LOCUS       NM_017805               3199 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens Ras interacting protein 1 (RASIP1), mRNA.
ACCESSION   NM_017805
VERSION     NM_017805.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3199)
  AUTHORS   Xing,X., Wang,X., Liu,M., Guo,Q. and Wang,H.
  TITLE     Ras interacting protein 1 facilitated proliferation and invasion of
            diffuse large B-cell lymphoma cells
  JOURNAL   Cancer Biol Ther 24 (1), 2193114 (2023)
   PUBMED   36967521
  REMARK    GeneRIF: Ras interacting protein 1 facilitated proliferation and
            invasion of diffuse large B-cell lymphoma cells.
REFERENCE   2  (bases 1 to 3199)
  AUTHORS   Rossi,T., Pistoni,M., Sancisi,V., Gobbi,G., Torricelli,F.,
            Donati,B., Ribisi,S., Gugnoni,M. and Ciarrocchi,A.
  TITLE     RAIN Is a Novel Enhancer-Associated lncRNA That Controls RUNX2
            Expression and Promotes Breast and Thyroid Cancer
  JOURNAL   Mol Cancer Res 18 (1), 140-152 (2020)
   PUBMED   31624086
  REMARK    GeneRIF: RAIN Is a Novel Enhancer-Associated lncRNA That Controls
            RUNX2 Expression and Promotes Breast and Thyroid Cancer.
REFERENCE   3  (bases 1 to 3199)
  AUTHORS   Gingras,A.R., Puzon-McLaughlin,W., Bobkov,A.A. and Ginsberg,M.H.
  TITLE     Structural Basis of Dimeric Rasip1 RA Domain Recognition of the Ras
            Subfamily of GTP-Binding Proteins
  JOURNAL   Structure 24 (12), 2152-2162 (2016)
   PUBMED   27839947
  REMARK    GeneRIF: Results show that Rasip1 RA domain formed a dimer that can
            bind two Rap1 or Ras molecules and solved the Rap1-RRA complex and
            found that Rasip1 binds Rap1 in the Switch I region, and Rap1
            binding induces few conformation changes to Rasip1 stabilizing a
            beta strand and an unstructured loop.
REFERENCE   4  (bases 1 to 3199)
  AUTHORS   de Kreuk,B.J., Gingras,A.R., Knight,J.D., Liu,J.J., Gingras,A.C.
            and Ginsberg,M.H.
  TITLE     Heart of glass anchors Rasip1 at endothelial cell-cell junctions to
            support vascular integrity
  JOURNAL   Elife 5, e11394 (2016)
   PUBMED   26780829
  REMARK    GeneRIF: These studies establish that the binding of HEG1 to Rasip1
            mediates Rap1-dependent recruitment of Rasip1 to and stabilization
            of endothelial cell cell-cell junctions.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3199)
  AUTHORS   Keene,K.L., Chen,W.M., Chen,F., Williams,S.R., Elkhatib,S.D.,
            Hsu,F.C., Mychaleckyj,J.C., Doheny,K.F., Pugh,E.W., Ling,H.,
            Laurie,C.C., Gogarten,S.M., Madden,E.B., Worrall,B.B. and Sale,M.M.
  TITLE     Genetic Associations with Plasma B12, B6, and Folate Levels in an
            Ischemic Stroke Population from the Vitamin Intervention for Stroke
            Prevention (VISP) Trial
  JOURNAL   Front Public Health 2, 112 (2014)
   PUBMED   25147783
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3199)
  AUTHORS   McKnight,N.C., Jefferies,H.B., Alemu,E.A., Saunders,R.E.,
            Howell,M., Johansen,T. and Tooze,S.A.
  TITLE     Genome-wide siRNA screen reveals amino acid starvation-induced
            autophagy requires SCOC and WAC
  JOURNAL   EMBO J 31 (8), 1931-1946 (2012)
   PUBMED   22354037
REFERENCE   7  (bases 1 to 3199)
  CONSRTM   Psychiatric GWAS Consortium Bipolar Disorder Working Group
  TITLE     Large-scale genome-wide association analysis of bipolar disorder
            identifies a new susceptibility locus near ODZ4
  JOURNAL   Nat Genet 43 (10), 977-983 (2011)
   PUBMED   21926972
  REMARK    Erratum:[Nat Genet. 2012 Sep;44(9):1072. Fullerton, Janice M
            [added]; Hyoun, Phil L [corrected to Lee, Phil H]; Meng, Fan Guo
            [corrected to Meng, Fan]]
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3199)
  AUTHORS   Franke,A., McGovern,D.P., Barrett,J.C., Wang,K.,
            Radford-Smith,G.L., Ahmad,T., Lees,C.W., Balschun,T., Lee,J.,
            Roberts,R., Anderson,C.A., Bis,J.C., Bumpstead,S., Ellinghaus,D.,
            Festen,E.M., Georges,M., Green,T., Haritunians,T., Jostins,L.,
            Latiano,A., Mathew,C.G., Montgomery,G.W., Prescott,N.J.,
            Raychaudhuri,S., Rotter,J.I., Schumm,P., Sharma,Y., Simms,L.A.,
            Taylor,K.D., Whiteman,D., Wijmenga,C., Baldassano,R.N., Barclay,M.,
            Bayless,T.M., Brand,S., Buning,C., Cohen,A., Colombel,J.F.,
            Cottone,M., Stronati,L., Denson,T., De Vos,M., D'Inca,R.,
            Dubinsky,M., Edwards,C., Florin,T., Franchimont,D., Gearry,R.,
            Glas,J., Van Gossum,A., Guthery,S.L., Halfvarson,J.,
            Verspaget,H.W., Hugot,J.P., Karban,A., Laukens,D., Lawrance,I.,
            Lemann,M., Levine,A., Libioulle,C., Louis,E., Mowat,C., Newman,W.,
            Panes,J., Phillips,A., Proctor,D.D., Regueiro,M., Russell,R.,
            Rutgeerts,P., Sanderson,J., Sans,M., Seibold,F., Steinhart,A.H.,
            Stokkers,P.C., Torkvist,L., Kullak-Ublick,G., Wilson,D.,
            Walters,T., Targan,S.R., Brant,S.R., Rioux,J.D., D'Amato,M.,
            Weersma,R.K., Kugathasan,S., Griffiths,A.M., Mansfield,J.C.,
            Vermeire,S., Duerr,R.H., Silverberg,M.S., Satsangi,J.,
            Schreiber,S., Cho,J.H., Annese,V., Hakonarson,H., Daly,M.J. and
            Parkes,M.
  TITLE     Genome-wide meta-analysis increases to 71 the number of confirmed
            Crohn's disease susceptibility loci
  JOURNAL   Nat Genet 42 (12), 1118-1125 (2010)
   PUBMED   21102463
REFERENCE   9  (bases 1 to 3199)
  AUTHORS   Ikram,M.K., Sim,X., Jensen,R.A., Cotch,M.F., Hewitt,A.W.,
            Ikram,M.A., Wang,J.J., Klein,R., Klein,B.E., Breteler,M.M.,
            Cheung,N., Liew,G., Mitchell,P., Uitterlinden,A.G., Rivadeneira,F.,
            Hofman,A., de Jong,P.T., van Duijn,C.M., Kao,L., Cheng,C.Y.,
            Smith,A.V., Glazer,N.L., Lumley,T., McKnight,B., Psaty,B.M.,
            Jonasson,F., Eiriksdottir,G., Aspelund,T., Harris,T.B.,
            Launer,L.J., Taylor,K.D., Li,X., Iyengar,S.K., Xi,Q.,
            Sivakumaran,T.A., Mackey,D.A., Macgregor,S., Martin,N.G.,
            Young,T.L., Bis,J.C., Wiggins,K.L., Heckbert,S.R., Hammond,C.J.,
            Andrew,T., Fahy,S., Attia,J., Holliday,E.G., Scott,R.J.,
            Islam,F.M., Rotter,J.I., McAuley,A.K., Boerwinkle,E., Tai,E.S.,
            Gudnason,V., Siscovick,D.S., Vingerling,J.R. and Wong,T.Y.
  CONSRTM   Global BPgen Consortium
  TITLE     Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the
            microcirculation in vivo
  JOURNAL   PLoS Genet 6 (10), e1001184 (2010)
   PUBMED   21060863
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
            Erratum:[PLoS Genet. 2010;6(11). doi:
            10.1371/annotation/841bfadf-85d1-4059-894f-2863d73fa963. Xueling,
            Sim [corrected to Sim, Xueling]]
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3199)
  AUTHORS   Mitin,N.Y., Ramocki,M.B., Zullo,A.J., Der,C.J., Konieczny,S.F. and
            Taparowsky,E.J.
  TITLE     Identification and characterization of rain, a novel
            Ras-interacting protein with a unique subcellular localization
  JOURNAL   J Biol Chem 279 (21), 22353-22361 (2004)
   PUBMED   15031288
  REMARK    GeneRIF: Rain is a novel protein that can serve as an effector of
            endomembrane-localized Ras
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC042111.1, BC028614.1 and BC021860.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017805.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028614.1, AY378097.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222145.9/ ENSP00000222145.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               BC042111.1         112-286
            176-2310            BC028614.1         151-2285
            2311-3199           BC021860.1         544-1432
FEATURES             Location/Qualifiers
     source          1..3199
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..3199
                     /gene="RASIP1"
                     /gene_synonym="RAIN"
                     /note="Ras interacting protein 1"
                     /db_xref="GeneID:54922"
                     /db_xref="HGNC:HGNC:24716"
                     /db_xref="MIM:609623"
     exon            1..90
                     /gene="RASIP1"
                     /gene_synonym="RAIN"
                     /inference="alignment:Splign:2.1.0"
     exon            91..231
                     /gene="RASIP1"
                     /gene_synonym="RAIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..2986
                     /gene="RASIP1"
                     /gene_synonym="RAIN"
                     /codon_start=1
                     /product="ras-interacting protein 1"
                     /protein_id="NP_060275.2"
                     /db_xref="CCDS:CCDS12731.1"
                     /db_xref="GeneID:54922"
                     /db_xref="HGNC:HGNC:24716"
                     /db_xref="MIM:609623"
                     /translation="MLSGERKEGGSPRFGKLHLPVGLWINSPRKQLAKLGRRWPSAAS
                     VKSSSSDTGSRSSEPLPPPPPHVELRRVGAVKAAGGASGSRAKRISQLFRGSGTGTTG
                     SSGAGGPGTPGGAQRWASEKKLPELAAGVAPEPPLATRATAPPGVLKIFGAGLASGAN
                     YKSVLATARSTARELVAEALERYGLAGSPGGGPGESSCVDAFALCDALGRPAAAGVGS
                     GEWRAEHLRVLGDSERPLLVQELWRARPGWARRFELRGREEARRLEQEAFGAADSEGT
                     GAPSWRPQKNRSRAASGGAALASPGPGTGSGAPAGSGGKERSENLSLRRSVSELSLQG
                     RRRRQQERRQQALSMAPGAADAQIGTADPGDFDQLTQCLIQAPSNRPYFLLLQGYQDA
                     QDFVVYVMTREQHVFGRGGNSSGRGGSPAPYVDTFLNAPDILPRHCTVRAGPEHPAMV
                     RPSRGAPVTHNGCLLLREAELHPGDLLGLGEHFLFMYKDPRTGGSGPARPPWLPARPG
                     ATPPGPGWAFSCRLCGRGLQERGEALAAYLDGREPVLRFRPREEEALLGEIVRAAAAG
                     SGDLPPLGPATLLALCVQHSARELELGHLPRLLGRLARLIKEAVWEKIKEIGDRQPEN
                     HPEGVPEVPLTPEAVSVELRPLMLWMANTTELLSFVQEKVLEMEKEADQEDPQLCNDL
                     ELCDEAMALLDEVIMCTFQQSVYYLTKTLYSTLPALLDSNPFTAGAELPGPGAELGAM
                     PPGLRPTLGVFQAALELTSQCELHPDLVSQTFGYLFFFSNASLLNSLMERGQGRPFYQ
                     WSRAVQIRTNLDLVLDWLQGAGLGDIATEFFRKLSMAVNLLCVPRTSLLKASWSSLRT
                     DHPTLTPAQLHHLLSHYQLGPGRGPPAAWDPPPAEREAVDTGDIFESFSSHPPLILPL
                     GSSRLRLTGPVTDDALHRELRRLRRLLWDLEQQELPANYRHGPPVATSP"
     exon            232..917
                     /gene="RASIP1"
                     /gene_synonym="RAIN"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1273
                     /gene="RASIP1"
                     /gene_synonym="RAIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1927
                     /gene="RASIP1"
                     /gene_synonym="RAIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..1965
                     /gene="RASIP1"
                     /gene_synonym="RAIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2117
                     /gene="RASIP1"
                     /gene_synonym="RAIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2221
                     /gene="RASIP1"
                     /gene_synonym="RAIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2465
                     /gene="RASIP1"
                     /gene_synonym="RAIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2638
                     /gene="RASIP1"
                     /gene_synonym="RAIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2786
                     /gene="RASIP1"
                     /gene_synonym="RAIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2787..3199
                     /gene="RASIP1"
                     /gene_synonym="RAIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3175..3180
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASIP1"
                     /gene_synonym="RAIN"
                     /note="hexamer: AATAAA"
     polyA_site      3199
                     /gene="RASIP1"
                     /gene_synonym="RAIN"
                     /note="major polyA site"
ORIGIN      
        1 agtgctggga gccgtggcag aggcaagagc agtggaactg acccaggcca gtggagccag
       61 ggcctccggg tgtgccggac ccgaagcagg ggccatgctg tctggtgaac ggaaggaggg
      121 cggaagcccc cgcttcggga agcttcatct ccccgtgggc ctgtggatca attcccccag
      181 gaagcagctg gcgaagctgg ggcggcgctg gcccagcgca gcctctgtca agtcttcttc
      241 gtcggacacg gggagccgca gcagcgagcc gctacctccg cccccgccgc acgtggagct
      301 gcggcgagtg ggcgctgtca aggcggccgg gggagcctcc ggtagccgcg ccaagcgcat
      361 ctcccagctc ttccggggct cggggaccgg gaccacgggg tccagcggcg caggaggccc
      421 tgggaccccg gggggcgcgc agcgctgggc cagcgagaag aagctgccgg agctggcggc
      481 gggcgtggcc cccgagcccc cgctggctac ccgcgccacg gcgcctccgg gggtcctcaa
      541 gatcttcggc gccggactgg catcgggcgc caactacaag agcgtgctgg ccacggcgcg
      601 ctccacggcg cgcgagctcg tggccgaggc gctagagcgc tacggcctag caggcagccc
      661 cggcggtggc cccggcgaga gcagctgcgt ggacgccttc gctttgtgcg acgctctggg
      721 ccggcccgcg gcggcgggcg tgggaagcgg cgagtggcgg gcggagcacc tgcgcgtgct
      781 gggcgactcc gagcgcccgc tgctggtgca ggagctgtgg cgggcgcggc ccggctgggc
      841 gcggcgcttc gagttgcgcg gccgcgagga ggcgcggcgc ctggagcagg aggccttcgg
      901 ggccgcggac agcgaaggca ccggcgcccc ttcgtggcgg ccacagaaga accgctcccg
      961 ggcggcgtcg ggtggggcag cgctggccag tcctggcccg gggaccggat caggggcccc
     1021 agctgggtct ggaggcaagg agcgctcaga aaacttgtct ttgcggcgca gcgtgtcgga
     1081 gcttagcctt caggggcggc ggcggcggca gcaggagcgg agacagcagg cacttagcat
     1141 ggccccaggg gcagccgacg cccaaatcgg aactgcagac cccggggact tcgatcagtt
     1201 gactcagtgc ctcatccagg cccccagcaa ccgcccctac ttcctgctgc tccagggcta
     1261 ccaggacgcc caggactttg tggtgtatgt gatgacgcga gagcagcacg tgtttgggcg
     1321 aggtgggaac tcgtctggcc gcggggggtc cccggctccc tatgtggaca ccttcctcaa
     1381 cgccccggac atcctgccgc gtcactgcac agtgcgcgcg ggccctgagc acccggccat
     1441 ggtgcgcccg tcccggggcg ccccagtcac gcacaacggg tgcctcctgc tgcgggaggc
     1501 tgagctgcac ccgggcgacc tcctggggct gggcgagcac ttcctgttca tgtacaagga
     1561 cccccgcact gggggctcgg ggcctgcgag gccgccgtgg ctgcccgcgc gccccggggc
     1621 cacgccgcca ggccctggct gggccttctc ctgtcgcctg tgcggccgcg gcctgcagga
     1681 gcgcggcgag gcactggccg cctacctgga cggccgtgag ccagtcctgc gcttccggcc
     1741 gcgcgaggag gaggcgctgc tgggcgagat cgtgcgcgcc gcagccgccg gctcgggaga
     1801 cctgccgccc ctcgggcccg ccacgctgct ggcgctgtgc gtgcagcatt ccgcccgtga
     1861 gctggagctg ggccacctgc cacgactgct gggccgcctg gcccggctca tcaaggaggc
     1921 cgtctgggaa aagattaagg aaattggaga ccgtcagcca gaaaaccacc ctgagggggt
     1981 ccccgaggtg cccctgactc ctgaagctgt gtctgtggag ctgcggccac tcatgctgtg
     2041 gatggccaac accacggagc tgcttagctt tgtgcaggag aaggtgctgg aaatggagaa
     2101 ggaggctgac caagaggacc cacagctctg caatgacttg gaattatgtg atgaggccat
     2161 ggccctcctg gatgaggtca tcatgtgtac cttccagcag tctgtctact acctcaccaa
     2221 gactctctat tcaacgctgc ctgctctcct ggatagtaac cctttcacag ctggtgcaga
     2281 gctgccgggg cctggcgcgg agctgggggc catgcctcca ggattgagac ctaccctggg
     2341 cgtgttccag gcagccttgg agctgaccag ccagtgcgag ctgcaccctg acctcgtgtc
     2401 tcagactttt ggctacttgt tcttcttctc caacgcatcc cttctcaact cgctgatgga
     2461 acgaggtcaa ggccggcctt tctatcaatg gtcccgagct gttcaaatcc gaaccaacct
     2521 ggacctcgtc ttggactggc tacagggagc tgggctgggc gacattgcca ctgagttctt
     2581 ccggaaactc tccatggctg tgaacctgct ctgtgtgccc cgcacttccc tgctcaaggc
     2641 ttcatggagc agcctaagaa ccgaccaccc caccttgacc cccgcccagc tgcaccatct
     2701 gctcagccac tatcagctgg gccctggccg cgggccgcca gccgcgtggg accctccccc
     2761 tgcagagcgg gaggctgtgg acacagggga catcttcgaa agcttctcct cgcacccgcc
     2821 cctcatcctc cccctgggga gctcgcgcct gcgcctcact ggtccagtga cggacgatgc
     2881 cttgcaccgt gaactccgta ggctccgccg cctcctctgg gatcttgagc agcaggagct
     2941 gccagccaat tatcgccatg ggcctcccgt ggccacgtct ccttgagaac caataccaaa
     3001 cgagcgcgcg aaccttgaaa tgtcacgggc ttctacggac aggagcccgc ctgagcgcaa
     3061 agctttctgg gagttgtagt tcttatcccg cgtggaatgt tgggagattg agttttcggg
     3121 aagtagcgga tgggacggtg ggagcatggg cttaggatgt gaatgccagg gagcaataaa
     3181 ggtatccgtg gtatcggca
//
