LOCUS       NM_001301202            3368 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens RAS protein activator like 1 (RASAL1), transcript
            variant 4, mRNA.
ACCESSION   NM_001301202 XM_005253951
VERSION     NM_001301202.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3368)
  AUTHORS   Zeng,X., An,R., Guo,R. and Li,H.
  TITLE     Hypermethylated RASAL1's promotive role in chemoresistance and
            tumorigenesis of choriocarcinoma was regulated by TET2 but not
            DNMTs
  JOURNAL   BMC Cancer 24 (1), 977 (2024)
   PUBMED   39118077
  REMARK    GeneRIF: Hypermethylated RASAL1's promotive role in chemoresistance
            and tumorigenesis of choriocarcinoma was regulated by TET2 but not
            DNMTs.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3368)
  AUTHORS   Cuellar,J., Valpuesta,J.M., Wittinghofer,A. and Sot,B.
  TITLE     Domain topology of human Rasal
  JOURNAL   Biol Chem 399 (1), 63-72 (2017)
   PUBMED   28885980
  REMARK    GeneRIF: Domain topology of human Rasal
REFERENCE   3  (bases 1 to 3368)
  AUTHORS   Knief,J., Reddemann,K., Lazar-Karsten,P., Herhahn,T., Petrova,E.,
            Wellner,U. and Thorns,C.
  TITLE     Prognostic implications of RASAL1 expression in oesophagogastric
            adenocarcinoma
  JOURNAL   J Clin Pathol 70 (3), 274-276 (2017)
   PUBMED   28011578
  REMARK    GeneRIF: our study showed significantly longer overall survival
            times for oesophagogastric adenocarcinoma patients without RASAL1
            expression
REFERENCE   4  (bases 1 to 3368)
  AUTHORS   Jin,W., Chen,L., Cai,X., Zhang,Y., Zhang,J., Ma,D., Cai,X., Fu,T.,
            Yu,Z., Yu,F. and Chen,G.
  TITLE     Long non-coding RNA TUC338 is functionally involved in
            sorafenib-sensitized hepatocarcinoma cells by targeting RASAL1
  JOURNAL   Oncol Rep 37 (1), 273-280 (2017)
   PUBMED   27878301
  REMARK    GeneRIF: RASAL1 role in in sorafenib-resistance of liver cancer
            cells
REFERENCE   5  (bases 1 to 3368)
  AUTHORS   McDonnell,F., Irnaten,M., Clark,A.F., O'Brien,C.J. and Wallace,D.M.
  TITLE     Hypoxia-Induced Changes in DNA Methylation Alter RASAL1 and
            TGFbeta1 Expression in Human Trabecular Meshwork Cells
  JOURNAL   PLoS One 11 (4), e0153354 (2016)
   PUBMED   27124111
  REMARK    GeneRIF: DNA methylation, TGFbeta1 and RASAL1 appear to have an
            interacting relationship.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3368)
  AUTHORS   Ohta,M., Seto,M., Ijichi,H., Miyabayashi,K., Kudo,Y., Mohri,D.,
            Asaoka,Y., Tada,M., Tanaka,Y., Ikenoue,T., Kanai,F., Kawabe,T. and
            Omata,M.
  TITLE     Decreased expression of the RAS-GTPase activating protein RASAL1 is
            associated with colorectal tumor progression
  JOURNAL   Gastroenterology 136 (1), 206-216 (2009)
   PUBMED   18992247
  REMARK    GeneRIF: Decreased expression of the RAS-GTPase activating protein
            RASAL1 is associated with colorectal tumor progression.
REFERENCE   7  (bases 1 to 3368)
  AUTHORS   Jin,H., Wang,X., Ying,J., Wong,A.H., Cui,Y., Srivastava,G.,
            Shen,Z.Y., Li,E.M., Zhang,Q., Jin,J., Kupzig,S., Chan,A.T.,
            Cullen,P.J. and Tao,Q.
  TITLE     Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating
            protein RASAL defines a new mechanism of Ras activation in human
            cancers
  JOURNAL   Proc Natl Acad Sci U S A 104 (30), 12353-12358 (2007)
   PUBMED   17640920
  REMARK    GeneRIF: RASAL constitutes a tumor suppressor gene and therefore
            further emphasized the importance of Ca(2+) in the regulation of
            Ras signaling and has established that deregulation of this pathway
            is an important step in Ras-mediated tumorigenesis
REFERENCE   8  (bases 1 to 3368)
  AUTHORS   Liu,Q., Walker,S.A., Gao,D., Taylor,J.A., Dai,Y.F., Arkell,R.S.,
            Bootman,M.D., Roderick,H.L., Cullen,P.J. and Lockyer,P.J.
  TITLE     CAPRI and RASAL impose different modes of information processing on
            Ras due to contrasting temporal filtering of Ca2+
  JOURNAL   J Cell Biol 170 (2), 183-190 (2005)
   PUBMED   16009725
  REMARK    GeneRIF: RASAL preservs of Ca2+ frequency information
REFERENCE   9  (bases 1 to 3368)
  AUTHORS   Schmitt,J.M. and Stork,P.J.
  TITLE     Galpha and Gbeta gamma require distinct Src-dependent pathways to
            activate Rap1 and Ras
  JOURNAL   J Biol Chem 277 (45), 43024-43032 (2002)
   PUBMED   12221082
  REMARK    GeneRIF: Galpha and Gbeta gamma require distinct Src-dependent
            pathways for its activation
REFERENCE   10 (bases 1 to 3368)
  AUTHORS   Allen,M., Chu,S., Brill,S., Stotler,C. and Buckler,A.
  TITLE     Restricted tissue expression pattern of a novel human
            rasGAP-related gene and its murine ortholog
  JOURNAL   Gene 218 (1-2), 17-25 (1998)
   PUBMED   9751798
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC089999.20.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Mar 31, 2021 this sequence version replaced NM_001301202.1.
            
            Summary: The protein encoded by this gene is member of the GAP1
            family of GTPase-activating proteins. These proteins stimulate the
            GTPase activity of normal RAS p21 but not its oncogenic
            counterpart. Acting as a suppressor of RAS function, the protein
            enhances the weak intrinsic GTPase activity of RAS proteins
            resulting in the inactive GDP-bound form of RAS, thereby allowing
            control of cellular proliferation and differentiation. This
            particular family member contains domains which are characteristic
            of the GAP1 subfamily of RasGAP proteins but, in contrast to the
            other GAP1 family members, this protein is strongly and selectively
            expressed in endocrine tissues. Alternatively spliced transcript
            variants that encode different isoforms have been described
            [provided by RefSeq, Jul 2010].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC143261.1, SRR14038194.3830088.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000548055.2/ ENSP00000448510.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-364               AC089999.20        115254-115617
            365-421             AC089999.20        120074-120130
            422-535             AC089999.20        122837-122950
            536-597             AC089999.20        123142-123203
            598-727             AC089999.20        129377-129506
            728-809             AC089999.20        131572-131653
            810-941             AC089999.20        131756-131887
            942-1030            AC089999.20        133854-133942
            1031-1148           AC089999.20        134964-135081
            1149-1302           AC089999.20        135227-135380
            1303-1367           AC089999.20        135751-135815
            1368-1480           AC089999.20        136103-136215
            1481-1673           AC089999.20        138737-138929
            1674-1811           AC089999.20        142793-142930
            1812-1956           AC089999.20        143774-143918
            1957-2129           AC089999.20        145129-145301
            2130-2267           AC089999.20        146717-146854
            2268-2403           AC089999.20        146934-147069
            2404-2524           AC089999.20        149006-149126
            2525-2577           AC089999.20        150335-150387
            2578-3368           AC089999.20        150947-151737
FEATURES             Location/Qualifiers
     source          1..3368
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.13"
     gene            1..3368
                     /gene="RASAL1"
                     /gene_synonym="RASAL"
                     /note="RAS protein activator like 1"
                     /db_xref="GeneID:8437"
                     /db_xref="HGNC:HGNC:9873"
                     /db_xref="MIM:604118"
     exon            1..364
                     /gene="RASAL1"
                     /gene_synonym="RASAL"
                     /inference="alignment:Splign:2.1.0"
     CDS             300..2717
                     /gene="RASAL1"
                     /gene_synonym="RASAL"
                     /note="isoform 4 is encoded by transcript variant 4; ras
                     GTPase-activating-like protein; GAP1 like protein;
                     rasGAP-activating-like protein 1"
                     /codon_start=1
                     /product="rasGAP-activating-like protein 1 isoform 4"
                     /protein_id="NP_001288131.1"
                     /db_xref="CCDS:CCDS73529.1"
                     /db_xref="GeneID:8437"
                     /db_xref="HGNC:HGNC:9873"
                     /db_xref="MIM:604118"
                     /translation="MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTAT
                     VWRSLGPFWGEEYTVHLPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGID
                     SWINLSRVDPDAEVQGEICLSVQMLEDGQGRCLRCHVLQARDLAPRDISGTSDPFARV
                     FWGSQSLETSTIKKTRFPHWDEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFS
                     PKTLQQKPPKGWFRLLPFPRAEEDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLME
                     SVQGPAEEDTASPLALLEELTLGDCRQDLATKLVKLFLGRGLAGRFLDYLTRREVART
                     MDPNTLFRSNSLASKSMEQFMKLVGMPYLHEVLKPVISRVFEEKKYMELDPCKMDLGR
                     TRRISFKGALSEEQMRETSLGLLTGYLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEE
                     RFPQAEHQDVKYLAISGFLFLRFFAPAILTPKLFDLRDQHADPQTSRSLLLLAKAVQS
                     IGNLGQQLGQGKELWMAPLHPFLLQCVSRVRDFLDRLVDVDGDEEAGVPARALFPPSA
                     IVREGYLLKRKEEPAGLATRFAFKKRYVWLSGETLSFSKSPEWQMCHSIPVSHIRAVE
                     RVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVNELNQWLSALRKASAPNPNKLAAC
                     HPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSDPLDPDAEAQTVYRQLLLGRDQ
                     LRLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEVLADLDRAHEEFQQQERGKA
                     ALGPLGP"
     exon            365..421
                     /gene="RASAL1"
                     /gene_synonym="RASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            422..535
                     /gene="RASAL1"
                     /gene_synonym="RASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            536..597
                     /gene="RASAL1"
                     /gene_synonym="RASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            598..727
                     /gene="RASAL1"
                     /gene_synonym="RASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            728..809
                     /gene="RASAL1"
                     /gene_synonym="RASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            810..941
                     /gene="RASAL1"
                     /gene_synonym="RASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1030
                     /gene="RASAL1"
                     /gene_synonym="RASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1148
                     /gene="RASAL1"
                     /gene_synonym="RASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1302
                     /gene="RASAL1"
                     /gene_synonym="RASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1367
                     /gene="RASAL1"
                     /gene_synonym="RASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1480
                     /gene="RASAL1"
                     /gene_synonym="RASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1673
                     /gene="RASAL1"
                     /gene_synonym="RASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1811
                     /gene="RASAL1"
                     /gene_synonym="RASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1956
                     /gene="RASAL1"
                     /gene_synonym="RASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2129
                     /gene="RASAL1"
                     /gene_synonym="RASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2267
                     /gene="RASAL1"
                     /gene_synonym="RASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2403
                     /gene="RASAL1"
                     /gene_synonym="RASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2524
                     /gene="RASAL1"
                     /gene_synonym="RASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2577
                     /gene="RASAL1"
                     /gene_synonym="RASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2578..3368
                     /gene="RASAL1"
                     /gene_synonym="RASAL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3115..3120
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASAL1"
                     /gene_synonym="RASAL"
                     /note="hexamer: ACTAAA"
     polyA_site      3133
                     /gene="RASAL1"
                     /gene_synonym="RASAL"
                     /note="major polyA site"
     regulatory      3345..3350
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASAL1"
                     /gene_synonym="RASAL"
                     /note="hexamer: TATAAA"
     polyA_site      3368
                     /gene="RASAL1"
                     /gene_synonym="RASAL"
ORIGIN      
        1 gcccagcctg cttgtctgga gctccagacg cctcggcaag agcccgctgc gccccctgcg
       61 cgctcctcct gctcggagca cggctcctac ctgtagagtc cggacgggcg ctccctcccc
      121 gggcacctac accttctcct ctttcggaaa tctcccatcc agctacccgg gtctcggaca
      181 ggcggcactg ggaccacgag gcagggagcc aggcttgaag caggtgacat gtagacgtcc
      241 cctggtccag cctcggaacc tgagcgccct tctgcctgga aagtttgtgg ctaggcgcca
      301 tggccaagag cagctccctg aatgttcgcg tggtggaggg ccgcgcgctg cctgccaagg
      361 acgtgtctgg gagcagcgac ccctactgcc tagtgaaagt ggacgacgag gtggtggcca
      421 ggacagctac tgtctggagg agcctgggcc ccttctgggg ggaggagtac acggtgcacc
      481 tgcctctgga tttccaccag ctggccttct acgtgctgga tgaggacact gtcgggcacg
      541 acgacatcat cggcaagatc tcgctgagca gggaggcgat tacagccgac ccccgaggga
      601 ttgacagctg gattaacttg agccgagtgg acccagatgc agaagtgcag ggtgagatct
      661 gcctgtcagt gcagatgctg gaggatgggc agggccgctg ccttcgctgc catgtgcttc
      721 aggccaggga cctggctccc agagacatct ctggcacatc tgacccattt gcacgtgtgt
      781 tttggggcag ccagagcttg gagacctcaa ccatcaagaa gactcgcttc ccgcactggg
      841 atgaagtgct ggagctgcgg gagatgccag gtgccccgtc cccactgcgg gtggagctct
      901 gggactggga catggtgggc aagaatgact tcttgggcat ggtggagttc tctccaaaga
      961 ccctccagca gaagccacct aaaggctggt tccgcctcct gccctttccc agagccgagg
     1021 aggattctgg ggggaacctg ggtgccctgc gagtgaaggt acgcctgatt gaggaccgcg
     1081 tcctgccctc ccagtgctac cagcctctca tggagctgct catggagtct gtgcaggggc
     1141 cagcagagga ggacactgct agccccttgg ctttgctgga agagctgacc ttgggggact
     1201 gccgccagga ccttgccacc aagctggtga aactctttct tggccgggga ctggctgggc
     1261 gctttctgga ctatctcacc cggcgtgagg tggctcggac catggacccc aacaccctct
     1321 tccgttctaa ctccctggca tccaagtcga tggaacagtt tatgaagctc gtgggcatgc
     1381 cctacctgca cgaggtcctg aagcctgtga ttagccgtgt ctttgaggag aagaagtaca
     1441 tggagctgga tccctgcaag atggacctgg gccgcacccg gaggatctcc ttcaaaggcg
     1501 cactctcgga ggagcagatg cgggagacca gcctggggct gctgacgggc tacctggggc
     1561 ccatcgtgga cgccatcgtg ggctccgtgg ggcgctgccc gcccgccatg cgcctcgcct
     1621 tcaagcagct gcaccggcga gtggaggagc gcttccccca ggccgagcac caggatgtga
     1681 agtacctggc catcagtgga tttctcttct tgcgattctt cgcacctgcc atccttaccc
     1741 caaagctgtt tgaccttcgg gaccaacacg cggaccccca gactagccgc tcactgctgt
     1801 tgcttgccaa ggctgtgcag agcattggaa acctgggcca gcagctgggc caaggcaagg
     1861 aactgtggat ggcccccctg caccccttcc tgctgcagtg tgtctcacgt gtgagagact
     1921 tcctggaccg gctggtggat gtggatgggg atgaagaagc tggtgtccca gccagggccc
     1981 tgttcccgcc ctcggccatt gttcgagaag gctatctgct gaagcgcaag gaggagcctg
     2041 ccggcctggc cacgcgcttt gccttcaaga agcgctacgt ctggctcagc ggggagaccc
     2101 tctccttctc caagagtcct gagtggcaga tgtgtcactc catccccgtg tctcacatcc
     2161 gcgccgtgga gcgcgtagac gagggcgcct tccaactgcc ccacgtgatg caggtggtga
     2221 cgcaggacgg cacgggggcg ctgcacacca cctacctcca gtgcaagaat gtgaatgagc
     2281 tcaaccagtg gctctcggcc ttgcgcaagg ccagcgcccc caacccgaac aagctggccg
     2341 cctgccaccc cggtgccttc cgcagcgcgc gctggacctg ctgcctccag gctgagcgct
     2401 cagccgccgg ctgcagccgt acacactcag ctgtcaccct gggggactgg agtgacccac
     2461 tggatcctga tgctgaggcc cagacagtgt atcggcagct gctcctgggg cgggaccagc
     2521 tcaggctgaa attactggag gattctaaca tggatacaac tctggaggca gacacagggg
     2581 cctgtcctga ggtcctggcc cggcaaagag cagcaactgc ccgcctgctg gaggtgctcg
     2641 cagacctgga tcgtgcccac gaggagttcc agcagcagga gcgagggaag gcggccctgg
     2701 gcccccttgg cccctaagga aatgccagag ctagcccgga aggaggagca agagccaggg
     2761 ggccctcttc agcgcatcct gccccgggag tctcctgtct ccttggacct ctttgattct
     2821 gtggtttgga ggctcccaga gacgtgccta gtcctgtgtg ccttgagtcc agaactcagg
     2881 gcatggaagc cctttggcag gggccagcct tgcactgagt gaaacttgcc ctctggcttg
     2941 attcagactg gagtggatag gataaggaac ctgacttatt tgactgagac tggggtctct
     3001 acttcaccaa actggcctct atccatacca aggaggccag cctggccctg agctgctgga
     3061 tacagctgga cctgaattcc tgatgcccat gtgatgttgt tgccccagat gggcactaaa
     3121 tggcctcact ccttcctgtt ttcatgtctg ctaatcccta taacctcact gattcttctg
     3181 taccctgccc ttggcctagg actccaacca caagcttcca gaatcaggtg ccctcaggaa
     3241 gaaccaaggc tgggtggggg tccagtgtgc caaactcaga cccttggagc ctgggagacc
     3301 ttgggccagg ctgtttatct ctctctgggt ctcagattac cctgtataaa aagaggaggg
     3361 aaagtcta
//
