LOCUS       NM_006506               5638 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens RAS p21 protein activator 2 (RASA2), transcript
            variant 3, mRNA.
ACCESSION   NM_006506
VERSION     NM_006506.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5638)
  AUTHORS   Xie,B., Yang,Z.Y. and Tang,X.N.
  TITLE     [Effect of circRASA2 targeting miR-543/TRAF6 axis on LPS-induced
            periodontal ligament cell proliferation and osteogenic
            differentiation]
  JOURNAL   Shanghai Kou Qiang Yi Xue 32 (2), 147-153 (2023)
   PUBMED   37153995
  REMARK    GeneRIF: [Effect of circRASA2 targeting miR-543/TRAF6 axis on
            LPS-induced periodontal ligament cell proliferation and osteogenic
            differentiation].
REFERENCE   2  (bases 1 to 5638)
  AUTHORS   Carnevale,J., Shifrut,E., Kale,N., Nyberg,W.A., Blaeschke,F.,
            Chen,Y.Y., Li,Z., Bapat,S.P., Diolaiti,M.E., O'Leary,P., Vedova,S.,
            Belk,J., Daniel,B., Roth,T.L., Bachl,S., Anido,A.A., Prinzing,B.,
            Ibanez-Vega,J., Lange,S., Haydar,D., Luetke-Eversloh,M.,
            Born-Bony,M., Hegde,B., Kogan,S., Feuchtinger,T., Okada,H.,
            Satpathy,A.T., Shannon,K., Gottschalk,S., Eyquem,J., Krenciute,G.,
            Ashworth,A. and Marson,A.
  TITLE     RASA2 ablation in T cells boosts antigen sensitivity and long-term
            function
  JOURNAL   Nature 609 (7925), 174-182 (2022)
   PUBMED   36002574
  REMARK    GeneRIF: RASA2 ablation in T cells boosts antigen sensitivity and
            long-term function.
REFERENCE   3  (bases 1 to 5638)
  AUTHORS   Lin,E., Tsai,S.J., Kuo,P.H., Liu,Y.L., Yang,A.C., Conomos,M.P. and
            Thornton,T.A.
  TITLE     Genome-wide association study in the Taiwan Biobank identifies four
            novel genes for human height: NABP2, RASA2, RNF41 and SLC39A5
  JOURNAL   Hum Mol Genet 30 (23), 2362-2369 (2021)
   PUBMED   34270706
  REMARK    GeneRIF: Genome-wide association study in the Taiwan Biobank
            identifies four novel genes for human height: NABP2, RASA2, RNF41
            and SLC39A5.
REFERENCE   4  (bases 1 to 5638)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 5638)
  AUTHORS   Jiang,M., Shi,X., Zhu,H., Wei,W. and Li,J.
  TITLE     Two GEO MicroRNA Expression Profile Based High-Throughput Screen to
            Identify MicroRNA-31-3p Regulating Growth of Medullary Thyroid
            Carcinoma Cell by Targeting RASA2
  JOURNAL   Med Sci Monit 25, 5170-5180 (2019)
   PUBMED   31298226
  REMARK    GeneRIF: Authors found that knockdown of RASA2 inhibited MTC cell
            proliferation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5638)
  AUTHORS   Lockyer,P.J., Bottomley,J.R., Reynolds,J.S., McNulty,T.J.,
            Venkateswarlu,K., Potter,B.V., Dempsey,C.E. and Cullen,P.J.
  TITLE     Distinct subcellular localisations of the putative inositol
            1,3,4,5-tetrakisphosphate receptors GAP1IP4BP and GAP1m result from
            the GAP1IP4BP PH domain directing plasma membrane targeting
  JOURNAL   Curr Biol 7 (12), 1007-1010 (1997)
   PUBMED   9382842
REFERENCE   7  (bases 1 to 5638)
  AUTHORS   Kobayashi,M., Masui,T., Kusuda,J., Kameoka,Y., Hashimoto,K. and
            Iwashita,S.
  TITLE     Human rasGTPase-activating protein (human counterpart of GAP1m):
            sequence of the cDNA, primary structure of the protein, production
            and chromosomal localization
  JOURNAL   Gene 175 (1-2), 173-177 (1996)
   PUBMED   8917095
REFERENCE   8  (bases 1 to 5638)
  AUTHORS   Li,S., Satoh,H., Watanabe,T., Nakamura,S. and Hattori,S.
  TITLE     cDNA cloning and chromosomal mapping of a novel human GAP (GAP1M),
            a GTPase-activating protein of Ras
  JOURNAL   Genomics 35 (3), 625-627 (1996)
   PUBMED   8812506
REFERENCE   9  (bases 1 to 5638)
  AUTHORS   Hattori,S. and Baba,H.
  TITLE     [Heterogeneity of GTPase-activating proteins for Ras in the
            regulation of Ras signal transduction pathway]
  JOURNAL   Yakugaku Zasshi 116 (1), 21-38 (1996)
   PUBMED   8699317
  REMARK    Review article
REFERENCE   10 (bases 1 to 5638)
  AUTHORS   Roberts,A.E.
  TITLE     Noonan Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301303
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010184.18, DA792257.1,
            AF115573.1, D78155.1, D82880.1, BM968286.1, DA152165.1, AK025305.1
            and AA214345.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 31, 2019 this sequence version replaced NM_006506.4.
            
            Summary: The protein encoded by this gene is member of the GAP1
            family of GTPase-activating proteins. The gene product stimulates
            the GTPase activity of normal RAS p21 but not its oncogenic
            counterpart. Acting as a suppressor of RAS function, the protein
            enhances the weak intrinsic GTPase activity of RAS proteins
            resulting in the inactive GDP-bound form of RAS, thereby allowing
            control of cellular proliferation and differentiation. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Dec 2014].
            
            Transcript Variant: This variant (3) lacks an in-frame exon in the
            3' coding region, compared to variant 1. The encoded isoform (3) is
            shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853566.20243.1,
                                           SRR11853565.21070.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2144335
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000286364.9/ ENSP00000286364.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC010184.18        52763-52782         c
            21-57               DA792257.1         1-37
            58-740              AF115573.1         1-683
            741-741             D78155.1           684-684
            742-2216            AF115573.1         685-2159
            2217-2217           D82880.1           2172-2172
            2218-2649           AF115573.1         2161-2592
            2650-3016           BM968286.1         76-442              c
            3017-3269           DA152165.1         310-562
            3270-5636           AK025305.1         70-2436
            5637-5638           AA214345.1         30-31               c
FEATURES             Location/Qualifiers
     source          1..5638
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q23"
     gene            1..5638
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /note="RAS p21 protein activator 2"
                     /db_xref="GeneID:5922"
                     /db_xref="HGNC:HGNC:9872"
                     /db_xref="MIM:601589"
     exon            1..190
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..2607
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /note="isoform 3 is encoded by transcript variant 3;
                     GTPase-activating protein of RAS; ras GTPase-activating
                     protein 2; GTPase-activating protein 1m"
                     /codon_start=1
                     /product="ras GTPase-activating protein 2 isoform 3"
                     /protein_id="NP_006497.2"
                     /db_xref="CCDS:CCDS3117.1"
                     /db_xref="GeneID:5922"
                     /db_xref="HGNC:HGNC:9872"
                     /db_xref="MIM:601589"
                     /translation="MAAAAPAAAAASSEAPAASATAEPEAGDQDSREVRVLQSLRGKI
                     CEAKNLLPYLGPHKMRDCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRTFQYL
                     SFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKETWFSLQPVDSNSEVQGKVHLELKLN
                     ELITENGTVCQQLVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTSN
                     PQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPV
                     NVLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLL
                     KSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLVPFATAVAELDLKDTQDA
                     NTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLKEGDNVE
                     NNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPHVQYSAVSSFV
                     FLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSKSSFKETFM
                     CEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRAQGRTRIGKK
                     NFKKRWFCLTSRELTYHKQPGKDAIYTIPVKNILAVEKLEESSFNKKNMFQVIHTEKP
                     LYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENTLGCKPC
                     TAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKMEEACGTIAVYQGPQKEPDDYSNF
                     VIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGSKENPIVGKAS"
     exon            191..308
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            309..412
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            413..507
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            508..584
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            585..668
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            669..741
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            742..818
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            819..920
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1077
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1226
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1341
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1416
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1540
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1647
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1731
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1809
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1883
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..1990
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2073
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2282
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2386
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2576
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..5638
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5617..5622
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /note="hexamer: AATAAA"
     polyA_site      5638
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /note="major polyA site"
ORIGIN      
        1 gctccgcctc gcccggctac gcaggcggca gggctgcggc acgggccggg cggcaccatg
       61 gcggcggcgg cgcctgctgc tgcggcggct tcttccgagg cgccagcggc gagtgcgact
      121 gcagagcccg aggccgggga ccaggacagt cgcgaggttc gagtgttgca gagcctgcgg
      181 ggcaagatct gtgaagcaaa aaatttattg ccatatcttg gaccccacaa aatgagagat
      241 tgtttctgta ccataaattt ggaccaggaa gaagtttatc gtacccaagt tgtggaaaaa
      301 tctttaagcc catttttcag tgaagaattt tactttgaga ttccaagaac tttccagtat
      361 ttgtctttct atgtttatga taagaatgtt ttacaaagag atctccgtat aggaaaagta
      421 gccatcaaaa aagaagactt gtgtaatcac agtggcaaag aaacttggtt ttcattacag
      481 cctgttgact ccaattcaga ggttcagggt aaagttcacc ttgaattaaa actgaatgaa
      541 ctgataacgg agaatggaac tgtatgccag cagcttgttg tacacatcaa ggcatgccat
      601 gggttgcctc tcataaatgg ccaaagctgt gacccttatg caacagtttc tctagtgggc
      661 ccttctagga atgaccaaaa gaagacaaaa gtaaagaaga aaacaagcaa tccgcagttt
      721 aatgaaatct tttattttga ggtaaccaga tccagtagtt acaccagaaa gtcccagttc
      781 caggtagaag aggaggacat tgaaaagcta gaaatcagga tcgacttgtg gaacaatgga
      841 aacctagtcc aagatgtttt cctaggtgag attaaggttc ctgtgaacgt attaagaact
      901 gattcctctc atcaagcctg gtacttgcta cagccaagag acaatggaaa caagtcatcc
      961 aaaactgatg acctggggtc tcttcgatta aatatatgtt atacagaaga ctacgtgctt
     1021 ccttcagagt actatggtcc tttgaaaact ttgctgctaa aatcaccaga tgttcaacca
     1081 atatctgcct cagctgctta cattttgagt gaaatatgtc gagataaaaa tgatgctgtt
     1141 ttgccccttg tacgactgct gctgcaccat gataaacttg ttccttttgc cactgctgtg
     1201 gctgaattag acttgaagga tacacaagat gcaaacacaa tttttagagg aaattccctg
     1261 gctacccgat gtctggatga gatgatgaaa atagtgggag ggcactacct gaaagtaaca
     1321 ttaaaaccta ttcttgatga gatatgtgac tcctcaaaat cctgtgaaat cgatcctatt
     1381 aaattgaaag agggagataa tgtagaaaat aataaggaga atctgcgcta ctatgtagac
     1441 aagttattca atacaattgt aaaatcaagt atgagctgcc ccactgtaat gtgtgatatc
     1501 ttttattctc taaggcagat ggctactcag agatttccta atgaccctca tgttcagtat
     1561 tctgcagtga gcagctttgt atttcttcgt ttctttgctg tagccgtagt atcacctcat
     1621 acttttcatt tgcgacctca tcatccagat gcacagacaa ttagaacatt aactctcatc
     1681 tcaaaaacta tacaaacttt gggaagctgg gggagtctgt ccaaaagcaa gtcaagtttc
     1741 aaagagacat tcatgtgtga atttttcaaa atgtttcaag aagaaggata tattatagca
     1801 gttaaaaagt tcttggatga aatttcatct actgaaacta aagagtccag tggtacgagt
     1861 gagcctgtgc acctgaaaga aggtgagatg tataaaagag ctcaaggaag aactcggatt
     1921 ggaaaaaaga attttaagaa acgatggttc tgcttaacaa gcagagagct cacctaccac
     1981 aaacagccag gcaaagatgc aatctacaca atcccagtaa aaaacattct tgctgtggaa
     2041 aaactggaag agagctcttt caacaagaaa aatatgttcc aagtaataca tacggagaaa
     2101 ccactctatg tccaggcaaa taactgtgta gaagctaatg aatggataga cgtactctgc
     2161 agggtgagcc gatgcaatca aaacaggctc agtttttatc atccctctgt gtatctgaac
     2221 ggaaattggc tctgctgtca ggagactggt gaaaacactc tcggctgcaa gccatgtact
     2281 gcaggtgtcc ctgcagacat ccaaatagat attgatgaag acagagaaac agaaagaatt
     2341 tattcccttt ttaccctcag tttacttaag ctgcagaaga tggaagaggc ttgtggaact
     2401 attgcagtct atcaaggacc acagaaagag cctgatgatt attctaactt tgtaatcgag
     2461 gattctgtaa caacctttaa gacaattcag caaataaaaa gcataattga gaagctggat
     2521 gaacctcatg aaaaatatag gaagaaaaga tccagtagtg caaaatatgg gagcaaggaa
     2581 aatccaattg ttgggaaagc atcttagagt ttaacagatt ggttcagaag aactggaaaa
     2641 tattattttt cttggagctt ttcaattcat catgtatttt gttcatggta tttaagaatg
     2701 agcatccgct tcaatgtcat ctgcctccac attgtattta atatttaata attgaaatta
     2761 attgtttggg aatcctggta ttgatgtatt actagagaat ttaaagccca agattccctt
     2821 catacctgtg tgaccaaatc catgtttctg caacttcttt ttaatcgaaa gaatcttcct
     2881 agaaaagctt tgtaacaaag ggagaactcc tccgtagcaa gaaaccatct cttcttgtaa
     2941 cactctgttc tgtggacttg ttttcactac catcagtgcc tgctctatac tgccaacatt
     3001 gtgttttact agaaaattcc aattcatgac agttcagagc ttttcattta gttcatgtag
     3061 accctcccac tttaaaaaag aaaaaaaata agaagtgttt ttcctttggt ccatcagtca
     3121 ttacaggttc cattcaagac agtgatagaa actttagaaa actgccagag catacttgaa
     3181 agttggtaga tccttttgcc taaagatgta aacaaaactc aagacagaag gaatcaggga
     3241 atatgtgcta ttgtgtgcat cttgtttaca tttgggatca gtgatggcaa aagaagtaat
     3301 gagaccactg aaattgtttt cattgtttta aataccaggt actcattttc ttgatttgaa
     3361 agtttaacat gacttctaag gacatctctt caaaaagaaa gtaaacaggg aatgaaggtg
     3421 gtgggaaaat cacttcactt cacccactat ttcatgttgt aataagggcc accataagga
     3481 tgccctcctc atagtgttcg gttctgatct tcctcgagaa cagtcacttg gcgcacttta
     3541 ataatctgga ctgctccaga tttgacttta gatactccat ggtatctagt ctttatgatc
     3601 agttgaatga tcagtgttta agtctaaaaa taatgctttc ctgaaaatgt ttatatttca
     3661 ttgctgtttc cttattgcct gctagccaaa tggaatttgg gcaagcaact ctttgaagac
     3721 ttttttaccc tagaaattta cttttgtcct aaaaacccta actgtaaata agcagtcgaa
     3781 gcaagttgcc accttgaagt tgagggatac actttgcttc atcagtatta aaaaccatgg
     3841 tactcttatt ttgtcttttt taattcaaaa cattttctaa atgtggtact ttgaaccttg
     3901 gagtatttac atgtttctgt tcaaaactgt gacttattaa tgtaagtctg ctagtagtac
     3961 tttttttgtc tgagcataag ctatatttca agatatactt tgccaatttt gttattggtg
     4021 ggtaatcatt tttaaattat attgttatta ggtaattatt tttaaagact actggcatac
     4081 aatcaaagtt gttccataaa agaatataac tgagcaatgt atttctctaa atgacttgta
     4141 aaaatcaatg aattatgttt aagtctgcat tatggtaggt tattactccc agctcatttt
     4201 aaagacaagt ttgaaagagt cctttaaatt ttataagctt gtagattcca taaactacac
     4261 tgatttatac atttgaaaga atttagccat ttaataaatt tcttattctc aaattgcatt
     4321 tagattaaaa ttccttttaa gagtgtctga aatgtctgcc tgcgaagaac atgtaaacat
     4381 tgccagatac cagtcattat tctttagtgg ctttttagtc ctctgctttt ttttttaagg
     4441 caaaagaaat atgcatctag catttctaat accaaatccc caattgtgat tgttttaaag
     4501 atcatggtat gatcacaggg accaaggctg tgtgcatata taactctgga tttgaaagga
     4561 ggagagttca gccatctagt tcttttcttc acatgacact tttaaacagc cagtttgact
     4621 ggaattaacc aacttggcac agcctaaaaa aggagtaatg tgaaattaaa ttatttttct
     4681 ttgaaagtct tttgaaataa gagaccatgt aagtaggacc ctaagacaac caaggaattt
     4741 gcttccaggg ccctcattcc tctgctgtta cttacaaatg ttttaatttt tactacctga
     4801 tattctttct ctaccttttc cacatttgaa aatatacaag gcagctcact tcatcctaaa
     4861 aacctaaaaa ctccaggaag gaaagaaaag gatgatatgg ggaaatttgc cataaatgcc
     4921 ggttctggtt cttagtttag ccatttccat cagttgaaat tgtggtgtga tctgttgctt
     4981 gtttcgttgt tgttttgttt ttgtgtagct ttgtttttta atattcattt aataagatga
     5041 tgggcaatag caaacatttt tactcccagg aatataattt atcaaattga actattttat
     5101 ttgccaaaga aacttgtttt taatatcacg ggtaatgggt aagtgtgaaa actaggcttt
     5161 tttttatgaa acaaaaaaag gtgacgaata atatggcttt tgtttctgtt tctgaagcct
     5221 gatttcattt atgccaggtt ttgaaaaaca gatctttttc ttaagtgaaa gcacctttaa
     5281 tttgctctaa cggtacatcc tgtaaagaca gaattctgca tagcctttta ggtgttttta
     5341 cagtatgtga aaaatacaag actcattcta gagttaaatt accaatcttg gttgatatta
     5401 tctgcttcca tttttattaa tttggaaatt aatatgttgc tagtaaatat tggtttttac
     5461 agtacccagt ttgaaaatgt aagttatcaa aacttaatgt agtgaatttg tgtaaccatg
     5521 ttgtattgtt gagaatgtat ttttatttaa attttatttt cttatcaaga gtattataaa
     5581 aattaacttt tgtaactgtc gcttggaaat aactcaaata aattacaaga agcctgtc
//
