LOCUS       NM_170692               9843 bp    mRNA    linear   PRI 08-FEB-2025
DEFINITION  Homo sapiens RAS protein activator like 2 (RASAL2), transcript
            variant 2, mRNA.
ACCESSION   NM_170692
VERSION     NM_170692.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9843)
  AUTHORS   Zhang,Y., Yang,Y., Hu,X., Wei,B., Shen,Q., Shi,C. and Chen,P.
  TITLE     RAS protein activator-like 2 (RASAL2) initiates peritubular
            capillary rarefaction in hypoxic renal interstitial fibrosis
  JOURNAL   Transl Res 269, 14-30 (2024)
   PUBMED   38453052
  REMARK    GeneRIF: RAS protein activator-like 2 (RASAL2) initiates
            peritubular capillary rarefaction in hypoxic renal interstitial
            fibrosis.
REFERENCE   2  (bases 1 to 9843)
  AUTHORS   Singharajkomron,N., Yodsurang,V., Limprasutr,V., Wattanathamsan,O.,
            Iksen,I., Hayakawa,Y. and Pongrakhananon,V.
  TITLE     CAMSAP2 enhances lung cancer cell metastasis by mediating RASAL2
            degradation
  JOURNAL   Life Sci 338, 122391 (2024)
   PUBMED   38159595
  REMARK    GeneRIF: CAMSAP2 enhances lung cancer cell metastasis by mediating
            RASAL2 degradation.
REFERENCE   3  (bases 1 to 9843)
  AUTHORS   Wills,C., Watts,K., Maughan,T.S., Fisher,D., Al-Tassan,N.A.,
            Houlston,R.S., Escott-Price,V. and Cheadle,J.P.
  TITLE     Germline variation in RASAL2 may predict survival in patients with
            RAS-activated colorectal cancer
  JOURNAL   Genes Chromosomes Cancer 62 (6), 332-341 (2023)
   PUBMED   36790221
  REMARK    GeneRIF: Germline variation in RASAL2 may predict survival in
            patients with RAS-activated colorectal cancer.
REFERENCE   4  (bases 1 to 9843)
  AUTHORS   Yue,Y., Wu,K., Qian,W., Zhu,Z., Zhang,S., Zhang,W., Zhang,W.,
            Wu,S., Li,L., Wu,Z., Ma,Q., Xie,K. and Wang,Z.
  TITLE     RASAL2 mediated the enhancement of YAP1/TIAM1 signaling promotes
            malignant phenotypes of pancreatic ductal adenocarcinoma
  JOURNAL   Int J Biol Sci 18 (10), 4245-4259 (2022)
   PUBMED   35844783
  REMARK    GeneRIF: RASAL2 mediated the enhancement of YAP1/TIAM1 signaling
            promotes malignant phenotypes of pancreatic ductal adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9843)
  AUTHORS   Hu,Y., Zhang,P., Shi,Y., Dong,X., Wu,Y., Dong,D., Li,E. and Fan,Y.
  TITLE     Inhibition of Ras protein activator like 2 produces antitumor
            effects in gastric cancer via the suppression of YAP1 activation
  JOURNAL   Environ Toxicol 37 (3), 527-538 (2022)
   PUBMED   34826200
  REMARK    GeneRIF: Inhibition of Ras protein activator like 2 produces
            antitumor effects in gastric cancer via the suppression of YAP1
            activation.
            Erratum:[Environ Toxicol. 2022 Jun;37(6):1543. doi:
            10.1002/tox.23527.. PMID: 35366044]
REFERENCE   6  (bases 1 to 9843)
  AUTHORS   Melen,E., Himes,B.E., Brehm,J.M., Boutaoui,N., Klanderman,B.J.,
            Sylvia,J.S. and Lasky-Su,J.
  TITLE     Analyses of shared genetic factors between asthma and obesity in
            children
  JOURNAL   J Allergy Clin Immunol 126 (3), 631-7 (2010)
   PUBMED   20816195
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 9843)
  AUTHORS   Shibui,T., Kobayashi,T. and Shiratori,M.
  TITLE     Isolation of cross-reacting antigen candidates by mRNA-display
            using a mixed cDNA library
  JOURNAL   Biotechnol Lett 30 (12), 2037-2043 (2008)
   PUBMED   18633578
REFERENCE   8  (bases 1 to 9843)
  AUTHORS   de Chassey,B., Navratil,V., Tafforeau,L., Hiet,M.S., Aublin-Gex,A.,
            Agaugue,S., Meiffren,G., Pradezynski,F., Faria,B.F., Chantier,T.,
            Le Breton,M., Pellet,J., Davoust,N., Mangeot,P.E., Chaboud,A.,
            Penin,F., Jacob,Y., Vidalain,P.O., Vidal,M., Andre,P.,
            Rabourdin-Combe,C. and Lotteau,V.
  TITLE     Hepatitis C virus infection protein network
  JOURNAL   Mol Syst Biol 4, 230 (2008)
   PUBMED   18985028
REFERENCE   9  (bases 1 to 9843)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   10 (bases 1 to 9843)
  AUTHORS   Noto,S., Maeda,T., Hattori,S., Inazawa,J., Imamura,M., Asaka,M. and
            Hatakeyama,M.
  TITLE     A novel human RasGAP-like gene that maps within the prostate cancer
            susceptibility locus at chromosome 1q25
  JOURNAL   FEBS Lett 441 (1), 127-131 (1998)
   PUBMED   9877179
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK311017.1, AL160281.17,
            BC110611.2 and AL035702.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 8, 2020 this sequence version replaced NM_170692.3.
            
            Summary: This gene encodes a protein that contains the GAP-related
            domain (GRD), a characteristic domain of GTPase-activating proteins
            (GAPs). GAPs function as activators of Ras superfamily of small
            GTPases. The protein encoded by this gene is able to complement the
            defective RasGAP function in a yeast system. Two alternatively
            spliced transcript variants of this gene encoding distinct isoforms
            have been reported. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and 5'
            coding region, and uses an alternate in-frame splice site in the
            central coding region, compared to variant 1. The resulting isoform
            (2) has a distinct N-terminus and is longer than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110611.2, SRR1803616.158295.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367649.8/ ENSP00000356621.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-312               AK311017.1         375-686
            313-313             AL160281.17        5502-5502
            314-393             AK311017.1         688-767
            394-4415            BC110611.2         1-4022
            4416-9843           AL035702.7         18563-23990         c
FEATURES             Location/Qualifiers
     source          1..9843
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.2"
     gene            1..9843
                     /gene="RASAL2"
                     /gene_synonym="NGAP"
                     /note="RAS protein activator like 2"
                     /db_xref="GeneID:9462"
                     /db_xref="HGNC:HGNC:9874"
                     /db_xref="MIM:606136"
     exon            1..591
                     /gene="RASAL2"
                     /gene_synonym="NGAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             390..4232
                     /gene="RASAL2"
                     /gene_synonym="NGAP"
                     /note="isoform 2 is encoded by transcript variant 2; Ras
                     protein activator like 1; ras GTPase-activating protein
                     nGAP; RASAL2/ACVR1 fusion"
                     /codon_start=1
                     /product="ras GTPase-activating protein nGAP isoform 2"
                     /protein_id="NP_733793.2"
                     /db_xref="CCDS:CCDS1321.2"
                     /db_xref="GeneID:9462"
                     /db_xref="HGNC:HGNC:9874"
                     /db_xref="MIM:606136"
                     /translation="MELSPSSGGAAEALSWPEMFPALESDSPLPPEDLDAVVPVSGAV
                     AGGMLDRILLESVCQQQSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCILTDSQL
                     VLLNKEKEIPVEGGQEQQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAERSP
                     RRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPS
                     LRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFE
                     VTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKK
                     YFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKN
                     NYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYK
                     EFAEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRC
                     GEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSS
                     ELIDHQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISAS
                     LFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMN
                     DFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKATV
                     AKLGPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSD
                     LHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDT
                     HAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQP
                     GGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSM
                     EDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLP
                     HSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSP
                     VDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSR
                     RLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEE
                     LKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRLMSALTQVKERYSMQVRNGISPT
                     NPTKLSITENGEFKNSSC"
     exon            592..719
                     /gene="RASAL2"
                     /gene_synonym="NGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            720..846
                     /gene="RASAL2"
                     /gene_synonym="NGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            847..953
                     /gene="RASAL2"
                     /gene_synonym="NGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1063
                     /gene="RASAL2"
                     /gene_synonym="NGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1217
                     /gene="RASAL2"
                     /gene_synonym="NGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1316
                     /gene="RASAL2"
                     /gene_synonym="NGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1871
                     /gene="RASAL2"
                     /gene_synonym="NGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..2016
                     /gene="RASAL2"
                     /gene_synonym="NGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2161
                     /gene="RASAL2"
                     /gene_synonym="NGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2398
                     /gene="RASAL2"
                     /gene_synonym="NGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2600
                     /gene="RASAL2"
                     /gene_synonym="NGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2779
                     /gene="RASAL2"
                     /gene_synonym="NGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2780..3641
                     /gene="RASAL2"
                     /gene_synonym="NGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3642..3776
                     /gene="RASAL2"
                     /gene_synonym="NGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3777..3979
                     /gene="RASAL2"
                     /gene_synonym="NGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3980..4067
                     /gene="RASAL2"
                     /gene_synonym="NGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4068..9843
                     /gene="RASAL2"
                     /gene_synonym="NGAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9823..9828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASAL2"
                     /gene_synonym="NGAP"
                     /note="hexamer: AATAAA"
     polyA_site      9843
                     /gene="RASAL2"
                     /gene_synonym="NGAP"
                     /note="major polyA site"
ORIGIN      
        1 agagcctggt ctgaccgcga gagacgccgg cggggctgaa gaaggcggct ccgaggaggt
       61 gggagggcga gcctcccctc ccgggttctt ctgcgtcctc tcccgggagg gacccacaca
      121 cacctgagcc cggacccacc cttggtcggg gccacgctgg atcctcctcc cggcctgggt
      181 cccgcccgcc gactgcaggt gggctgcatc gcccgagcct cgggcagtgg gcgacgggga
      241 aggaggtgag aggtgtccgc gccggctgcc gctcgggtcc ctgccctcgc tgcgcgctct
      301 cctcctcccc ttaccgcagg cagggcgcgg agccgcgcgc cagcccgccc cgaagccgcc
      361 gcctcgtccc cctcccgcct cggggcacca tggagctctc tccgtcgtcc ggaggagccg
      421 cggaggcgct gtcctggccg gagatgttcc cggcgctgga gtccgactcg ccgctgcccc
      481 cggaggacct ggacgcggtt gtcccagtca gtggagccgt cgccggtggc atgttggatc
      541 ggatccttct ggagtccgtg tgccagcaac agagctgggt ccgggtgtac gatgtgaaag
      601 gaccacccac ccaccgtctg tcttgtggtc agtcacccta caccgagaca acaacgtggg
      661 agcggaagta ttgcatcctc acagacagcc agttggtatt gctcaacaag gagaaggaga
      721 tacctgtgga agggggacag gagcagcaga cagattccac caaagggcga tgcctgagga
      781 gaactgtcag tgtcccttcc gagggtcagt ttcccgagta cccaccagag ggcgccacta
      841 aactggaggt accagcagaa aggtcccctc gtagacggag tatctcaggg accagtacat
      901 cagagaaacc caactccatg gacactgcaa atacctcacc cttcaaagta ccaggattct
      961 tcagcaagcg cctgaaaggc tccatcaaga ggaccaaaag ccagtcaaag cttgacagaa
     1021 acacgagctt tcggcttcca tcccttcgca gtacagatga caggtctcgt gggctgccta
     1081 aactaaaaga gtcacgttcc catgaatcct tgctgagccc atgcagcaca gtggaatgtc
     1141 tggatcttgg tagaggggaa cctgtatcag tgaaaccact tcatagtagc atccttggac
     1201 aagacttctg ctttgaggtt acctacttaa gtggaagtaa atgcttcagc tgtaattctg
     1261 cttctgagag agacaagtgg atggaaaacc ttcgcaggac agttcaacct aataaggaca
     1321 attgcaggcg agctgaaaat gttcttcgtt tatggatcat tgaagccaag gaccttgccc
     1381 ctaaaaagaa atatttctgc gaactgtgcc ttgatgatac cctctttgct cgtacaacca
     1441 gcaagaccaa agcagacaat attttctggg gcgaacattt tgaattcttc agccttccac
     1501 ctcttcatag tatcacagtt cacatttaca aggatgtgga aaaaaagaaa aaaaaggaca
     1561 agaataatta tgtagggcta gtcaacatcc ccactgccag tgtgactggt cgccaatttg
     1621 tagaaaagtg gtatccagtg agtacaccta cacccaacaa aggaaagaca ggaggacctt
     1681 ctattcggat taaatcacgt ttccaaacta tcaccattct gcctatggag caatacaaag
     1741 aatttgcaga atttgtcacc agcaactaca ccatgctgtg ttctgtcctt gagccagtaa
     1801 ttagtgtgag aaataaagag gagttggctt gtgccttagt gcacattctt caaagtactg
     1861 gcagagccaa ggattttctg actgacttgg tgatgtctga ggtggatcgt tgtggagagc
     1921 atgatgtctt gatcttcaga gagaacacta ttgccaccaa atccattgag gaatacctca
     1981 agttggtggg acaacagtat cttcatgacg cactggggga gtttatcaaa gctttgtatg
     2041 agtccgatga gaactgtgaa gtggatccca gcaaatgttc atctagtgaa ctgatagacc
     2101 atcagagcaa cctgaaaatg tgctgtgagc tggctttctg caagatcatc aactcttact
     2161 gtgttttccc tcgtgagttg aaagaagtgt ttgcatcatg gaagcagcag tgcctgaacc
     2221 gtggcaagca agacatcagc gagaggctca tcagtgcctc attatttctc cgttttctgt
     2281 gtccagccat tatgtctccc agtcttttca accttatgca ggagtatcct gatgaccgca
     2341 catctcggac tctaactctt attgccaagg tcattcagaa cctggccaac tttgccaagt
     2401 ttggtaacaa agaggaatac atggcattca tgaatgattt tttagaacat gaatggggtg
     2461 gaatgaagcg ctttcttttg gagatctcta atccagacac catctcaaac accccaggct
     2521 ttgatggtta cattgatctg ggccgagagc tttcagtttt gcattcctta ctgtgggaag
     2581 tagtttccca acttgataag gcgaccgtgg caaaattggg gcctctccct cgtgttcttg
     2641 ctgatattac caagtcattg actaatccta cgccaataca acagcaactg agacgcttca
     2701 ctgaacataa ctccagtcca aatgtcagtg gaagcctctc ctctgggctg cagaaaatat
     2761 ttgaagaccc cactgacagt gatttgcata aactaaaatc tccaagccag gacaacacag
     2821 acagctactt cagagggaaa acattattgc tggttcagca agcctcctct cagagcatga
     2881 cttattctga aaaggatgaa agggaaagta gccttcctaa tggtcggagc gtctccctca
     2941 tggacctcca ggacactcat gctgctcaag tggagcatgc atctgtcatg cttgatgtgc
     3001 ctatacgctt gaccggaagc cagctttcca taacccaggt ggccagcatc aaacagctgc
     3061 gggaaaccca gagcactccc caaagtgcac cccaagtgag aaggcccctg cacccagcct
     3121 tgaaccagcc aggtggcctt cagcccttgt cgttccagaa ccctgtctat cacctcaata
     3181 acccaattcc agcaatgcca aaggcctcta tagattccag tttggagaac ctaagcactg
     3241 ccagttccag aagccaaagt aacagtgaag acttcaagct cagtggaccc agcaatagca
     3301 gcatggaaga tttcactaaa cgtagcactc agagtgagga cttctccagg cggcacacgg
     3361 tgccagatag acacatacct cttgctttgc cacgacaaaa tagtactggg caggcccaga
     3421 tccgaaaagt ggaccagggt gggttaggtg cccgagccaa agccccacca tccctgccac
     3481 acagtgcttc tttacgtagc accgggagca tgtcagtggt gtccgcagcc ctggtggccg
     3541 aacctgtgca gaatgggagc cggtcccggc agcagtcctc ttcctccaga gagagccctg
     3601 ttcccaaagt tagagcaatc cagagacaac agacacagca ggttcagtca cctgtggact
     3661 ctgccacaat gtccccagta gagaggacag cagcctgggt tctgaacaat gggcagtatg
     3721 aagaggatgt ggaagaaact gagcaaaatc tagatgaagc caagcatgct gagaagtatg
     3781 aacaagaaat tactaaactg aaggagcgcc tgagagtttc cagccggcga ctggaggaat
     3841 atgaacgccg cttgctggtg caggagcagc agatgcagaa gctgctgctg gaatacaagg
     3901 cccgactgga ggacagcgag gagcggctcc gaagacagca ggaagaaaaa gatagccaga
     3961 tgaaaagcat catcagcagg ctaatggctg tggaagagga actgaagaag gatcatgctg
     4021 agatgcaagc agttattgat gcaaagcaga aaataattga tgcacaggaa aaacggatcg
     4081 tgtccctgga ttcagccaac accagactga tgagcgcgct gacccaagtg aaggagcggt
     4141 acagcatgca ggtccgcaat ggcatctccc ccaccaaccc caccaagctt tccatcacgg
     4201 agaatggtga attcaaaaac agcagctgct gacgggcttt gtctgtggaa ggagacagaa
     4261 ggaaattgac ccactctcct atctccagac ctttacctag cccctccagg tttacagaat
     4321 gttgctactt cacaatggcg atgtggtgag aaactcctga atgaagaaag gaaccttgtc
     4381 tttcagggca taaggcggcg acttccaagg tcaatgcttt tcccccacat ctctatgtac
     4441 atagggaact tagttctggg ccatgtacag aaaatatcac tgtaatatac caaaaggaag
     4501 ttaataatgt agattacctt tttgattatt gctattttta ttattgtttt cctcttgttg
     4561 aaagcactgc agttgttaca ggaagtaaag taggaactgt tgtgtgagcg agacatgagc
     4621 ctgtaggttc agtaggtaga gaccaagcat ctatctgata gaagcacatg gagtgcaata
     4681 ggacattgtg agaaggaatt tttcagggat tcatctacta gtttaaaaac cccactctgg
     4741 ccctcttgtc ctttcagaaa acatgcaaat accaagatcc atacaaaaca ataatttatt
     4801 ccactgatca accaagactg gttctggttg gacagctaat ctgatttggg gattcactgt
     4861 ttcagaggac acagacaaaa gctgttgcat caaaactgga ctttaggagt aatttctatt
     4921 gaactcctgt caatatgttt atttcctctg tctacagcag atgggagtct tctcttttag
     4981 acaggggctt tttgttttta accccaattg taataaaggg tgttcttttt cctctttaga
     5041 gtttacaaaa ctataaatat ttgtgtctcc acataccatc ttcatcttca cacattcact
     5101 gtgctttcct ccccatagtg ggagctgtca tcaccaacag ggtttactct cccctggaga
     5161 ggttatttaa atagctgtcc ataagccatc cagatcaaca ccctttcttc catacagaaa
     5221 agggctaacc ataccacagc tggaatctct gaatatttcc tattaaaaat tttttctatg
     5281 tgttgttata atttttgttt gggataaaga ctctatccat tgtactagca aatctatggg
     5341 gggtaatttt atctccatct ttaactttta aagtacttct tccccttatc ccctcaataa
     5401 agaaaggaaa tccaaatttg aagcatcact ctcttaaaag aaaaagaaaa taatggaaag
     5461 tgtcaggatg gcacattcca gttattattc caatgctcgt agatctgaca ataatgaccc
     5521 aatttcaaca cttgtcatcc atagccttat tattatagaa cagaaaaagt catggaaacg
     5581 aattcatttc cttttttcca gaggtgtgca atgtcatctt gaatgcaacc ttgattacca
     5641 gaagtatgga aggttacatg ttaaacagac attatatata caaatatata tataatatat
     5701 attcacacat atgtacatat aactgcacaa ataggaaaag ttcatgcctt ctatgctgtt
     5761 cagatataat gttaaaaggg tctcaaacct ctttaagcaa gatctaagta gttgttttat
     5821 attgagaaag caacaatgtt tctcgaataa gttgatgttg attttaaatt ataagcttta
     5881 aagaattttt tttctagaaa aaggggatgg aaaaaaaagg acctgaggga gccatatgca
     5941 tcaagtgagt gtttctccat aacagaatat ttataagaga acatgtatag tgccctcttt
     6001 tgagtgatgc cgacagacac caagccctcc ttttcaccaa gtcccaggct tgcattccag
     6061 cctcttgagc tctgccctct ctcaggtgga tctttgtgtt ggaccttacg tttcagcaac
     6121 ctcaccatgg ccacataacc cacaaccttt taaaacagtt tctttcatag caatccctgt
     6181 ttctgccaga cagatctaaa atgggagttt ctcactgtgt ttatctgatc tgcacacttt
     6241 atatccagct gttttggcac ttttacgttt tcttcacctt tggttttggt ttgcaaattc
     6301 ttacaccttc tctccaagcg gagggcacac tgtggtcaaa atcacttatt ttattaggaa
     6361 aaagaggtaa ctgttccaaa gtgtagtgtc ctttgttgaa ggaggaggga tgtaagcata
     6421 gatttgttct tgtttctggc tattctcagc tcaagccatg tttaattcat tctttgtaaa
     6481 agccttcaat tgtgccacag aaaacctggt aagagaattg tcagtttcat tggccataag
     6541 tatgtaatgt gggtgatgtc ttgccattga ggtttggaag ctcttaagtg ccgattatgg
     6601 attacagagg gctgataaaa ttacttatat tgggaattga gagaagcccc aaaaaatcaa
     6661 atgtgctttt gatggataga gtgtatctta ttagcattat gggagctcct tagagggctg
     6721 tcttcactga aagatttaat gcccaaaaca tttggacaga ttatgcagcc ttctactacc
     6781 aggttatctt gaatgaagaa gaaatagtaa aaaataataa taatagagca ttaccaataa
     6841 gctaaaagtt cagagttgct gatagatgtt aaatgttaag ttatcctgtg agcctactcc
     6901 tgtccaacct tttttctcag tatttcttta gagaatgctg caatctgtat aagttactct
     6961 gaaggatttt ttaagaagag aagccaccaa caggtgataa tttttatgga gatgtttctt
     7021 aattggcttt ccctcagttc aagtaggtaa ataactttgt ttgctgggag gaggtacatg
     7081 gctgaagaga ggcaaataga ttaagatagc aatgtcttgc acttcctgtt tccctcaaaa
     7141 caacaccaca ttgtggggcg caggatagat cagggttgag tggaatttgg aattcaggtg
     7201 aagtgcttgt aaagtgcatg tctagctgac aacagacttg accattaatg aggacagtgt
     7261 tggtaggagt cagaaaagag cttcatattc cccttttata ttactgaagc aataagcaat
     7321 ctgagctgaa gcagcaaaaa gagtcacatt tccatcaggt catcatattc cctgagtctc
     7381 tgcagcaaaa gccatgtcag aggggagatt ataactaggt aactataaca agcacttgag
     7441 cacttaccat gttccaagca ctatcaccaa ggtactgttg gggtttatgg cagtctaacg
     7501 gtaagaaaaa tgtggtaaaa tgaggtaatc atgctgctat agctttttgc tttttttcat
     7561 atagtatcaa gttggtcaga attagctttc tctgactggt ctgcttccgt gtttctctgt
     7621 gatggtgtta agattatgaa agaaaaagaa gattacctaa gactgctaca agtgttaact
     7681 atatgccctt aagaatgagc ttgactttgg aagtaaagct tttcagatct tagtctaccc
     7741 ggggcctttg ttgatgggtc tgtggttctg tagacccctg gctttcactg tgttctcaga
     7801 ggtacaccag attgagagca gagttcttct ttggaagtcc cagagcaaaa taactgccat
     7861 caagtgagtt tgcattcgta tttgtttccc cttccataga gggttagttt tagttacctc
     7921 tagcttggag ttcctgagaa ggctggttat aggactgagc gtgggaaagg aaccctcttc
     7981 aggattacct cagtcccatc agtctacccc attgtgacat tgagcccaac acacacgctt
     8041 gacaccagac tagacttgtc acagggccaa acccaacagc cacatgccat agcttcactg
     8101 cattttcagc tacacctttg gaggccacct tctcctatca actgtggaaa gccagaaggg
     8161 ctcccttctc cattctcctt ccctttttca agtctaatag tgaaatctcc tgcttacccc
     8221 agcagtaaat agttgccttc ctacccctta cctgggggcc gataatttga gatactttgt
     8281 tttttcaatg cgtcagttga aggatttagt ttcttaaaag caagaaatgt tggagtgttg
     8341 aatttttaaa tagaatctct tttcatgttt gaatgattgt tattagttct agaagcattc
     8401 tctttgtcat gacccgatta tgtatactct tgggtttagg aaggacaaaa gtgatgaaat
     8461 ttgcatgaga tagaataaat atcttaggag gagtgaaaga acctgaggaa gagacacgac
     8521 cctaagggaa tgaatgcata agcagtcttc tcagtagccc agagtttcca ggaaacagga
     8581 atatttatat cccttgccca ctcttaaaat acatagatac ataaaaaggc agtctctgta
     8641 gacaacacat gcacacaccc acacaaaaca taattcctgg ggcttccttt ttctgaatgt
     8701 taatccattt tatcgagcag tgattcccaa actttgagat tttcagattt tatgctctcg
     8761 tctgttagat tttatgacat tctatcatcc taaaaaatgt actatatgtg ttatatgtat
     8821 atataagtta aagcaacttg aaattgactt ggtttggcat tgtctcaaga accctagata
     8881 tcattattga taccatgggg aatcatagaa ataaagttga atatcattga tctgagagta
     8941 ggatccagaa ataagtagtt tcagttcctg atcagttaag cctcaagtgt ttgagtaacc
     9001 aacacagcaa gacttgggaa atgcagtgag cacccgagga aaggaaagtg gtagtctttg
     9061 cctgcatttc agcatgcatt ttcctttcct actcagttgc tatcttccac ttaaataccc
     9121 tcatttgacc ctaggaagtt ttttgttttt ttttttagtt tgagacttaa aaccagattt
     9181 atttgttgtt gtagagagat ttccacagaa gttgtgtttt agggacctcc atcatctttg
     9241 tgggggtaca gatatttatg tgtaaatatc attttatgtg atttccaaat tttcgaggga
     9301 aacatttcaa ttcccagttc aacaaaaggt taaatactaa ttgactcaat gaccaccttc
     9361 aggaaagtta aatagtaaat taggttaaat tttgactggt gcttagacat ttcctagtta
     9421 tattaactta agcagacagc agcacattaa cctgagttac acctgtgagg aaatgacctt
     9481 ctaaatttga ttttgttttt catctccagg gccttaataa gagtgtgtta acacacgact
     9541 attttacaat gatagctcta aataatttat tttttatttc aagaaagaga aatacacctt
     9601 agaaaaacaa aacccaagat tttattttat ttttaaagcc atatttttgt gctagtagca
     9661 tttagattat tccgtatgtg agatccgtat cagcatttca ttacctgggt ttgttctaaa
     9721 gaagatttat ttttgttctg tgaataattt ttgacagttc ttgtacatgt acagatatag
     9781 atacgtttga ggtcttttat tgatattcct acaaagaata caaataaact ttaactttaa
     9841 aca
//
