LOCUS       NM_006989               5604 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens RAS p21 protein activator 4 (RASA4), transcript
            variant 1, mRNA.
ACCESSION   NM_006989 XM_936264
VERSION     NM_006989.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5604)
  AUTHORS   Chen,J., Huang,J., Huang,Q., Li,J., Chen,E. and Xu,W.
  TITLE     RASA4 inhibits the HIFalpha signaling pathway to suppress
            proliferation of cervical cancer cells
  JOURNAL   Bioengineered 12 (2), 10723-10733 (2021)
   PUBMED   34752201
  REMARK    GeneRIF: RASA4 inhibits the HIFalpha signaling pathway to suppress
            proliferation of cervical cancer cells.
REFERENCE   2  (bases 1 to 5604)
  AUTHORS   Xu,X., Wen,X., Moosa,A., Bhimani,S. and Jin,T.
  TITLE     Ras inhibitor CAPRI enables neutrophil-like cells to chemotax
            through a higher-concentration range of gradients
  JOURNAL   Proc Natl Acad Sci U S A 118 (43) (2021)
   PUBMED   34675073
  REMARK    GeneRIF: Ras inhibitor CAPRI enables neutrophil-like cells to
            chemotax through a higher-concentration range of gradients.
REFERENCE   3  (bases 1 to 5604)
  AUTHORS   Malone,E.T., Ganther,S., Mena,N., Radaic,A., Shariati,K.,
            Kindberg,A., Tafolla,C., Kamarajan,P., Fenno,J.C., Zhan,L. and
            Kapila,Y.L.
  TITLE     Treponema denticola-Induced RASA4 Upregulation Mediates
            Cytoskeletal Dysfunction and MMP-2 Activity in Periodontal
            Fibroblasts
  JOURNAL   Front Cell Infect Microbiol 11, 671968 (2021)
   PUBMED   34094999
  REMARK    GeneRIF: Treponema denticola-Induced RASA4 Upregulation Mediates
            Cytoskeletal Dysfunction and MMP-2 Activity in Periodontal
            Fibroblasts.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5604)
  AUTHORS   Poetsch,A.R., Lipka,D.B., Witte,T., Claus,R., Nollke,P.,
            Zucknick,M., Olk-Batz,C., Fluhr,S., Dworzak,M., De Moerloose,B.,
            Stary,J., Zecca,M., Hasle,H., Schmugge,M., van den
            Heuvel-Eibrink,M.M., Locatelli,F., Niemeyer,C.M., Flotho,C. and
            Plass,C.
  TITLE     RASA4 undergoes DNA hypermethylation in resistant juvenile
            myelomonocytic leukemia
  JOURNAL   Epigenetics 9 (9), 1252-1260 (2014)
   PUBMED   25147919
  REMARK    GeneRIF: RASA4 isoform 2 promoter methylation correlated with
            clinical parameters predicting poor prognosis (older age, elevated
            fetal hemoglobin), with higher risk of relapse after hematopoietic
            stem cell transplantation, and with PTPN11 mutation.
REFERENCE   5  (bases 1 to 5604)
  AUTHORS   Dai,Y., Walker,S.A., de Vet,E., Cook,S., Welch,H.C. and
            Lockyer,P.J.
  TITLE     Ca2+-dependent monomer and dimer formation switches CAPRI Protein
            between Ras GTPase-activating protein (GAP) and RapGAP activities
  JOURNAL   J Biol Chem 286 (22), 19905-19916 (2011)
   PUBMED   21460216
  REMARK    GeneRIF: Ca2+-dependent monomer and dimer formation switches CAPRI
            Protein between Ras GTPase-activating protein (GAP) and RapGAP
            activities
REFERENCE   6  (bases 1 to 5604)
  AUTHORS   Liu,Q., Walker,S.A., Gao,D., Taylor,J.A., Dai,Y.F., Arkell,R.S.,
            Bootman,M.D., Roderick,H.L., Cullen,P.J. and Lockyer,P.J.
  TITLE     CAPRI and RASAL impose different modes of information processing on
            Ras due to contrasting temporal filtering of Ca2+
  JOURNAL   J Cell Biol 170 (2), 183-190 (2005)
   PUBMED   16009725
  REMARK    GeneRIF: CAPRI seems to low-pass filter the Ca2+ signal, converting
            different intensities of stimulation into different durations of
            Ras activity.
REFERENCE   7  (bases 1 to 5604)
  AUTHORS   Bivona,T.G., Perez De Castro,I., Ahearn,I.M., Grana,T.M.,
            Chiu,V.K., Lockyer,P.J., Cullen,P.J., Pellicer,A., Cox,A.D. and
            Philips,M.R.
  TITLE     Phospholipase Cgamma activates Ras on the Golgi apparatus by means
            of RasGRP1
  JOURNAL   Nature 424 (6949), 694-698 (2003)
   PUBMED   12845332
REFERENCE   8  (bases 1 to 5604)
  AUTHORS   Minagawa,T., Fukuda,M. and Mikoshiba,K.
  TITLE     Distinct phosphoinositide binding specificity of the GAP1 family
            proteins: characterization of the pleckstrin homology domains of
            MRASAL and KIAA0538
  JOURNAL   Biochem Biophys Res Commun 288 (1), 87-90 (2001)
   PUBMED   11594756
REFERENCE   9  (bases 1 to 5604)
  AUTHORS   Lockyer,P.J., Kupzig,S. and Cullen,P.J.
  TITLE     CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK
            pathway
  JOURNAL   Curr Biol 11 (12), 981-986 (2001)
   PUBMED   11448776
  REMARK    GeneRIF: CAPRI (Ca2+-promoted Ras inactivator) a Ca2+-dependent Ras
            GTPase-activating protein (Ras GAP). Switches off the Ras-MAPK
            pathway following G protein-coupled receptor stimulated
            intracellular Ca2+ elevation that recruits CAPRI to the plasma
            membrane.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC105052.3 and AC093668.4.
            
            On Nov 22, 2019 this sequence version replaced NM_006989.5.
            
            Summary: This gene encodes a member of the GAP1 family of
            GTPase-activating proteins that suppresses the
            Ras/mitogen-activated protein kinase pathway in response to Ca(2+).
            Stimuli that increase intracellular Ca(2+) levels result in the
            translocation of this protein to the plasma membrane, where it
            activates Ras GTPase activity. Consequently, Ras is converted from
            the active GTP-bound state to the inactive GDP-bound state and no
            longer activates downstream pathways that regulate gene expression,
            cell growth, and differentiation. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB011110.2, SRR14038197.1860852.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262940.12/ ENSP00000262940.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               AC105052.3         30366-30497         c
            133-189             AC105052.3         24827-24883         c
            190-303             AC105052.3         23082-23195         c
            304-365             AC105052.3         22502-22563         c
            366-495             AC105052.3         19599-19728         c
            496-577             AC105052.3         16065-16146         c
            578-709             AC105052.3         13998-14129         c
            710-804             AC105052.3         13601-13695         c
            805-922             AC105052.3         9753-9870           c
            923-1073            AC105052.3         9375-9525           c
            1074-1138           AC105052.3         9046-9110           c
            1139-1251           AC105052.3         8188-8300           c
            1252-1444           AC105052.3         7791-7983           c
            1445-1582           AC105052.3         7448-7585           c
            1583-1727           AC105052.3         6735-6879           c
            1728-1897           AC105052.3         6026-6195           c
            1898-2035           AC105052.3         3900-4037           c
            2036-2171           AC105052.3         1376-1511           c
            2172-2292           AC093668.4         198168-198288       c
            2293-2357           AC093668.4         196954-197018       c
            2358-5604           AC093668.4         193596-196842       c
FEATURES             Location/Qualifiers
     source          1..5604
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..5604
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /note="RAS p21 protein activator 4"
                     /db_xref="GeneID:10156"
                     /db_xref="HGNC:HGNC:23181"
                     /db_xref="MIM:607943"
     exon            1..132
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..2479
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /note="isoform 1 is encoded by transcript variant 1; Ras
                     GTPase-activating protein 4; Ca2+-promoted Ras
                     inactivator; calcium-promoted Ras inactivator;
                     rasGAP-activating-like protein 2"
                     /codon_start=1
                     /product="ras GTPase-activating protein 4 isoform 1"
                     /protein_id="NP_008920.5"
                     /db_xref="CCDS:CCDS5725.1"
                     /db_xref="GeneID:10156"
                     /db_xref="HGNC:HGNC:23181"
                     /db_xref="MIM:607943"
                     /translation="MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTAT
                     VWKTLCPFWGEEYQVHLPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFS
                     GWAHLTEVDPDEEVQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRV
                     RYKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVID
                     VQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLL
                     CHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSR
                     TSETNTLFRSNSLASKSMESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVK
                     DVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVR
                     ERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQ
                     NVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDFITKLVDIEEKDELDLQRTLSLQAP
                     PVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKSALIKLANIRAAE
                     KVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVSINNTGLLGSY
                     HPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYRHLLGVEAM
                     LWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPPSEPNCL
                     LELQT"
     exon            133..189
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            190..303
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            304..365
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            366..495
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            496..577
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            578..709
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            710..804
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            805..922
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1073
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1138
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1251
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1444
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1582
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1727
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1897
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2035
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2171
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2292
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            2293..2357
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..5604
                     /gene="RASA4"
                     /gene_synonym="CAPRI; GAPL"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccagcgc ccgccgcccg ccaccccgga ccccggtgtc tggcttcccc cgagccggga
       61 ccccgcgatg gccaagcgca gctcgctgta catccgcatc gtggagggga agaaccttcc
      121 cgccaaggac atcactggca gcagcgaccc ctactgcatc gtgaaggtgg acaatgagcc
      181 catcatcagg acagccacag tgtggaagac cctgtgcccc ttctggggtg aggagtacca
      241 agtgcacctg ccgcccacct tccacgctgt ggctttctat gtcatggatg aggatgccct
      301 cagccgggac gacgttatcg gaaaggtctg ccttacaagg gacaccatag cctctcaccc
      361 taagggtttc agcgggtggg cccacctgac ggaggtcgac cccgatgagg aggtgcaggg
      421 cgagatccac ctgcggctgg aagtgtggcc aggggcccgg gcctgccggc tacgctgctc
      481 tgtgctggag gccagggatc tggccccaaa ggaccgcaat ggcacatctg accccttcgt
      541 ccgagtgcgc tacaagggcc ggacacggga gacctcgatc gtgaagaagt catgctaccc
      601 acgctggaat gagacgtttg aatttgagct gcaggagggg gccatggagg cgctgtgcgt
      661 ggaggcctgg gactgggacc ttgtcagccg aaacgacttc ctgggcaaag tggtgattga
      721 tgtccagaga ctgcgggtgg tgcagcagga ggagggctgg ttccggctgc agcccgacca
      781 gtccaagagc cggcggcatg acgagggcaa cctgggctcc ttgcagctgg aggtgcggct
      841 gcgggacgag acggtgctgc cctccagcta ctaccagcca ctggtgcacc tgctgtgcca
      901 cgaggtcaag ctgggcatgc agggcccagg gcagctgatc ccactcatcg aggagacaac
      961 cagcaccgag tgtcgccagg acgtggccac gaacctgctc aagctcttcc tggggcaggg
     1021 gctggccaag gacttcctgg acctgctctt ccagctggag ctgagtcgca ccagtgagac
     1081 caacaccctg ttccggagca actctctggc ctcaaagtcc atggagtctt ttctgaaggt
     1141 ggccgggatg cagtacctgc acggcgtcct gggccccatc atcaacaagg tgtttgagga
     1201 gaagaagtac gtggagctgg accccagcaa agtggaagtt aaggatgtag ggtgctccgg
     1261 gctgcaccgc ccgcagaccg aggccgaggt gctggagcag agcgcgcaga cgctgcgcgc
     1321 ccacctgggg gccctgctga gcgcgctcag ccgctcggtt cgcgcgtgcc ccgccgtggt
     1381 gcgcgccacc ttccgccagc tcttccggcg cgtgcgcgag cgcttccccg gcgcccagca
     1441 cgagaatgta ccgttcatcg ccgtcaccag cttcctgtgc ctgcgcttct tctctcccgc
     1501 catcatgtcg cccaagctct tccacctgcg ggagcgccac gcggacgccc gcaccagccg
     1561 caccctgctc ctgttggcca aggcagtcca gaacgtgggc aacatggaca cgccggcttc
     1621 cagggccaag gaggcttgga tggagccgct gcagcccacc gtgcgccagg gcgtggcgca
     1681 gctgaaggac ttcatcacca agctcgtgga catcgaggag aaggacgagc tggacctgca
     1741 gcggacgctg agtttgcagg cgccacctgt gaaggagggg ccactcttca tccacaggac
     1801 caagggcaag ggccccctca tgtcctcctc cttcaagaag ctctacttct ccctcactac
     1861 cgaggccctc agcttcgcga agacgcccag ctccaagaaa agcgccctca tcaagttagc
     1921 caacatccgg gcagcggaaa aggttgagga aaagagcttt ggcggctcgc acgtcatgca
     1981 ggtcatctac acggacgacg ccggcaggcc ccagactgcc tacctgcagt gcaagtgtgt
     2041 gaatgagctt aaccagtggc tgtctgcgct gcggaaggtg agcatcaaca acaccggact
     2101 gctgggctcc taccaccctg gcgtcttccg tggggacaag tggagctgct gccaccaaaa
     2161 agagaagaca ggtcagggct gcgataagac ccggtcacgg gtgaccctgc aggagtggaa
     2221 tgaccctctt gaccatgacc ttgaggccca gctcatctac cggcacctgc tgggcgtgga
     2281 ggccatgctg tgggagaggc accgggagct gagcgggggc gcagaggcag gcacggtgcc
     2341 cacgagccct ggcaaagtcc ccgaggactc attggcccgg ctgctccggg tgctgcagga
     2401 cctccgcgag gcccatagct ccagcccggc cggctcccca ccctcagagc ccaactgcct
     2461 cctggagctg cagacgtgag gcccgcccta cgctcccctt gctgagtccc ctgccaagcg
     2521 ctcggagccc ccccaggaca ctctgcaccc cctcaccccg gtcctcctca ttagggtgca
     2581 gggcctaggt ctcttccagg tgggggaggg gggagagtca ggaataaggg gatccccaga
     2641 agtgcagagc tgagcaggct tgggcctgtc atggctggcc ggaagtgtcc ccagctccct
     2701 acagacgctg tagccatcac tgcctctcca gggaccctcc tctcctgccc aggacagacc
     2761 cagccagaac cactgctagg atgggccgca cccaggggtc tggcctccag ggacctagag
     2821 aatgggaggg agaacggggc cccaggagac ccggccgcca ccccacccgc tacccttggg
     2881 tgccacaggg ctgtgctgtt gccaacagta aacctgctct tactgtccag gctctggggt
     2941 cttgtgatga gggtctgggg agaaagtggg cccgggggga ccccggaggc tgtcggtgga
     3001 tgtgccgatg atggggctga cagtatgggc tctgggcatc cctgttcccc cctctttctt
     3061 ccccccactc ttctggggtc gggggttcct ttcccttccc agttgctgtc cctgggtccc
     3121 ctctttcatg tcccacaggc cacagagccc agtgtgtcca accagctgtt ctctcctcaa
     3181 agcagccccc aagcaagtcc cttctctagg gtgtccctga ggacagcaca gaggcgggac
     3241 tcagagaccc cattcctctt cacgcagccc ttaccccaag ccctctagct gtgtggctgg
     3301 cagtgttggc cacgtagggg ctcccatccc cccaccattg tgtcacatgg gctgccaggc
     3361 tcagctccca gctgcgtcca cagtgacctg gatcagggtg gggacaagga ctggaccctc
     3421 cttctccaga aggccttcag ctcttgcctt gccatgcagt cacctccttc cccctctgac
     3481 cccagatccc aaaggtgcac cgttgcccca gcccctttct ggccccatgg ggtttctctg
     3541 atgccttcat catagaggcc cggggctggt ccgatggttg gcaaaacttg actccggccc
     3601 agtccccact cttggggact tagaacccct gctgtcctgg gatctggcct gcctttcttt
     3661 ggtcagtccc tgtggtcccc caccagctcc ccctcccata gggctgccca ccaagccctg
     3721 cccccagccc aagaggagcc cccactgcct gcggggcagt gatgtctggc caccggctca
     3781 caccaatgac ttggtcctgg ggtggcagaa gcagcaggtg acaggagcag ggcccctgtc
     3841 cctctcttct ggccctgtgg tacccaggcc acacgttgtg cccgctcttg gggctgaccg
     3901 gctgtaggga ccaccagccg ctgctactgt gggccgcccc ggggcagggt gggcagggct
     3961 tttgtgggtt atgaggacac agaagtccct gaggccccca gacctggctc agccaacctc
     4021 cttcctcccc cggttgcccc ccactctaaa gcctcctccc tcccagcgtc cactggctcc
     4081 aggctcctca caacagcagc tcatagacac ggggcgtctc caggtggtcc cagccctcca
     4141 gatgtttcta gctctccagg tgggcgctgt tttcacgtct gcctgcatcc attcattcct
     4201 tcattcctca cctttatcct gttatctcta tttttttaag ctaccaggaa ggaaagggaa
     4261 gaagagatca cgaaactggg acccccagaa aggaggagtg ggctttgaac ttagacatct
     4321 acctcagagc tcaaataggt tgtttaaaat cacattcaat tttcagatga aggggaactt
     4381 tatagttttt tttttttttt tttttttgag acagagtctc actgtgttgc ccaggctgga
     4441 gtgcaaatgg cttgatcttg gttcactgca acctctgcct cccaggttca agcaattctc
     4501 ttgcctcagc ctcccgagta gctgggacta aaggcgtgtg ccaccatgcc cagctaattc
     4561 ttgtattttt agtagagacg gagtttctcc atgttggcca gactggtctc gaactcctga
     4621 cctcaggtga tctgaccgcc ttggcctccg aaagtgctga gattacagtt gcgagccact
     4681 gtgcgtggcc agaactttat aataagagac ttgaagctgg gtgtgacggt gcacacctct
     4741 agtcccagct actcgggagg ccaagacaga aggatcacct tgaggccagg agtttaaggc
     4801 cagcctgggc aacatagcaa aacctagtcc ctaaaattaa aaaaaaaaaa aaaaaaaaaa
     4861 ggaaaataaa ggagacttga aatttttgaa ctaaatagtg gtgatggcta cacattgtga
     4921 atgtaattaa caccactgag ttaaacactt aaaatggtta aaatggcaaa ttgtatgtta
     4981 tacctatttt actacaataa aaagtataaa aaagagaaga tatttaggtg acttacagca
     5041 accaattgca acaaaacaaa atgttaagaa atgatctttt tatgaggcaa ttggaaattt
     5101 gaacactgat caactatagg atgattggaa ttattaattt ttaaaggtgt gataagatac
     5161 tgcacttggc tgggcacagt ggcacatgcc tgtaatccca gctacttggc aggctgaggt
     5221 gggagaatcg cttgagctca ggagttcgag accagcctgg gcaacgtggc gaaatccccg
     5281 tctttacaaa aacaaacaaa caaacaaaaa agatattgca gttgtgttgt aagcgtcctt
     5341 atctttcaga gctacatagt ggaatgttta tggaatattt aggataaatg atataggcat
     5401 ttgggatttg ctgcaaaatg acccagaggc aggggtcagg gggagaggta gagatgagac
     5461 aagaggtaga ggggagaggt agaggtagcc acgagctgat aattacagac aagagatgcg
     5521 gagtatgtgg gggctcatta tcctgcatag tctatctttg tatatctttg aacttttcaa
     5581 gaataaaaaa gcttaaaaag tata
//
