LOCUS       NM_001243732            2552 bp    mRNA    linear   PRI 03-AUG-2024
DEFINITION  Homo sapiens retinoic acid receptor gamma (RARG), transcript
            variant 3, mRNA.
ACCESSION   NM_001243732
VERSION     NM_001243732.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2552)
  AUTHORS   Li,X.M., Yang,Y., Jiang,F.Q., Hu,G., Wan,S., Yan,W.Y., He,X.S.,
            Xiao,F., Yang,X.M., Guo,X., Lu,J.H., Yang,X.Q., Chen,J.J., Ye,W.L.,
            Liu,Y., He,K., Duan,H.X., Zhou,Y.J., Gan,W.J., Liu,F. and Wu,H.
  TITLE     Histone lactylation inhibits RARgamma expression in macrophages to
            promote colorectal tumorigenesis through activation of
            TRAF6-IL-6-STAT3 signaling
  JOURNAL   Cell Rep 43 (2), 113688 (2024)
   PUBMED   38245869
  REMARK    GeneRIF: Histone lactylation inhibits RARgamma expression in
            macrophages to promote colorectal tumorigenesis through activation
            of TRAF6-IL-6-STAT3 signaling.
REFERENCE   2  (bases 1 to 2552)
  AUTHORS   Gunduz,A., Duman,D., Basbinar,Y., Tasdelen,B., Kupeli,S. and
            Karpuz,D.
  TITLE     The Role of RARG rs2229774, SLC28A3 rs7853758, and UGT1A6*4
            rs17863783 Single-nucleotide Polymorphisms in the
            Doxorubicin-induced Cardiotoxicity in Solid Childhood Tumors
  JOURNAL   J Pediatr Hematol Oncol 46 (1), e65-e70 (2024)
   PUBMED   37828659
  REMARK    GeneRIF: The Role of RARG rs2229774, SLC28A3 rs7853758, and
            UGT1A6*4 rs17863783 Single-nucleotide Polymorphisms in the
            Doxorubicin-induced Cardiotoxicity in Solid Childhood Tumors.
REFERENCE   3  (bases 1 to 2552)
  AUTHORS   Zhang,F.X., Xu,P., Zhang,L.J., Fan,R., Zhang,H.X., Liu,D.H., Liu,K.
            and Shen,D.Y.
  TITLE     RARgamma promotes the invasion and metastasis of thyroid carcinoma
            by activating the JAK1-STAT3-CD24/MMPs axis
  JOURNAL   Int Immunopharmacol 125 (Pt A), 111129 (2023)
   PUBMED   37897947
  REMARK    GeneRIF: RARgamma promotes the invasion and metastasis of thyroid
            carcinoma by activating the JAK1-STAT3-CD24/MMPs axis.
REFERENCE   4  (bases 1 to 2552)
  AUTHORS   Ji,K., Dou,W., Zhang,N., Wen,B., Zhong,M., Zhang,Q., Xu,S., Zhou,J.
            and Liu,J.
  TITLE     Retinoic acid receptor gamma is required for proliferation of
            pancreatic cancer cells
  JOURNAL   Cell Biol Int 47 (1), 144-155 (2023)
   PUBMED   36183362
  REMARK    GeneRIF: Retinoic acid receptor gamma is required for proliferation
            of pancreatic cancer cells.
REFERENCE   5  (bases 1 to 2552)
  AUTHORS   Homma,H., Watanabe,M., Inoue,N., Isono,M., Hidaka,Y. and Iwatani,Y.
  TITLE     Polymorphisms in Vitamin A-Related Genes and Their Functions in
            Autoimmune Thyroid Disease
  JOURNAL   Thyroid 31 (11), 1749-1756 (2021)
   PUBMED   34470463
  REMARK    GeneRIF: Polymorphisms in Vitamin A-Related Genes and Their
            Functions in Autoimmune Thyroid Disease.
REFERENCE   6  (bases 1 to 2552)
  AUTHORS   Lehmann,J.M., Zhang,X.K. and Pfahl,M.
  TITLE     RAR gamma 2 expression is regulated through a retinoic acid
            response element embedded in Sp1 sites
  JOURNAL   Mol Cell Biol 12 (7), 2976-2985 (1992)
   PUBMED   1320193
REFERENCE   7  (bases 1 to 2552)
  AUTHORS   Vollberg,T.M. Sr., Nervi,C., George,M.D., Fujimoto,W., Krust,A. and
            Jetten,A.M.
  TITLE     Retinoic acid receptors as regulators of human epidermal
            keratinocyte differentiation
  JOURNAL   Mol Endocrinol 6 (5), 667-676 (1992)
   PUBMED   1318502
REFERENCE   8  (bases 1 to 2552)
  AUTHORS   Leid,M., Kastner,P., Lyons,R., Nakshatri,H., Saunders,M.,
            Zacharewski,T., Chen,J.Y., Staub,A., Garnier,J.M., Mader,S. et al.
  TITLE     Purification, cloning, and RXR identity of the HeLa cell factor
            with which RAR or TR heterodimerizes to bind target sequences
            efficiently
  JOURNAL   Cell 68 (2), 377-395 (1992)
   PUBMED   1310259
  REMARK    Erratum:[Cell. 1992 Nov 27;71(5):887.. PMID: 1330328]
REFERENCE   9  (bases 1 to 2552)
  AUTHORS   Mattei,M.G., Riviere,M., Krust,A., Ingvarsson,S., Vennstrom,B.,
            Islam,M.Q., Levan,G., Kautner,P., Zelent,A., Chambon,P. et al.
  TITLE     Chromosomal assignment of retinoic acid receptor (RAR) genes in the
            human, mouse, and rat genomes
  JOURNAL   Genomics 10 (4), 1061-1069 (1991)
   PUBMED   1655630
REFERENCE   10 (bases 1 to 2552)
  AUTHORS   Lehmann,J.M., Hoffmann,B. and Pfahl,M.
  TITLE     Genomic organization of the retinoic acid receptor gamma gene
  JOURNAL   Nucleic Acids Res 19 (3), 573-578 (1991)
   PUBMED   1849262
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK297277.1, DC294855.1 and
            BC072462.1.
            
            On May 31, 2019 this sequence version replaced NM_001243732.1.
            
            Summary: This gene encodes a retinoic acid receptor that belongs to
            the nuclear hormone receptor family. Retinoic acid receptors (RARs)
            act as ligand-dependent transcriptional regulators. When bound to
            ligands, RARs activate transcription by binding as heterodimers to
            the retinoic acid response elements (RARE) found in the promoter
            regions of the target genes. In their unbound form, RARs repress
            transcription of their target genes. RARs are involved in various
            biological processes, including limb bud development, skeletal
            growth, and matrix homeostasis. Alternatively spliced transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (3) contains an alternate 5'
            terminal exon, and lacks another coding exon compared to variant 1.
            This results in translation initiation from an alternate start
            codon, and a shorter isoform (3) with a distinct N-terminus
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.4291707.1,
                                           SRR18074967.3774139.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AK297277.1         52-148
            98-98               DC294855.1         85-85
            99-1728             AK297277.1         150-1779
            1729-2552           BC072462.1         2087-2910
FEATURES             Location/Qualifiers
     source          1..2552
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..2552
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /note="retinoic acid receptor gamma"
                     /db_xref="GeneID:5916"
                     /db_xref="HGNC:HGNC:9866"
                     /db_xref="MIM:180190"
     exon            1..413
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..1445
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /note="isoform 3 is encoded by transcript variant 3;
                     RAR-gamma; nuclear receptor subfamily 1 group B member 3"
                     /codon_start=1
                     /product="retinoic acid receptor gamma isoform 3"
                     /protein_id="NP_001230661.1"
                     /db_xref="CCDS:CCDS58237.1"
                     /db_xref="GeneID:5916"
                     /db_xref="HGNC:HGNC:9866"
                     /db_xref="MIM:180190"
                     /translation="MLALPLPPCWSGAPPGEEGESAAGPWCFQHPVSLQAGSRCTTVW
                     KRLPRVRDGCTGRPGPGPACCAEPPAAPVSPDLNLLPGRNPPACNGFFRRSIQKNMVY
                     TCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYEL
                     SPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIK
                     IVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQ
                     MHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEP
                     LLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIRE
                     MLENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA"
     exon            414..555
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            556..716
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            717..893
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1098
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1257
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..2552
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2533..2538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /note="hexamer: AATAAA"
     polyA_site      2552
                     /gene="RARG"
                     /gene_synonym="NR1B3; RARC; RARgamma"
                     /note="major polyA site"
ORIGIN      
        1 agtgctagct gccgaagcac ccagataaga gctggacgga ggctaaagcg gcagccccag
       61 cttcgcgccc cgcccagtcc ctttcccctg ctggggatcc cccctcttcc ccgcccaccc
      121 cttacccgca tgcagcccag cgccctatgc tagccctccc cctccccccc tgctggagcg
      181 gggcgccgcc gggggaggag ggggaatcgg ctgcgggtcc ttggtgtttc cagcacccag
      241 tttcccttca agccgggtcg cgatgtacga ctgtatggaa acgtttgccc cgggtccgcg
      301 acggctgtac ggggcggccg ggcccggggc cggcttgctg cgcagagcca ccggcggctc
      361 ctgtttcgcc ggacttgaat cttttgcctg gccgcaaccc gccagcctgc aatggcttct
      421 ttcgccgaag catccagaag aacatggtgt acacgtgtca ccgcgacaaa aactgtatca
      481 tcaacaaggt gaccaggaat cgctgccagt actgccggct acagaagtgc ttcgaagtgg
      541 gcatgtccaa ggaagctgtg cgaaatgacc ggaacaagaa gaagaaagag gtgaaggaag
      601 aagggtcacc tgacagctat gagctgagcc ctcagttaga agagctcatc accaaggtca
      661 gcaaagccca tcaggagact ttcccctcgc tctgccagct gggcaagtat accacgaact
      721 ccagtgcaga ccaccgcgtg cagctggatc tggggctgtg ggacaagttc agtgagctgg
      781 ctaccaagtg catcatcaag atcgtggagt ttgccaagcg gttgcctggc tttacagggc
      841 tcagcattgc tgaccagatc actctgctca aagctgcctg cctagatatc ctgatgctgc
      901 gtatctgcac aaggtacacc ccagagcagg acaccatgac cttctccgac gggctgaccc
      961 tgaaccggac ccagatgcac aatgccggct tcgggcccct cacagacctt gtctttgcct
     1021 ttgctgggca gctcctgccc ctggagatgg atgacaccga gacagggctg ctcagcgcca
     1081 tctgcctcat ctgcggagac cgcatggacc tggaggagcc cgaaaaagtg gacaagctgc
     1141 aggagccact gctggaagcc ctgaggctgt acgcccggcg ccggcggccc agccagccct
     1201 acatgttccc aaggatgcta atgaaaatca ccgacctccg gggcatcagc actaagggag
     1261 ctgaaagggc cattactctg aagatggaga ttccaggccc gatgcctccc ttaatccgag
     1321 agatgctgga gaaccctgaa atgtttgagg atgactcctc gcagcctggt ccccacccca
     1381 atgcctctag cgaggatgag gttcctgggg gccagggcaa agggggcctg aagtccccag
     1441 cctgaccagg gcccctgacc tccccgctgt gggggttggg gcttcaggca gcagactgac
     1501 catctcccag accgccagtg actgggggag gacctgctct gccctctccc caccccttcc
     1561 aatgagctcc ttgtttttgc caaagtttct aggggtgcct ctgtgttcat ccccttcctg
     1621 atctaaccgg ctccctcgcc agtcccgggg gcctgccctg ctcccaccag gagagagggc
     1681 aaagggatga gcctgggttt ggactctaaa atctcagcac tgccccatgg gtcctagact
     1741 tcccagggca agaggaagac cctgccattc cacagcccct tcctctgcca ggtgcttggc
     1801 tctctgagag caaacaggaa cactagagac caaaaagggg acaaaggaga agggctgagc
     1861 ccaccttctt gctcctaccc ttggtgccta atgctgtgtg atgcacctgc agggtgtgtg
     1921 ctagcctctg tgccccgtcc ttgtgccagg tcaaggtggg ggcaggctgg gccctgcatt
     1981 tctggggcag gaacagaggg tgaaagggac agatagatgc aggtccattc tgcacctctt
     2041 ggctcgggtg cagagttcac cctgtgccct ccgttataag tccctccccc agccctgtca
     2101 tgtgccttgg gctcctcctg ccctccatct cagccattgg ggcagggacc ctcctacact
     2161 acagaggggc caggggatcc ctctctccct agtgccttcc accctttact ccccagagca
     2221 gcttggccca gggagggggg atgctgctta gctgatcccg ccctgaccca gaggaagcct
     2281 ctatttattt attagctttt gtttacaccg tggaattgac cccttcctcc aggggtcttg
     2341 ggtgggggag cccagggccc ctgtgacccc tcctttcttc ctccaatccc cagtttgtat
     2401 ttagctgcca aataagattc ccattggctc cctgtgttct cttggggggt cagggtgctg
     2461 tcccctcccc tctgtttaca tctcccctct accccgctgt atcgcatatt gctgagtttt
     2521 ctatttttgc aaaataaagt gatggaaact ca
//
