LOCUS       NM_016084               1748 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens ras related dexamethasone induced 1 (RASD1),
            transcript variant 1, mRNA.
ACCESSION   NM_016084
VERSION     NM_016084.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1748)
  AUTHORS   Durmaz,C.D., Karabulut,H.G., Saka,M.C., Sucularli,C., Gumus
            Akay,G., Atbasoglu,C. and Ilgin Ruhi,H.
  TITLE     Genetic Analysis of RASD1 as a Candidate Gene for Schizophrenia
  JOURNAL   Balkan Med J 39 (6), 422-428 (2022)
   PUBMED   36305088
  REMARK    GeneRIF: Genetic Analysis of RASD1 as a Candidate Gene for
            Schizophrenia
REFERENCE   2  (bases 1 to 1748)
  AUTHORS   Lu,R.Q., Wu,L.X., Zhang,J., Qin,Y.Z., Liu,Y.R., Lai,Y.Y., Jiang,H.,
            Chang,Y.J., Ruan,G.R. and Huang,X.J.
  TITLE     Prognostic value of RASD1 transcript levels in adult
            Philadelphia-negative B-cell acute lymphoblastic leukemia
  JOURNAL   Hematology 26 (1), 9-15 (2021)
   PUBMED   33357137
  REMARK    GeneRIF: Prognostic value of RASD1 transcript levels in adult
            Philadelphia-negative B-cell acute lymphoblastic leukemia.
REFERENCE   3  (bases 1 to 1748)
  AUTHORS   Zellinger,B., Bodenhofer,U., Englander,I.A., Kronberger,C.,
            Strasser,P., Grambozov,B., Fastner,G., Stana,M., Reitsamer,R.,
            Sotlar,K., Sedlmayer,F. and Zehentmayr,F.
  TITLE     Hsa-miR-375/RASD1 Signaling May Predict Local Control in Early
            Breast Cancer
  JOURNAL   Genes (Basel) 11 (12), 1404 (2020)
   PUBMED   33255991
  REMARK    GeneRIF: Hsa-miR-375/RASD1 Signaling May Predict Local Control in
            Early Breast Cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1748)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1748)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1748)
  AUTHORS   Fang,M., Jaffrey,S.R., Sawa,A., Ye,K., Luo,X. and Snyder,S.H.
  TITLE     Dexras1: a G protein specifically coupled to neuronal nitric oxide
            synthase via CAPON
  JOURNAL   Neuron 28 (1), 183-193 (2000)
   PUBMED   11086993
REFERENCE   7  (bases 1 to 1748)
  AUTHORS   St Croix,B., Rago,C., Velculescu,V., Traverso,G., Romans,K.E.,
            Montgomery,E., Lal,A., Riggins,G.J., Lengauer,C., Vogelstein,B. and
            Kinzler,K.W.
  TITLE     Genes expressed in human tumor endothelium
  JOURNAL   Science 289 (5482), 1197-1202 (2000)
   PUBMED   10947988
REFERENCE   8  (bases 1 to 1748)
  AUTHORS   Cismowski,M.J., Ma,C., Ribas,C., Xie,X., Spruyt,M., Lizano,J.S.,
            Lanier,S.M. and Duzic,E.
  TITLE     Activation of heterotrimeric G-protein signaling by a ras-related
            protein. Implications for signal integration
  JOURNAL   J Biol Chem 275 (31), 23421-23424 (2000)
   PUBMED   10840027
REFERENCE   9  (bases 1 to 1748)
  AUTHORS   Tu,Y. and Wu,C.
  TITLE     Cloning, expression and characterization of a novel human
            Ras-related protein that is regulated by glucocorticoid hormone
  JOURNAL   Biochim Biophys Acta 1489 (2-3), 452-456 (1999)
   PUBMED   10673050
REFERENCE   10 (bases 1 to 1748)
  AUTHORS   Cismowski,M.J., Takesono,A., Ma,C., Lizano,J.S., Xie,X.,
            Fuernkranz,H., Lanier,S.M. and Duzic,E.
  TITLE     Genetic screens in yeast to identify mammalian nonreceptor
            modulators of G-protein signaling
  JOURNAL   Nat Biotechnol 17 (9), 878-883 (1999)
   PUBMED   10471929
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073621.21.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_016084.4.
            
            Summary: This gene encodes a member of the Ras superfamily of small
            GTPases and is induced by dexamethasone. The encoded protein is an
            activator of G-protein signaling and acts as a direct nucleotide
            exchange factor for Gi-Go proteins. This protein interacts with the
            neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor
            protein FE65, which interacts with the Alzheimer's disease amyloid
            precursor protein. This gene may play a role in
            dexamethasone-induced alterations in cell morphology, growth and
            cell-extracellular matrix interactions. Epigenetic inactivation of
            this gene is closely correlated with resistance to dexamethasone in
            multiple myeloma cells. Alternatively spliced transcript variants
            encoding different isoforms have been found for this gene.[provided
            by RefSeq, Sep 2011].
            
            Transcript Variant: This variant (1) is the longer transcript and
            encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.722759.1,
                                           SRR3476690.810915.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000225688.4/ ENSP00000225688.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-500               AC073621.21        2953-3452
            501-1748            AC073621.21        3664-4911
FEATURES             Location/Qualifiers
     source          1..1748
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..1748
                     /gene="RASD1"
                     /gene_synonym="AGS1; DEXRAS1; MGC:26290"
                     /note="ras related dexamethasone induced 1"
                     /db_xref="GeneID:51655"
                     /db_xref="HGNC:HGNC:15828"
                     /db_xref="MIM:605550"
     exon            1..500
                     /gene="RASD1"
                     /gene_synonym="AGS1; DEXRAS1; MGC:26290"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1060
                     /gene="RASD1"
                     /gene_synonym="AGS1; DEXRAS1; MGC:26290"
                     /EC_number="3.6.5.2"
                     /note="isoform 1 proprotein is encoded by transcript
                     variant 1; ras-related protein; activator of G-protein
                     signaling 1; RAS, dexamethasone-induced 1"
                     /codon_start=1
                     /product="dexamethasone-induced Ras-related protein 1
                     isoform 1 proprotein"
                     /protein_id="NP_057168.1"
                     /db_xref="CCDS:CCDS11185.1"
                     /db_xref="GeneID:51655"
                     /db_xref="HGNC:HGNC:15828"
                     /db_xref="MIM:605550"
                     /translation="MKLAAMIKKMCPSDSELSIPAKNCYRMVILGSSKVGKTAIVSRF
                     LTGRFEDAYTPTIEDFHRKFYSIRGEVYQLDILDTSGNHPFPAMRRLSILTGDVFILV
                     FSLDNRDSFEEVQRLRQQILDTKSCLKNKTKENVDVPLVICGNKGDRDFYREVDQREI
                     EQLVGDDPQRCAYFEISAKKNSSLDQMFRALFAMAKLPSEMSPDLHRKVSVQYCDVLH
                     KKALRNKKLLRAGSGGGGGDPGDAFGIVAPFARRPSVHSDLMYIREKASAGSQAKDKE
                     RCVIS"
     exon            501..1748
                     /gene="RASD1"
                     /gene_synonym="AGS1; DEXRAS1; MGC:26290"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1730..1735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASD1"
                     /gene_synonym="AGS1; DEXRAS1; MGC:26290"
                     /note="hexamer: AATAAT"
     polyA_site      1748
                     /gene="RASD1"
                     /gene_synonym="AGS1; DEXRAS1; MGC:26290"
                     /note="major polyA site"
ORIGIN      
        1 agagcaagcg gcctgtgccc agatcctggg agaaccccag ccgagcccag cctagcccga
       61 gcccagcccg agcggagccg gagccccaag cccgagccgc gcccagcccg agcagagccc
      121 tccagccgct caccccgcgt gccaccccag cgaccctcag ccgctctctg cccttctctc
      181 ggccccgcgc ccgccctcgc ggcccctctg cccaatgaaa ctggccgcga tgatcaagaa
      241 gatgtgcccg agcgactcgg agctgagtat cccggccaag aactgctatc gcatggtcat
      301 cctcggctcg tccaaggtgg gcaagacggc catcgtgtcg cgcttcctca ccggccgctt
      361 cgaggacgcc tacacgccta ccatcgagga cttccaccgc aagttctact ccatccgcgg
      421 cgaggtctac cagctcgaca tcctcgacac gtccggcaac cacccgttcc ccgccatgcg
      481 gcgcctctcc atcctcacag gagacgtttt catcctggtg ttcagtctgg acaaccgcga
      541 ctccttcgag gaggtgcagc ggctcaggca gcagatcctc gacaccaagt cttgcctcaa
      601 gaacaaaacc aaggagaacg tggacgtgcc cctggtcatc tgcggcaaca agggtgaccg
      661 cgacttctac cgcgaggtgg accagcgcga gatcgagcag ctggtgggcg acgaccccca
      721 gcgctgcgcc tacttcgaga tctcggccaa gaagaacagc agcctggacc agatgttccg
      781 cgcgctcttc gccatggcca agctgcccag cgagatgagc ccagacctgc accgcaaggt
      841 ctcggtgcag tactgcgacg tgctgcacaa gaaggcgctg cggaacaaga agctgctgcg
      901 ggccggcagc ggcggcggcg gcggcgaccc gggcgacgcc tttggcatcg tggcaccctt
      961 cgcgcgccgg cccagcgtac acagcgacct catgtacatc cgcgagaagg ccagcgccgg
     1021 cagccaggcc aaggacaagg agcgctgcgt catcagctag gagccccgcc gcgctggcga
     1081 cacaacctaa ggaggacctt tttgttaagt caaatccaac ggcccggtgc gccccaggcc
     1141 gggagcgcgc gcggactggc gtctcccctc ccggcgatcc gcccccagca ctggggaggc
     1201 gccactgaac cgagaaggga cggtcatctg ctccggaagg aaagagaacg ggccaagact
     1261 gggactattc cccacccccg gtcccccatt gaggcccgcc acccccataa ctttgggagc
     1321 gagggcccag ccgagggtgg atttatcttc tcaaagacct aagagtgagc gcggggtggg
     1381 ggagggatgt gaagttatcc agcctctgct aggcttcaag aaaccgtcat gcccgcttga
     1441 gggtcaggac ccacggggca ttatcttgtc tgtgattccg ggttgctgtg acagccggta
     1501 gagcctctgc cctcccaaaa ctaagcgggg gggcgtgggt caaatcatag ccaagtgact
     1561 tgtttacatg tgagtgaaac tgcacaaagg aacacaaaac aaaacttgca ctttaacggt
     1621 agttccggtg tcaacatgga cacgaacaaa accttaccca ggtgtttata ctgtgtgtgt
     1681 ctgaggtctt taaagttatt gctttatttg gttttttaat atacaataaa ataatttaaa
     1741 atggaaaa
//
