LOCUS       NM_033315               3215 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens RAS like family 10 member B (RASL10B), mRNA.
ACCESSION   NM_033315
VERSION     NM_033315.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3215)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3215)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3215)
  AUTHORS   Rybkin,I.I., Kim,M.S., Bezprozvannaya,S., Qi,X., Richardson,J.A.,
            Plato,C.F., Hill,J.A., Bassel-Duby,R. and Olson,E.N.
  TITLE     Regulation of atrial natriuretic peptide secretion by a novel
            Ras-like protein
  JOURNAL   J Cell Biol 179 (3), 527-537 (2007)
   PUBMED   17984325
  REMARK    GeneRIF: RRP17 is a component of the cellular machinery involved in
            regulated secretion within the heart and potential mediator of the
            endocrine influence of the heart on other tissues
REFERENCE   4  (bases 1 to 3215)
  AUTHORS   Zou,H., Hu,L., Li,J., Zhan,S. and Cao,K.
  TITLE     Cloning and characterization of a novel small monomeric GTPase,
            RasL10B, with tumor suppressor potential
  JOURNAL   Biotechnol Lett 28 (23), 1901-1908 (2006)
   PUBMED   17028781
  REMARK    GeneRIF: RasL10B is a new member of Ras superfamily with tumor
            suppressor potential
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006237.1, AK122652.1, BC041133.1 and DA250459.1.
            
            On May 17, 2019 this sequence version replaced NM_033315.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC041133.1, AK122652.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000603017.2/ ENSP00000474230.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AC006237.1         56340-56360         c
            22-712              AK122652.1         1-691
            713-1803            BC041133.1         613-1703
            1804-1957           DA250459.1         380-533
            1958-3188           AC006237.1         44505-45735         c
            3189-3215           BC041133.1         3088-3114
FEATURES             Location/Qualifiers
     source          1..3215
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..3215
                     /gene="RASL10B"
                     /gene_synonym="RRP17; VTS58635"
                     /note="RAS like family 10 member B"
                     /db_xref="GeneID:91608"
                     /db_xref="HGNC:HGNC:30295"
                     /db_xref="MIM:612128"
     exon            1..240
                     /gene="RASL10B"
                     /gene_synonym="RRP17; VTS58635"
                     /inference="alignment:Splign:2.1.0"
     exon            241..603
                     /gene="RASL10B"
                     /gene_synonym="RRP17; VTS58635"
                     /inference="alignment:Splign:2.1.0"
     CDS             388..999
                     /gene="RASL10B"
                     /gene_synonym="RRP17; VTS58635"
                     /EC_number="3.6.5.2"
                     /note="ras-like protein VTS58635; Ras-related protein 17;
                     alternative protein RASL10B"
                     /codon_start=1
                     /product="ras-like protein family member 10B"
                     /protein_id="NP_201572.1"
                     /db_xref="CCDS:CCDS11297.1"
                     /db_xref="GeneID:91608"
                     /db_xref="HGNC:HGNC:30295"
                     /db_xref="MIM:612128"
                     /translation="MVSTYRVAVLGARGVGKSAIVRQFLYNEFSEVCVPTTARRLYLP
                     AVVMNGHVHDLQILDFPPISAFPVNTLQEWADTCCRGLRSVHAYILVYDICCFDSFEY
                     VKTIRQQILETRVIGTSETPIIIVGNKRDLQRGRVIPRWNVSHLVRKTWKCGYVECSA
                     KYNWHILLLFSELLKSVGCARCKHVHAALRFQGALRRNRCAIM"
     exon            604..728
                     /gene="RASL10B"
                     /gene_synonym="RRP17; VTS58635"
                     /inference="alignment:Splign:2.1.0"
     exon            729..3215
                     /gene="RASL10B"
                     /gene_synonym="RRP17; VTS58635"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3180..3185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASL10B"
                     /gene_synonym="RRP17; VTS58635"
                     /note="hexamer: ATTAAA"
     polyA_site      3215
                     /gene="RASL10B"
                     /gene_synonym="RRP17; VTS58635"
                     /note="major polyA site"
ORIGIN      
        1 cttccagcgc gagcaggcgg cgcgctccgg agggagagct ggggctggag gttcctaccc
       61 cctcggcggc ccgcatctgc ccccgcgcgc ccgccctgag cccgccccga ctgggcaggc
      121 gggggagccc ctacttctct ccccccgggc gggggagccg gggggcagcg ccggagcccg
      181 gggggagctc agccccgccg accggccggc cagggcaggg ggcagctagg acggccccgg
      241 tccaggtgga ggccgcagag ggcccagggc aagcagaggc agcaatggtt ggtcctgacg
      301 gtggctgagc ccccagcccc tggaatatgc agcccggggg agccccagac agcggcaagg
      361 acgaggtggc ggagtggggc gggaggcatg gtctccacct accgggtggc cgtgctgggg
      421 gcgcgaggtg tgggcaagag tgccatcgtg cgccagttct tgtacaacga gttcagcgag
      481 gtctgcgtcc ccaccaccgc ccgccgcctt tacctgcctg ctgtcgtcat gaacggccac
      541 gtgcacgacc tccagatcct cgactttcca cccatcagcg ccttccctgt caatacgctc
      601 caggagtggg cagacacctg ctgcagggga ctccggagtg tccacgccta catcctggtc
      661 tacgacatct gctgctttga cagctttgag tacgtcaaga ccatccgcca gcagatcctg
      721 gagacgaggg tgatcggaac ctcagagacg cccatcatca tcgtgggcaa caagcgggac
      781 ctgcagcgcg gacgcgtgat cccgcgctgg aacgtgtcgc acctggtacg caagacctgg
      841 aagtgcggct acgtggaatg ctcggccaag tacaactggc acatcctgct gctcttcagc
      901 gagctgctca agagcgtcgg ctgcgcccgt tgcaagcacg tgcacgctgc cctgcgcttc
      961 cagggcgcgc tgcgccgcaa ccgctgcgcc atcatgtgac gcctgcgcgc ccctcgggct
     1021 gcaccggcac tggccgagcg gagggcgggg ccgtactgcg gggctggggc ggggagcggg
     1081 cgggaaatgg aactgtgacg gtcccggcct gaggcccctg cagccacgca cctcccggtg
     1141 agaagcagag cgcgagaggg agccctccgt aactgcccag ccctgcccct tgcccccgtg
     1201 gcttcctggg acagccgcct tcagtgctgt atttagtgca gtgcccggcc cgacccgcgg
     1261 gggtgccaca gccttttggg atgggggtga gcgtgcaatg gaggctgggg gtggcgaggt
     1321 gccgccttgg ccgggccccc acgtgtcttc tccagaatgt gtctgtcttt gcctggtgtc
     1381 ttcctttccc gtgtccgccc accccagcgt ctgttggtac ttacctgtct cacctaccct
     1441 ccagtcccct cccagctccg ctcacagggc tctcatttcg tccatcccct tgtcgcagat
     1501 cctggcagct tctttgtgag gccaggcctt ctgactgtca gcaccaccgg cacagggcag
     1561 agatgcgggt ggcccaagga ccacgatcaa ggggtccggg ggaccgaggt cccagatcag
     1621 tgaggggaga aggttgagct ctccggcttc cagggagacc tccccgccca gcagccccca
     1681 gagacacaac aacctacctt ccagccttaa ctcgatggtc cgtccctgcc aggtgcccct
     1741 cactcttcct gaccccaaag ccagatcacc ccctgggtta aaactttttt tctttttttt
     1801 ttttggacag agtgtggaaa gggagccccc caaaggatag cttctttttc atgatgccag
     1861 gctccagtcc tttattccct tctgcatact gcaatctgat ctgtcagact ggggaatgtt
     1921 gggttctggg gtctggtcgt gggcaggatg gtgcccagaa gggggttagg ttgtcccagt
     1981 gaaaattctg ttgccccgtc tcaaccccat ctgactaccc cagactctgc ctgcctcaga
     2041 tctcagacta tcctgattaa tctggggaag aacagagcca gggaaagaat ggtggggacc
     2101 cctgtacttg ggggagacac acctgcatct tcctcctgcc acagatggag gccctcagga
     2161 tctgacaccc tcttgtccca acaccagtca gccctatacc ctaactcact ccaccccatt
     2221 ttctccggct gcctggccgg gtttctacct ctcgtcaccg gagctgatca ctgtcagttt
     2281 tgtaccgatt tagaaataac aataataatg aagattctag gaatggcatg agggattgat
     2341 gggggacttg gagggaggga caagtggtgc cctgtcccct gctcccctgg ccaaagaaag
     2401 ctgtccttga ggctgagccc tcagccctgg cctggtgggg ggacagcaag gtcccttgtt
     2461 ataagagggg cagagaggac aactccgctt tggccaacct agccaaggct gcagcatata
     2521 gaccaggaaa tcaggtagcc cagactggtg atggagcaga gtctggggga agggtcgtgg
     2581 gtggggaatt tatcaccaac atccattgta gggggaatct atgattctgc ttccccagcg
     2641 gattcccact ctgtccacca agtggggggt agcacagcct cacagcaacc gccctgacct
     2701 tgggcagtct agtgttcctg cattctagtc cctgctgtgc tgcaggactt tgggcaagtg
     2761 acctgccctc tgtgagcctc cctctgacac agaggaggtg gctccccttc cccacacctt
     2821 agagtggctg ggagggtaac aaagagggcc tgccccttta gtctcctgca cccctgcccc
     2881 ctggttcacc agagggagcg gatgaaggat ggcagcatct cacatgcccc atcaccaact
     2941 ctgaggcacc tggggtgggg gggcggagcc caggcctctg gctgctcccc tgtgggagcc
     3001 attggaatgt atcccctgac aggccccctt ccgcctccac ctcaacccag gtcttggatt
     3061 tcaggtccct ccacccccat tctgagtctc tgtccttctc cttccacccg ctcccagggt
     3121 ttcccaccac agggtctgga agtgtgtgtg acgcccattg agctgttacc cgaagtcaga
     3181 ttaaaaatca gggagtgttt tccctcgttt ctgta
//
