LOCUS       NM_175062               2297 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens RasGEF domain family member 1C (RASGEF1C), mRNA.
ACCESSION   NM_175062
VERSION     NM_175062.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2297)
  AUTHORS   Jafarian,Z., Khamse,S., Afshar,H., Khorshid,H.R.K., Delbari,A. and
            Ohadi,M.
  TITLE     Natural selection at the RASGEF1C (GGC) repeat in human and
            divergent genotypes in late-onset neurocognitive disorder
  JOURNAL   Sci Rep 11 (1), 19235 (2021)
   PUBMED   34584172
  REMARK    GeneRIF: Natural selection at the RASGEF1C (GGC) repeat in human
            and divergent genotypes in late-onset neurocognitive disorder.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2297)
  AUTHORS   Pannekoek,W.J., Linnemann,J.R., Brouwer,P.M., Bos,J.L. and
            Rehmann,H.
  TITLE     Rap1 and Rap2 antagonistically control endothelial barrier
            resistance
  JOURNAL   PLoS One 8 (2), e57903 (2013)
   PUBMED   23469100
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104115.3, BC036802.1, BF967301.1, BM729117.1 and AC122713.2.
            
            On Nov 22, 2018 this sequence version replaced NM_175062.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036802.1, SRR1660807.78894.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361132.9/ ENSP00000354963.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AC104115.3         57143-57223         c
            82-570              BC036802.1         19-507
            571-628             BF967301.1         513-570
            629-1493            BC036802.1         566-1430
            1494-1717           BM729117.1         254-477
            1718-2297           AC122713.2         63381-63960
FEATURES             Location/Qualifiers
     source          1..2297
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..2297
                     /gene="RASGEF1C"
                     /note="RasGEF domain family member 1C"
                     /db_xref="GeneID:255426"
                     /db_xref="HGNC:HGNC:27400"
     exon            1..184
                     /gene="RASGEF1C"
                     /inference="alignment:Splign:2.1.0"
     exon            185..367
                     /gene="RASGEF1C"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1591
                     /gene="RASGEF1C"
                     /codon_start=1
                     /product="ras-GEF domain-containing family member 1C"
                     /protein_id="NP_778232.2"
                     /db_xref="CCDS:CCDS4452.1"
                     /db_xref="GeneID:255426"
                     /db_xref="HGNC:HGNC:27400"
                     /translation="MPQTLSASDMVTPGSLSPPPTEPTDGEQAGQPLLDGAPSSASLE
                     TLIQHLVPTADYYPEKAYIFTFLLSSRLFIEPRELLARVCHLCIEQQQLDKPVLDKAR
                     VRKFGPKLLQLLAEWTETFPRDFQEESTIGHLKDVVGRIAPCDEAYRKRMHQLLQALH
                     QKLAALRQGPEGLVGADKPISYRTKPPASIHRELLGVCSDPYTLAQQLTHVELERLRH
                     IGPEEFVQAFVNKDPLASTKPCFSDKTSNLEAYVKWFNRLCYLVATEICMPAKKKQRA
                     QVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVRTAKFFILEHQMDP
                     TGNFCNYRTALRGAAHRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNF
                     EKFLELAKQVGEFITWKQVECPFEQDASITHYLYTAPIFSEDGLYLASYESESPENQT
                     EKERWKALRSSILGKT"
     exon            368..490
                     /gene="RASGEF1C"
                     /inference="alignment:Splign:2.1.0"
     exon            491..628
                     /gene="RASGEF1C"
                     /inference="alignment:Splign:2.1.0"
     exon            629..829
                     /gene="RASGEF1C"
                     /inference="alignment:Splign:2.1.0"
     exon            830..904
                     /gene="RASGEF1C"
                     /inference="alignment:Splign:2.1.0"
     exon            905..994
                     /gene="RASGEF1C"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1097
                     /gene="RASGEF1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1177
                     /gene="RASGEF1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1273
                     /gene="RASGEF1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1369
                     /gene="RASGEF1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1493
                     /gene="RASGEF1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1566
                     /gene="RASGEF1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..2297
                     /gene="RASGEF1C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2276..2281
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASGEF1C"
                     /note="hexamer: TATAAA"
     polyA_site      2297
                     /gene="RASGEF1C"
                     /note="major polyA site"
ORIGIN      
        1 gcgttgctcc ggggccgccg ccaggcgctc gtgcgggctg cgctgggagc cgggcggtcg
       61 ggcggcggcg gcggcggcgg cggcggcggc ggcggcggcg ggcggcgccc cggtccgcgg
      121 cgccgaggct cgcaccggga gctgcccatg ggccgggccc ggagttccgg cgcgccggga
      181 gccggcagac atgccacaga cgctgagtgc ctccgacatg gtcaccccag gcagcctcag
      241 cccacccccc accgagccca cagatggcga acaggctggg cagcccctcc tggatggagc
      301 gccatcctca gcctccctgg aaacactgat ccagcacctg gtgcccacag ccgactacta
      361 ccccgagaaa gcctacatct tcaccttcct gctgagctct cgcctcttca tcgagccccg
      421 ggagctcctg gcccgggtct gccacctgtg catcgagcag cagcagctgg acaagccggt
      481 gctggacaag gcccgggtcc ggaagttcgg ccccaaactg ctgcagctgt tggccgagtg
      541 gaccgagacc ttcccaaggg acttccagga agagtcgact atcgggcacc ttaaggacgt
      601 cgtgggccgc atcgccccct gtgacgaggc ataccggaag aggatgcatc agctcctaca
      661 ggctctgcac cagaagctgg cggctctgcg ccaggggcca gaaggtctgg tgggtgccga
      721 caagcccatc tcctacagga ccaagccacc agcctccatc cacagggagc tccttggtgt
      781 ctgcagcgac ccctacacac tggcccagca gctgacccac gtggaactgg agcggctgcg
      841 gcacatcggg cctgaggagt ttgtccaggc ctttgtgaac aaggaccctc tggccagcac
      901 aaagccctgc ttcagtgaca agaccagcaa cctggaggct tatgtgaaat ggttcaacag
      961 gctgtgctac ctggtggcaa ctgagatctg catgccagcc aagaagaagc agagggccca
     1021 ggtgattgag ttcttcatcg acgtggcccg cgagtgcttc aacatcggca acttcaactc
     1081 cctcatggcc atcatctccg gcatgaacat gagccctgtc tccaggctga agaagacctg
     1141 ggccaaagtg aggacggcca agtttttcat cctcgagcac cagatggacc caacggggaa
     1201 tttctgcaac tacaggacag ccctgcgcgg ggcggcccac cgctccctga cggcccacag
     1261 cagccgagag aagattgtca ttcctttctt cagcctgctc atcaaagaca tctacttcct
     1321 gaatgagggc tgcgccaacc gccttcccaa tggacacgtc aactttgaga aattcctgga
     1381 gctggccaag caggtggggg agttcatcac ctggaaacaa gtggagtgtc ccttcgagca
     1441 agacgccagc atcacccact acctgtacac cgcccccatc ttcagtgagg atggtcttta
     1501 tttggcttct tacgaaagtg agagcccaga gaaccaaaca gaaaaagaaa gatggaaagc
     1561 tctaagatct tctattttgg ggaagacatg aaagcgctga gctgagggac gaggaagagc
     1621 tggagcccgc agaagccgtc cacagccctg cctcagtggc ccagtgggca gaggccaggg
     1681 agtgcctcac tattttgcaa atgccgaccc tgtggcctgc tgcccgcccc cccccccccc
     1741 acagtggcca tacgggcaca ggagaccttt tatgggactt tggccctggc aggacccagg
     1801 gcctccagac gtgcgggcgg cacatgcctt ggggacatcc tgccttcagg accgtggggc
     1861 ctggtcagtc tgtccatcct cggcaaggac acaacactgc cccagagggt gggaccactg
     1921 caagctcgag accttgcttg gtgacatgtg ccactttggc caccacccac agtctgtcac
     1981 cacgtggctt gggaacttct ggagccacag caggcatcac ggtgcgacgt gagatgcctg
     2041 cgccagcccc gagcccactg gcagccactg ccattccacc catggtccct caccctgccc
     2101 tgccgacgag cttgtctctg cagccccagg tacccccttc ctggatgctg ctggccccag
     2161 gagatagctt tccggtgaca gctgtggaac gcgtcaacag gacaaactgg acacatggag
     2221 ttacagtgtg tacacggcag tcccgccacc cagccccctt gtaaactcta gtcactataa
     2281 acacacccgt acgccta
//
