac
      361 tcccgggggc gtccagatcc aagacagcct cccccaggtc gtcgattccc tgtccaaatg
      421 cgtgcagtgg gccgagggtt ttctgctggt ctattccatc acagactatg acagctactt
      481 gtccatccga cccctttatc agcacatccg gaaggtccac cctgactcta aagcccctgt
      541 catcatcgtg ggcaacaagg gggacctttt gcatgcccgg caggtgcaga cacaggacgg
      601 tattcagcta gccaatgagc tgggcagcct gttccttgaa atttccacta gcgaaaacta
      661 cgaagatgtc tgtgatgtgt ttcagcatct ctgcaaagaa gtgagcaaga tgcacggcct
      721 cagtggggaa agaagaagag cctccatcat ccctcggccc cgctctccca acatgcagga
      781 cctgaagaga cgcttcaagc aggctctgtc tcccaaagtc aaagccccct ctgcactggg
      841 gtgaactatc tcagacagat gcctctcctt tttaatacgc atttgtgcag ctaaaagact
      901 gggcttctcg ctttttaatc acacattcag agtttatttt tataaaaaaa ttgattttca
      961 agtacatgtg tatttctgaa aattcaaaca gtgattgcct agaagctgga taaaattttg
     1021 ttttgtttta ttaaaagaac tttttttttt tttttttttt tttttttttt actgtaactg
     1081 ctggccactt ttccattaaa ggcaaaatgg caacattgct cattgttttc tcaatgtctt
     1141 tttatagaaa ttgtacttgc accagcgccc agtgctgctc catgcttgcc ctcagtctga
     1201 actctgattg gtgtctcgca gtggggagga gttcatgtag agggagtctg ttgtgggaga
     1261 aaggaaagta tgtggaggag gagagggatt ttaataacgg caggaggtct ttaaatggga
     1321 cactgccacc agtcatgaaa ttgacactgt gtgattttca agggaagggg tacaatgcta
     1381 aaacgttaca agccatgagt aacatttatt ggtgcaaatg caagtttata ctctacccat
     1441 attaaaaaac aacccctttt ctagtattcc ttatgtcagt aagtggaccc taccacccaa
     1501 aagttgcctc aaaattctcc ttcccttcca atagggcacc agatatgtcc atcctcactc
     1561 ctgtttttct ctaaagcctc actgtccctt aatctagacc tccctttgac tggcaggcaa
     1621 gaatctaggc aagactcatg tttcttgcct tctagaatga catctcctaa ttgtctcttc
     1681 acatcagaac aatgctacta aaactaaccc taatcatttt atttctataa aaaacccagc
     1741 tggtttcccc ttagctactg gttaagatag acatgagaca tggcatcaag attctttacc
     1801 acctctccag gcttatcaac ccctccttcc aaaacacaca ccagcagtca gtccattcca
     1861 acagattgtc tttctcagct gctccaggct ctttcatgtc ttcctgcctt ggcacaaact
     1921 atccctttgc ctcaaatatt ttttctgatt ctacacataa tggcttgcta actcatcttt
     1981 aaaaacccaa gtcacatgct atattcagct ctgaaatgcc ttctctggtc ttcctctatt
     2041 cctggagcat ttgtgttata acccaaccct gtcaggtagc tatttgttac tccattagaa
     2101 ggagtccccc tcgagggcag tagctgcatt ttatgatcct gtcttccaat cttctagttc
     2161 agtgcttccc catagagtgg taagttttaa gtaaacatat aatgaataaa tgaatgaatg
     2221 caccacttat ggtgccaagg gtcaatgatg ggagattacc atgaaacaaa ttgttacttc
     2281 tgcagggcaa ggacaggtgt tctgagtaat taaagatagc tgtggtggaa agggactgac
     2341 atatgcagct tctggcaatc acagaccatt acccttccaa aaggacagct ctgtccagac
     2401 ctgtgatgtc agcaccactt ttccctgtag ttgaagggag tctacctata caaaatggca
     2461 tgaagggtta agaaaattag atgatgcatg tctaaaagag tgtccaaata aaatattaat
     2521 ttggattcca tcttttaaaa aa
//
