LOCUS       NM_001303246            5650 bp    mRNA    linear   PRI 13-OCT-2024
DEFINITION  Homo sapiens RAS p21 protein activator 2 (RASA2), transcript
            variant 1, mRNA.
ACCESSION   NM_001303246
VERSION     NM_001303246.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5650)
  AUTHORS   Xie,B., Yang,Z.Y. and Tang,X.N.
  TITLE     [Effect of circRASA2 targeting miR-543/TRAF6 axis on LPS-induced
            periodontal ligament cell proliferation and osteogenic
            differentiation]
  JOURNAL   Shanghai Kou Qiang Yi Xue 32 (2), 147-153 (2023)
   PUBMED   37153995
  REMARK    GeneRIF: [Effect of circRASA2 targeting miR-543/TRAF6 axis on
            LPS-induced periodontal ligament cell proliferation and osteogenic
            differentiation].
REFERENCE   2  (bases 1 to 5650)
  AUTHORS   Carnevale,J., Shifrut,E., Kale,N., Nyberg,W.A., Blaeschke,F.,
            Chen,Y.Y., Li,Z., Bapat,S.P., Diolaiti,M.E., O'Leary,P., Vedova,S.,
            Belk,J., Daniel,B., Roth,T.L., Bachl,S., Anido,A.A., Prinzing,B.,
            Ibanez-Vega,J., Lange,S., Haydar,D., Luetke-Eversloh,M.,
            Born-Bony,M., Hegde,B., Kogan,S., Feuchtinger,T., Okada,H.,
            Satpathy,A.T., Shannon,K., Gottschalk,S., Eyquem,J., Krenciute,G.,
            Ashworth,A. and Marson,A.
  TITLE     RASA2 ablation in T cells boosts antigen sensitivity and long-term
            function
  JOURNAL   Nature 609 (7925), 174-182 (2022)
   PUBMED   36002574
  REMARK    GeneRIF: RASA2 ablation in T cells boosts antigen sensitivity and
            long-term function.
REFERENCE   3  (bases 1 to 5650)
  AUTHORS   Lin,E., Tsai,S.J., Kuo,P.H., Liu,Y.L., Yang,A.C., Conomos,M.P. and
            Thornton,T.A.
  TITLE     Genome-wide association study in the Taiwan Biobank identifies four
            novel genes for human height: NABP2, RASA2, RNF41 and SLC39A5
  JOURNAL   Hum Mol Genet 30 (23), 2362-2369 (2021)
   PUBMED   34270706
  REMARK    GeneRIF: Genome-wide association study in the Taiwan Biobank
            identifies four novel genes for human height: NABP2, RASA2, RNF41
            and SLC39A5.
REFERENCE   4  (bases 1 to 5650)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 5650)
  AUTHORS   Jiang,M., Shi,X., Zhu,H., Wei,W. and Li,J.
  TITLE     Two GEO MicroRNA Expression Profile Based High-Throughput Screen to
            Identify MicroRNA-31-3p Regulating Growth of Medullary Thyroid
            Carcinoma Cell by Targeting RASA2
  JOURNAL   Med Sci Monit 25, 5170-5180 (2019)
   PUBMED   31298226
  REMARK    GeneRIF: Authors found that knockdown of RASA2 inhibited MTC cell
            proliferation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5650)
  AUTHORS   Lockyer,P.J., Bottomley,J.R., Reynolds,J.S., McNulty,T.J.,
            Venkateswarlu,K., Potter,B.V., Dempsey,C.E. and Cullen,P.J.
  TITLE     Distinct subcellular localisations of the putative inositol
            1,3,4,5-tetrakisphosphate receptors GAP1IP4BP and GAP1m result from
            the GAP1IP4BP PH domain directing plasma membrane targeting
  JOURNAL   Curr Biol 7 (12), 1007-1010 (1997)
   PUBMED   9382842
REFERENCE   7  (bases 1 to 5650)
  AUTHORS   Kobayashi,M., Masui,T., Kusuda,J., Kameoka,Y., Hashimoto,K. and
            Iwashita,S.
  TITLE     Human rasGTPase-activating protein (human counterpart of GAP1m):
            sequence of the cDNA, primary structure of the protein, production
            and chromosomal localization
  JOURNAL   Gene 175 (1-2), 173-177 (1996)
   PUBMED   8917095
REFERENCE   8  (bases 1 to 5650)
  AUTHORS   Li,S., Satoh,H., Watanabe,T., Nakamura,S. and Hattori,S.
  TITLE     cDNA cloning and chromosomal mapping of a novel human GAP (GAP1M),
            a GTPase-activating protein of Ras
  JOURNAL   Genomics 35 (3), 625-627 (1996)
   PUBMED   8812506
REFERENCE   9  (bases 1 to 5650)
  AUTHORS   Hattori,S. and Baba,H.
  TITLE     [Heterogeneity of GTPase-activating proteins for Ras in the
            regulation of Ras signal transduction pathway]
  JOURNAL   Yakugaku Zasshi 116 (1), 21-38 (1996)
   PUBMED   8699317
  REMARK    Review article
REFERENCE   10 (bases 1 to 5650)
  AUTHORS   Roberts,A.E.
  TITLE     Noonan Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301303
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010184.18, DA792257.1,
            AF115573.1, D78155.1, D82880.1, BM968286.1, DA152165.1, AK025305.1
            and AA214345.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001303246.2.
            
            Summary: The protein encoded by this gene is member of the GAP1
            family of GTPase-activating proteins. The gene product stimulates
            the GTPase activity of normal RAS p21 but not its oncogenic
            counterpart. Acting as a suppressor of RAS function, the protein
            enhances the weak intrinsic GTPase activity of RAS proteins
            resulting in the inactive GDP-bound form of RAS, thereby allowing
            control of cellular proliferation and differentiation. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Dec 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D82880.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC010184.18        52763-52782         c
            21-57               DA792257.1         1-37
            58-740              AF115573.1         1-683
            741-741             D78155.1           684-684
            742-1990            AF115573.1         685-1933
            1991-2229           D82880.1           1934-2172
            2230-2661           AF115573.1         2161-2592
            2662-3028           BM968286.1         76-442              c
            3029-3281           DA152165.1         310-562
            3282-5648           AK025305.1         70-2436
            5649-5650           AA214345.1         30-31               c
FEATURES             Location/Qualifiers
     source          1..5650
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q23"
     gene            1..5650
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /note="RAS p21 protein activator 2"
                     /db_xref="GeneID:5922"
                     /db_xref="HGNC:HGNC:9872"
                     /db_xref="MIM:601589"
     exon            1..190
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..2619
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /note="isoform 1 is encoded by transcript variant 1;
                     GTPase-activating protein of RAS; ras GTPase-activating
                     protein 2; GTPase-activating protein 1m"
                     /codon_start=1
                     /product="ras GTPase-activating protein 2 isoform 1"
                     /protein_id="NP_001290175.1"
                     /db_xref="GeneID:5922"
                     /db_xref="HGNC:HGNC:9872"
                     /db_xref="MIM:601589"
                     /translation="MAAAAPAAAAASSEAPAASATAEPEAGDQDSREVRVLQSLRGKI
                     CEAKNLLPYLGPHKMRDCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRTFQYL
                     SFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKETWFSLQPVDSNSEVQGKVHLELKLN
                     ELITENGTVCQQLVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTSN
                     PQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPV
                     NVLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLL
                     KSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLVPFATAVAELDLKDTQDA
                     NTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLKEGDNVE
                     NNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPHVQYSAVSSFV
                     FLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSKSSFKETFM
                     CEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRAQGRTRIGKK
                     NFKKRWFCLTSRELTYHKQPEFIERKDAIYTIPVKNILAVEKLEESSFNKKNMFQVIH
                     TEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENTLG
                     CKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKMEEACGTIAVYQGPQKEPDD
                     YSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGSKENPIVGKAS"
     exon            191..308
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            309..412
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            413..507
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            508..584
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            585..668
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            669..741
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            742..818
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            819..920
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1077
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1226
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1341
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1416
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1540
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1647
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1731
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1809
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1883
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..1990
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2002
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2085
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2294
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2398
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2588
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            2589..5650
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5629..5634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /note="hexamer: AATAAA"
     polyA_site      5650
                     /gene="RASA2"
                     /gene_synonym="GAP1M"
                     /note="major polyA site"
ORIGIN      
        1 gctccgcctc gcccggctac gcaggcggca gggctgcggc acgggccggg cggcaccatg
       61 gcggcggcgg cgcctgctgc tgcggcggct tcttccgagg cgccagcggc gagtgcgact
      121 gcagagcccg aggccgggga ccaggacagt cgcgaggttc gagtgttgca gagcctgcgg
      181 ggcaagatct gtgaagcaaa aaatttattg ccatatcttg gaccccacaa aatgagagat
      241 tgtttctgta ccataaattt ggaccaggaa gaagtttatc gtacccaagt tgtggaaaaa
      301 tctttaagcc catttttcag tgaagaattt tactttgaga ttccaagaac tttccagtat
      361 ttgtctttct atgtttatga taagaatgtt ttacaaagag atctccgtat aggaaaagta
      421 gccatcaaaa aagaagactt gtgtaatcac agtggcaaag aaacttggtt ttcattacag
      481 cctgttgact ccaattcaga ggttcagggt aaagttcacc ttgaattaaa actgaatgaa
      541 ctgataacgg agaatggaac tgtatgccag cagcttgttg tacacatcaa ggcatgccat
      601 gggttgcctc tcataaatgg ccaaagctgt gacccttatg caacagtttc tctagtgggc
      661 ccttctagga atgaccaaaa gaagacaaaa gtaaagaaga aaacaagcaa tccgcagttt
      721 aatgaaatct tttattttga ggtaaccaga tccagtagtt acaccagaaa gtcccagttc
      781 caggtagaag aggaggacat tgaaaagcta gaaatcagga tcgacttgtg gaacaatgga
      841 aacctagtcc aagatgtttt cctaggtgag attaaggttc ctgtgaacgt attaagaact
      901 gattcctctc atcaagcctg gtacttgcta cagccaagag acaatggaaa caagtcatcc
      961 aaaactgatg acctggggtc tcttcgatta aatatatgtt atacagaaga ctacgtgctt
     1021 ccttcagagt actatggtcc tttgaaaact ttgctgctaa aatcaccaga tgttcaacca
     1081 atatctgcct cagctgctta cattttgagt gaaatatgtc gagataaaaa tgatgctgtt
     1141 ttgccccttg tacgactgct gctgcaccat gataaacttg ttccttttgc cactgctgtg
     1201 gctgaattag acttgaagga tacacaagat gcaaacacaa tttttagagg aaattccctg
     1261 gctacccgat gtctggatga gatgatgaaa atagtgggag ggcactacct gaaagtaaca
     1321 ttaaaaccta ttcttgatga gatatgtgac tcctcaaaat cctgtgaaat cgatcctatt
     1381 aaattgaaag agggagataa tgtagaaaat aataaggaga atctgcgcta ctatgtagac
     1441 aagttattca atacaattgt aaaatcaagt atgagctgcc ccactgtaat gtgtgatatc
     1501 ttttattctc taaggcagat ggctactcag agatttccta atgaccctca tgttcagtat
     1561 tctgcagtga gcagctttgt atttcttcgt ttctttgctg tagccgtagt atcacctcat
     1621 acttttcatt tgcgacctca tcatccagat gcacagacaa ttagaacatt aactctcatc
     1681 tcaaaaacta tacaaacttt gggaagctgg gggagtctgt ccaaaagcaa gtcaagtttc
     1741 aaagagacat tcatgtgtga atttttcaaa atgtttcaag aagaaggata tattatagca
     1801 gttaaaaagt tcttggatga aatttcatct actgaaacta aagagtccag tggtacgagt
     1861 gagcctgtgc acctgaaaga aggtgagatg tataaaagag ctcaaggaag aactcggatt
     1921 ggaaaaaaga attttaagaa acgatggttc tgcttaacaa gcagagagct cacctaccac
     1981 aaacagccag agttcattga acgcaaagat gcaatctaca caatcccagt aaaaaacatt
     2041 cttgctgtgg aaaaactgga agagagctct ttcaacaaga aaaatatgtt ccaagtaata
     2101 catacggaga aaccactcta tgtccaggca aataactgtg tagaagctaa tgaatggata
     2161 gacgtactct gcagggtgag ccgatgcaat caaaacaggc tcagttttta tcatccctct
     2221 gtgtatctga acggaaattg gctctgctgt caggagactg gtgaaaacac tctcggctgc
     2281 aagccatgta ctgcaggtgt ccctgcagac atccaaatag atattgatga agacagagaa
     2341 acagaaagaa tttattccct ttttaccctc agtttactta agctgcagaa gatggaagag
     2401 gcttgtggaa ctattgcagt ctatcaagga ccacagaaag agcctgatga ttattctaac
     2461 tttgtaatcg aggattctgt aacaaccttt aagacaattc agcaaataaa aagcataatt
     2521 gagaagctgg atgaacctca tgaaaaatat aggaagaaaa gatccagtag tgcaaaatat
     2581 gggagcaagg aaaatccaat tgttgggaaa gcatcttaga gtttaacaga ttggttcaga
     2641 agaactggaa aatattattt ttcttggagc ttttcaattc atcatgtatt ttgttcatgg
     2701 tatttaagaa tgagcatccg cttcaatgtc atctgcctcc acattgtatt taatatttaa
     2761 taattgaaat taattgtttg ggaatcctgg tattgatgta ttactagaga atttaaagcc
     2821 caagattccc ttcatacctg tgtgaccaaa tccatgtttc tgcaacttct ttttaatcga
     2881 aagaatcttc ctagaaaagc tttgtaacaa agggagaact cctccgtagc aagaaaccat
     2941 ctcttcttgt aacactctgt tctgtggact tgttttcact accatcagtg cctgctctat
     3001 actgccaaca ttgtgtttta ctagaaaatt ccaattcatg acagttcaga gcttttcatt
     3061 tagttcatgt agaccctccc actttaaaaa agaaaaaaaa taagaagtgt ttttcctttg
     3121 gtccatcagt cattacaggt tccattcaag acagtgatag aaactttaga aaactgccag
     3181 agcatacttg aaagttggta gatccttttg cctaaagatg taaacaaaac tcaagacaga
     3241 aggaatcagg gaatatgtgc tattgtgtgc atcttgttta catttgggat cagtgatggc
     3301 aaaagaagta atgagaccac tgaaattgtt ttcattgttt taaataccag gtactcattt
     3361 tcttgatttg aaagtttaac atgacttcta aggacatctc ttcaaaaaga aagtaaacag
     3421 ggaatgaagg tggtgggaaa atcacttcac ttcacccact atttcatgtt gtaataaggg
     3481 ccaccataag gatgccctcc tcatagtgtt cggttctgat cttcctcgag aacagtcact
     3541 tggcgcactt taataatctg gactgctcca gatttgactt tagatactcc atggtatcta
     3601 gtctttatga tcagttgaat gatcagtgtt taagtctaaa aataatgctt tcctgaaaat
     3661 gtttatattt cattgctgtt tccttattgc ctgctagcca aatggaattt gggcaagcaa
     3721 ctctttgaag acttttttac cctagaaatt tacttttgtc ctaaaaaccc taactgtaaa
     3781 taagcagtcg aagcaagttg ccaccttgaa gttgagggat acactttgct tcatcagtat
     3841 taaaaaccat ggtactctta ttttgtcttt tttaattcaa aacattttct aaatgtggta
     3901 ctttgaacct tggagtattt acatgtttct gttcaaaact gtgacttatt aatgtaagtc
     3961 tgctagtagt actttttttg tctgagcata agctatattt caagatatac tttgccaatt
     4021 ttgttattgg tgggtaatca tttttaaatt atattgttat taggtaatta tttttaaaga
     4081 ctactggcat acaatcaaag ttgttccata aaagaatata actgagcaat gtatttctct
     4141 aaatgacttg taaaaatcaa tgaattatgt ttaagtctgc attatggtag gttattactc
     4201 ccagctcatt ttaaagacaa gtttgaaaga gtcctttaaa ttttataagc ttgtagattc
     4261 cataaactac actgatttat acatttgaaa gaatttagcc atttaataaa tttcttattc
     4321 tcaaattgca tttagattaa aattcctttt aagagtgtct gaaatgtctg cctgcgaaga
     4381 acatgtaaac attgccagat accagtcatt attctttagt ggctttttag tcctctgctt
     4441 ttttttttaa ggcaaaagaa atatgcatct agcatttcta ataccaaatc cccaattgtg
     4501 attgttttaa agatcatggt atgatcacag ggaccaaggc tgtgtgcata tataactctg
     4561 gatttgaaag gaggagagtt cagccatcta gttcttttct tcacatgaca cttttaaaca
     4621 gccagtttga ctggaattaa ccaacttggc acagcctaaa aaaggagtaa tgtgaaatta
     4681 aattattttt ctttgaaagt cttttgaaat aagagaccat gtaagtagga ccctaagaca
     4741 accaaggaat ttgcttccag ggccctcatt cctctgctgt tacttacaaa tgttttaatt
     4801 tttactacct gatattcttt ctctaccttt tccacatttg aaaatataca aggcagctca
     4861 cttcatccta aaaacctaaa aactccagga aggaaagaaa aggatgatat ggggaaattt
     4921 gccataaatg ccggttctgg ttcttagttt agccatttcc atcagttgaa attgtggtgt
     4981 gatctgttgc ttgtttcgtt gttgttttgt ttttgtgtag ctttgttttt taatattcat
     5041 ttaataagat gatgggcaat agcaaacatt tttactccca ggaatataat ttatcaaatt
     5101 gaactatttt atttgccaaa gaaacttgtt tttaatatca cgggtaatgg gtaagtgtga
     5161 aaactaggct tttttttatg aaacaaaaaa aggtgacgaa taatatggct tttgtttctg
     5221 tttctgaagc ctgatttcat ttatgccagg ttttgaaaaa cagatctttt tcttaagtga
     5281 aagcaccttt aatttgctct aacggtacat cctgtaaaga cagaattctg catagccttt
     5341 taggtgtttt tacagtatgt gaaaaataca agactcattc tagagttaaa ttaccaatct
     5401 tggttgatat tatctgcttc catttttatt aatttggaaa ttaatatgtt gctagtaaat
     5461 attggttttt acagtaccca gtttgaaaat gtaagttatc aaaacttaat gtagtgaatt
     5521 tgtgtaacca tgttgtattg ttgagaatgt atttttattt aaattttatt ttcttatcaa
     5581 gagtattata aaaattaact tttgtaactg tcgcttggaa ataactcaaa taaattacaa
     5641 gaagcctgtc
//
