LOCUS       NM_152573               5585 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens RAS and EF-hand domain containing (RASEF), mRNA.
ACCESSION   NM_152573
VERSION     NM_152573.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5585)
  AUTHORS   Wang,Y., Huynh,W., Skokan,T.D., Lu,W., Weiss,A. and Vale,R.D.
  TITLE     CRACR2a is a calcium-activated dynein adaptor protein that
            regulates endocytic traffic
  JOURNAL   J Cell Biol 218 (5), 1619-1633 (2019)
   PUBMED   30814157
REFERENCE   2  (bases 1 to 5585)
  AUTHORS   Kumar,S., Lee,H.J., Park,H.S. and Lee,K.
  TITLE     Testis-Specific GTPase (TSG): An oligomeric protein
  JOURNAL   BMC Genomics 17 (1), 792 (2016)
   PUBMED   27724860
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5585)
  AUTHORS   Kaplon,J., Homig-Holzel,C., Gao,L., Meissl,K., Verdegaal,E.M., van
            der Burg,S.H., van Doorn,R. and Peeper,D.S.
  TITLE     Near-genomewide RNAi screening for regulators of BRAF(V600E)
            -induced senescence identifies RASEF, a gene epigenetically
            silenced in melanoma
  JOURNAL   Pigment Cell Melanoma Res 27 (4), 640-652 (2014)
   PUBMED   24703243
  REMARK    GeneRIF: Near-genomewide RNAi screening for regulators of
            BRAF(V600E) -induced senescence identifies RASEF, a gene
            epigenetically silenced in melanoma.
REFERENCE   4  (bases 1 to 5585)
  AUTHORS   Tian,L., McClafferty,H., Knaus,H.G., Ruth,P. and Shipston,M.J.
  TITLE     Distinct acyl protein transferases and thioesterases control
            surface expression of calcium-activated potassium channels
  JOURNAL   J Biol Chem 287 (18), 14718-14725 (2012)
   PUBMED   22399288
REFERENCE   5  (bases 1 to 5585)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   6  (bases 1 to 5585)
  AUTHORS   Nakamura,S., Takemura,T., Tan,L., Nagata,Y., Yokota,D., Hirano,I.,
            Shigeno,K., Shibata,K., Fujie,M., Fujisawa,S. and Ohnishi,K.
  TITLE     Small GTPase RAB45-mediated p38 activation in apoptosis of chronic
            myeloid leukemia progenitor cells
  JOURNAL   Carcinogenesis 32 (12), 1758-1772 (2011)
   PUBMED   21890458
  REMARK    GeneRIF: overexpression of RAB45 increased the phosphorylation
            levels of p38, resulting in the induction of apoptosis and
            inhibition of proliferation of CML progenitor cells
REFERENCE   7  (bases 1 to 5585)
  AUTHORS   Maat,W., Beiboer,S.H., Jager,M.J., Luyten,G.P., Gruis,N.A. and van
            der Velden,P.A.
  TITLE     Epigenetic regulation identifies RASEF as a tumor-suppressor gene
            in uveal melanoma
  JOURNAL   Invest Ophthalmol Vis Sci 49 (4), 1291-1298 (2008)
   PUBMED   18385040
  REMARK    GeneRIF: Homozygosity, in combination with methylation, appears to
            be the mechanism targeting RASEF in uveal melanoma, and allelic
            imbalance at this locus supports a TSG role for RASEF.
REFERENCE   8  (bases 1 to 5585)
  AUTHORS   Shintani,M., Tada,M., Kobayashi,T., Kajiho,H., Kontani,K. and
            Katada,T.
  TITLE     Characterization of Rab45/RASEF containing EF-hand domain and a
            coiled-coil motif as a self-associating GTPase
  JOURNAL   Biochem Biophys Res Commun 357 (3), 661-667 (2007)
   PUBMED   17448446
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL499602.6, BC023566.1 and
            BM982321.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152573.3.
            
            Summary: This gene is a member of the Rab family of GTPases that
            are involved in regulation of membrane traffic. The encoded protein
            contains an N-terminal EF-hand domain, a coiled-coil motif and a
            C-terminal Rab domain. A potential role as tumor suppressor has
            been indicated for this gene. [provided by RefSeq, Nov 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023566.1, AK290986.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376447.4/ ENSP00000365630.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AL499602.6         86859-86872         c
            15-2775             BC023566.1         1-2761
            2776-4893           AL499602.6         4012-6129           c
            4894-5585           BM982321.1         24-715              c
FEATURES             Location/Qualifiers
     source          1..5585
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.32"
     gene            1..5585
                     /gene="RASEF"
                     /gene_synonym="RAB45; TSG"
                     /note="RAS and EF-hand domain containing"
                     /db_xref="GeneID:158158"
                     /db_xref="HGNC:HGNC:26464"
                     /db_xref="MIM:611344"
     exon            1..706
                     /gene="RASEF"
                     /gene_synonym="RAB45; TSG"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..2498
                     /gene="RASEF"
                     /gene_synonym="RAB45; TSG"
                     /note="ras-related protein Rab-45"
                     /codon_start=1
                     /product="ras and EF-hand domain-containing protein"
                     /protein_id="NP_689786.2"
                     /db_xref="CCDS:CCDS6662.1"
                     /db_xref="GeneID:158158"
                     /db_xref="HGNC:HGNC:26464"
                     /db_xref="MIM:611344"
                     /translation="MEADGDGEELARLRSVFAACDANRSGRLEREEFRALCTELRVRP
                     ADAEAVFQRLDADRDGAITFQEFARGFLGSLRGGRRRDWGPLDPAPAVSEAGPETHDS
                     EEDEGDEDAAAALATSCGPASPGRAWQDFQARLGDEAKFIPREEQVSTLYQNINLVEP
                     RLIQPYEHVIKNFIREIRLQSTEMENLAIAVKRAQDKAAMQLSELEEEMDQRIQAAEH
                     KTRKDEKRKAEEALSDLRRQYETEVGDLQVTIKKLRKLEEQSKRVSQKEDVAALKKQI
                     YDLSMENQKVKKDLLEAQTNIAFLQSELDALKSDYADQSLNTERDLEIIRAYTEDRNS
                     LERQIEILQTANRKLHDSNDGLRSALENSYSKFNRSLHINNISPGNTISRSSPKFIGH
                     SPQPLGYDRSSRSSYVDEDCDSLALCDPLQRTNCEVDSLPESCFDSGLSTLRDPNEYD
                     SEVEYKHQRGFQRSHGVQESFGGDASDTDVPDIRDEETFGLEDVASVLDWKPQGSVSE
                     GSIVSSSRKPISALSPQTDLVDDNAKSFSSQKAYKIVLAGDAAVGKSSFLMRLCKNEF
                     RENISATLGVDFQMKTLIVDGERTVLQLWDTAGQERFRSIAKSYFRKADGVLLLYDVT
                     CEKSFLNIREWVDMIEDAAHETVPIMLVGNKADIRDTAATEGQKCVPGHFGEKLAMTY
                     GALFCETSAKDGSNIVEAVLHLAREVKKRTDKDDSRSITNLTGTNSKKSPQMKNCCNG
                     "
     exon            707..853
                     /gene="RASEF"
                     /gene_synonym="RAB45; TSG"
                     /inference="alignment:Splign:2.1.0"
     exon            854..944
                     /gene="RASEF"
                     /gene_synonym="RAB45; TSG"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1040
                     /gene="RASEF"
                     /gene_synonym="RAB45; TSG"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1118
                     /gene="RASEF"
                     /gene_synonym="RAB45; TSG"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1234
                     /gene="RASEF"
                     /gene_synonym="RAB45; TSG"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1303
                     /gene="RASEF"
                     /gene_synonym="RAB45; TSG"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1388
                     /gene="RASEF"
                     /gene_synonym="RAB45; TSG"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1477
                     /gene="RASEF"
                     /gene_synonym="RAB45; TSG"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1712
                     /gene="RASEF"
                     /gene_synonym="RAB45; TSG"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1850
                     /gene="RASEF"
                     /gene_synonym="RAB45; TSG"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1998
                     /gene="RASEF"
                     /gene_synonym="RAB45; TSG"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2080
                     /gene="RASEF"
                     /gene_synonym="RAB45; TSG"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2195
                     /gene="RASEF"
                     /gene_synonym="RAB45; TSG"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2315
                     /gene="RASEF"
                     /gene_synonym="RAB45; TSG"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2392
                     /gene="RASEF"
                     /gene_synonym="RAB45; TSG"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..5585
                     /gene="RASEF"
                     /gene_synonym="RAB45; TSG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5564..5569
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASEF"
                     /gene_synonym="RAB45; TSG"
                     /note="hexamer: AATAAA"
     polyA_site      5585
                     /gene="RASEF"
                     /gene_synonym="RAB45; TSG"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcagga ggcgctcctt ggcggtgcct ggagcccggg cgcaccccac cgctcccggg
       61 acctgttggg ggctggcccg aaccgtcgtc gaagggagcc gctcggccac ccccgacgtt
      121 cctcgccccg cccgacgttc cctcaagtgg ccgaaccagc cggacgagcc aaactcgccg
      181 ggcctcccgg cggcagcagg tggccccgtc cttccaggga gggccctgcg ccccgcggcg
      241 ctccggagcc ctctcggccg cccccgccag gcgggatgga ggcggatggg gacggagagg
      301 agctggcccg gctgcgctca gtcttcgccg cctgcgacgc gaaccgctcg gggcgcctgg
      361 agcgcgagga gttccgggca ctgtgcacgg agctgcgggt gcggccggcc gacgccgagg
      421 cagtattcca gcggctggac gccgaccgtg acggcgccat caccttccag gagttcgcgc
      481 gtggcttcct cgggtccctc cgcggggggc ggcgccggga ctggggtcct ctggatcccg
      541 cgcccgccgt gtctgaggcg gggccggaga cacacgacag cgaggaggac gaaggcgacg
      601 aggacgcggc ggcggcgctg gccacctcgt gcggcccggc gagtcccggc cgggcttggc
      661 aggatttcca ggcgcgactt ggggacgaag ccaagttcat tcccagagaa gagcaagtta
      721 gtaccttgta ccaaaacatc aaccttgtgg agccaagatt aattcagcca tatgaacatg
      781 ttataaagaa cttcatccgt gagatcagac ttcaaagcac agaaatggaa aatttggcca
      841 ttgcggtgaa gagagcccag gacaaggcag ctatgcagtt gagtgagttg gaagaggaaa
      901 tggatcagag gattcaggct gcagaacata agacacggaa agacgaaaaa cgcaaagctg
      961 aggaagccct cagtgacctc agacgtcagt atgaaactga agtaggagat ctgcaggtga
     1021 ccattaaaaa gctaagaaag ctcgaagaac aatcaaaacg cgtaagtcaa aaggaagatg
     1081 tggctgcatt gaaaaaacaa atttatgatt tatcaatgga aaaccagaaa gttaagaaag
     1141 accttttaga agcacagaca aacatagcct ttcttcagag tgagttagat gctttgaaaa
     1201 gtgattatgc tgatcagagt ctgaatactg aaagggatct ggaaataatc cgagcataca
     1261 cagaagatcg aaatagtctt gagaggcaaa ttgaaatact ccaaacagct aaccggaagc
     1321 tacatgacag taatgatggc cttagaagtg cccttgaaaa cagttatagc aagttcaaca
     1381 gatctttgca tataaataat atctcaccag ggaatacaat ttctagaagc agtcccaaat
     1441 tcattggtca ttcccctcaa cctctaggct atgacaggtc atcccgctct tcctatgtgg
     1501 atgaggactg tgactccctg gccctctgtg atcctctgca gaggacaaat tgtgaagttg
     1561 acagcctgcc tgaaagctgc ttcgacagcg gcttgtctac cttgagagat cccaatgagt
     1621 atgactcaga agtggaatac aagcaccaga ggggatttca gaggtcacac ggggtgcagg
     1681 agagctttgg aggtgatgct tcagacacag atgttcctga cataagggat gaagagacat
     1741 ttggtttaga agatgtggct tccgtcttag actggaagcc ccaagggtct gttagtgaag
     1801 gcagcattgt tagttcatca agaaagccca tctcagcact ctcgccccag acagacctgg
     1861 tagatgacaa cgctaaatct tttagctcac agaaggctta caagattgta cttgctgggg
     1921 acgctgcagt ggggaagtct agtttcctca tgagactttg caagaatgaa tttcgagaaa
     1981 atataagcgc caccctggga gttgatttcc aaatgaaaac cctcattgtg gatggagaac
     2041 gaacagttct gcagctctgg gatacagctg gtcaggagag attcagaagt attgccaagt
     2101 cttacttcag aaaggcagat ggtgttttgc tgctgtatga tgttacatgt gagaaaagct
     2161 ttcttaacat acgagaatgg gtagatatga ttgaggatgc agcccatgag actgttccca
     2221 ttatgctggt aggaaacaag gctgacattc gtgacactgc tgctacagag ggacaaaaat
     2281 gtgtcccagg gcactttgga gagaaactgg ccatgacgta tggggcatta ttctgtgaaa
     2341 caagtgccaa agatggttct aacatagtgg aggctgttct gcaccttgct cgagaagtga
     2401 aaaagagaac tgacaaggat gacagcagat ccattaccaa tctaaccggg accaattcca
     2461 aaaagtcacc acagatgaag aattgttgca atggctaaat cccaaacatc cttggcctgt
     2521 gaagtcttca tttccagaat actgaatttg tgtgacttat ttggctctta acagagtggc
     2581 acatcctact gacactgtcc tatggagagt tacagtgcag gaaacctgaa cccagctctc
     2641 aggtccctct ggaactttgg ctcttctttg ttttgtctca gtgagtgatt tgggccctct
     2701 ggctaaatag actagtcatg tccttacagg tcttaaaaga taacatgtaa atgtttttaa
     2761 aatggtaaaa aaaaagaaaa gaaaagaaat cacatgctca gatcaaagct gtagaggaaa
     2821 ctgacataat tagattcatg tggtagctga attaggttac ccacaaagtc agcatttaaa
     2881 tatttgatac taaagttcta gtaagaaggg attctcatcc tagctttgct gttaactggc
     2941 cttgtgacct tggacatgtc acaagcccat gtcggatctg tttcttcatc tgtaaaatgt
     3001 gcagcttgcc ctcaaaggcc ttgcagccct tggcacctca gattctgtgg gaagcagtag
     3061 gacagagagt gtggtggccc acagttaata atagaactat ggttattcct gctttttaat
     3121 attggagtat tgatttttct cacttctgaa ataaggacag aatttgatta aaaaatggaa
     3181 acagaaatat ctatttttta tgtataaaga aacatgtttg agacaaaaat agttgtatat
     3241 aaaaggatat ttcataatct cagaatagtt acaaagctca ctgcttgaat ttggtgttaa
     3301 aaattctaat ggaaacatgt aaagccacat actactgaaa gcacaatgcc caggaaagtt
     3361 gtcactcttc acttaaggga gtggttgcca ggggctgaga aagggaggat ggggagtgac
     3421 tgctaatagg tatgtggttt ctttgggcga tgatgagaat gttctggaat tggaatagtg
     3481 gtgatagttg tataactgtt tgaatgtact aggaaccact gaattgtata ctttgaaagg
     3541 gtgaatttta tggttgtgaa ttatctcact aaaaaaaatg ctagtactta gagtgatgta
     3601 acattttgca aaattttcat tttcgtatcc ctgctgattt caaaccttcc catggtttag
     3661 aagcataacc tgtaatgtaa tgcaagtccc ctaactccct ggttgctaac attaacttcc
     3721 ttaagtaata atcaatgaaa gaaattctat gcatggtttt gaaataatat ccttgaaaga
     3781 ggaatcacca ttaggaaagg tgagtcaggg tcctttgttt aatgtgacta gtggctcatc
     3841 atcaccagtg acctggttgg gcctactctc cttccagaac ctgcattgct tcccagacct
     3901 ccccactgag atgcctctaa gagccaaagg agtcaacact tgagcctagg gtgggctaca
     3961 acaaaagatt ctaatttacc ttgcttcatc taggtccagg ccccaagtag cttgctgaag
     4021 gaacttaaaa agtagctgtt atttattgta ttgtataagc taaaaacatt tatttttgtt
     4081 gaatcgaaac aattccatgt agcaatcttt tttctgttca cggtgtttgt gatagaacct
     4141 taaattccgc aagcatcagt tttttgaaaa aatgggaatt gaccggatag ttacaggcaa
     4201 agattataaa tagctacaac atcatttaac ttttataaac atgccttctc tctattgaag
     4261 acatctgata tttttgctgg aaagttggat ctatcctcag taactctgcc atgaattcct
     4321 gtttcctggt tccagaaaaa gaaaagatta catttctgat cataaagaat gtcttgcata
     4381 tgggaaattt ttcaaaataa ggggggtatt atttatgtgg catgggaaaa cttttgccat
     4441 ggctgtttgt cttagtggca tcttttgatg acattggatc agatatatgt agatgctgat
     4501 atatgggaca catgtttagg ttttggtgca gttgcacaaa actgtgttag tttatatgtt
     4561 actgtgttgc ctttatttat tctctccaaa gtgtctcttt atatttgttt tacaatctgt
     4621 gaaagagtat accataatac agaagtattt tcatagtctt tacctctgga ttgtcctgtc
     4681 agtatagcca cgttgatgag attacaccag tgcctttgat ggtcaaccaa tcatctttaa
     4741 gtatttgagc cctgataaat attttggtaa cataatccaa attagagact tagagctctg
     4801 gttagcaatc atgtttaaag agaagcttct taaagctctg tatgctggga gattcatgat
     4861 tattaccaac gttttgattt catgaaggtg ttctcaaatt taaagcacat tttcagtaag
     4921 aacaaaaata tttaatgttt ttatcttaga cttgatacat ttgcatatta ctatggaagt
     4981 tattcacctt gtccctgttt ttctttaaga tattttaaaa tcatagttat actacagtcc
     5041 ttttttaaat gtatcctgat acattgtaaa atattttaat ttcattgtgg aaaataatgt
     5101 tggataagga gatatttttc actgttaact tttagcccat gcattttcat aatttatttt
     5161 tttcacttgc tgctttatat gacatatgtg acatttgatt atttaacact tgatgtgatc
     5221 tgcataaacc caagttgcac aaccctcctg ctgaagataa aattgaggtt aaagataaag
     5281 atttattttc atatttgtac agtgatcggc ttcagtgatg gtttttgtgg gcatttattg
     5341 tgtgtgtgta agaaatttca tatgtatata ttaagtaggc ctctgagtat tgaataattg
     5401 ttttatgatt ttgatttata tggtttacat tttcattgtg tgggccatat ttcgtttata
     5461 ctgtttattt ctcttcaaac cttaataatt ataccataaa gtgtaatttt tatagcaatg
     5521 caaatgtcta aggaactaca aatattttct acgttgtaaa ttcaataaag cttgcttcct
     5581 ttggc
//
