LOCUS       NM_005739               5031 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens RAS guanyl releasing protein 1 (RASGRP1), transcript
            variant 1, mRNA.
ACCESSION   NM_005739
VERSION     NM_005739.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5031)
  AUTHORS   Zhou,J., Xu,B., He,F., Shu,Y., Chen,X., Liu,Z., Sun,B. and Zhang,W.
  TITLE     Association of RASGRP1 polymorphism with vascular complications in
            Chinese diabetic patients with glycemic control and
            antihypertensive treatment
  JOURNAL   Cardiovasc Diabetol 23 (1), 166 (2024)
   PUBMED   38730425
  REMARK    GeneRIF: Association of RASGRP1 polymorphism with vascular
            complications in Chinese diabetic patients with glycemic control
            and antihypertensive treatment.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5031)
  AUTHORS   Hsu,T.C., Rodrigues,G.O.L., Winer,H., Hixon,J.A., Li,W.,
            Tarasova,N.I. and Durum,S.K.
  TITLE     A Focused Review of Ras Guanine Nucleotide-Releasing Protein 1 in
            Immune Cells and Cancer
  JOURNAL   Int J Mol Sci 24 (2), 1652 (2023)
   PUBMED   36675167
  REMARK    GeneRIF: A Focused Review of Ras Guanine Nucleotide-Releasing
            Protein 1 in Immune Cells and Cancer.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5031)
  AUTHORS   De Rosa,A., Di Maio,A., Torretta,S., Garofalo,M., Giorgelli,V.,
            Masellis,R., Nuzzo,T., Errico,F., Bertolino,A., Subramaniam,S.,
            Rampino,A. and Usiello,A.
  TITLE     Abnormal RasGRP1 Expression in the Post-Mortem Brain and Blood
            Serum of Schizophrenia Patients
  JOURNAL   Biomolecules 12 (2), 328 (2022)
   PUBMED   35204828
  REMARK    GeneRIF: Abnormal RasGRP1 Expression in the Post-Mortem Brain and
            Blood Serum of Schizophrenia Patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5031)
  AUTHORS   Baars,M.J.D., Douma,T., Simeonov,D.R., Myers,D.R., Kulhanek,K.,
            Banerjee,S., Zwakenberg,S., Baltissen,M.P., Amini,M., de Roock,S.,
            van Wijk,F., Vermeulen,M., Marson,A., Roose,J.P. and Vercoulen,Y.
  TITLE     Dysregulated RASGRP1 expression through RUNX1 mediated
            transcription promotes autoimmunity
  JOURNAL   Eur J Immunol 51 (2), 471-482 (2021)
   PUBMED   33065764
  REMARK    GeneRIF: Dysregulated RASGRP1 expression through RUNX1 mediated
            transcription promotes autoimmunity.
REFERENCE   5  (bases 1 to 5031)
  AUTHORS   Rchiad,Z., Haidar,M., Ansari,H.R., Tajeri,S., Mfarrej,S., Ben
            Rached,F., Kaushik,A., Langsley,G. and Pain,A.
  TITLE     Novel tumour suppressor roles for GZMA and RASGRP1 in Theileria
            annulata-transformed macrophages and human B lymphoma cells
  JOURNAL   Cell Microbiol 22 (12), e13255 (2020)
   PUBMED   32830401
  REMARK    GeneRIF: Novel tumour suppressor roles for GZMA and RASGRP1 in
            Theileria annulata-transformed macrophages and human B lymphoma
            cells.
REFERENCE   6  (bases 1 to 5031)
  AUTHORS   Topham,M.K. and Prescott,S.M.
  TITLE     Diacylglycerol kinase zeta regulates Ras activation by a novel
            mechanism
  JOURNAL   J Cell Biol 152 (6), 1135-1143 (2001)
   PUBMED   11257115
REFERENCE   7  (bases 1 to 5031)
  AUTHORS   Ebinu,J.O., Stang,S.L., Teixeira,C., Bottorff,D.A., Hooton,J.,
            Blumberg,P.M., Barry,M., Bleakley,R.C., Ostergaard,H.L. and
            Stone,J.C.
  TITLE     RasGRP links T-cell receptor signaling to Ras
  JOURNAL   Blood 95 (10), 3199-3203 (2000)
   PUBMED   10807788
REFERENCE   8  (bases 1 to 5031)
  AUTHORS   Bottorff,D., Ebinu,J. and Stone,J.C.
  TITLE     RasGRP, a Ras activator: mouse and human cDNA sequences and
            chromosomal positions
  JOURNAL   Mamm Genome 10 (4), 358-361 (1999)
   PUBMED   10087292
REFERENCE   9  (bases 1 to 5031)
  AUTHORS   Kawasaki,H., Springett,G.M., Toki,S., Canales,J.J., Harlan,P.,
            Blumenstiel,J.P., Chen,E.J., Bany,I.A., Mochizuki,N., Ashbacher,A.,
            Matsuda,M., Housman,D.E. and Graybiel,A.M.
  TITLE     A Rap guanine nucleotide exchange factor enriched highly in the
            basal ganglia
  JOURNAL   Proc Natl Acad Sci U S A 95 (22), 13278-13283 (1998)
   PUBMED   9789079
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Jan 5;96(1):318]
REFERENCE   10 (bases 1 to 5031)
  AUTHORS   Ebinu,J.O., Bottorff,D.A., Chan,E.Y., Stang,S.L., Dunn,R.J. and
            Stone,J.C.
  TITLE     RasGRP, a Ras guanyl nucleotide- releasing protein with calcium-
            and diacylglycerol-binding motifs
  JOURNAL   Science 280 (5366), 1082-1086 (1998)
   PUBMED   9582122
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124306.4, DA993002.1,
            AK314091.1, BC109296.1, BU431038.1, AF081195.1 and AA742351.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005739.3.
            
            Summary: This gene is a member of a family of genes characterized
            by the presence of a Ras superfamily guanine nucleotide exchange
            factor (GEF) domain. It functions as a diacylglycerol
            (DAG)-regulated nucleotide exchange factor specifically activating
            Ras through the exchange of bound GDP for GTP. It activates the
            Erk/MAP kinase cascade and regulates T-cells and B-cells
            development, homeostasis and differentiation. Alternatively spliced
            transcript variants encoding different isoforms have been
            identified. Altered expression of the different isoforms of this
            protein may be a cause of susceptibility to systemic lupus
            erythematosus (SLE). [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript, and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF081195.1, BC032849.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310803.10/ ENSP00000310244.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC124306.4         45468-45475         c
            9-13                DA993002.1         1-5
            14-136              AK314091.1         6-128
            137-2630            BC109296.1         1-2494
            2631-2817           BU431038.1         286-472
            2818-4740           AF081195.1         2735-4657
            4741-5031           AA742351.1         26-316              c
FEATURES             Location/Qualifiers
     source          1..5031
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q14"
     gene            1..5031
                     /gene="RASGRP1"
                     /gene_synonym="CALDAG-GEFI; CALDAG-GEFII; IMD64; RASGRP"
                     /note="RAS guanyl releasing protein 1"
                     /db_xref="GeneID:10125"
                     /db_xref="HGNC:HGNC:9878"
                     /db_xref="MIM:603962"
     exon            1..221
                     /gene="RASGRP1"
                     /gene_synonym="CALDAG-GEFI; CALDAG-GEFII; IMD64; RASGRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..2580
                     /gene="RASGRP1"
                     /gene_synonym="CALDAG-GEFI; CALDAG-GEFII; IMD64; RASGRP"
                     /note="isoform a is encoded by transcript variant 1;
                     guanine nucleotide exchange factor, calcium- and
                     DAG-regulated, Rap1A; RAS guanyl nucleotide-releasing
                     protein 1; calcium and DAG-regulated guanine nucleotide
                     exchange factor II; ras activator RasGRP; RAS guanyl
                     releasing protein 1 (calcium and DAG-regulated); calcium-
                     and diacylglycerol-regulated guanine nucleotide exchange
                     factor II"
                     /codon_start=1
                     /product="RAS guanyl-releasing protein 1 isoform a"
                     /protein_id="NP_005730.2"
                     /db_xref="CCDS:CCDS45222.1"
                     /db_xref="GeneID:10125"
                     /db_xref="HGNC:HGNC:9878"
                     /db_xref="MIM:603962"
                     /translation="MGTLGKAREAPRKPSHGCRAASKARLEAKPANSPFPSHPSLAHI
                     TQFRMMVSLGHLAKGASLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAEL
                     LQKVITLYKDALAKNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAK
                     GEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEF
                     KSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFI
                     KFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSS
                     RNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVHKLLALYNHISE
                     LVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPV
                     VVDWASGVSPKPDPKTISKHVQRMVDSVFKNYDHDQDGYISQEEFEKIAASFPFSFCV
                     MDKDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVI
                     KQGYRCKDCGMNCHKQCKDLVVFECKKRAKNPVAPTENNTSVGPVSNLCSLGAKDLLH
                     APEEGPFTFPNGEAVEHGEESKDRTIMLMGVSSQKISLRLKRAVAHKATQTESQPWIG
                     SEGPSGPFVLSSPRKTAQDTLYVLPSPTSPCPSPVLVRKRAFVKWENKDSLIKSKEEL
                     RHLRLPTYQELEQEINTLKADNDALKIQLKYAQKKIESLQLEKSNHVLAQMEQGDCS"
     exon            222..406
                     /gene="RASGRP1"
                     /gene_synonym="CALDAG-GEFI; CALDAG-GEFII; IMD64; RASGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            407..512
                     /gene="RASGRP1"
                     /gene_synonym="CALDAG-GEFI; CALDAG-GEFII; IMD64; RASGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            513..575
                     /gene="RASGRP1"
                     /gene_synonym="CALDAG-GEFI; CALDAG-GEFII; IMD64; RASGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            576..707
                     /gene="RASGRP1"
                     /gene_synonym="CALDAG-GEFI; CALDAG-GEFII; IMD64; RASGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            708..861
                     /gene="RASGRP1"
                     /gene_synonym="CALDAG-GEFI; CALDAG-GEFII; IMD64; RASGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1035
                     /gene="RASGRP1"
                     /gene_synonym="CALDAG-GEFI; CALDAG-GEFII; IMD64; RASGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1152
                     /gene="RASGRP1"
                     /gene_synonym="CALDAG-GEFI; CALDAG-GEFII; IMD64; RASGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1428
                     /gene="RASGRP1"
                     /gene_synonym="CALDAG-GEFI; CALDAG-GEFII; IMD64; RASGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1509
                     /gene="RASGRP1"
                     /gene_synonym="CALDAG-GEFI; CALDAG-GEFII; IMD64; RASGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1614
                     /gene="RASGRP1"
                     /gene_synonym="CALDAG-GEFI; CALDAG-GEFII; IMD64; RASGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1724
                     /gene="RASGRP1"
                     /gene_synonym="CALDAG-GEFI; CALDAG-GEFII; IMD64; RASGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1869
                     /gene="RASGRP1"
                     /gene_synonym="CALDAG-GEFI; CALDAG-GEFII; IMD64; RASGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..1906
                     /gene="RASGRP1"
                     /gene_synonym="CALDAG-GEFI; CALDAG-GEFII; IMD64; RASGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2059
                     /gene="RASGRP1"
                     /gene_synonym="CALDAG-GEFI; CALDAG-GEFII; IMD64; RASGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2445
                     /gene="RASGRP1"
                     /gene_synonym="CALDAG-GEFI; CALDAG-GEFII; IMD64; RASGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..5031
                     /gene="RASGRP1"
                     /gene_synonym="CALDAG-GEFI; CALDAG-GEFII; IMD64; RASGRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3800..3805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASGRP1"
                     /gene_synonym="CALDAG-GEFI; CALDAG-GEFII; IMD64; RASGRP"
                     /note="hexamer: AATAAA"
     polyA_site      3841
                     /gene="RASGRP1"
                     /gene_synonym="CALDAG-GEFI; CALDAG-GEFII; IMD64; RASGRP"
     regulatory      5006..5011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASGRP1"
                     /gene_synonym="CALDAG-GEFI; CALDAG-GEFII; IMD64; RASGRP"
                     /note="hexamer: GATAAA"
     polyA_site      5031
                     /gene="RASGRP1"
                     /gene_synonym="CALDAG-GEFI; CALDAG-GEFII; IMD64; RASGRP"
                     /note="major polyA site"
ORIGIN      
        1 gcgctcgcac aaagtttgtg cctgcggtgc acctcggtcg ggctcgccgg gctcgagggc
       61 tggcgggcgc cggggctacg aggcccgggg gggagagagc cggcaggcgg cggcggtggt
      121 ggcgggggcg atgcgccgcg cccggccgcg ctaggtgagc cggcaccggg agcgcgggcc
      181 gcggccatgg gcaccctggg caaggcgaga gaggctccgc ggaaaccttc ccatggctgc
      241 agagctgcct ctaaagcaag actagaggca aagccagcca acagcccctt cccctcccat
      301 cccagcttgg cccacatcac ccagttccga atgatggtgt ctctgggaca tttagccaaa
      361 ggagccagcc tggacgatct cattgacagc tgcattcaat cttttgatgc agatggaaac
      421 ctgtgtcgaa gtaaccaact gttgcaagtc atgctgacca tgcaccgaat tgtcatctcc
      481 tctgcagaac tgctccaaaa agttatcacc ctctataagg atgctttggc aaagaattca
      541 ccaggacttt gcctgaagat ctgttatttt gtaaggtatt ggataacaga attctgggtc
      601 atgtttaaaa tggacgccag cttgacagac actatggagg agtttcagga actggtgaaa
      661 gctaagggtg aggagttaca ttgccgcctg attgacacaa ctcaaatcaa tgcccgtgac
      721 tggtccagga aacttactca aaggataaaa tcaaatacca gcaagaaacg gaaagtctcc
      781 ctgctctttg accatctgga accagaagag ctatccgagc acctcaccta ccttgagttc
      841 aagtctttcc ggaggatatc gttctctgat tatcagaatt accttgtaaa tagctgtgtg
      901 aaggaaaacc ccaccatgga gcgatctatt gctctgtgca acggcatctc ccagtgggta
      961 caactgatgg ttctcagccg ccccacgccg cagctccgag cagaagtctt catcaagttc
     1021 atccaggtgg ctcagaagct ccaccaacta cagaacttca atacactgat ggctgtgata
     1081 ggtgggctgt gtcacagctc aatctcgagg ctcaaggaga caagttcgca tgtcccacat
     1141 gaaatcaata aggttctcgg tgagatgact gagctgctgt cctcctccag aaactacgac
     1201 aattaccggc gagcctatgg agagtgcacc gacttcaaga tccccattct gggtgtgcat
     1261 ctcaaggacc tcatctccct gtatgaagcc atgcctgact atctggagga cgggaaagtg
     1321 aacgtccata agctactggc cctatacaat catatcagtg aattggtcca gctgcaagag
     1381 gtggccccac ccttggaggc taacaaggac ttggtacact tgctgacgtt atccctggat
     1441 ctttactaca ctgaggatga aatctatgag ctttcctatg cccgggaacc aaggaaccac
     1501 agagctccac cactaacacc ttcaaagcca ccagtagtag tggactgggc ttctggagtg
     1561 tctcccaaac ctgatccaaa aaccattagc aaacacgtcc agaggatggt ggattctgtc
     1621 ttcaagaact atgatcacga ccaggatgga tacatttctc aggaagaatt tgaaaagatt
     1681 gctgcgagtt ttccattttc cttctgtgtg atggacaaag acagggaagg cctcatcagc
     1741 agggatgaga tcacagccta cttcatgaga gccagctcaa tctattccaa gctgggcctg
     1801 ggctttcctc acaacttcca agagaccacc tacctgaagc ccactttttg tgacaactgt
     1861 gctggatttc tctggggagt gatcaaacaa ggatatcgat gtaaagactg cgggatgaac
     1921 tgtcacaaac aatgcaaaga tctggttgtg tttgagtgta agaagcgagc caagaaccca
     1981 gtagctccca cagagaacaa cacttctgtg gggccagtgt ccaacctttg ctcattggga
     2041 gccaaagatc tgctccatgc acctgaggaa ggacctttta cattccctaa tggggaggct
     2101 gtggaacatg gtgaggagag taaggatcgg accatcatgc tgatgggagt gtcctcacag
     2161 aagatttctc ttcggctgaa gagggctgtt gcccacaagg ccacccagac tgaatcacag
     2221 ccttggattg gcagtgaggg cccttcaggt ccctttgtgc tgtcttcccc aaggaagaca
     2281 gcccaggata ctctatatgt gcttcccagt cccacctctc catgtcctag cccagtcttg
     2341 gtcagaaagc gggcttttgt caagtgggag aataaagact ccctcataaa atcaaaggag
     2401 gagctccgtc acctcagact gcctacctac caagaactgg aacaggaaat aaatactctg
     2461 aaagcagata atgatgccct aaagatccaa ctgaaatatg cacagaagaa aatagaatcc
     2521 ctccagcttg aaaaaagcaa tcatgtctta gctcaaatgg agcagggtga ctgttcttag
     2581 cccagaaact aagtagcaca atctgtagat gagtatagtg atctcatttc ctaaactgta
     2641 atgcacagac ctgaggaact ttacactgac cagctttaaa acagtacttt aaaaggaaaa
     2701 gcctgttact gtttatttac ctaaaagatt cctaatgtgc agcactgttt tctctttcag
     2761 ttagttgact caaaggggga aaactaaaga atgcaaaact tttgctattc ataccactga
     2821 tgttcatcaa aagtatgcga tctaaaacat gactatcatt tcctgacaat ggggcatctc
     2881 ggtggcctgc ctggctgatt cttccttaaa actaaaatct ctggaaaatg gatttgcttc
     2941 ttaccctgtg ttttctgcaa actgacttac tttgttccag ccaaagcttg ctaataatag
     3001 aaaactaccc atattccaaa agtagatttc ctctgtatcc cagcatactt tgtgaacctg
     3061 gctccttctt cactacctca gatctaatca attagtccat gtaccctcct tcctcactac
     3121 agtcataaca catgagcata tctacctaga agccaatttc tactgatgta gccacaactt
     3181 tttagaggcc tattaaacat gacgttatcc aattgcaggt caacttatag ttgtagcctt
     3241 acaacttaca ggcatcagaa aataagtaat caaattaggt acctggaaac atagctatta
     3301 ccatctcata ttactgtcta attaaaataa acataacgca aacatgtttg tccttatata
     3361 ttctacagtg gatagaatta ggaattgatg gcttaaaaaa aaaagtctat gaagagtctg
     3421 tttaactctt catgttccat ctttctcttc tgaagtaaac tattttgaaa gttctctttt
     3481 tgaaatgaat ttgtgcttaa ctgtcttcac tattaatact atttagaaat aagctaattg
     3541 gatcagtggc ttaaataata gctgactgtg tgtacatatg tatataatat gtatatacaa
     3601 tatcaggcat gcatgtggct tggaattttg tttcctccat aaaatgtgga agtgaattaa
     3661 acaagtttta gtcatttata caaagtcaca aatataaagt tcagtttgtc acaagattaa
     3721 attgctcaca aggtaaaatt gtattgtttg gcaaaatcac aagtaacaat cctgtgagtt
     3781 ttctattatg aaggttaata ataaatgggc tcatttagtt gcctgggcac ctattcacaa
     3841 attcatttgt cagcctcttt ttagttctct taaaaaaaaa aaaatcatat gatcattttc
     3901 ctttttgggg gtacttagct tccatgccta taaagtctgg taccagactg acttgaaatt
     3961 cataaacaag ttgtccaatt gccaagaata tgttaacaat taaaagttcc aaactaaagc
     4021 caatagcacc aagtcttcat aagaatacaa agtatacata cagtattgct tacctggagg
     4081 attcagatca tttaggaatt ctctttgatg aaagatcagt tcccatttga gttcctcctt
     4141 gcactgagtt ttagtgatat agaactagct tgtagttagt gtttcattac attataaaga
     4201 atagttttac acacgtattt accgttttcc aaatttaaac tcagaaatac ccaaagcagg
     4261 cctgcttaag cccactacct ggcatataaa cttatagtaa cactttgtta ctttcttttt
     4321 aataggacaa gcatgagtta ggacaaactc taaaaattca tattcttcac tattcttgtt
     4381 ttcctttgat tgatatagac caaagatggt gtactctaat tttttaaaac agtaatggaa
     4441 cacaattttt ttcattcttc ctcctctcca ttcgaagtaa agatccccag ttagttttta
     4501 tataaataat ctatagggat tcaaaaggtg tcacagtcca cttaattagt caaattagca
     4561 atggctaaac agtatcaagt actgcagaat ttatcactga aatggataag aggaaatagt
     4621 ttagtcacag gtttttacag tccagcaagg gccaaagagg tatagtatac aagttaatag
     4681 tatttgtgtt gagcaacatg gggctagtgg gatcacagaa atctggaaaa aaaaaaaaaa
     4741 ggctttggct tatcaagcct agtgtaaatt tctgcatctc acacgacttt agtttggcca
     4801 ggtatttatc tgccaaaaca aggacaaatc ttgttgtatt aacagcaggg tcacttctca
     4861 ttttctttgc tgacttacct ttttactgac cgttgtgaat ttctgtctca aaatgtataa
     4921 tatagaaatg caagaaaaaa acaaatgtac agattgtaaa gttttttgat acctaatgta
     4981 agttttcttt gtgtaatatt tatatgataa aagacattag gatccctaca a
//
