LOCUS       NM_006477               1431 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens RAS like family 10 member A (RASL10A), mRNA.
ACCESSION   NM_006477
VERSION     NM_006477.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1431)
  AUTHORS   Wolpin,B.M., Rizzato,C., Kraft,P., Kooperberg,C., Petersen,G.M.,
            Wang,Z., Arslan,A.A., Beane-Freeman,L., Bracci,P.M., Buring,J.,
            Canzian,F., Duell,E.J., Gallinger,S., Giles,G.G., Goodman,G.E.,
            Goodman,P.J., Jacobs,E.J., Kamineni,A., Klein,A.P., Kolonel,L.N.,
            Kulke,M.H., Li,D., Malats,N., Olson,S.H., Risch,H.A., Sesso,H.D.,
            Visvanathan,K., White,E., Zheng,W., Abnet,C.C., Albanes,D.,
            Andreotti,G., Austin,M.A., Barfield,R., Basso,D., Berndt,S.I.,
            Boutron-Ruault,M.C., Brotzman,M., Buchler,M.W.,
            Bueno-de-Mesquita,H.B., Bugert,P., Burdette,L., Campa,D.,
            Caporaso,N.E., Capurso,G., Chung,C., Cotterchio,M., Costello,E.,
            Elena,J., Funel,N., Gaziano,J.M., Giese,N.A., Giovannucci,E.L.,
            Goggins,M., Gorman,M.J., Gross,M., Haiman,C.A., Hassan,M.,
            Helzlsouer,K.J., Henderson,B.E., Holly,E.A., Hu,N., Hunter,D.J.,
            Innocenti,F., Jenab,M., Kaaks,R., Key,T.J., Khaw,K.T., Klein,E.A.,
            Kogevinas,M., Krogh,V., Kupcinskas,J., Kurtz,R.C., LaCroix,A.,
            Landi,M.T., Landi,S., Le Marchand,L., Mambrini,A., Mannisto,S.,
            Milne,R.L., Nakamura,Y., Oberg,A.L., Owzar,K., Patel,A.V.,
            Peeters,P.H., Peters,U., Pezzilli,R., Piepoli,A., Porta,M.,
            Real,F.X., Riboli,E., Rothman,N., Scarpa,A., Shu,X.O.,
            Silverman,D.T., Soucek,P., Sund,M., Talar-Wojnarowska,R.,
            Taylor,P.R., Theodoropoulos,G.E., Thornquist,M., Tjonneland,A.,
            Tobias,G.S., Trichopoulos,D., Vodicka,P., Wactawski-Wende,J.,
            Wentzensen,N., Wu,C., Yu,H., Yu,K., Zeleniuch-Jacquotte,A.,
            Hoover,R., Hartge,P., Fuchs,C., Chanock,S.J.,
            Stolzenberg-Solomon,R.S. and Amundadottir,L.T.
  TITLE     Genome-wide association study identifies multiple susceptibility
            loci for pancreatic cancer
  JOURNAL   Nat Genet 46 (9), 994-1000 (2014)
   PUBMED   25086665
REFERENCE   2  (bases 1 to 1431)
  AUTHORS   Chen,R., Yang,L., Fang,J., Huo,L., Zhang,M., Chen,F., Liu,J., Wu,J.
            and Wang,Y.
  TITLE     RRP22: a novel neural tumor suppressor for astrocytoma
  JOURNAL   Med Oncol 29 (1), 332-339 (2012)
   PUBMED   21264544
  REMARK    GeneRIF: RRP22 is a special neural tumor suppressor for human
            astrocytomas
REFERENCE   3  (bases 1 to 1431)
  AUTHORS   Schmidt,N., Windmann,S., Reifenberger,G. and Riemenschneider,M.J.
  TITLE     DNA hypermethylation and histone modifications downregulate the
            candidate tumor suppressor gene RRP22 on 22q12 in human gliomas
  JOURNAL   Brain Pathol 22 (1), 17-25 (2012)
   PUBMED   21631628
  REMARK    GeneRIF: Both 5'-CpG island hypermethylation and histone
            modifications contribute to the frequent and prognostically
            unfavorable transcriptional downregulation of RRP22 in malignant
            gliomas.
REFERENCE   4  (bases 1 to 1431)
  AUTHORS   Roizen,N.J., Higgins,A.M., Antshel,K.M., Fremont,W., Shprintzen,R.
            and Kates,W.R.
  TITLE     22q11.2 deletion syndrome: are motor deficits more than expected
            for IQ level?
  JOURNAL   J Pediatr 157 (4), 658-661 (2010)
   PUBMED   20646714
  REMARK    GeneRIF: chromosome 22 have specific motor deficits in axial
            stability and graphomotor skills.
REFERENCE   5  (bases 1 to 1431)
  AUTHORS   Rybkin,I.I., Kim,M.S., Bezprozvannaya,S., Qi,X., Richardson,J.A.,
            Plato,C.F., Hill,J.A., Bassel-Duby,R. and Olson,E.N.
  TITLE     Regulation of atrial natriuretic peptide secretion by a novel
            Ras-like protein
  JOURNAL   J Cell Biol 179 (3), 527-537 (2007)
   PUBMED   17984325
REFERENCE   6  (bases 1 to 1431)
  AUTHORS   Elam,C., Hesson,L., Vos,M.D., Eckfeld,K., Ellis,C.A., Bell,A.,
            Krex,D., Birrer,M.J., Latif,F. and Clark,G.J.
  TITLE     RRP22 is a farnesylated, nucleolar, Ras-related protein with tumor
            suppressor potential
  JOURNAL   Cancer Res 65 (8), 3117-3125 (2005)
   PUBMED   15833841
  REMARK    GeneRIF: RRP22 localizes to the nucleolus in a GTP-dependent manner
            and can serve as a potential tumor suppressor.
REFERENCE   7  (bases 1 to 1431)
  AUTHORS   Wennerberg,K., Rossman,K.L. and Der,C.J.
  TITLE     The Ras superfamily at a glance
  JOURNAL   J Cell Sci 118 (Pt 5), 843-846 (2005)
   PUBMED   15731001
  REMARK    Review article
REFERENCE   8  (bases 1 to 1431)
  AUTHORS   Zucman-Rossi,J., Legoix,P. and Thomas,G.
  TITLE     Identification of new members of the Gas2 and Ras families in the
            22q12 chromosome region
  JOURNAL   Genomics 38 (3), 247-254 (1996)
   PUBMED   8975699
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC002059.3, Y07847.1 and BX111994.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006477.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022473.1, Y07847.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154405, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216101.7/ ENSP00000216101.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-436               AC002059.3         33194-33629         c
            437-1426            Y07847.1           307-1296
            1427-1431           BX111994.1         533-537
FEATURES             Location/Qualifiers
     source          1..1431
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.2"
     gene            1..1431
                     /gene="RASL10A"
                     /gene_synonym="RRP22"
                     /note="RAS like family 10 member A"
                     /db_xref="GeneID:10633"
                     /db_xref="HGNC:HGNC:16954"
                     /db_xref="MIM:602220"
     exon            1..670
                     /gene="RASL10A"
                     /gene_synonym="RRP22"
                     /inference="alignment:Splign:2.1.0"
     CDS             452..1063
                     /gene="RASL10A"
                     /gene_synonym="RRP22"
                     /EC_number="3.6.5.2"
                     /note="ras-like protein RRP22; ras-related protein on
                     chromosome 22"
                     /codon_start=1
                     /product="ras-like protein family member 10A"
                     /protein_id="NP_006468.1"
                     /db_xref="CCDS:CCDS13854.1"
                     /db_xref="GeneID:10633"
                     /db_xref="HGNC:HGNC:16954"
                     /db_xref="MIM:602220"
                     /translation="MGGSLRVAVLGAPGVGKTAIIRQFLFGDYPERHRPTDGPRLYRP
                     AVLLDGAVYDLSIRDGDVAGPGSSPGGPEEWPDAKDWSLQDTDAFVLVYDICSPDSFD
                     YVKALRQRIAETRPAGAPEAPILVVGNKRDRQRLRFGPRRALAALVRRGWRCGYLECS
                     AKYNWHVLRLFRELLRCALVRARPAHPALRLQGALHPARCSLM"
     exon            671..795
                     /gene="RASL10A"
                     /gene_synonym="RRP22"
                     /inference="alignment:Splign:2.1.0"
     exon            796..1431
                     /gene="RASL10A"
                     /gene_synonym="RRP22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1410..1415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASL10A"
                     /gene_synonym="RRP22"
                     /note="hexamer: AATAAA"
     polyA_site      1431
                     /gene="RASL10A"
                     /gene_synonym="RRP22"
                     /note="major polyA site"
ORIGIN      
        1 gactccaggc gcggaagcga gagaaggata gaggcacaga ggctccggga ggcagcgctg
       61 ccccccgcgc cccgcaccgc tgcgggaccc gcgccgcgag aggggcggac ttcggcgcct
      121 cgcgcgtccg ccggcgcctg ggttggcgct gcggggcgga ggcggtgtct gagcgccgct
      181 ccggctctgc tctctctcga gcttcggcac ccgcccgagc cgctcgcgcg cccgccacct
      241 gtctgcccac tcggctgtct gtctgccctc ccgccgccag ctcctgcctc gggcctgccc
      301 tctccggtct cggtgctccg aggggcgacg agaagcgcga cggggccgtg gcgcaccggg
      361 cagggcgcgc ggggcgcacg gcctgggggc gcacggtgcg gcgccggccc atgaggcttt
      421 ccagcgcggg gagcgacagc gccggccggc catggggggt agcctgcggg tggccgttct
      481 aggcgccccg ggcgtgggca agacggccat catccgccag ttcctgttcg gtgactaccc
      541 cgagcgccac cggcccacgg acgggccgcg cctctaccga cccgcggtgc tgctcgacgg
      601 cgccgtctac gacttgagca tccgcgacgg cgacgtcgct ggccccggct cgagccccgg
      661 gggtccggag gagtggccag acgctaagga ctggagcttg caggacacgg acgccttcgt
      721 gctcgtctac gacatctgca gcccggacag tttcgactac gtgaaggccc tgcggcagcg
      781 catcgcggag accaggccgg cgggcgcgcc cgaagcgccc atcctcgtgg taggcaacaa
      841 gcgggacagg cagcggctgc gcttcggacc gcggcgcgcg ctggccgccc tagtgcgcag
      901 gggctggcgc tgcggctacc tcgagtgctc cgccaagtac aactggcacg tgctgcgtct
      961 cttccgcgag ctgctgcgct gcgctctggt gcgcgcgcgc cctgcacacc cggccctgcg
     1021 cctgcagggg gcgctgcatc ccgcgcgctg cagcctcatg tgacccgatc ggacagtgcc
     1081 atccatgggc cccaccttgt gactgggaca atcagggacc tggattggac gggatcgccc
     1141 aacttcactg ggactggaca gggaagtctc cgccctgatt ggatgaggaa agctccaacc
     1201 cagtctccta agcgactggc ccccttttga acctcattgg acccaaccag gtcccaagct
     1261 ccattggaga tgaccagtcc tttctgggac ctcaatgggt cacaatccca ttggatggaa
     1321 aggacttggc tatgaacttg actggaaaca cgcagcctgc tcctggagct tcactggaca
     1381 tattctttat gccacaccta ccacgggata ataaaaggga aaataatttg a
//
