LOCUS       NM_206963               1713 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens retinoic acid receptor responder 1 (RARRES1),
            transcript variant 1, mRNA.
ACCESSION   NM_206963
VERSION     NM_206963.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1713)
  AUTHORS   Feng,Y., Sun,Z., Fu,J., Zhong,F., Zhang,W., Wei,C., Chen,A.,
            Liu,B.C., He,J.C. and Lee,K.
  TITLE     Podocyte-derived soluble RARRES1 drives kidney disease progression
            through direct podocyte and proximal tubular injury
  JOURNAL   Kidney Int 106 (1), 50-66 (2024)
   PUBMED   38697478
  REMARK    GeneRIF: Podocyte-derived soluble RARRES1 drives kidney disease
            progression through direct podocyte and proximal tubular injury.
REFERENCE   2  (bases 1 to 1713)
  AUTHORS   Wang,C.H., Tzeng,I.S., Wang,L.K., Wu,C.C., Chen,M.L., Kuo,C.Y.,
            Shyu,R.Y. and Tsai,F.M.
  TITLE     Tazarotene-induced Gene 1 Induces Melanoma Cell Death by Triggering
            Endoplasmic Reticulum Stress Response
  JOURNAL   Front Biosci (Landmark Ed) 29 (6), 233 (2024)
   PUBMED   38940043
  REMARK    GeneRIF: Tazarotene-induced Gene 1 Induces Melanoma Cell Death by
            Triggering Endoplasmic Reticulum Stress Response.
REFERENCE   3  (bases 1 to 1713)
  AUTHORS   Liu,M., Bai,R., Zhang,G., Liu,X., Wang,Z., He,K., Gan,X., Zhou,X.,
            Yin,P., Zheng,Y. and Wang,G.
  TITLE     RARRES1 identified by comprehensive bioinformatic analysis and
            experimental validation as a promising biomarker in Skin Cutaneous
            Melanoma
  JOURNAL   Sci Rep 14 (1), 14113 (2024)
   PUBMED   38898266
  REMARK    GeneRIF: RARRES1 identified by comprehensive bioinformatic analysis
            and experimental validation as a promising biomarker in Skin
            Cutaneous Melanoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1713)
  AUTHORS   Zhang,H., Mulya,A., Nieuwoudt,S., Vandanmagsar,B., McDowell,R.,
            Heintz,E.C., Zunica,E.R.M., Collier,J.J., Bozadjieva-Kramer,N.,
            Seeley,R.J., Axelrod,C.L. and Kirwan,J.P.
  TITLE     GDF15 Mediates the Effect of Skeletal Muscle Contraction on
            Glucose-Stimulated Insulin Secretion
  JOURNAL   Diabetes 72 (8), 1070-1082 (2023)
   PUBMED   37224335
  REMARK    GeneRIF: GDF15 Mediates the Effect of Skeletal Muscle Contraction
            on Glucose-Stimulated Insulin Secretion.
REFERENCE   5  (bases 1 to 1713)
  AUTHORS   Wang,C.H., Wang,L.K., Wu,C.C., Chen,M.L., Kuo,C.Y., Shyu,R.Y. and
            Tsai,F.M.
  TITLE     TIG1 Inhibits the mTOR Signaling Pathway in Malignant Melanoma
            Through the VAC14 Protein
  JOURNAL   Anticancer Res 43 (6), 2635-2643 (2023)
   PUBMED   37247911
  REMARK    GeneRIF: TIG1 Inhibits the mTOR Signaling Pathway in Malignant
            Melanoma Through the VAC14 Protein.
REFERENCE   6  (bases 1 to 1713)
  AUTHORS   Youssef,E.M., Chen,X.Q., Higuchi,E., Kondo,Y., Garcia-Manero,G.,
            Lotan,R. and Issa,J.P.
  TITLE     Hypermethylation and silencing of the putative tumor suppressor
            Tazarotene-induced gene 1 in human cancers
  JOURNAL   Cancer Res 64 (7), 2411-2417 (2004)
   PUBMED   15059893
  REMARK    GeneRIF: Silencing of TIG1 promoter by hypermethylation is common
            in human cancers and may contribute to the loss of retinoic acid
            responsiveness in some neoplastic cells.
REFERENCE   7  (bases 1 to 1713)
  AUTHORS   Zhang,J., Liu,L. and Pfeifer,G.P.
  TITLE     Methylation of the retinoid response gene TIG1 in prostate cancer
            correlates with methylation of the retinoic acid receptor beta gene
  JOURNAL   Oncogene 23 (12), 2241-2249 (2004)
   PUBMED   14691453
REFERENCE   8  (bases 1 to 1713)
  AUTHORS   Jing,C., El-Ghany,M.A., Beesley,C., Foster,C.S., Rudland,P.S.,
            Smith,P. and Ke,Y.
  TITLE     Tazarotene-induced gene 1 (TIG1) expression in prostate carcinomas
            and its relationship to tumorigenicity
  JOURNAL   J Natl Cancer Inst 94 (7), 482-490 (2002)
   PUBMED   11929948
REFERENCE   9  (bases 1 to 1713)
  AUTHORS   Duvic,M., Nagpal,S., Asano,A.T. and Chandraratna,R.A.
  TITLE     Molecular mechanisms of tazarotene action in psoriasis
  JOURNAL   J Am Acad Dermatol 37 (2 Pt 3), S18-S24 (1997)
   PUBMED   9270552
  REMARK    Review article
REFERENCE   10 (bases 1 to 1713)
  AUTHORS   Nagpal,S., Patel,S., Asano,A.T., Johnson,A.T., Duvic,M. and
            Chandraratna,R.A.
  TITLE     Tazarotene-induced gene 1 (TIG1), a novel retinoic acid
            receptor-responsive gene in skin
  JOURNAL   J Invest Dermatol 106 (2), 269-274 (1996)
   PUBMED   8601727
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM919188.1, AK130079.1,
            BC029640.1 and AC080013.17.
            
            On Nov 22, 2018 this sequence version replaced NM_206963.1.
            
            Summary: This gene was identified as a retinoid acid (RA)
            receptor-responsive gene. It encodes a type 1 membrane protein. The
            expression of this gene is upregulated by tazarotene as well as by
            retinoic acid receptors. The expression of this gene is found to be
            downregulated in prostate cancer, which is caused by the
            methylation of its promoter and CpG island. Alternatively spliced
            transcript variant encoding distinct isoforms have been observed.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. It encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK130079.1, BC029640.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000237696.10/ ENSP00000237696.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-551               BM919188.1         156-706
            552-1495            AK130079.1         552-1495
            1496-1497           BC029640.1         1461-1462
            1498-1713           AC080013.17        30786-31001         c
FEATURES             Location/Qualifiers
     source          1..1713
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.32"
     gene            1..1713
                     /gene="RARRES1"
                     /gene_synonym="LXNL; PERG-1; TIG1"
                     /note="retinoic acid receptor responder 1"
                     /db_xref="GeneID:5918"
                     /db_xref="HGNC:HGNC:9867"
                     /db_xref="MIM:605090"
     exon            1..318
                     /gene="RARRES1"
                     /gene_synonym="LXNL; PERG-1; TIG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..927
                     /gene="RARRES1"
                     /gene_synonym="LXNL; PERG-1; TIG1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; latexin-like; phorbol ester-induced gene 1
                     protein; retinoic acid receptor responder protein 1;
                     RAR-responsive protein TIG1; retinoic acid receptor
                     responder (tazarotene induced) 1; tazarotene-induced gene
                     1 protein"
                     /codon_start=1
                     /product="retinoic acid receptor responder protein 1
                     isoform 1 precursor"
                     /protein_id="NP_996846.1"
                     /db_xref="CCDS:CCDS3184.1"
                     /db_xref="GeneID:5918"
                     /db_xref="HGNC:HGNC:9867"
                     /db_xref="MIM:605090"
                     /translation="MQPRRQRLPAPWSGPRGPRPTAPLLALLLLLAPVAAPAGSGDPD
                     DPGQPQDAGVPRRLLQQAARAALHFFNFRSGSPSALRVLAEVQEGRAWINPKEGCKVH
                     VVFSTERYNPESLLQEGEGRLGKCSARVFFKNQKPRPTINVTCTRLIEKKKRQQEDYL
                     LYKQMKQLKNPLEIVSIPDNHGHIDPSLRLIWDLAFLGSSYVMWEMTTQVSHYYLAQL
                     TSVRQWKTNDDTIDFDYTVLLHELSTQEIIPCRIHLVWYPGKPLKVKYHCQELQTPEE
                     ASGTEEGSAVVPTELSNF"
     exon            319..381
                     /gene="RARRES1"
                     /gene_synonym="LXNL; PERG-1; TIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            382..577
                     /gene="RARRES1"
                     /gene_synonym="LXNL; PERG-1; TIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            578..714
                     /gene="RARRES1"
                     /gene_synonym="LXNL; PERG-1; TIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            715..777
                     /gene="RARRES1"
                     /gene_synonym="LXNL; PERG-1; TIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            778..1713
                     /gene="RARRES1"
                     /gene_synonym="LXNL; PERG-1; TIG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1047..1052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RARRES1"
                     /gene_synonym="LXNL; PERG-1; TIG1"
                     /note="hexamer: AGTAAA"
     polyA_site      1068
                     /gene="RARRES1"
                     /gene_synonym="LXNL; PERG-1; TIG1"
                     /note="major polyA site"
     regulatory      1473..1478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RARRES1"
                     /gene_synonym="LXNL; PERG-1; TIG1"
                     /note="hexamer: AATAAA"
     polyA_site      1497
                     /gene="RARRES1"
                     /gene_synonym="LXNL; PERG-1; TIG1"
                     /note="major polyA site"
     regulatory      1565..1570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RARRES1"
                     /gene_synonym="LXNL; PERG-1; TIG1"
                     /note="hexamer: AATGAA"
     polyA_site      1593
                     /gene="RARRES1"
                     /gene_synonym="LXNL; PERG-1; TIG1"
     regulatory      1604..1609
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RARRES1"
                     /gene_synonym="LXNL; PERG-1; TIG1"
                     /note="hexamer: AATAGA"
     polyA_site      1626
                     /gene="RARRES1"
                     /gene_synonym="LXNL; PERG-1; TIG1"
     regulatory      1680..1685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RARRES1"
                     /gene_synonym="LXNL; PERG-1; TIG1"
                     /note="hexamer: ATTAAA"
     polyA_site      1713
                     /gene="RARRES1"
                     /gene_synonym="LXNL; PERG-1; TIG1"
ORIGIN      
        1 gagcccgtgt ctgtcgggtg ccgagccaac tttcctgcgt ccatgcagcc ccgccggcaa
       61 cggctgcctg ctccctggtc cgggcccagg ggcccgcgcc ccaccgcccc gctgctcgcg
      121 ctgctgctgt tgctcgcccc ggtggcggcg cccgcggggt ccggggaccc cgacgaccct
      181 gggcagcctc aggatgctgg ggtcccgcgc aggctcctgc agcaggcggc gcgcgcggcg
      241 cttcacttct tcaacttccg gtccggctcg cccagcgcgc tacgagtgct ggccgaggtg
      301 caggagggcc gcgcgtggat taatccaaaa gagggatgta aagttcacgt ggtcttcagc
      361 acagagcgct acaacccaga gtctttactt caggaaggtg agggacgttt ggggaaatgt
      421 tctgctcgag tgtttttcaa gaatcagaaa cccagaccaa ccatcaatgt aacttgtaca
      481 cggctcatcg agaaaaagaa aagacaacaa gaggattacc tgctttacaa gcaaatgaag
      541 caactgaaaa accccttgga aatagtcagc atacctgata atcatggaca tattgatccc
      601 tctctgagac tcatctggga tttggctttc cttggaagct cttacgtgat gtgggaaatg
      661 acaacacagg tgtcacacta ctacttggca cagctcacta gtgtgaggca gtggaaaact
      721 aatgatgata caattgattt tgattatact gttctacttc atgaattatc aacacaggaa
      781 ataattccct gtcgcattca cttggtctgg taccctggca aacctcttaa agtgaagtac
      841 cactgtcaag agctacagac accagaagaa gcctccggaa ctgaagaagg atcagctgta
      901 gtaccaacag agcttagtaa tttctaaaaa gaaaaaatga tctttttccg acttctaaac
      961 aagtgactat actagcataa atcattcttc tagtaaaaca gctaaggtat agacattcta
     1021 ataatttggg aaaacctatg attacaagta aaaactcaga aatgcaaaga tgttggtttt
     1081 ttgtttctca gtctgcttta gcttttaact ctggaagcgc atgcacactg aactctgctc
     1141 agtgctaaac agtcaccagc aggttcctca gggtttcagc cctaaaatgt aaaacctgga
     1201 taatcagtgt atgttgcacc agaatcagca tttttttttt aactgcaaaa aatgatggtc
     1261 tcatctctga atttatattt ctcattcttt tgaacatact atagctaata tattttatgt
     1321 tgctaaattg cttctatcta gcatgttaaa caaagataat atactttcga tgaaagtaaa
     1381 ttataggaaa aaaattaact gttttaaaaa gaacttgatt atgttttatg atttcaggca
     1441 agtattcatt tttaacttgc tacctacttt taaataaatg tttacatttc taaataatga
     1501 aatgtgttga atgttctcgt gaagatttgt atacaaagga aaaatttgtg ctaaactgga
     1561 attaaatgaa atggtaatat tgcttaactt aaattttaca aataatagaa cgtctgtctc
     1621 accagataaa gctgtctgca aacatgcatc aaaagaaaca ctgatgtaac tgaaagtata
     1681 ttaaatattt acaattttca tttacaagga caa
//
