LOCUS       NM_001367767            6095 bp    mRNA    linear   PRI 12-FEB-2024
DEFINITION  Homo sapiens RAS p21 protein activator 4B (RASA4B), transcript
            variant 2, mRNA.
ACCESSION   NM_001367767 XM_005250084
VERSION     NM_001367767.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6095)
  AUTHORS   Lockyer,P.J., Kupzig,S. and Cullen,P.J.
  TITLE     CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK
            pathway
  JOURNAL   Curr Biol 11 (12), 981-986 (2001)
   PUBMED   11448776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093668.4.
            
            On Aug 27, 2019 this sequence version replaced NM_001367767.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.2004093.1,
                                           SRR14038196.1158475.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000465829.6/ ENSP00000417895.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               AC093668.4         131596-131727       c
            133-189             AC093668.4         125875-125931       c
            190-303             AC093668.4         124129-124242       c
            304-365             AC093668.4         123549-123610       c
            366-495             AC093668.4         120645-120774       c
            496-577             AC093668.4         117113-117194       c
            578-709             AC093668.4         115046-115177       c
            710-804             AC093668.4         114649-114743       c
            805-922             AC093668.4         110797-110914       c
            923-1073            AC093668.4         110419-110569       c
            1074-1138           AC093668.4         110090-110154       c
            1139-1251           AC093668.4         109228-109340       c
            1252-1444           AC093668.4         108831-109023       c
            1445-1582           AC093668.4         108488-108625       c
            1583-1727           AC093668.4         107775-107919       c
            1728-1897           AC093668.4         107066-107235       c
            1898-2035           AC093668.4         104936-105073       c
            2036-2171           AC093668.4         102413-102548       c
            2172-2292           AC093668.4         98989-99109         c
            2293-2357           AC093668.4         97775-97839         c
            2358-6095           AC093668.4         93926-97663         c
FEATURES             Location/Qualifiers
     source          1..6095
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..6095
                     /gene="RASA4B"
                     /note="RAS p21 protein activator 4B"
                     /db_xref="GeneID:100271927"
                     /db_xref="HGNC:HGNC:35202"
     exon            1..132
                     /gene="RASA4B"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..2479
                     /gene="RASA4B"
                     /note="isoform 2 is encoded by transcript variant 2;
                     putative Ras GTPase-activating protein 4B; ras
                     GTPase-activating protein 4B"
                     /codon_start=1
                     /product="ras GTPase-activating protein 4B isoform 2"
                     /protein_id="NP_001354696.1"
                     /db_xref="CCDS:CCDS94160.1"
                     /db_xref="GeneID:100271927"
                     /db_xref="HGNC:HGNC:35202"
                     /translation="MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTAT
                     VWKTLCPFWGEEYQVHLPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFS
                     GWAHLTEVDPDEEVQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRV
                     RYKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVID
                     VQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLL
                     CHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSR
                     TSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVK
                     DVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVR
                     ERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQ
                     NVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEKDELDLQRTLSLQAP
                     PVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKSALIKLANIRAAE
                     KVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVSINNTGLLGSY
                     HPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYRHLLGVEAM
                     LWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPPSEPNCL
                     LELQT"
     exon            133..189
                     /gene="RASA4B"
                     /inference="alignment:Splign:2.1.0"
     exon            190..303
                     /gene="RASA4B"
                     /inference="alignment:Splign:2.1.0"
     exon            304..365
                     /gene="RASA4B"
                     /inference="alignment:Splign:2.1.0"
     exon            366..495
                     /gene="RASA4B"
                     /inference="alignment:Splign:2.1.0"
     exon            496..577
                     /gene="RASA4B"
                     /inference="alignment:Splign:2.1.0"
     exon            578..709
                     /gene="RASA4B"
                     /inference="alignment:Splign:2.1.0"
     exon            710..804
                     /gene="RASA4B"
                     /inference="alignment:Splign:2.1.0"
     exon            805..922
                     /gene="RASA4B"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1073
                     /gene="RASA4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1138
                     /gene="RASA4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1251
                     /gene="RASA4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1444
                     /gene="RASA4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1582
                     /gene="RASA4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1727
                     /gene="RASA4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1897
                     /gene="RASA4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2035
                     /gene="RASA4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2171
                     /gene="RASA4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2292
                     /gene="RASA4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2293..2357
                     /gene="RASA4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..6095
                     /gene="RASA4B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6074..6079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASA4B"
                     /note="hexamer: AATAAA"
     polyA_site      6095
                     /gene="RASA4B"
                     /note="major polyA site"
ORIGIN      
        1 agtccagcgc ccgccgcccg ccaccccgga ccccggtgtc tggcttcccc cgagccggca
       61 ccccgcgatg gccaagcgca gctcgctgta catccgcatc gtggagggga agaaccttcc
      121 cgccaaggac atcactggca gcagcgaccc ctactgcatc gtgaaggtgg acaatgagcc
      181 catcatcagg acagccacag tgtggaagac cctgtgcccc ttctggggtg aggagtacca
      241 agtgcacctg ccgcccacct tccacgctgt ggctttctat gtcatggatg aggatgccct
      301 cagccgggac gacgttatcg gaaaggtctg ccttacaagg gacaccatag cctctcaccc
      361 taagggtttc agcgggtggg cccacctgac agaggtcgac cccgacgagg aggtgcaggg
      421 cgagatccac ctgcggctgg aagtgtggcc aggggcccgg gcctgccggc tacgctgctc
      481 tgtgctggag gccagggatc tggccccaaa ggaccgcaat ggcacatctg accccttcgt
      541 ccgagtgcgc tacaagggcc ggacacggga gacctcgatc gtgaagaagt catgctaccc
      601 acgctggaat gagacgtttg aatttgagct gcaggagggg gccatggagg cgctgtgcgt
      661 ggaggcctgg gactgggacc ttgtcagccg aaacgacttc ctgggcaaag tggtgattga
      721 tgtccagaga ctgcgggtgg tgcagcagga ggagggctgg ttccggctgc agcccgacca
      781 gtccaagagc cggcggcatg acgagggcaa cctgggctcc ttgcagctgg aggtgcggct
      841 gcgggacgag acggtgctgc cctccagcta ctaccagcca ctggtgcacc tgctgtgcca
      901 cgaggtcaag ctgggcatgc agggcccagg gcagctgatc ccactcatcg aggagacaac
      961 cagcaccgag tgtcgccagg acgtggccac gaacctgctc aagctcttcc tggggcaggg
     1021 gctggccaag gacttcctgg acctgctctt ccagctggag ctgagtcgca ccagtgagac
     1081 caacaccctg ttccggagca actctctggc ctcaaagtcc gtggagtctt ttctgaaggt
     1141 ggccgggatg cagtacctgc acggcgtcct gggccccatc atcaacaagg tgtttgagga
     1201 gaagaagtac gtggagctgg accccagcaa agtggaagtt aaggatgtag ggtgctccgg
     1261 gctgcaccgc ccgcagaccg aggccgaggt gctggagcag agcgcgcaga cgctgcgcgc
     1321 ccacctgggg gccctgctga gcgcgctcag ccgctcggtt cgcgcgtgcc ccgccgtggt
     1381 gcgcgccacc ttccgccagc tcttccggcg cgtgcgcgag cgcttccccg gcgcccagca
     1441 cgagaatgta ccgttcatcg ccgtcaccag cttcctgtgc ctgcgcttct tctctcccgc
     1501 catcatgtcg cccaagctct tccacctgcg ggagcgccac gcggacgccc gcaccagccg
     1561 caccctgctc ctgttggcca aggcagtcca gaacgtgggc aacatggaca cgccggcttc
     1621 cagggccaag gaggcttgga tggagccgct gcagcccacc gtgcaccagg gcgtggcgca
     1681 gctgaaggac ttcatcacca agctcgtgga catcgaggag aaggacgagc tggacctgca
     1741 gcggacgctg agtttgcagg cgccacctgt gaaggagggg ccactcttca tccacaggac
     1801 caagggcaag ggccccctca tgtcctcctc cttcaagaag ctctacttct ccctcactac
     1861 cgaggccctc agcttcgcga agacgcccag ctccaagaaa agcgccctca tcaagttagc
     1921 caacatccgg gcagcggaaa aggttgagga aaagagcttt ggcggctcgc acgtcatgca
     1981 ggtcatctac acggacgacg ccggcaggcc ccagactgcc tacctgcagt gcaagtgtgt
     2041 gaatgagctt aaccagtggc tgtctgcgct gcggaaggtg agcatcaaca acaccggact
     2101 gctgggctcc taccaccctg gcgtcttccg tggggacaag tggagctgct gccaccaaaa
     2161 agagaagaca ggtcagggct gcgataagac ccggtcacgg gtgaccctgc aggagtggaa
     2221 tgaccctctt gaccatgacc ttgaggccca gctcatctac cggcacctgc tgggcgtgga
     2281 ggccatgctg tgggagaggc accgggagct gagcgggggc gcagaggcag gcacggtgcc
     2341 cacgagccct ggcaaagtcc ccgaggactc attggcccgg ctgctccggg tgctgcagga
     2401 cctccgcgag gcccatagct ccagcccggc cggctcccca ccctcagagc ccaactgcct
     2461 cctggagctg cagacgtgag gcccgcccta cgctcccctt gctgagtccc ctgccaagcg
     2521 ctcggagccc ccccaggaca ctctgcaccc cctcaccccg gtcctcctca ttagggtgca
     2581 gggcctaggt ctcttccagg tgggggaggg gggagagtca ggaataaggg gatccccaga
     2641 agtgcagagc tgagcaggct tgggcctgtc atggctggcc ggaagtgtcc ccagctccct
     2701 acagacgctg tagccatcac tgcctctcca gggaccctcc tctcctgccc aggacagacc
     2761 cagccagaac cactgctagg atgggccgca cccaggggtc tggcctccag ggacctagag
     2821 aatgggaggg agaacggggc cccaggagac ccggccgcca ccccacccgc tacccttggg
     2881 tgccacaggg ctgtgctgtt gccaacagta aacctgctct tactgtccag gctctggggt
     2941 cttgtgatga gggtctgggg agaaagtggg cccgggggga ccccggaggc tgtcggtgga
     3001 tgtgccgatg atggggctga cagtatgggc tctgggcatc cctgttcccc cctctttctt
     3061 ccccccactc ttctggggtc gggggttcct ttcccttccc agttgctgtc cctgggtccc
     3121 ctctttcatg tcccacaggc cacagagccc agtgtgtcca accagctgtt ctctcctcaa
     3181 agcagccccc aagcaagtcc cttctctagg gtgtccctga ggacagcaca gaggcgggac
     3241 tcagagaccc cattcctctt cacgcagccc ttaccccaag ccctctagct gtgtggctgg
     3301 cagtgttggc cacgtagggg ctcccatccc cccaccattg tgtcacatgg gctgccaggc
     3361 tcagctccca gctgcgtcca cagtgacctg gatcagggtg gggacaagga ctggaccctc
     3421 cttctccaga aggccttcag ctcttgcctt gccatgcagt cacctccttc cccctctgac
     3481 cccagatccc aaaggtgcac cgttgcccca gcccctttct ggccccatgg ggtttctctg
     3541 atgccttcat catagaggcc cggggctggt ccgatggttg gcaaaacttg actccggccc
     3601 agtccccact cttggggact tagaacccct gctgtcctgg gatctggcct gcctttcttt
     3661 ggtcagtccc tgtggtcccc caccagctcc ccctcccata gggctgccca ccaagccctg
     3721 cccccagccc aagaggagcc cccactgcct gcggggcagt gatgtctggc caccggctca
     3781 caccaatgac ttggtcctgg ggtggcagaa gcagcaggtg acaggagcag ggcccctgtc
     3841 cctctcttct ggccctgtgg tacccaggcc acacgttgtg cccgctcttg gggctgaccg
     3901 gctgcaggga ccaccagccg ctgctactgt gggccgcccc ggggcagggt gggcagggct
     3961 tttgtgggtt atgaggacac agaagtccct gaggccccca gacctggctc agccaacctc
     4021 cttcctcccc cggttgcccc ccactctaaa gcctcctccc tcccagcgtc cactggctcc
     4081 aggctcctca caacagcagc tcatagacac ggggcatctc caggtggtcc tagccctcca
     4141 gatgtttcta gctctccagg tgggcgctgt tttcacgtct gcctgcatcc attcattcct
     4201 tcattcctca cctttatcct gttatctcta tttttttaag ctaccaggaa ggaaagggaa
     4261 gaagagatca cgaaactggg acccccagaa gggaggagtg ggctttgaac ttagacatct
     4321 acctcagagc tcaaataggt tgtttaaaat cacattcaat tttcagatga aggggaactt
     4381 tataattttt tttttttttt tttttgagac agagtctcac tgtgttgccc aggctggagt
     4441 gcaaatggct tgatcttggt tcactgcaac ctctgcctcc caggttcaag caattctctt
     4501 gcctcagcct cccgagtagc tgggactaaa ggcgtgtgcc accatgccca gctaattctt
     4561 gtatttttag tagagacgga gtttctccat gttggccaga ctggtctcga actcctgacc
     4621 tcaggtgatc tgaccgcctt ggcctccgaa agtgctgaga ttacagttgc gagccactgt
     4681 gcgtggccag aactttataa taagagactt gaagctgggt gtgacggtgc acacctctag
     4741 tcccagctac tcgggaggcc aagacagaag gatcaccttg aggccaggag tttaaggcca
     4801 gcctgggcaa catagcaaaa cctagtccct aaaattaaaa aaaaaaaaaa aaaaaaggga
     4861 aaataaagga gacttgaaat ttttgaacta aatagtggtg atggctacac attgtgaatg
     4921 taattaacac cactgagtta aacacttaaa atggttaaaa tggcaaattg tatgttatac
     4981 ctattttact acaataaaaa gtataaaaaa gagaagatat ttaaccaatt gcaacaaaac
     5041 aaaatgttaa gaaatgatct ttttatgagg caattggaaa tttgaacact aatcaactat
     5101 aggatgattg gaattattaa ttttgtaaag gtgtgataag atactgcact tggctgggca
     5161 cagtggcaca tgcctgtaat cccagctact tggcaggctg aggtgggaga atcgcttgag
     5221 ctcaggagtt cgagaccagc ctgggcaacg tggcgaaatc cccgtcttta caaaaacaaa
     5281 caaacaaaca aaaaagatat tgcagttgtg ttgtaagcgt ccttatcttt cagagctaca
     5341 tagtggaatg tttatggaat atttaggata aatgatatag gcatttggga tttgctgcaa
     5401 aatgacccag aggcaggggt cagggggaga ggtagagatg agacaagagg tagaggggag
     5461 aggtagaggt agccacgagc tgataattac agacaagaga tgcggagtat gtgggggctc
     5521 attatcctgc atagtctatc tttgtatatc tttgaacttt tcaagaataa aaaagcttaa
     5581 aaagtataca tggcctggtc ctaccagaga ctcacccaat gccagcctcc agccagggag
     5641 agccaagttt gcattttcac acgcatctca cactcctctg cactctcaac ttggagagct
     5701 ccaaacaggg aaaccccaag ccttgctggc ttctgccaac cccctgagca gaagcatggg
     5761 tccccctgat caccacctca ccaccctcat cctgatctca ctgtacactc cctttcctgg
     5821 tctgctaagt agcgggtgtt tttccttgac actaacgcta cagctagacc acggtgggct
     5881 tggcaacagg tgtcttccca gatgctggcg ttaccgctag accaaggagc cctctggtgg
     5941 ccctgtccgg gcataacaga aagctcgcac tcttgtcttc tggtcactcc tcattgtccc
     6001 ctcagctcct atctctgtat ggcctggtgt ttcctaggtt atgattgtag agcgaggatt
     6061 attataatat tggaataaag aataattact acaaa
//
