LOCUS       NM_002889                685 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens retinoic acid receptor responder 2 (RARRES2), mRNA.
ACCESSION   NM_002889 XM_005250032
VERSION     NM_002889.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 685)
  AUTHORS   Liu,A., Liu,Y., Chen,G., Lyu,W., Ye,F., Wang,J., Liao,Q., Zhu,L.,
            Du,Y. and Ye,R.D.
  TITLE     Structure of G protein-coupled receptor GPR1 bound to full-length
            chemerin adipokine reveals a chemokine-like reverse binding mode
  JOURNAL   PLoS Biol 22 (10), e3002838 (2024)
   PUBMED   39466725
  REMARK    GeneRIF: Structure of G protein-coupled receptor GPR1 bound to
            full-length chemerin adipokine reveals a chemokine-like reverse
            binding mode.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 685)
  AUTHORS   Zhu,X.J., Qiu,H., Liu,S.L., Dai,W., Hu,H.B. and Huang,H.
  TITLE     [Research progress of chemerin in polycystic ovary syndrome]
  JOURNAL   Sheng Li Xue Bao 76 (3), 429-437 (2024)
   PUBMED   38939937
  REMARK    GeneRIF: [Research progress of chemerin in polycystic ovary
            syndrome].
            Review article
REFERENCE   3  (bases 1 to 685)
  AUTHORS   Gokdemir,G.S., Gokdemir,M.T., Arac,S. and Yokus,B.
  TITLE     Prognostic significance of the chemerin level in coronavirus
            disease 2019 patients
  JOURNAL   Medicine (Baltimore) 103 (14), e37743 (2024)
   PUBMED   38579052
  REMARK    GeneRIF: Prognostic significance of the chemerin level in
            coronavirus disease 2019 patients.
REFERENCE   4  (bases 1 to 685)
  AUTHORS   Lu,Z., Liu,J., Wan,Q., Wu,Y., Wu,W. and Chen,Y.
  TITLE     Chemerin promotes invasion of oral squamous cell carcinoma by
            stimulating IL-6 and TNF-alpha production via STAT3 activation
  JOURNAL   Mol Biol Rep 51 (1), 436 (2024)
   PUBMED   38520551
  REMARK    GeneRIF: Chemerin promotes invasion of oral squamous cell carcinoma
            by stimulating IL-6 and TNF-alpha production via STAT3 activation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 685)
  AUTHORS   Ma,J., Chen,Z., Li,Q., Wang,L., Chen,J., Yang,X., Yang,C. and
            Quan,Z.
  TITLE     RARRES2 is involved in the 'lock-and-key' interactions between
            osteosarcoma stem cells and tumor-associated macrophages
  JOURNAL   Sci Rep 14 (1), 2267 (2024)
   PUBMED   38280909
  REMARK    GeneRIF: RARRES2 is involved in the 'lock-and-key' interactions
            between osteosarcoma stem cells and tumor-associated macrophages.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 685)
  AUTHORS   Zabel,B.A., Kwitniewski,M., Banas,M., Zabieglo,K., Murzyn,K. and
            Cichy,J.
  TITLE     Chemerin regulation and role in host defense
  JOURNAL   Am J Clin Exp Immunol 3 (1), 1-19 (2014)
   PUBMED   24660117
  REMARK    GeneRIF: Chemerin functions in host defense as a broad spectrum
            antimicrobial protein against bacteria and fungi and as a leukocyte
            attractant for macrophages.
            Review article
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 685)
  AUTHORS   Wittamer,V., Franssen,J.D., Vulcano,M., Mirjolet,J.F., Le Poul,E.,
            Migeotte,I., Brezillon,S., Tyldesley,R., Blanpain,C., Detheux,M.,
            Mantovani,A., Sozzani,S., Vassart,G., Parmentier,M. and Communi,D.
  TITLE     Specific recruitment of antigen-presenting cells by chemerin, a
            novel processed ligand from human inflammatory fluids
  JOURNAL   J Exp Med 198 (7), 977-985 (2003)
   PUBMED   14530373
REFERENCE   8  (bases 1 to 685)
  AUTHORS   Yokoyama-Kobayashi,M., Yamaguchi,T., Sekine,S. and Kato,S.
  TITLE     Selection of cDNAs encoding putative type II membrane proteins on
            the cell surface from a human full-length cDNA bank
  JOURNAL   Gene 228 (1-2), 161-167 (1999)
   PUBMED   10072769
REFERENCE   9  (bases 1 to 685)
  AUTHORS   Duvic,M., Nagpal,S., Asano,A.T. and Chandraratna,R.A.
  TITLE     Molecular mechanisms of tazarotene action in psoriasis
  JOURNAL   J Am Acad Dermatol 37 (2 Pt 3), S18-S24 (1997)
   PUBMED   9270552
  REMARK    Review article
REFERENCE   10 (bases 1 to 685)
  AUTHORS   Nagpal,S., Patel,S., Jacobe,H., DiSepio,D., Ghosn,C., Malhotra,M.,
            Teng,M., Duvic,M. and Chandraratna,R.A.
  TITLE     Tazarotene-induced gene 2 (TIG2), a novel retinoid-responsive gene
            in skin
  JOURNAL   J Invest Dermatol 109 (1), 91-95 (1997)
   PUBMED   9204961
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX448753.2 and BM919890.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002889.3.
            
            Summary: This gene encodes a secreted chemotactic protein that
            initiates chemotaxis via the ChemR23 G protein-coupled
            seven-transmembrane domain ligand. Expression of this gene is
            upregulated by the synthetic retinoid tazarotene and occurs in a
            wide variety of tissues. The active protein has several roles,
            including that as an adipokine and as an antimicrobial protein with
            activity against bacteria and fungi. [provided by RefSeq, Nov
            2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U77594.2, BI824025.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000223271.8/
                                                  ENSP00000223271.3
            Protein has antimicrobial activity :: PMID: 24660117
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-507               BX448753.2         46-552
            508-685             BM919890.1         488-665
FEATURES             Location/Qualifiers
     source          1..685
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..685
                     /gene="RARRES2"
                     /gene_synonym="HP10433; TIG2"
                     /note="retinoic acid receptor responder 2"
                     /db_xref="GeneID:5919"
                     /db_xref="HGNC:HGNC:9868"
                     /db_xref="MIM:601973"
     exon            1..52
                     /gene="RARRES2"
                     /gene_synonym="HP10433; TIG2"
                     /inference="alignment:Splign:2.1.0"
     exon            53..246
                     /gene="RARRES2"
                     /gene_synonym="HP10433; TIG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..564
                     /gene="RARRES2"
                     /gene_synonym="HP10433; TIG2"
                     /note="retinoic acid receptor responder protein 2;
                     chemerin; RAR-responsive protein TIG2; tazarotene-induced
                     gene 2 protein; retinoic acid receptor responder
                     (tazarotene induced) 2"
                     /codon_start=1
                     /product="retinoic acid receptor responder protein 2
                     precursor"
                     /protein_id="NP_002880.1"
                     /db_xref="CCDS:CCDS5902.1"
                     /db_xref="GeneID:5919"
                     /db_xref="HGNC:HGNC:9868"
                     /db_xref="MIM:601973"
                     /translation="MRRLLIPLALWLGAVGVGVAELTEAQRRGLQVALEEFHKHPPVQ
                     WAFQETSVESAVDTPFPAGIFVRLEFKLQQTSCRKRDWKKPECKVRPNGRKRKCLACI
                     KLGSEDKVLGRLVHCPIETQVLREAEEHQETQCLRVQRAGEDPHSFYFPGQFAFSKAL
                     PRS"
     exon            247..351
                     /gene="RARRES2"
                     /gene_synonym="HP10433; TIG2"
                     /inference="alignment:Splign:2.1.0"
     exon            352..447
                     /gene="RARRES2"
                     /gene_synonym="HP10433; TIG2"
                     /inference="alignment:Splign:2.1.0"
     exon            448..574
                     /gene="RARRES2"
                     /gene_synonym="HP10433; TIG2"
                     /inference="alignment:Splign:2.1.0"
     exon            575..685
                     /gene="RARRES2"
                     /gene_synonym="HP10433; TIG2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      668..673
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RARRES2"
                     /gene_synonym="HP10433; TIG2"
                     /note="hexamer: AATAAA"
     polyA_site      685
                     /gene="RARRES2"
                     /gene_synonym="HP10433; TIG2"
                     /note="major polyA site"
ORIGIN      
        1 aagatttcag ctgcgggacg gtcaggggag acctccaggc gcagggaagg acggccaggg
       61 tgacacggaa gcatgcgacg gctgctgatc cctctggccc tgtggctggg tgcggtgggc
      121 gtgggcgtcg ccgagctcac ggaagcccag cgccggggcc tgcaggtggc cctggaggaa
      181 tttcacaagc acccgcccgt gcagtgggcc ttccaggaga ccagtgtgga gagcgccgtg
      241 gacacgccct tcccagctgg aatatttgtg aggctggaat ttaagctgca gcagacaagc
      301 tgccggaaga gggactggaa gaaacccgag tgcaaagtca ggcccaatgg gaggaaacgg
      361 aaatgcctgg cctgcatcaa actgggctct gaggacaaag ttctgggccg gttggtccac
      421 tgccccatag agacccaagt tctgcgggag gctgaggagc accaggagac ccagtgcctc
      481 agggtgcagc gggctggtga ggacccccac agcttctact tccctggaca gttcgccttc
      541 tccaaggccc tgccccgcag ctaagccagc actgagatgc gtggtgcctc caggaccgct
      601 gcgggtggta accagtggaa gaccccagcc cccagggaga ggaacccgtt ctatccccag
      661 ccatgataat aaagctgctc tccca
//
